New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series
Tools
Tools
Tools
Stauffer, Frederic, Furet, Pascal, Floersheimer, Andreas and Lang, Marc (2012) New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series. Bioorganic & Medicinal Chemistry Letters, 22 (5). pp. 1860-1863. ISSN 0960-894X
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Abstract
Aromatase inhibition is the new standard of care for estrogen receptor positive breast cancer and has also potential for treatment of other diseases such as endometriosis. Simple and readily available 3-pyridyl arylethers and 1-aryl pyrrolo[2,3-c]pyridines recapitulating the key pharmacophore element of Letrozole (1) are described and their structure activity relationships are discussed.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | Aromatase CYP19 Aromatase inhibition |
| Related URLs: | |
| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/5453 |