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New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series

Stauffer, Frederic and Furet, Pascal and Floersheimer, Andreas and Lang, Marc (2012) New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series. Bioorganic & Medicinal Chemistry Letters, 22 (5). pp. 1860-1863. ISSN 0960-894X

Abstract

Aromatase inhibition is the new standard of care for estrogen receptor positive breast cancer and has also potential for treatment of other diseases such as endometriosis. Simple and readily available 3-pyridyl arylethers and 1-aryl pyrrolo[2,3-c]pyridines recapitulating the key pharmacophore element of Letrozole (1) are described and their structure activity relationships are discussed.

Item Type: Article
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Keywords: Aromatase CYP19 Aromatase inhibition
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/5453

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