Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Items where Year is 2013

Up a level
Export as [feed] RSS
Group by: Creators | Item Type | No Grouping
Jump to: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | R | S | T | U | V | W | X | Y | Z
Number of items: 513.


Abazeed, Mohamed E. and Adams, Drew J. and Hurov, Kristen and Tamayo, Pablo and Creighton, Chad J. and Sonkin, Dmitriy and Giacomelli, Andrew O. and Pashtan, Itai and Du, Charles and Fries, Daniel F. and Wong, Kwok-Kin and Mesirov, Jill P. and Loeffler, Jay S. and Schreiber, Stuart L. and Hammerman, Peter S. and Meyerson, Matthew (2013) Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Research, 73 (20). pp. 6289-6298. ISSN 0008-5472.CAN-13-1616

Adamo, Roberto and Proietti, Daniela and Gavini, Massimiliano and Romano, Maria Rosaria and Maclennan, Calman Alexander and Costantino, Paolo and Berti, Francesco (2013) Meningococcal X polysaccharide quantification by high-performance anion-exchange chromatography with pulsed amperometric detection using synthetic N-acetylglucosamine-4-phosphate as standard. Analytical Biochemistry, 44. pp. 259-261.

Alajati, A and Sausgruber, N and Aceto, N and Duss, S and Sarret, S and Voshol, H and Bonenfant, D and Bentires-Alj, M (2013) Mammary Tumor Formation and Metastasis Evoked by a HER2 Splice Variant. CANCER RESEARCH. pp. 5320-5327.


Altstein, L and Li, G (2013) Latent Subgroup Analysis of a Randomized Clinical Trial through a Semiparametric Accelerated Failure Time Mixture Model. BIOMETRICS. pp. 52-61.

Anna-Lena, Gessler and Warncke, Max (2013) Master Thesis: Pathogenese und Keimzentrumsreaktion im Typ 1 Diabetes Mausmodell (Pathogenesis and germinal center reaction in the NOD T1D mouse model). University Freiburg.

Antoine, Daniel and Dear, James and Starkey-Lewis, Philip and Platt, Vivien and Coyle, Judy and Masson, Moyra and Thanacoody, Ruben and Gray, Alastair and Moggs, Jonathan and Bateman, Nicholas and Goldring, Christopher and Park, Kevin (2013) Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital. Journal of Hepatology, 58. ISSN 0168-8278

Antony, D and Becker-Heck, A and Zariwala, MA and Schmidts, M and Onoufriadis, A and Forouhan, M and Wilson, R and Taylor-Cox, T and Dewar, A and Jackson, C and Goggin, P and Loges, NT and Olbrich, H and Jaspers, M and Jorissen, M and Leigh, MW and Wolf, WE and Daniels, MLA and Noone, PG and Ferkol, TW and Sagel, SD and Rosenfeld, M and Rutman, A and Dixit, A and O'Callaghan, C and Lucas, JS and Hogg, C and Scambler, PJ and Emes, RD and Chung, EMK and Shoemark, A and Knowles, MR and Omran, H and Mitchison, HM (2013) Mutations in CCDC39 and CCDC40 are the Major Cause of Primary Ciliary Dyskinesia with Axonemal Disorganization and Absent Inner Dynein Arms. Human Mutation. pp. 462-472.

Arias, HR and Fedorov, NB and Benson, LC and Lippiello, PM and Gatto, GJ and Feuerbach, Dominik and Ortells, MC (2013) Functional and Structural Interaction of (-)-Reboxetine with the Human alpha4beta2 Nicotinic Acetylcholine Receptor. Journal of Pharmacology and experimental therapeutics, 344 (3). pp. 113-123. ISSN 112.197905

Arias, HR and Lopez, JJ and Feuerbach, D and Fierro, A and Ortells, MO and Perez, EG (2013) The International Journal of Biochemistry & Cell Biology. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. pp. 2420-2430.

Arias, HR and Ortells, MO and Feuerbach, Dominik (2013) Interaction of (-)-reboxetine with nicotinic acetylcholine receptors in different conformational states. International Journal of biochemistry and cell biology.

Assenberg, Rene and Wan, Paul and Geisse, Sabine and Mayr, Lorenz (2013) Advances in heterologous expression of recombinant proteins. Current opinion in Structural Biology, 23 (3). pp. 393-402. ISSN 0959-440X

Atassi, F and Behme, RJ and Patel, PJ (2013) Mesomorphous versus traces of crystallinity: The itraconazole example. THERMOCHIMICA ACTA. pp. 133-139.

Auclair, JR and Johnson, JL and Liu, Q and Salisbury, JP and Rotunno, MS and Petsko, GA and Ringe, D and Brown, J and Bosco, DA and Agar, JN (2013) Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage. Biochemistry. pp. 6137-6144.

Auld, D and Lea, W and Davis, MI and Simeonov, A (2013) Literature Search and Review: 3D Cocultures of Multiple Cell Types: What do they do and Where do they Go? Assay and Drug Development Technologies, 11 (8). pp. 457-467.

Auld, D and Lea, W and Davis, MI and Simeonov, A (2013) Literature Search and Review: BLI Coupled with DNA Tetrahedron. Assay and Drug Development Technologies, 11 (3). pp. 139-151. ISSN 1540-658X1557-8127

Auld, D and Lea, W and Davis, MI and Simeonov, A (2013) Literature Search and Review: Better Biosensors for FBDD. Assay and Drug Development Technologies, 11 (5). pp. 289-298. ISSN 1540-658X1557-8127

Auld, D and Lea, W and Davis, MI and Simeonov, A (2013) Literature Search and Review: Detected Through A Quick Glance. Assay and Drug Development Technologies, 11 (1). pp. 1-8. ISSN 1540-658X1557-8127

Auld, DS and Veith, H and Cali, JJ (2013) Bioluminescent assays for cytochrome P450 enzymes. Methods in Molecular Biology. pp. 1-9.

Auld, Douglas and Breault, Lyne and Pandey, Pramod and Ho, Pei-I and Harbinski, Fred and Hill, William (2013) Reporter enzyme inhibitor study to aid assembly of orthogonal reporter gene assays. ACS Chemical Biology, 8 (5). pp. 1009-1017. ISSN 1554-8929

Azzaoui, Kamal and Jacoby, Edgar and Senger, Stefan and Cuadrado Rodríguez, Emiliano and Loza, Mabel and Zdrazil, Barbara and Pinto, Marta and Williams, Antony J and de la Torre, Victor and Mestres, Jordi and Taboureau, Olivier and Rarey, Matthias and Ecker, Gerhard F (2013) Analysis of the scientific competency questions followed by the IMI OpenPHACTS consortium for the development of the semantic web-based molecular information system OPS. Drug Discovery Today, 18 (17-18). pp. 843-852. ISSN 1878-5832


Baba, Nobuyasu and Van, VuQuang and Wakahara, Keiko and Weckbecker, Gisbert and Kolbinger, Frank and Heusser, Christoph and Huber, Thomas and Welzenbach, Karl and Sarfati, Marika (2013) CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med..

Baeten, Dominique and Baraliakos, Xenofon and Braun, Juergen and Sieper, Joachim and Emery, Paul and Van der Heijde, Desiree and McInnes, Iain and Van Laar, Jacob and Landewé, Robert and Wordsworth, Paul and Wollenhaupt, Jürgen and Kellner, Herbert and Paramarta, Jacqueline and Wei, Jiawei and Brachat, Arndt Holger and Bek, Stephan and Laurent, Didier and Li, Yali and Bertolino, Arthur and Gsteiger, Sandro and Wright, Andrew and Hueber, Wolfgang (2013) Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial. The Lancet, 382 (9906). pp. 1705-1713. ISSN 01406736

Balibar, Carl and Mcguire, Dorothy and Dean, Charles (2013) Elongation Factor P is dispensable in Escherichia coli and Pseudomonas aeruginosa. Current Microbiology, 284. ISSN 0343-8651

Ballabeni, A and Zamponi, R and Moore, JK and Helin, K and Kirschner, MW (2013) Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. E2848-E2853.

Ballard, Sarah and Engeloch, Caroline and Baeschlin, Daniel (2013) Automated compound management evolves to meet the drug discovery demands of the future. Drug Discovery world.

Baltus, Christine and Press, Neil and Coles, Simon and Tizzard, Graham and Spencer, John and Chuckowree, Irina and Day, Iain (2013) Olefin cross-metathesis/Suzuki-Miyaura reactions on 4-vinylphenylboronic acid pinacol ester. Tetrahedron Letters, 54 (10). pp. 1211-1217. ISSN 0040-4039

Bardelli, M and Alleri, L and Angiolini, F and Buricchi, F and Tavarini, S and Sammicheli, C and Nuti, S and Degl'Innocenti, E and Isnardi, I and Fragapane, E and Del, GG and Castellino, F and Galli, G (2013) Ex Vivo Analysis of Human Memory B Lymphocytes Specific for A and B Influenza Hemagglutinin by Polychromatic Flow-Cytometry. PLoS One.

Barnes, David and Jain, Monish and Bell, Leslie and Ferreira, Suzie and Cohen, Scott and Chen, Xiao-Hui and Amin, Jakal and Snodgrass, Bradley and Hatsis, Panagiotis (2013) Metabolically Stable tert-Butyl Replacement. ACS Medicinal Chemistry Letters. ISSN 1948-5875

Barteau, Samuel and Heudi, Olivier and Kameni Tcheudji, Jacques and Streckfuss, Judith and Tukulula, Matshawandile and Njoroge, Mathew and Mugumbate, Grace and Little, Susan and Grut, Jiri and Rosenthal, Philip J and Wan, Baojie and Franzblau, Scott G and Chibale, Kelly (2013) Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial and antituberculosis agents. Journal of medicinal chemistry, 21 (17). pp. 4904-4913. ISSN 09680896

Bartels, Christian and Looby, Michael and Sechaud, Romain and Kaiser, Guenther (2013) Determination of the pharmacokinetics of glycopyrronium in the lung using a population pharmacokinetic modeling approach. Britisch Journal of Clinical Pharmacology. ISSN 0306-5251

Basu, A and Bodycombe, NE and Cheah, JH and Price, EV and Liu, K and Schaefer, GI and Ebright, RY and Stewart, ML and Ito, D and Wang, S and Bracha, AL and Liefeld, T and Wawer, M and Gilbert, JC and Wilson, AJ and Stransky, N and Kryukov, GV and Dancik, V and Barretina, J and Garraway, LA and Hon, CSY and Munoz, B and Bittker, JA and Stockwell, BR and Khabele, D and Stern, AM and Clemons, PA and Shamji, AF and Schreiber, SL (2013) An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. pp. 1151-1161.

Beck, Valerie and Leighton-Davies, Juliet and Beibel, Martin and Roma, Guglielmo and Oakeley, Edward James and Hamon, Jacques and Barbieri, Samuel and Preuss, Inga and Lasbennes-Eckerlen, Marie-Christine and Sailer, Andreas and Suply, Thomas and Seuwen, Klaus and Parker, Christian and Bassilana, Frederic and Lannoy, Vincent and bernard, Jerome and Hannedouche, Sebastien (2013) The identification of the C3a Receptor (C3AR1) as the target of the VGF derived peptide TLQP-21 in rodent cells. Journal of Biological Chemistry, 288 (38). pp. 27434-27443. ISSN 0021-9258

Beckett, Martin (2013) Book Review: Practical Process Research and Development, second edition by Neal G. Anderson, Elsevier, 2012. Chemistry and Industry, Januar. p. 49.

Beckett, Martin (2013) Book review: Organic Synthesis: State of the Art 2009-2011 by Douglass F Taber, Wiley, 2013. Chemistry and Industry, Septem (Septem). pp. 46-47.

Beckman, David and Schneider, Marilynn and Decristofaro, Marc and Samadfam, Rana and Smith, Susan and Pouliot, Louise (2013) Assessment of a nonsteroidal aromatase inhibitor, letrozole, in juvenile rats. Birth Defects Research, 98 (5). pp. 374-390. ISSN 1542-9741

Beckman, David and Youreneff, Maureen and Butt, Mark (2013) Neurotoxicity assessment of artemether in juvenile rats. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 98 (2). pp. 183-199. ISSN 1542-9741

Beckmann, N and Kaltashov, IA (2013) Delivery of biopharmaceuticals: advanced analytical and biophysical methods Preface. ADVANCED DRUG DELIVERY REVIEWS. 1001-.

Bentz, J and O'Connor, MP and Bednarczyk, D and Coleman, J and Lee, C and Palm, J and Pak, YA and Perloff, ES and Reyner, E and Balimane, P and Brannstrom, M and Chu, X and Funk, C and Guo, A and Hanna, I and Heredi-Szabo, K and Hillgren, K and Li, L and Hollnack-Pusch, E and Jamei, M and Lin, X and Mason, AK and Neuhoff, S and Patel, A and Podila, L and Plise, E and Rajaraman, G and Salphati, L and Sands, E and Taub, ME and Taur, JS and Weitz, D and Wortelboer, HM and Xia, CQ and Xiao, G and Yabut, J and Yamagata, T and Zhang, L and Ellens, H (2013) Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria. DRUG METABOLISM AND DISPOSITION. pp. 1347-1366.

Bereau, T and Kramer, C and Monnard, FW and Nogueira, ES and Ward, TR and Meuwly, M (2013) Scoring Multipole Electrostatics in Condensed-Phase Atomistic Simulations. JOURNAL OF PHYSICAL CHEMISTRY B. pp. 5460-5471.

Betschart, Claudia and Hintermann, Samuel and Behnke, Dirk and Cotesta, Simona and Fendt, Markus and Gee, Christine and Jacobson, Laura and Laue, Grit and Ofner, Silvio and Chaudhari, Vinod and Badiger, Sangamesh and Pandit, Chetan and Wagner, Juergen and Hoyer, Daniel (2013) Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia. Journal of Medicinal Chemistry.

Bian, X and Fu, J and Plaza, A and Herrmann, J and Pistorius, D and Stewart, AF and Zhang, Y and Muller, R (2013) In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation. ChemBioChem, 14 (10). pp. 1194-1197. ISSN 14394227

Bignon, Alexandre and Gaudin, Françoise and Hémon, Patrice and Tharinger, Hugo and Loetscher, Pius and Peuchmaur, Michel and Berrebi, Dominique and Balabanian, Karl (2013) Pivotal role of Ccr1 in murine lupus nephritis. Journal of Immunology.

Billedeau, RJ and Klein, KR and Kaplan, D and Lou, Y (2013) A New Pyrrole Synthesis via Silver(I)-Catalyzed Cycloaddition of Vinylogous Diazoester and Nitrile. ORGANIC LETTERS. pp. 1421-1423.

Billich, Andreas and Baumruker, Thomas and Beerli, Christian and Bigaud, Marc and Bruns, Christian and Calzascia, Thomas and Isken, Andrea and Kinzel, Bernd and Loetscher, Erika and Metzler, Barbara and Mueller, Matthias and Nuesslein-Hildesheim, Barbara and Kleylein-Sohn, Bernadette (2013) Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLOS ONE, 8 (3). e59630. ISSN 1932-6203

Billich, Andreas and Beerli, Christian and Bruns, Christian and Loetscher, Erika (2013) Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. Analytical Biochemistry, 434 (2). pp. 247-253. ISSN 0003-2697

Biukovic, Goran and Basak, Sandip and Manimekalai, Malathy Sony Subramanian and Rishikeshan, Sankaranarayanana and Roessle, Manfred and Dick, Thomas and Rao, Srinivasa and Hunke, Cornelia and Gruber, Gerhard (2013) Variations of subunit Varepsilon of the Mycobacterium tuberculosis F-1Fo ATP Synthase and Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207. Antimicrobial Agents and Chemotherapy, 57 (1). pp. 168-176. ISSN 0066-4804

Blache, U and Silvan, U and Plodinec, M and Suetterlin, R and Jakob, R and Klebba, I and Bentires-Alj, M and Aebi, U and Schoenenberger, CA (2013) A Tumorigenic Actin Mutant Alters Fibroblast Morphology and Multicellular Assembly Properties. CYTOSKELETON. pp. 635-650.

Bobardt, M and Hopkins, S and Baugh, J and Chatterji, U and Hernandez, F and Hiscott, J and Sluder, A and Lin, K and Gallay, PA (2013) HCV NS5A and IRF9 compete for CypA binding. JOURNAL OF HEPATOLOGY. pp. 16-23.

Bolton, SA and Sutton, JC and Anumula, R and Bisacchi, GS and Jacobson, B and Slusarchyk, WA and Treuner, UD and Wu, SC and Zhao, G and Pi, Z and Sheriff, S and Smirk, RA and Bisaha, S and Cheney, DL and Wei, A and Schumacher, WA and Hartl, KS and Liu, E and Zahler, R and Seiler, SM (2013) Discovery of nonbenzamidine factor VIla inhibitors using a biaryl acid scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. pp. 5239-5243.

Bouchez, Laure and Ruffner, Heinz and Spanka, Carsten and Patoor, Maude (2013) Synthesis of a Series of Promising Isobenzofurans for the Reduction of Acute Mucositis Risk after Chemo- and Radiotherapy. Synlett- special edition.

Boulton, C and David, OJ and Meiser, K and Schmouder, R (2013) Tolerability and pulmonary pharmacodynamic effects during treatment initiation of once-daily oral fingolimod in subjects with moderate asthma. Clinical Pharmacology in Drug Development. pp. 2-10.

Bowman, SK and Simon, MD and Deaton, AM and Tolstorukov, M and Borowsky, ML and Kingston, RE (2013) Multiplexed Illumina sequencing libraries from picogram quantities of DNA. BMC Genomics.

Brauchle, Michael and Yao, Zhiping and Arora, Rishi and Clay, Ieuan and Inverardi, Bruno and Gerrits, Bertran and Voshol, Johannes and Bauer, Andreas and Schuebeler, Dirk and Bouwmeester, Antonius and Ruffner, Heinz and Thigale, Sachin (2013) A systematic comparison of enzymatic activity and protein interaction analysis of the KDM3 histone demethylase subfamily. PLOS ONE, 8 (4). e60549. ISSN 1932-6203

Breckner, Anke and Gerwin, Nicole and Richter, Jens and Rausch, Martin and Marcellin, David and Ganz, Magdalena (2013) Effect of calstabin1 depletion on calcium transients and energy utilization in FDB muscle fibers and potential treatment opportunities based on RyR1 stabilizers. The Journal of Biological Chemistry, 8 (11). ISSN 1932-6203

Breitenstein, Werner and Cumin, Frederic and Ehrhardt, Claus and Jacoby, Edgar and Lorthiois, Edwige and Ostermann, Nils and Sellner, Holger and Kosaka, Takatoshi and Webb, Randy and Hassiepen, Ulrich and Wagner, Beatrix and Maibaum, Juergen Klaus (2013) Discovery from in silico 3D Pharmacophore Searches of Novel 3(R),4(S)-disubstituted Pyrrolidine Inhibitors of the Human Aspartyl Protease Renin. Journal of Medicinal Chemistry, 56 (6). pp. 2207-2217. ISSN 0022-2623

Bridges, James P. and Ludwig, Marie-Gabrielle and Mueller, Matthias and Kinzel, Bernd and Sato, Atsuyasu and Xu, Yan and Whitsett, Jeffery A. and Ikegami, Machiko (2013) The Orphan G Protein-Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size. American Journal of Respiratory Cell and Molecular Biology. ISSN 1044-1549

Britschgi, Adrian and Bill, Anke and Brinkhaus, Heike and Rothwell, Christopher and Clay, Ieuan and Duss, Stephan and Rebhan, Michael and Raman, Pichai and Guy, Chantale and Wetzel, Kristie and George, Elizabeth and Popa, Oana and Lilley, Sarah and Choudhury, Hedaythul and Gosling, Martin and Wang, Louis and Fitzgerald, Stephanie and Borawski, Jason and Baffoe, Jonathan and Labow, Mark and Gaither, Larry and Bentires-Alj, Mohamed (2013) Inhibition of the 11q13 amplified calcium activated chloride channel ANO1 reduces Head and Neck and Breast cancer growth. PNAS, 110 (11). E1026-E1034. ISSN 0027-8424

Bulliard, Yannick and Jolicoeur, Rose and Windman, Maurice and Rue, Sarah M and Ettenberg, Seth and Knee, Deborah A and Wilson, Nicholas S and Dranoff, Glenn and Brogdon, Jennifer L (2013) Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. The Journal of Experimental Medicine, 210 (9). pp. 1685-1693. ISSN 1540-9538

Burger, Matthew and Han, Wooseok and Lan, Jiong and Nishiguchi, Gisele and Bellamacina, Cornelia and Lindvall, Mika and Atallah, Gordana and Ding, Yu and Mathur, Michelle and Mcbride, Christopher and Mieuli, Elizabeth and Muller, Kristine and Tamez Jr., Victoriano and Zhang, Yanchen and Huh, Kay and Feucht, Paul and Zavorotinskaya, Tatiana and Dai, Yumin and Holash, Jocelyn and Langowski, John and Garcia, Pablo (2013) Structure Guided Optimization, In Vitro Activity and In Vivo Activity of Pan-PIM Kinase Inhibitors. American Chemical Society Medicinal Chemistry Letters, 4 (12). pp. 1193-1197.

Burmester, Gerd and Durez, Patrick and Shestakova, Galina and Genovese, Mark and Schulze-Koops, Hendrik and Li, Yue and Lewitzky, Steven and Koroleva, Irina and Agarwal, Anni and Lee, David and Hueber, Wolfgang (2013) Caspase 8 modulates the polarisome to prevent lung fibrosis in a murine SSC-like disease model. Arthritis and Rheumatism, 65 (Suppl.). S1171. ISSN 00043591

Butendeich, Heike and Pierret, Noelle and Numao, Shin (2013) Evaluation of a liquid dispenser for assay development and enzymology in 1536 well format. Journal of Laboratory Automation, 18 (3). pp. 245-250. ISSN 2211-0682

Byun, M and Ma, CS and Akcay, A and Pedergnana, V and Palendira, U and Myoung, J and Avery, DT and Liu, Y and Abhyankar, A and Lorenzo, L and Schmidt, M and Lim, HK and Cassar, O and Migaud, M and Rozenberg, F and Canpolat, N and Aydogan, G and Fleckenstein, B and Bustamante, J and Picard, C and Gessain, A and Jouanguy, E and Cesarman, E and Olivier, M and Gros, P and Abel, L and Croft, M and Tangye, SG and Casanova, JL (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. JOURNAL OF EXPERIMENTAL MEDICINE. pp. 1743-1759.


Cai, Mi and Yang, Yi (2013) Targeted genome editing tools for disease modeling and gene therapy. Current Gene Therapy.

Cai, Xinming and Xu, Yongyao and Cheung, Atwood and Tomlinson, Ronald and Alcazer-Roman, Abel and Murphy, Leon and Billich, Andreas and Feng, Yan and Zhang, Bailin and Klumpp, Martin and Rondeau, Jean-Michel and Fazal, Aleem and Wilson, Christopher and Myer, Vic and Joberty, Gerard and Bouwmeester, Antonius and Labow, Mark and Finan, Peter and Porter, Jeffrey and Ploegh, Hidde and Baird, Daniel and De Camilli, Pietro and Tallarico, John and Huang, Qian (2013) PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling. Chemistry & Biology, 20. pp. 912-921.

Callander, Gabrielle E. and Olorunda, Morenike and Monna, Dominique and Schuepbach, Edi and Langenegger, Daniel and Betschart, Claudia and Hintermann, Samuel and Briard, Emmanuelle and Behnke, Dirk and Cotesta, Simona and Fendt, Markus and Laue, Grit and Ofner, Silvio and Gee, Christine and Jacobson, Laura and Hoyer, Daniel (2013) Kinetic properties of 'dual' orexin receptor antagonists at OX1 and Ox2 receptors. Frontiers in Neuroscience, Neuropharmacology., 7. p. 230. ISSN 1662-453X

Casado, P and Rodriguez-Prados, J and Cosulich, SC and Guichard, S and Vanhaesebroeck, B and Joel, S and Cutillas, PR (2013) Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Science Signaling. rs6-.

Castiello, MC and Bosticardo, M and Pala, F and Catucci, M and Chamberlain, N and van Zelm, MC and Driessen, GJ and Pac, M and Bernatowska, E and Scaramuzza, S and Aiuti, A and Sauer, AV and Traggiai, E and Meffre, E and Villa, A and van der Burg, M (2013) Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. Autoimmunity.

Catanese, MT and Loureiro, J and Jones, CT and Dorner, M and von, HT and Rice, MC (2013) Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission. Journal of Virology. pp. 8282-8293.

Chakraborty, Abhijit and Van, Linh and Skerjanec, Andrej and Floch, David and Klein, Ulf and Krammer, Gerhard and Sunkara, Gangadhar and Howard, Danny (2013) Pharmacokinetic and pharmacodynamic properties of canakinumab in patients with gouty arthritis. Journal of Clinical Pharmacology, 53 (12). pp. 1240-1251. ISSN 0091-2700

Chan, HCS and Kendrick, J and Neumann, MA and Leusen, FJJ (2013) Towards ab initio screening of co-crystal formation through lattice energy calculations and crystal structure prediction of nicotinamide, isonicotinamide, picolinamide and paracetamol multi-component crystals. CRYSTENGCOMM. pp. 3799-3807.

Chandriani, Sanjay and Skewes-Cox, Peter and Zhong, Weidong and Ganem, Donald and Divers, Thomas J. and Tennant, Bud C. and Van Blaricum, Anita J. and Kistler, Amy (2013) Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis. Proceedings of the National Academy of Sciences USA, 110 (15). E1407-1415. ISSN 0027-8424

Chang, Henry and Ganem, Donald (2013) A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity. Cell Host & Microbe, 13 (4). pp. 429-440. ISSN 1931-3128

Che, Jianwei and Guo, Zuojun and Li, Bo and Cheng, Li-Tien and Dzubiella, Joachim and McCammon, J. Andrew (2013) Evaluation of Hydration Free Energy by the Level-Set Variational Implicit-Solvent Model with the Coulomb-Field Approximation. Journal of chemical theory and computation. ISSN 1549-9618

Chen, Jinyun and Chung, Franklin and Yang, Guizhi and Pu, Minying and Gao, Hui and Jiang, Wei and Yin, Hong and Capka, Vladimir and Kasibhatla, Shailaja and Laffitte, Bryan and Pagliarini, Raymond and Chen, Yaoyu and Zhou, Wenlai (2013) Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget, 4 (12). pp. 2502-2511. ISSN 1949-2553

Chen, Y and Li, S (2013) Molecular signatures of chronic myeloid leukemia stem cells. Biomarker Research.

Chen, Yaoyu and Chen, Jinyun and Loo, Alice and Jaeger, Savina and Bagdasarian, Linda and Yu, Jianjun and Chung, Franklin and Korn, Joshua and Ruddy, David and Guo, Ribo and Mclaughlin, Megan and Stegmeier, Frank and Pagliarini, Raymond and Porter, Dale and Zhou, Wenlai (2013) Targeting HSF1 sensitizes cancer cells to HSP90 inhibitor. Oncotarget.

Cheng, CH and Leferovich, J and Zhang, XM and Bedelbaeva, K and Gourevitch, D and Hatcher, CJ and Basson, CT and Heber-Katz, E and Marx, KA (2013) Keratin gene expression profiles after digit amputation in C57BL/6 vs. regenerative MRL mice imply an early regenerative keratinocyte activated-like state. PHYSIOLOGICAL GENOMICS. pp. 409-421.

Cheng, DT and Kim, DK and Cockayne, DA and Belousov, A and Bitter, H and Cho, MH and Duvoix, A and Edwards, LD and Lomas, DA and Miller, BE and Reynaert, N and Tal-Singer, R and Wouters, EFM and Agusti, A and Fabbri, LM and Rames, A and Visvanathan, S and Rennard, SI and Jones, P and Parmar, H and MacNee, W and Wolff, G and Silverman, EK and Mayer, RJ and Pillai, SG (2013) Systemic Soluble Receptor for Advanced Glycation Endproducts Is a Biomarker of Emphysema and Associated with AGER Genetic Variants in Patients with Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. pp. 948-957.

Cheng, Tiewei and Roth, Beat and Woonyoung, Choi and Black, Peter and Dinney, Colin and McConkey, David J. (2013) Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: Implications for therapeutic targeting. PLoS ONE, 8 (2). e57284-e57284. ISSN 1932-6203

Chivers, Simon (2013) Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis. Birth Defects Research Part B - Developmental and Reproductive Toxicology, 98 (6). pp. 459-485. ISSN 1542-9733

Christensen, Jesper and Litherland, Karine and Van De Kerkhof, Esther and Natt, Francois and Hunziker, Juerg and Faller, Thomas and Krauser, Joel and Swart, Pieter Jacob (2013) Metabolism Studies of Unformulated Internally [3H]-labeled siRNAs in Mice. Drug metabolism Disposition, 41 (6). pp. 1211-1219. ISSN 0090-9556

Chung, LM and Ferguson, JP and Zheng, W and Qian, F and Bruno, V and Montgomery, RR and Zhao, HY (2013) Differential expression analysis for paired RNA-seq data. BMC Bioinformatics.

Cloutier, N and Tan, S and Boudreau, LH and Cramb, C and Subbaiah, R and Lahey, L and Albert, A and Shnayder, R and Gobezie, R and Nigrovic, PA and Farndale, RW and Robinson, WH and Brisson, A and Lee, DM and Boilard, E (2013) The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: The microparticle-associated immune complexes. EMBO Molecular Medicine. pp. 235-249.

Collman, Emilie and Bohnacker, Thomas and Marone, Romina and Dawson King, Janet and Rehburg, Markus and Stringer, Rowan and Krombach, Fritz and Burkhart, Christoph and Hirsch, Emilio and Hollingworth, Greg and Thomas, Matthew and Wymann, Matthias (2013) Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells’ route to allergy. Journal of Allergy and Clinical Immunology, 132 (4). pp. 959-968. ISSN 00916749

Corbin, AS and O'Hare, T and Gu, Z and Kraft, IL and Eiring, AM and Khorashad, JS and Pomicter, AD and Zhang, TY and Eide, CA and Manley, PW and Cortes, JE and Druker, BJ and Deininger, MW (2013) KIT Signaling Governs Differential Sensitivity of Mature and Primitive CML Progenitors to Tyrosine Kinase Inhibitors. CANCER RESEARCH. pp. 5775-5786.

Cotton, Graham and Bowen, Wayne and Grundy, Robert and Hassiepen, Ulrich (2013) Fluorescence Lifetime Assays. Drug Discovery World.


Dalvit, Claudio and Young Ko, Soo and Vulpetti, Anna (2013) Application of the rule of shielding in the design of novel fluorinated molecules and peptidomimetics. Journal of Fluorine Chemistry, 152. pp. 129-135. ISSN 0022-1139

Damiano, Jason and Wasserman, Ernesto (2013) Molecular Pathways: Blockade of the PRLR Signaling Pathway as a Novel Anti-hormonal Approach for the Treatment of Breast and Prostate Cancer. Clinical Cancer Research. ISSN 1078-0432

Dand , Nick and Weale, Michael and Schulz, Reiner and Oakey, Rebecca and Simpson, Michael and Schlitt, Thomas (2013) Network-informed gene ranking tackles genetic heterogeneity in exome-sequencing studies of monogenic disease. Human Mutation.

Das Thakur, Meghna and Stuart, Darrin (2013) The evolution of melanoma resistance reveals therapeutic opportunities. Cancer Research, 73 (20). pp. 6106-6110. ISSN 0008-5472

David, DeOrnellis (2013) An insurance policy (and more) for the animal care and use program. Lab Animal, 42 (11). ISSN 1548-4475

Davis, MI and Sasaki, AT and Shen, M and Emerling, BM and Thorne, N and Michael, S and Pragani, R and Boxer, M and Sumita, K and Takeuchi, K and Auld, DS and Li, Z and Cantley, LC and Simeonov, A (2013) A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation. PLoS One.

Day, ES and Capili, AD and Borysenko, CW and Zafari, M and Whitty, A (2013) Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore. Analytical Biochemistry. pp. 96-107.

De, N and Young, L and Lau, PW and Meisner, NC and Morrissey, DV and MacRae, IJ (2013) Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2. MOLECULAR CELL. pp. 344-355.

DeOrnellis, D (2013) An insurance policy (and more) for the animal care and use program. Lab Animal. 433-.

Deng, Y and Wang, Z and Wang, R and Zhang, X and Zhang, S and Wu, Y and Staufenbiel, M and Cai, F and Song, W (2013) Amyloid- protein (A) Glu11 is the major -secretase site of -site amyloid- precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to A Asp1 contributes to Alzheimer pathogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE. pp. 1962-1969.

Deornellis, David and D'Anna, Amy and Astrofsky, Keith (2013) Techniques Training: Rat. American Association for Laboratory Animal Science, Memphis, TN.

Dhuria, Shyeilla and Einolf, Heidi and Mangold, James and Sen, Suman and Wang, Lai and Gu, Huiping and Cameron, John (2013) Time-dependent inhibition and induction of human cytochrome P450A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects. Journal of Clinical Pharmacology, 63 (6). pp. 642-653. ISSN 0091-2700

Didiot, Marie-Cecile and Agarinis, Claudia and Varin, Thibault and Wu, Hua and Nelson, Thomas and Selinger, Douglas and King, Frederick and Schuffenhauer, Ansgar and Parker, Christian (2013) Glucocorticoid receptor ligands modulate EMCV Internal Ribosome Entry Site Activity. ASSAY and Drug Development Technologies, 11 (6). pp. 355-366.

Dienstmann, Rodrigo and Rodon, Jordi and Barretina, Jordi and Tabernero, Josep (2013) The genomic medicine frontier in human solid tumors: prospects and challenges. Journal of Clinical Oncology, 31 (15). pp. 1874-1884. ISSN 0732-183X

Dincer, Zuhal and Schadt, Heiko and Junker Walker, Ursula and Piaia, Alessandro and Pognan, Francois and Cordier, Andre and Spence, Fiona and Chibout, Salah-Dine (2013) The effects of PKC (Protein Kinase C) inhibitors on steroid hormones: a 2-week rat oral (gavage) investigative study focusing on pathology and hormone analysis in plasma and tissues. ESTP 2013 Congress.

Doberentz, E and Schumacher, R and Gembruch, U and Gasser, JA and Mueller, AM (2013) Coronal Vertebral Clefts: A Radiological Indicator for Chromosomal Aberrations. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. pp. 1-6.

Dodd, RD and Mito, JK and Eward, WC and Chitalia, R and Sachdeva, M and Ma, Y and Barretina, J and Dodd, L and Kirsch, DG (2013) NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to mek inhibition. MOLECULAR CANCER THERAPEUTICS. pp. 1906-1917.

Doelemeyer, Arno and De Vera Mudry, Maria Christina and Kohler, Manfred and Schorsch, Frederic (2013) The CEPA* industry working group’s approach to image analysis based cell proliferation studies using electronic images. Toxicologic Pathology.

Doucet, Julie and Fu, Jean and Zhao, An and Avrameas, Alexandre (2013) Development and validation of an ELISA at acidic pH for the quantitative determination of IL-13 in human plasma and serum. Journal of Pharmaceutical and Biomedical Analysis, 35. pp. 465-474. ISSN 0278-02401875-8630

Dranchak, P and MacArthur, R and Guha, R and Zuercher, WJ and Drewry, DH and Auld, DS and Inglese, J (2013) Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays. PLoS One.

Dreier, Oliver and Brasse, Hannah and Ingles, Sara and Schweigler, Patrick and Melkko, Samu (2013) Accurate, Fast and Facile Preparation of Compound Dilution Series by Digital Dispensing. GEN Genetic Engineering & Biotechnology News, 33 (11).

Dumitras, Swati and Sechaud, Romain and Drollmann, Anton Franz and Pal, Parasar and Vaidyanathan, Sivakumar and Camenisch, Gian P. and Kaiser, Guenther (2013) Effect of cimetidine, a model drug for inhibition of the organic cation transport in the kidney, on the pharmacokinetics of glycopyrronium. International Journal of Clinical Pharmacology and Therapeutics, 51 (10). pp. 771-779.

d'Offay, JM and Eberle, R and Wolf, RF and Kosanke, SD and Doocy, KR and Ayalew, S and Mansfeild, KG and White, GL (2013) Simian T-lymphotropic Virus-Associated Lymphoma in 2 Naturally Infected Baboons: T-cell Clonal Expansion and Immune Response during Tumor Development. COMPARATIVE MEDICINE. pp. 288-294.

de Lichtervelde, L and Boitano, AE and Wang, Y and Krastel, P and Petersen, F and Cooke, MP and Schultz, PG (2013) Eupalinilide E Inhibits Erythropoiesis and Promotes the Expansion of Hematopoietic Progenitor Cells. ACS CHEMICAL BIOLOGY. pp. 866-870.


Egerman, Marc and Glass, David (2013) Signaling pathways controlling skeletal muscle mass. Critical Reviews in Biochemistry and Molecular Biology, 49 (1). pp. 59-68. ISSN 1040-9238

Egger, Christine and Cannet, Catherine and Gerard Sachot, Christelle and Jarman, Elizabeth and Jarai, Gabor and Feige, Agnes and Suply, Thomas and Dunbar, Andrew W. and Tigani, Bruno and Beckmann, Nicolau (2013) Administration of Bleomycin via the Oropharyngeal Aspiration Route Leads to Sustained Lung Fibrosis in Mice and Rats as Quantified by UTE-MRI and Histology. PLoS ONE, 8 (5). ISSN 1932-6203

Einolf, Heidi and Chen, Liangfu and Fahmi, Odette and Gibson, Christopher and Obach, Scott and Shebley, Mohamad and Silva, Jose and Sinz, Michael and Unadkat, Jashvant and Zhang, Lei and Zhao, Ping (2013) Assessing modeling methods for predicting clinical CYP3A induction: A collaborative effort among academic, government regulatory, and pharmaceutical industry scientists. Clinical Pharmacology and Therapeutics, 95 (2). pp. 179-188. ISSN 1532-6535

Elkabets, Moshe and Vora, Sadhna and Juric, Dejan and Morse, Natasha and Mino-Kenudson, Mari and Muranen, Taru and Tao, Jessica and Bosch Campos, Ana and Rodon, Jordi and Ibrahim, Yasir and Rodrik-Outmezguine, Vanessa and Quadt, Cornelia and Huang, Alan and Brugge, Joan and Rosen, Neal and Engelman, Jeffrey A. and Scaltriti, Maurizio and Baselga, Jose (2013) mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PI3CA-mutant breast cancer. Science Translational Medicine, 5 (196).

Ellens, H and Deng, S and Coleman, J and Bentz, J and Taub, ME and Ragueneau-Majlessi, I and Chung, SP and Heredi-Szabo, K and Neuhoff, S and Palm, J and Balimane, P and Zhang, L and Jamei, M and Hanna, I and O'Connor, M and Bednarczyk, D and Forsgard, M and Chu, X and Funk, C and Guo, A and Hillgren, KM and Li, L and Pak, AY and Perloff, ES and Rajaraman, G and Salphati, L and Taur, JS and Weitz, D and Wortelboer, HM and Xia, CQ and Xiao, G and Yamagata, T and Lee, CA (2013) Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions. DRUG METABOLISM AND DISPOSITION. pp. 1367-1374.

Erdemli, Gul (2013) Phenotypic screening in the 21st century. Frontiers in Pharmacology Research Topics, 5. p. 264. ISSN 1663-9812

Erdemli, Gul and Mikhailov, Dmitri and Kim, Albert (2013) Indirect modulation of cardiac ion channels and implications for preclinical safety assessment. European Pharmaceutical Review.

Ertl, Peter and Bienfait, Bruno (2013) JSME: a Free Molecule Editor in JavaScript. Journal of Cheminformatics, 5 (24). p. 24. ISSN 1758-2946

Erve, JCL and Gauby, S and Maynard, JW and Svensson, MA and Tonn, G and Quinn, KP (2013) Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry. Chemical Research in Toxicology. pp. 926-936.

Evensen, L and Odlo, K and Micklem, DR and Littlewood-Evans, A and Wood, J and Kuzniewski, C and Altmann, K and Hansen, TV and Lorens, JB (2013) Contextual compound screening for improved therapeutic discovery. ChemBioChem. pp. 2512-2518.

Evrot, Emeline and Ebel, Nicolas and Romanet, Vincent and Roelli, Claudia and Andraos-Rey, Rita and Qian, Zhiyan and Doelemeyer, Arno and Dammassa, Ernesta and Sterker, Dario and Hofmann, Francesco and Murakami, Masato and Baffert, Fabienne and Radimerski, Thomas (2013) JAK1/2 and pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease. Clinical Cancer Research.

Evrot, Emeline and Ebel, Nicolas and Romanet, Vincent and Roelli, Claudia and Andraos-Rey, Rita and Qian, Zhiyan and Doelemeyer, Arno and Dammassa, Ernesta and Sterker, Dario and Hofmann, Francesco and Murakami, Masato and Baffert, Fabienne and Radimerski, Thomas (2013) JAK1/2 and pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease. Clinical Cancer Research.


Favret, Sandra and Rubic-Schneider, Tina and Carballido, Jose and Sapieha, Przemyslaw (2013) Deficiency in the Metabolite-Sensing Receptor SUCNR1 (GPR91) Leads to Outer Retinal Lesions akin to dry-Age-Related Macular Degeneration. Aging, 5 (6). pp. 427-444.

Feldkamp, MD and Frank, AO and Kennedy, JP and Patrone, JD and Vangamudi, B and Waterson, AG and Fesik, SW and Chazin, WJ (2013) Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein a interaction motif of ATR interacting protein. Biochemistry. pp. 6515-6524.

Feldman, David and Jin, Liang and Xuan, Hong and Mueller, Dominik and Persohn, Elke and Scheutz, Helmut and Luft, Frederich and Zhou, Wei (2013) The direct renin inhibitor aliskiren localizes and persists in rat kidneys. American Journal of Physiology - Renal Physiology, 305 (11). F1593-F1602. ISSN 0363-6127

Felice, Dana / L and El-Shennawy, Lamiaa and Zhao, Shuangping and Lantvit, Daniel / L and Shen, Qi and Unterman, Terry / G and Swanson, Steven / M and Frasor, Jonna (2013) Growth Hormone potentiates 17beta-estradiol-dependent breast cancer cell proliferation in an IGF-I-independent manner. Endocrinology.

Fendt, Markus and Imobersteg, Stefan and Peterlik, Daniel and Chaperon, Frederique and Olpe, Hans-Rudolf and Mosbacher, Johannes and Vranesic, Ivan-Toma and van der Putten, Herman and Mcallister, Kevin and Flor, Peter J. and Gee, Christine E. (2013) Differential roles of mGlu7 and mGlu8 in amygdala physiology and in amygdala-dependent behavior. Neuropharmacology.

Feuerbach, Dominik and Arias, Hugo and Ortells, Marcello (2013) (-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurochemistry International.

Feuerbach, Dominik and Arias, Hugo R and De Rosa, Maria Jose and Bouzat, Cecilia (2013) Differential Pharmacological Activity of JN403 At α7 and Muscle Nicotinic Acetylcholine Receptors. The International Journal of Biochemistry & Cell Biology.

Filipovic, Georg (2013) How many test series does a market-ready medication need? Tecan Annual Report 2012. pp. 10-11.

Fishman, Mark and Cross, Robert and Tadmor, Brigitta (2013) Better connected. Nature, 493 (7434). p. 709. ISSN 0028-0836

Fletcher, E and Raman, M and Huebner, P and Liu, A and Mungas, D and Carmichael, O and DeCarli, C (2013) Loss of fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals. JAMA Neurology. pp. 1389-1395.

Flowerdew, SE and Wick, D and Himmelein, S and Horn, AKE and Sinicina, I and Strupp, M and Brandt, T and Theil, D and Hufner, K (2013) Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection. PLoS One.

Fornaro, Mara and Hinken, Aaron C. and Needle, Saul and Hu, Erding and Trendelenburg, Anne-Ulrike and Meyer, Angelika and Rosenstiel, Antonia and Chang, Calvin and Meier, Viktor and Billin, Andrew N. and Becherer, J. David and Evans, William J. and Glass, David and Russell, Alan J. (2013) Mechano Growth Factor peptide (MGF), the COOH terminus of unprocessed Insulin-like growth factor 1 (IGF-1), has no apparent effect on muscle myoblasts or primary muscle stem cells. American Journal of Physiology.

Frank, AO and Feldkamp, MD and Kennedy, JP and Waterson, AG and Pelz, NF and Patrone, JD and Vangamudi, B and Camper, DV and Rossanese, OW and Chazin, WJ and Fesik, SW (2013) Discovery of a potent inhibitor of replication protein A protein-protein interactions using a fragment-linking approach. Journal of Medicinal Chemistry. pp. 9242-9250.

Furegati, Markus and Ossola, Flavio and La Vecchia, Luigi and Kramer, Christian and Bakonyi, Bettina (2013) Concise synthesis of all four stereoisomers of 3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid. Journal of Organic Chemistry, 78 (18). pp. 9328-9339.

Furet, Pascal and Guagnano, Vito and Fairhurst, Robin and Imbach-Weese, Patricia and Bruce, Ian and Knapp, Mark and Fritsch, Christine and Blasco, Francesca and Blanz, Joachim and Aichholz, Reiner and Hamon, Jacques and Fabbro, Doriano and Caravatti, Giorgio (2013) Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorganic and Medicinal Chemistry Letters, 23 (13). pp. 3741-3748. ISSN 0960-894X

fu, jun and koul, dimpy and wang, shuzhen and yao, jun and yuan, yin and sulman, erik p. and lang, frederick f. and yung, alfred w.k. (2013) A Novel HSP90 inhibitor, NVP-HSP990 Targets the Cell Cycle Regulators to Produce Anti-glioma Effect in Olig2-expressing Glioma Stem Cells. Cancer Research, 73 (10). pp. 3062-3074.

fu, wei and chu, baoky and pledger, w.jack (2013) Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH 727965 and a heat shock protein 90 inhibitor. Cell Death and Disease, 4 (3). ISSN 2041-4889


Gadd, MS and Jacques, DA and Nisevic, I and Craig, VJ and Kwan, AH and Guss, JM and Matthews, JM (2013) A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. Journal of Biological Chemistry. pp. 21924-21935.

Ganesh, S and Iyer, AK and Gattacceca, F and Morrissey, DV and Amiji, MM (2013) In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles. JOURNAL OF CONTROLLED RELEASE. pp. 699-706.

Ganesh, S and Iyer, AK and Morrissey, DV and Amiji, MM (2013) Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors. BIOMATERIALS. pp. 3489-3502.

Ganesh, S and Iyer, AK and Weiler, J and Morrissey, DV and Amiji, MM (2013) Combination of siRNA-directed gene silencing with cisplatin reverses drug resistance in human non-small cell lung cancer. Molecular Therapy - Nucleic Acids.

Gantois, I. and Pop, A.S. and de Esch, C.E.F. and Buijsen, R.A.M. and Gasparini, Fabrizio and D'Hooge, R. and Willemsen, R. (2013) Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice. Behavioural Brain Research, 239 (1). pp. 72-79. ISSN 0166-4328

Garcia-Fortanet, J and Formentin, P and Diaz-Oltra, S and Murga, J and Carda, M and Alberto Marco, J (2013) Stereoselective synthesis of a C1-C18 fragment of amphidinolides G and H. TETRAHEDRON. pp. 3192-3196.

Garner, Andrew P. and Bialucha, Carl and Sprague, Elizabeth and Garrett, Joan T. and Sheng, Qing and Li, Xiao and Sineshchekova, Olga and Saxena, Parmita and Sutton, Cammie R. and Chen, Dongshu and Chen, Yan and Wang, Hui-Qin and Liang, Jinsheng and Das, Rita and Mosher, Rebecca and Gu, Jian and Huang, Alan and Haubst, Nicole and Zehetmeier, Carol and Haberl, Manuela and Kunz, Christian and Ellis, Winfried and Heidt, Analeah and Herlihy, Kara and Murtie, Joshua and Schuller, Alwin and Arteaga, Carlos L. and Sellers, William and Ettenberg, Seth (2013) LJM716, an anti-HER3 antibody that locks HER3 in the inactive conformation and inhibits both HER2 and neuregulin driven tumor growth. Cancer Research, 73 (19). pp. 6024-35. ISSN 1538-7445

Garofalo, AW and Adler, M and Aubele, DL and Bowers, S and Franzini, M and Goldbach, E and Lorentzen, C and Neitz, RJ and Probst, GD and Quinn, KP and Santiago, P and Sham, HL and Tam, D and Truong, AP and Ye, XM and Ren, Z (2013) Novel cinnoline-based inhibitors of LRRK2 kinase activity. Bioorganic and Medicinal Chemistry Letters. pp. 71-74.

Garon, Edward B. and Finn, Richard S. and Hamidi, Habib and Dering, Judy and Kamranpour, Naeimeh and Desai, Amrita J. and Hosmer, Wylie and Dubinett, Steven M. and Slamon, Dennis J. and Ide, Susan and Avsar, Emin and Jensen, Michael Rugaard and Quadt, Cornelia and Liu, Manway (2013) The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth. Molecular cancer therapeutics, 12 (6). pp. 890-900. ISSN 1538-8514

Garrett, Joan T. and Sutton, Cammie R. and Kurupi, Richard and Bialucha, Carl and Ettenberg, Seth and Collins, Scott and Sheng, Qing and Wallweber, Jerry and DeFazio-Eli, Lisa and Arteaga, Carlos L. (2013) Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks pi3k signaling and growth of HER2+ breast cancers. Cancer Research, 73 (19). pp. 6013-6023. ISSN 0008-5472

Genick, Christine and Ottl, Johannes (2013) Applications of Biophysics in High Throughput Screening Hit Validation. Journal of Biomolecular Screening, 19 (5). pp. 707-714. ISSN 1087-05711552-454X

Genovino, Julien and Luetz, Stephan and Toure, Bakary-Barry and Sames, Dalibor (2013) Complementation of Biotransformations with Chemical C-H Oxidation: Copper-Catalyzed Oxidation of Tertiary Amines in Complex Pharmaceuticals. Journal of the American Chemical Society, 135 (33). pp. 12346-12355. ISSN 0002-7863

Glynne, Richard and Mcnamara, Peter and Laffitte, Bryan and Li, Jing and Wu, Tom and Jin, Qihui and Baaten, Janine and Cho, Charles and Kamireddy, Anwesh and Zhang, You-Qing and Harb, George and Filippi, Christophe and Shen, Weijun and Tremblay, Matthew and Deshmukh, Vishal and Wang, Weidong and Swoboda, Jonathan and Wu, Xu and Herman, Ann and Schultz, Peter (2013) A small molecule inducer of β cell proliferation identified by high-throughput screening. Journal of the American Chemical Society, 135 (5). pp. 1669-1672. ISSN 0002-7863

Gomez-Mancilla, Baltazar and Johns, Donald and Kalkman, Hans O. and Hariry, Sam and Hans-Christoph, Diener and Brand, Ronald and Jürgens, Tim and Harmut, Göbel (2013) Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks. Cephalalgia.

Gong, C and Tang, Y and Maquat, LE (2013) mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. NATURE STRUCTURAL & MOLECULAR BIOLOGY. pp. 1214-1220.

Gong, Ting and Szustakowski, Joseph (2013) DeconRNA-Seq: A Statistical Framework for Deconvolution of He-terogeneous Tissue Samples Based on mRNA-Seq data. Bioinformatics.

Gubler, Hanspeter and Schopfer, Ulrich and Jacoby, Edgar (2013) Theoretical and Experimental Relationships between %-Inhibition and IC50 Data observed in HTS. Journal of Biomolecular Screening, 18 (1). pp. 1-13. ISSN 1087-0571

Gurumurthy, Meera and Rao, Srinivasa P.S. and Manjunatha, Ujjini Havaldar and Rao, Martin and Mukharjee, Tathagata and Boshoff, Helena and Dick, Thomas and Barry, Clifton (2013) An F420 dependent anti-oxidant mechanism protects Mycobacterium against oxidative stress and bactericidal agents. Molecular Microbiology. ISSN 0950-382X

Guérard, Melanie and Marchand, Christine and Plappert Helbig, Ulla (2013) Influence of experimental conditions on data variability in the liver comet assay. Tox Letters.

gillis, j and butler, L (2013) Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors. Oncotarget, 4 (5). pp. 691-704. ISSN 1949-2553


Hall, Michelle and Jorgensen, William and Whitehead, Lewis (2013) Automated cheminformatics and structure-based protocol for in silico prediction of Human Serum Albumin binding. Journal of Chemical Information & Modeling, 53 (4). pp. 907-922. ISSN 1549-9596

Hamann, Lawrence and Bryan, Marian and Dillon, Barry and Hughes, Greg and Kopach, Michael and Manley, Julie and Peterson, Emily and Pourashraf, Mehrnaz and Raheem, Izzat and Richardson, Paul and Richter, Daniel and Sneddon, Helen (2013) Sustainable practices in medicinal chemistry: Current state and future directions. Journal of Medicinal Chemistry, 56 (15). pp. 6007-6021. ISSN 0022-2623

Hannemann, Holger and Sung, Po-Yu and Bird, Jim and Lim, Siew Pheng and Davidson, Andrew (2013) Serotype Specific Differences in Dengue Virus Non-Structural Protein 5 Nuclear Localisation. Journal of Biological Chemistry.

Hao, L and He, Q and Wang, Z and Craven, M and Newton, MA and Ahlquist, P (2013) Limited Agreement of Independent RNAi Screens for Virus-Required Host Genes Owes More to False-Negative than False-Positive Factors. PLoS Computational Biology.

Haq, R and Yokoyama, S and Hawryluk, EB and Jonssond, GB and Frederick, DT and McHenry, K and Porter, D and Tran, TN and Love, KT and Langer, R and Anderson, DG and Garraway, LA and Duncan, LM and Morton, DL and Hoon, DSB and Wargo, JA and Song, JS and Fisher, DE (2013) BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 4321-4326.

Hara, Hisanori and Sechaud, Romain and Uziel-Fusi, Susan and Drollmann, Anton Franz and winkle, peter (2013) Glycopyrronium does not affect QT interval in healthy subjects: a randomized, three-period, cross-over, placebo- and positive-controlled study. Glycopyrronium does not affect QT interval in healthy subjects: a randomized, three-period, cross-over, placebo- and positive-controlled study .

Harner, MJ and Frank, AO and Fesik, SW (2013) Fragment-based drug discovery using NMR spectroscopy. Journal of Biomolecular NMR. pp. 65-75.

Hatzivassiliou, G and Haling, JR and Chen, H and Song, K and Price, S and Heald, R and Hewitt, JFM and Zak, M and Peck, A and Orr, C and Merchant, M and Hoeflich, KP and Chan, J and Luoh, S and Anderson, DJ and Ludlam, MJC and Wiesmann, C and Ultsch, M and Friedman, LS and Malek, S and Belvin, M (2013) Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature, 501 (7466). pp. 232-236. ISSN 0028-08361476-4687

Hau, Jean-Christophe and Erdmann, Dirk and Mesrouze, Yannick and Furet, Pascal and Fontana, Patrizia and Zimmermann, Catherine and Schmelzle, Tobias and Hofmann, Francesco and Chene, Patrick (2013) The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. ChemBioChem, 14 (10). pp. 1218-1225. ISSN 1439-4227

He, Feng and Dai, Miao and Zhang, Rui and Sun, Yingchuan and Miller-Moslin, Karen and McEwan, Michael and Lagu, Bharat and Wang, Kate and Kelleher Iii, Joseph and Dorsch, Marion and Buonamici, Silvia and Maniara, Wieslawa and Peukert, Stefan and Bourret, Aaron and Ramamurthy, Arun and Williams, Juliet and Green, John and Amaral, Adam and Vattay, Anthony and Wang, Anlai and Guo, Ribo and Yuan, Jing and Yusuff, Naeem (2013) Discovery of NVP-LEQ506, a second generation inhibitor of Smoothened. ChemMedChem, 8 (8). pp. 1261-1265. ISSN 1860-7179

He, YL and Foteinos, G and Neelakantham, S and Mattapalli, D and Kulmatycki, K and Forst, T and Taylor, A (2013) Differential effects of vildagliptin and glimepiride on glucose fluctuations in patients with type 2 diabetes mellitus assessed using continuous glucose monitoring. DIABETES OBESITY & METABOLISM. pp. 1111-1119.

He, Yan-Ling and Zhang, Yiming and Yan, Jing-He and Zhou, Wei and Komjathy, Steven and Taylor, Ann (2013) High-quality triplicate electrocardiogram monitoring in a first-in-man study: potential for early detection of drug-induced QT prolongation. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 51 (12). pp. 948-957. ISSN 0946-1965

Heimbach, Tycho and Xia, Binfeng and Lin, Tsu-han and He, Handan (2013) Case studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data. AAPS Journal, 15 (1). pp. 143-158. ISSN 1550-7416

Hellman, Maarit and Piirainen, Henni and Jaakola, Veli-Pekka and Permi, Perttu (2013) Bridge over troubled proline: assignment of intrinsically disordered proteins using (HCA)CON(CAN)H and (HCA)N(CA)CO(N)H experiments concomitantly with HNCO and i(HCA)CO(CA)NH. Journal of Biomolecular NMR, 58 (1). pp. 49-60. ISSN 0925-2738

Heudi, Olivier and Maganda, Betty and Cortinovis, Agnes and Picard, Franck and Kretz, Olivier (2013) A fast and reliable reversed phase high performance liquid chromatography method for simultaneous determination of selected anti-retroviral and lumefantrine in human plasma. Journal of Chromatography B, 919/92. pp. 52-60. ISSN 1570-0232

Heudi, Olivier and Van Baar, Ben and Rohde, Morten and Wieling, Jaap and Verhaeghe, Tom and Lüdtke, Silke and De Vries, Ronald and White, Steve and Cobb, Zoe and Timmerman, Philip (2013) Internal standard addition in bioanalysis of dried blood spots: results from the EBF DBS-microsampling consortium. Bioanalysis, 5 (17). pp. 2137-2145. ISSN 1757-6180

Hill, RJ and Lou, Y and Tan, SL (2013) B-Cell Antigen Receptor Signaling in Chronic Lymphocytic Leukemia: Therapeutic Targets and Translational Opportunities. INTERNATIONAL REVIEWS OF IMMUNOLOGY. pp. 377-396.

Hoffman, Gregory and Rahal, Rami and Buxton, Frank and Mcallister, Gregory and Xiang, Xiaoqin and Frias, Elizabeth and Huber, Janina and Lindeman, Alicia and Chen, Dongshu and Bagdasarian, Linda and Romero, Rodrigo and Ramadan, Nadire and Phadke, Tanushree and Haas, Kristy and Jaskelioff, Mariela and Wilson, Boris and Meyer, Matthew and Saenz-Vash, Veronica and Zhai, Huili and Mclaughlin, Margaret and Charles, Roberts and Myer, Vic and Porter, Jeffrey and Keen, Nicholas and Mickanin, Craig and Stegmeier, Frank and Jagani, Zainab (2013) A functional screen of the epigenome identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Molecular Cancer Therapeutics, 12 (11). ISSN 15357163

Hoffmaster, Keith and Brouwer, Kim and Keppler, Dietrich and Bow, Daniel and Cheng, Yaofeng and Lai, Yurong and Palm, Johan and Stieger, Bruno and Evers, Raymond (2013) In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. Clinical Pharmacology and Experimental Therapeutics.

Holderfield, Matthew and Merritt, Hanne and Chan, John and Wallroth, Marco and Tandeske, Laura and Zhai, Huili and Hardy, Stephen and Hekmat-Nejad, Mohammad and Stuart, Darrin and McCormick, Frank and Nagel, Tobi (2013) RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation. Cancer Cell, 23 (5). pp. 594-602. ISSN 1535-6108

Hopkins, Neil (2013) test. test.

Horman, SR and Janas, MM and Litterst, C and Wang, B and MacRae, IJ and Sever, MJ and Morrissey, DV and Graves, P and Luo, B and Umesalma, S and Qi, HH and Miraglia, LJ and Novina, CD and Orth, AP (2013) Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets. MOLECULAR CELL. pp. 356-367.

Hortobagyi, GN and Piccart-Gebhart, MJ and Rugo, HS and Burris, HA and Campone, M and Noguchi, S and Perez, AT and Deleu, I and Shtivelband, M and Provencher, L and Masuda, N and Dakhil, SR and Anderson, I and Chen, D and Damask, A and Huang, A and McDonald, R and Taran, T and Sahmoud, T and Baselga, J (2013) Correlation of molecular alterations with efficacy of everolimus in hormone-receptor-positive (HR+), HER2-negative advanced breast Cancer: Preliminary results from BOLERO-2. Journal of Clinical Oncology.

Hoyer, D and Durst, T and Fendt, M and Jacobson, LH and Betschart, C and Hintermann, S and Behnke, D and Cotesta, S and Laue, G and Ofner, S and Legangneux, E and Gee, CE (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Frontiers in Neuroscience. 235-.

Hoyer, Daniel and Duerst, Thomas and Fendt, Markus and Jacobson, Laura and Betschart, Claudia and Hintermann, Samuel and Behnke, Dirk and Cotesta, Simona and Laue, Grit and Ofner, Silvio and Legangneux, Eric and Gee, Christine (2013) Distinct effects of orexin 2 receptor antagonism and dual orexin 1,2 receptor antagonism on sleep architecture in mice. Frontiers in Neuroscience, Neuropharmacology..

Huang, G and Buckler-Pena, D and Nauta, T and Singh, M and Asmar, A and Shi, J and Kim, JY and Kandror, KV (2013) Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Molecular Biology of the Cell. pp. 3115-3122.

Huang, Zheng and Wu, Haiping and Chuai, Shannon and Xu, Fiona and Yan, Feng and Englund, Nathan and Wang, Zhaofu and Zhang, Hailong and Fang, Ming and Wang, Youzhen and Gu, Justin and Zhang, Maya and Yang, Teddy and Zhao, Kehao and Yu, Yanyan and Dai, Jingquan and Yi, Wei and Zhou, Shaolian and Li, Qian and Wu, Jing and Liu, Jun and Wu, Xu and Chan, Ho Man and Lu, Chris and Atadja, Peter and Li, En and Wang, Yan and Hu, Min (2013) The PHD domain targets NSD2 to oncogenic gene loci and drives tumorigenesis in multiple myeloma cells. Cancer Research, 73 (20). pp. 1-12.

Huebener, J and Weber, JJ and Richter, C and Honold, L and Weiss, A and Murad, F and Breuer, P and Wuellner, U and Bellstedt, P and Paquet-Durand, F and Takano, J and Saido, TC and Riess, O and Huu, PN (2013) Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). HUMAN MOLECULAR GENETICS. pp. 508-518.

Hutz, Janna and Nelson, Thomas and Wu, Hua and Mcallister, Gregory and Moutsatsos, Ioannis and Jaeger, Savina and Bandyopadhyay, Somnath and Nigsch, Florian and Cornett, Allen and Jenkins, Jeremy and Selinger, Douglas (2013) The multidimensional perturbation value: A single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. Journal of Biomolecular Screening, 18 (4). pp. 367-377. ISSN 1087-0571; 1552-454X


Imbert, Pierre-Eloi and Siebert, Daniela and Unterreiner, Vincent and Meyerhofer, Marco and Leder, Lukas and Mcallister, Kathryn and Gabriel, Daniela and Parker, Christian (2013) Development of an Image Based Assay to Detect C5a Receptor Occupancy. Abstracts for MipTec 2010.

Inta, D and Vogt, MA and Luoni, A and Filipovic, D and Lima-Ojeda, JM and Pfeiffer, N and Gasparini, F and Riva, MA and Gass, P (2013) Significant increase in anxiety during aging in mGlu5 receptor knockout mice. BEHAVIOURAL BRAIN RESEARCH. pp. 27-31.

Ioannou, Nikolaos and Seddon, Alan / M and Dalgleish, Angus and Mackintosh, David and Modjtahedi, Helmout (2013) Synergistic growth inhibition of human pancreatic cancer cells following treatment with a combination of ErbB family blocker afatinib and IGF-IR inhibitor NVP-AEW541. BMC Cancer, 13. pp. 41-52. ISSN 1471-2407

Iwata, H and Baselga, J and Campone, M and Arteaga, CL and Cortes, J and Jonat, W and De Laurentiis, M and Ciruelos, E and Janni, W and Bachelot, T and Lonning, PE and Ma, C and O'Regan, R and Di Tomaso, E and Bharani-Dharan, B and Duval, V and Lau, H and Germa, C and Urban, P and Di Leo, A (2013) Ph III randomized studies of the oral pan-PI3K inhibitor buparlisib (BKM120) with fulvestrant in postmenopausal women with HR+/HER2-locally advanced or metastatic breast cancer (BC) after aromatase inhibitor (AI; BELLE-2) or AI and mTOR inhibitor (BELLE-3) treatment. Journal of Clinical Oncology.

Iwata, N and Sekiguchi, M and Hattori, Y and Takahashi, A and Asai, M and Ji, B and Higuchi, M and Staufenbiel, M and Muramatsu, S and Saido, TC (2013) Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Scientific Reports.

infante, J and gerecitano, G and Chugh , r and cassier , P and ribrag, V and shapiro, G and witteveen, E and Matano, Alessandro and Chakraborty, Abhijit and Parasuraman, Sudha (2013) Phase 1 multicenter, open label, dose-escalation study of LEE011, an oral inhibitor of cyclin-dependent kinase 4/6, in patients with advanced solid tumors or lymphomas. Molecular Cancer Therapeutics, 12 (11). ISSN 1535-7163


Jaguva Vasudevan, AA and Mario, P and Bulliard, Y and Cichutek, K and Trono, D and Haussinger, D and Munk, C (2013) Prototype foamy virus bet impairs the dimerization and cytosolic solubility of human APOBEC3G. Journal of Virology. pp. 9030-9040.

Jain, Rishi and Beckwith, Rohan (2013) Recent advances in small molecule target identification methods. Annual Reports in Medicinal Chemistry, 48. pp. 301-315. ISSN 0065-7743

Jakab, Annamaria and Winter, Serge and Raccuglia, Marc and Picard, Franck and Dumitras, Swati and Woessner, Ralph and Mistry, Sanket and Chudasama, Jayraj and Guttikar, Swati and Kretz, Olivier (2013) Validation of an LC-MS/MS method for the quantitative determination of Mavoglurant (AFQ056) in human plasma. Analytical and Bioanalytical Chemistry, 405 (1). pp. 215-223. ISSN 1618-2642

Jalili, Ahmed and Mertz, Kirsten D and Romanov, Julia and Wagner, Christine and Kalthoff, Frank and Stuetz, Anton and Pathria, Gaurav and Gschaider, Melanie and Stingl, Georg and Wagner, Stephan N (2013) NVP-LDE225, a potent and selective smoothened antagonist possess anti-melanoma activity both in vitro and in vivo. PLoS One, 8 (7). pp. 1-10.

Jamontt, Joanna and Clark, Natalie and Petit, Stephanie and Parkinson, Scott James and Smith, Philip (2013) NOD2 signalling promotes hyper-responsive macrophages and colitis in IL-10 deficient mice. Journal of Immunology, 190. ISSN 0022-1767

Javaid, S and Zhang, J and Anderssen, E and Black, JC and Wittner, BS and Tajima, K and Ting, DT and Smolen, GA and Zubrowski, M and Desai, R and Maheswaran, S and Ramaswamy, S and Whetstine, JR and Haber, DA (2013) Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of snail-1. Cell Reports. pp. 1679-1689.

Jenkins, JL (2013) DRUG DISCOVERY Rethinking cellular drug response. NATURE CHEMICAL BIOLOGY. pp. 669-670.

Jimenez-Guri, E and Huerta-Cepas, J and Cozzuto, L and Wotton, KR and Kang, H and Himmelbauer, H and Roma, G and Gabaldon, T and Jaeger, J (2013) Comparative transcriptomics of early dipteran development. BMC Genomics.

Jurisic, G and Sundberg, JP and Detmar, M (2013) Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflammatory Bowel Diseases. pp. 1983-1989.


Kaendler, Kerstin and Warren, Andrew Paul and Lloyd, Peter and Sims, Jennifer and Sickert, Denise (2013) Evaluation of Dried Blood Spots for the Quantification of Therapeutic Monoclonal Antibodies and Detection of Anti-Drug Antibodies. Bioanalysis, 5 (5). pp. 613-622. ISSN 1757-6180

Kale, MG and Raichurkar, A and Shahul, HP and Waterson, D and McKinney, D and Manjunatha, MR and Kranthi, U and Koushik, K and Jena, LK and Shinde, V and Rudrapatna, S and Barde, S and Humnabadkar, V and Madhavapeddi, P and Basavarajappa, H and Ghosh, A and Ramya, V and Guptha, S and Sharma, S and Vachaspati, P and Kumar, KNM and Giridhar, J and Reddy, J and Panduga, V and Ganguly, S and Ahuja, V and Gaonkar, S and Kumar, CNN and Ogg, D and Tucker, JA and Boriack-Sjodin, PA and De Sousa, SM and Sambandamurthy, VK and Ghorpade, SR (2013) Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA gyrase B. Journal of Medicinal Chemistry. pp. 8834-8848.

Kalkeri, G and Lin, C and Gopilan, J and Sloan, K and Rijnbrand, R and Kwong, AD (2013) Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations. Antimicrobial Agents and Chemotherapy. pp. 4417-4426.

Kalliokoski, Tuomo and Kramer, Christian and Vulpetti, Anna (2013) Quality issues with public domain chemogenomics data. Molecular Informatics, 32 (11-12). pp. 898-905. ISSN 1868-1743

Kalliokoski, Tuomo and Kramer, Christian and Vulpetti, Anna and Gedeck, Peter (2013) Comparability of mixed IC50 data – A Statistical Analysis. PLOS ONE, 8 (4). e61007. ISSN 1932-6203

Kalliokoski, Tuomo and Olsson, Tjelvar and Vulpetti, Anna (2013) Sub-pocket analysis method for Fragment-Based Drug Discovery. Journal of Chemical Information and Modeling, 53 (1). pp. 131-141. ISSN 1549-9596

Kamel, A and Colizza, K and Obach, RS (2013) In vitro metabolism of the 5-hydroxytryptamine 1B receptor antagonist elzasonan. XENOBIOTICA. pp. 368-378.

Kammerer, M and Gutzwiller, S and Stauffer, D and Delhon, I and Seltenmeyer, Y and Fournier, B (2013) Estrogen Receptor alpha (ER alpha) and Estrogen Related Receptor alpha (ERR alpha) are both transcriptional regulators of the Runx2-I isoform. MOLECULAR AND CELLULAR ENDOCRINOLOGY. pp. 150-160.

Karkare, S and Chung, TTH and Collin, F and Mitchenall, LA and McKay, AR and Greive, SJ and Meyer, JJM and Lall, N and Maxwell, A (2013) The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. Journal of Biological Chemistry. pp. 5149-5156.

Kawanami, Toshio and Karns, Alexander and Adams, Christopher and Serrano-Wu, Michael (2013) Efficient preparation of Ellman’s imines from trifluoromethyl ketones promoted by zirconium tert-butoxide. Tetrahedron Letters.

Khokhlovich, Edward and Wahl, Daniel and Masiello, Anthony and Parisot, Pierre and Baumann, Stefan and Szustakowski, Joseph and Nirmala, Nanguneri and Tuch, David (2013) RAMP: A Bioinformatics Framework for Researching Imaging Agents through Molecular Pathways. Molecular Imaging, 12 (1). pp. 2-7. ISSN 1535-3508

Kim, H and Babu, CR and Burgess, DJ (2013) Quantification of protonation in organic solvents using solution NMR spectroscopy: Implication in salt formation. INTERNATIONAL JOURNAL OF PHARMACEUTICS. pp. 123-131.

Kim, SE and Patapoutian, A and Grandl, J (2013) Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations. PLoS One.

Kim, SG and Hoffman, GR and Poulogiannis, G and Buel, GR and Jang, YJ and Lee, KW and Kim, B and Erikson, RL and Cantley, LC and Choo, AY and Blenis, J (2013) Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex. MOLECULAR CELL. pp. 172-185.

Kim, Sunkyu and Caponigro, Giordano and Parasuraman, Sudha and Rader, JulieAnn and Maris, John and Russell, Mike and Hart, Lori and Nakazawa, Michael and Belcastro, Lili and Martinez, Daniel and Li, Yimei and Carpenter, Erica and Attiyeh, Edward and Schnepp, Robert and Wood, Andrew and Pawel, Bruce and Cole, Kristina (2013) Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clinical Cancer Research, 19 (22). pp. 6173-6182. ISSN 1078-0432

Kimmel, Dannielle W and Dole, William and Cliffel, David E (2013) Application of multianalyte microphysiometry to characterize macrophage metabolic responses to oxidized LDL and effects of an apoA-1 mimetic. Biochemical and Biophysical Research Communications, 431 (2). pp. 181-185. ISSN 0006291X

King, Daniel and Ma, Weilei and Yao, Danfeng and Tobias, Renee (2013) BLItz Application Note Instant Protein Analysis using BLItz for Faster, Easier Bioprocess Development and Production. Blitz Application Note.

Kinoshita, Katsuhiro and Aono, Yoshinori and Azuma, Momoyo and Kishi, Jun and Takezaki, Akio and Kishi, Masami and Makino, Hideki and Okazaki, Hiroyasu and Uehara, Hisanori and Izumi, Keisuke and Sone, Saburo and Nishioka, Yasuhiko (2013) Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-induced induced Pulmonary Fibrosis in Mice. American Journal of Respiratory Cell and Molecular Biology. ISSN 1044-1549

Kipp, Randy and Quinn, Christopher and Fortin, Pascal (2013) Enzyme-Dependent Lysine Deprotonation in EZH2 Catalysis. Biochemistry, 52 (39). pp. 6866-6878. ISSN 0006-2960

Kondreddi, Ravinder Reddy and Jiricek, Jan and Rao, Srinivasa P.S. and Lakshminarayana, Suresh Bangalore and Rao, Ranga Rao K.R. and Herve, Maxime Marcel and Bifani, Juan Pablo and Kuhen, Kelli and Manjunatha, Ujjini Havaldar and Smith, Paul William and Camacho, Luis and Ma, Ida and Goh, Anne and Chatterjee, Arnab (2013) Design, synthesis and biological evaluation of indole-2-carboxamides, a promising class of anti-tuberculosis agents. J. med Chem, 56. pp. 8849-8859.

Koromilas, AE and Mounir, Z (2013) Control of oncogenesis by eIF2alpha phosphorylation: Implications in PTEN and PI3K-Akt signaling and tumor treatment. Future Oncology. pp. 1005-1015.

Korpal, Manav and Korn, Joshua and Ruddy, David and Doshi, Shivang and Yuan, Jing and Kim, Sunkyu and Cooke, Vesselina and Stegmeier, Frank and Roberts, Thomas and Sellers, William and Zhou, Wenlai and Zhu, Ping (2013) An F876l mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (Enzalutamide). Cancer Discovery, 3 (9). pp. 1030-1043. ISSN 2159-8274

Kovarik, Jiri (2013) From Immunosuppression to Immunomodulation: Current Principles and Future Strategies. Pathobiology, 80 (6). pp. 275-281. ISSN PMID: 24013771

Kramer, Christian and Bereau, Tristan and Spinn, Alexander and Liedl, Klaus R. and Gedeck, Peter and Meuwly, Markus (2013) Deriving Static Atomic Multipoles from the Electrostatic Potential. Journal of Chemical Information and Modeling, 53. pp. 3410-3417.

Krauser, Joel (2013) A perspective on tritium versus carbon-14: ensuring optimal label selection in pharmaceutical research and development. Journal of Labelled Compounds and Radiopharmaceuticals. ISSN 0362-4803

Krumova, P and Weishaupt, JH (2013) Sumoylation in neurodegenerative diseases. CELLULAR AND MOLECULAR LIFE SCIENCES. pp. 2123-2138.

Kustermann, S and Boess, F and Buness, A and Schmitz, M and Watzele, M and Weiser, T and Singer, T and Suter, L and Roth, A (2013) A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects. Toxicology in Vitro. pp. 1589-1595.

Kutchukian, Peter and Lindvall, Mika and Wright, Kirk and Ottl, Johannes and Jacob, Jaison and Scheufler, Clemens and Marzinzik, Andreas and Natasja, Brooijmans and Glick, Meir (2013) Beyond Consensus: Leveraging Inherent Biases in Fragment Based Screening Technologies. Journal of medicinal chemistry.

kittan, nicolai and allen, ronald and dhaliwal, abhay and cavassani, karen and schaller, matthew and Jarai, Gabor and Westwick, John and kunkel, steven and hogaboam, cory (2013) Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes. PLoS ONE, 8 (10). ISSN 1932-6203


Lallifatidis, Georgios and Hoepfner, Dominic and Jaeg, Tiphaine and Guzman, Esther and Wright, Amy (2013) The Marine Natural Product Manzamine A targets Vacuolar ATPases and Autophagy in Pancreatic Cancer Cells. Marine Drugs, 12 (4). pp. 3500-3516. ISSN None

Lamacchia, C and Palmer, G and Rodriguez, E and Martin, P and Vigne, S and Seemayer, CA and Talabot-Ayer, D and Towne, JE and Gabay, C (2013) The severity of experimental arthritis is independent of IL-36 receptor signaling - art. no. R38. ARTHRITIS RESEARCH & THERAPY.

Laurent, Didier and Yerby, Brittany and Zhang, Bailin and Chen, Xiao-Hui and Gounarides, John and Gao, Jiaping and Duttaroy, Alokesh (2013) Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960. European Journal Of Pharmacology, 715 (1-3). pp. 89-95.

Lazic, SE (2013) Comment on 'Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice'. SCIENCE. 1-.

Lazic, SE and Essioux, L (2013) Improving basic and translational science by accounting for litter-to-litter variation in animal models. BMC Neuroscience.

Leary, Beth A. and Lawrence-Henderson, Rosemary and Mallozzi, Carolyn and Fernandez Ocana, Mireia and Duriga, Nicole and O'Hara, Denise and Kavosi, Mania and Qiang, Qu and Joyce, Alison (2013) Bioanalytical platform comparison using a generic human IgG PK assay format. Journal of Immunological Methods, 397 (1-2). pp. 28-36. ISSN 0022-1759

Leary, RJ and Sausen, M and Diaz, J and Velculescu, VE (2013) Cancer detection using whole-genome sequencing of cell free DNA. ONCOTARGET. pp. 1119-1120.

Lee, ACY and Epe, C and Bowman, DD (2013) Comparison of Ancylostoma caninum worm counts acquired by endoscopy and necropsy. Veterinary Parasitology. pp. 538-540.

Lee, David and Andrade, Felipe (2013) Cytotoxic cells induce cellular hypercitrullination and citrullinated autoantigen production via perforin. Science Translational Medicine.

Lee, JH and Gao, J and Kosinski, PA and Elliman, SJ and Hughes, TE and Gromada, J and Kemp, DM (2013) Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. pp. 1109-1113.

Leeds, Jennifer and Sachdeva, Meena and Mullin, Steve and Barnes, Whitney and Ruzin, Alexey (2013) In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin. Journal of Antimicrobial Chemotherapy. ISSN 0305-7453

Lefevre, Gilbert and Bhad, Prafulla and Jain, Jay Prakash and Kalluri, Sampath and Cheng, Yi and Dave, Hardik and Stein, Daniel (2013) Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem®) for bioequivalence in a randomized, open-label, two-period study. Malaria Journal, 12 (1). p. 312. ISSN 1475-2875

Leino, MS and Loxham, M and Blume, C and Swindle, EJ and Jayasekera, NP and Dennison, PW and Shamji, BWH and Edwards, MJ and Holgate, ST and Howarth, PH and Davies, DE (2013) Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors. PLoS One.

Lemmerer, Martin and London, Anne and Pannicucci, Alexandra and Gutierrez-Vargas, Cristina and Lihon, Michael (2013) Coupled Affinity and Sizing Chromatography: A novel in-process analytical tool to measure titer and trend Fc-protein aggregation. Journal of Immunological Methods, 393 (1/2). pp. 81-85. ISSN 0022-1759

Lepist, EI and Damaraju, VL and Zhang, J and Gati, WP and Yao, SYM and Smith, KM and Karpinski, E and Young, JD and Leung, KH and Cass, CE (2013) Transport of A(1) Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1. DRUG METABOLISM AND DISPOSITION. pp. 916-922.

Levy, JR and Campbell, KP and Glass, DJ (2013) MG53's new identity. Skeletal Muscle. 25-.

Lex, Alexander and Partl, Christian and Kalkofen, Denis and Streit, Marc and Gratzl, Samuel and Wassermann, Anne and Schmalstieg, Dieter and Pfister, Hanspeter (2013) Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets. IEEE Transactions on Visualization and Computer Graphics, 19 (12). pp. 2536-2545. ISSN 1077-2626

Li, C and Liu, B and Chang, J and Groessl, T and Zimmerman, M and He, YQ and Isbell, J and Tuntland, T (2013) A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery. DRUG DISCOVERY TODAY. pp. 71-78.

Li, D and Jin, L and Alesi, GN and Kim, YM and Fan, J and Seo, JH and Wang, D and Tucker, M and Gu, TL and Lee, BH and Taunton, J and Magliocca, KR and Chen, ZG and Shin, DM and Khuri, FR and Kang, S (2013) The Prometastatic Ribosomal S6 Kinase 2-cAMP Response Element-binding Protein (RSK2-CREB) Signaling Pathway Up-regulates the Actin-binding Protein Fascin-1 to Promote Tumor Metastasis. JOURNAL OF BIOLOGICAL CHEMISTRY. pp. 32528-32538.

Li, Q and Korzan, WJ and Ferrero, DM and Chang, RB and Roy, DS and Buchi, M and Lemon, JK and Kaur, AW and Stowers, L and Fendt, M and Liberles, SD (2013) Synchronous Evolution of an Odor Biosynthesis Pathway and Behavioral Response. CURRENT BIOLOGY. pp. 11-20.

Li, Shi-Hua and Dong, Hongping and Li, Xiao-Feng and Xie, Xuping and Zhao, Hui and Deng, Yong-Qiang and Wang, Xiao-Yu and Ye, Qing and Zhu, Shun-Ya and Wang, Hong-Jiang and Zhang, Bo and Qin, E-De and Qin, Cheng-Feng and Shi, Pei-Yong (2013) Rational design of a flavivirus vaccine through abolishing viral RNA 2′-O methylation. Journal of virology, 87 (10). pp. 5812-5819. ISSN 1098-5514; 0022-538X

Li, Shu and Gu, Justin and Hao, Qin and Fan, Hong and Li, Ling and Zhou, Shaolian and Zhao, Kehao and Chan, Ho Man and Wang, Yingqi (2013) A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases. Analytical Biochemistry, 443 (2). pp. 214-221. ISSN 0003-2697

Li, Wenkui and Lin, Hui and Flarakos, Jimmy and Tse, Francis (2013) Practical Approaches to Incurred Sample LC-MS/MS Reanalysis: Confirming Unexpected Results. Analytical Chemistry.

Li, Y and Zhang, T (2013) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts. Future Oncology. pp. 1097-1103.

Li, ZZ and Gilbert, JA and Zhang, Y and Zhang, M and Qiu, Q and Ramanujan, K and Shavlakadze, T and Eash, JK and Scaramozza, A and Goddeeris, MM and Kirsch, DG and Campbell, KP and Brack, AS and Glass, DJ (2013) An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis (vol 23, pg 1176, 2012). Developmental Cell. p. 112.

Li, Zhizhong and Glass, David and Zhang, Yunyu (2013) The HMGA2-IGF2BP2 Pathway Maintains Controls Mutated N-Ras Levels in Rhabdomyosarcoma. Cancer Research.

Liang, Y and Quenelle, D and Vogel, JL and Mascaro, C and Ortega, A and Kristie, TM (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio.

Liao, Rijing and Wu, Haiping and Deng, Haibing and Yu, Yanyan and Hu, Min and Zhai, Huili and Yang, Pengyuan and Zhou, Shaolian and Yi, Wei (2013) Specific and Efficient N-propionylation of histones with Propionic acid N-hydroxysuccinimide Ester for Histone Marks Characterization by LC-MS. Analytical Chemistry, 85 (4). pp. 2253-2259. ISSN 0003-2700

Lim, Siew Pheng and Koh, Hong Kiew Jolene and Seh, Cheah Chen and Liew, Chong Wai and Davidson, Andrew D and Chua, leng Shiew and Chandrasekaran, Ramya and Cornvik, Tobias and Shi, Pei-Yong and Lescar, Julien (2013) A novel crystal structure of the Dengue virus NS5 polymerase delineates inter-domain amino acids residues that enhance its thermostability and de novo initiation activities. Journal of Biological Chemistry.

Lim, Siew Pheng and Shi, Pei-Yong (2013) West Nile virus drug discovery. Viruses.

Lim, Siew Pheng and Shi, Pei-Yong and Soh, Sherryl and Zhao, Yongqian and Zheng , Jie and Phoo , Wint Wint and Swaminathan, Kunchithapadam and Cornvik , Tobias C. and Lescar , Julien and Vasudevan , Subhash G. and Luo , Dahai (2013) A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication. PLOS Pathogens.

Lim, Siew Pheng and Wang, Qingyin and Noble, Christian Guy and Chen, Yen Liang and Dong, Hongping and Zou, Bin and Yokokawa, Fumiaki and Nilar, Shahul Hameed and Smith, Paul William and Beer, David John and julien, lescar and Shi, Pei-Yong (2013) Ten years of dengue drug discovery: progress and prospects. Anti-viral Research Journal.

Linghu, B and Franzosa, EA and Xia, Y (2013) Construction of functional linkage gene networks by data integration. Data Mining for Systems Biology: Methods and Protocols. pp. 215-232.

Liu, Jun and Pan, Shifeng and Ng, Nicholas and Kasibhatla, Shailaja and Cheng, Dai and Li, Jie and Tompkins, Celin and Pferdekamper, Annemarie and Steffy, Auzon and Kowal, Colleen and Wang, Yan and Li, Chun and Wang, Tao and Mcnamara, Peter and Sellers, William and Petruzzelli, Lilli and Boral, Anthony and Seidel, Martin and Mclaughlin, Margaret and Che, Jianwei and Vanasse, K. Gary and Sun, Frank and Schuller, Alwin and Li, Allen and Cheng, Jane and Phung, Van and Guo, Guirong and Graham, Martin and Brenner, J. Chad and Villarroel, Maria and Schultz, Peter and Wu, Xu and Carey, Thomas and Hsieh, Hsin-I (2013) Targeting Wnt-driven Cancer Through the inhibition of Porcupine by LGK974. Proceedings of the National Academy of Sciences of the United States of America PNAS., 110 (50). pp. 20224-20229. ISSN 1091-6490; 0027-8424

Liu, LN and Wang, G and Hendricks, K and Lee, K and Bohnlein, E and Junker, Uwe and Mosca, JD (2013) Comparison of drug and cell-based delivery: engineered adult mesenchymal stem cells expressing soluble tumor necrosis factor receptor II prevent arthritis in mouse and rat animal models. Stem Cells Translational Medicine, 2 (5). pp. 362-375. ISSN 2157-6564

Liu, W and Collins, CM and Smith, MB and Yang, QX (2013) On consideration of radiated power in RF field simulations for MRI. MAGNETIC RESONANCE IN MEDICINE. pp. 290-294.

Liu, XH and Ide, JL and Norton, I and Marchionni, MA and Ebling, MC and Wang, LY and Davis, E and Sauvageot, CM and Kesari, S and Kellersberger, KA and Easterling, ML and Santagata, S and Stuart, DD and Alberta, J and Agar, JN and Stiles, CD and Agar, NYR (2013) Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Scientific Reports.

Liu, Yahua (2013) Fluorescent Probes for the Detection of Hydrogen Peroxide in Biological Systems. Current Organic Chemistry, 17 (6). pp. 654-669. ISSN 1385-2728

Lloyd, Peter (2013) Biological Therapeutics. Textbook of Pharmaceutical Medicine.

Loetscher, Erika and Beerli, Christian and Schneider, Karolina and Billich, Andreas (2013) Assay to measure the secretion of S1P from cells induced by S1P lyase inhibitors. Biochemical Biophysical Research Communications, 433 (3). pp. 345-348.

Lombardo, Franco and Waters, Nigel and Argikar, Upendra and Dennehy, Michelle and Zhan, Yu and Gunduz, Mithat and Harriman, Shawn and Berellini, Giuliano and Liric Rajlic, Ivana and Obach, R. Scott (2013) Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: Volume of distribution at steady state. Journal of Clinical Pharmacology, 53 (2). pp. 167-177. ISSN 0091-2700

Lombardo, Franco and Waters, Nigel and Argikar, Upendra and Dennehy, Michelle and Zhan, Yu and Gunduz, Mithat and Harriman, Shawn and Berellini, Giuliano and Liric Rajlic, Ivana and Obach, Scott (2013) Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: Clearance. Journal of Clinical Pharmacology, 53 (2). pp. 178-191. ISSN 0091-2700

Lomniczi, A and Loche, A and Castellano, JM and Ronnekleiv, OK and Bosch, M and Kaidar, G and Knoll, JG and Wright, H and Pfeifer, GP and Ojeda, SR (2013) Epigenetic control of female puberty. Nature Neuroscience. pp. 281-289.

Lotz, Gregor and Legleiter, Justin (2013) The role of amyloidogenic protein oligomerization in neurodegenerative disease. Neurotherapeutics. ISSN 1878-7479; 1933-7213

Lu, Boxun and Al-Ramahi, Ismael and Antonio, Valencia and Berenshteyn, Frada and Yang, Haidi and Gallego-Flores, Tatiana and Ichcho, Salah and Lacoste, Arnaud and Marian, Difiglia and Hild, Marc and Botas, Juan and Palacino, James and Wang, Qiong (2013) Identification of NUB1 as a Suppressor of Mutant Huntingtin Toxicity via Enhanced Protein Clearance. Nature Neuroscience. ISSN 1097-6256

Lu, Boxun and Palacino, James (2013) A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration. FASEB Journal. ISSN 0892-6638

Lu, Jing and Zavorotinskaya, Tatiana and Dai, Yumin and Niu, Xiaohong and Castillo, Joseph and Sim, Janet and Yu, Jianjun and Wang, Yingyun and Langowski, John and Holash, Jocelyn and Shannon, Kevin and Garcia, Pablo (2013) Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood, 122 (9). pp. 1610-1620. ISSN 1528-0020

Lu, Yang and Hongjing, Niu and Xianjun, Gao and Qingsong, Wang and Gang, Han and Liming, Cao and Chunquan, Cai and Weiler, Jan and Yin, HaiFang (2013) Effective Exon Skipping and Dystrophin Restoration by 2′-O-Methoxyethyl Antisense Oligonucleotide in Dystrophin-Deficient Mice. PLoS ONE, 8 (4). ISSN 1932-6203

Luetz, Stephan (2013) Book Review "Biocatalyst and Enzyme Technology", 2nd edition. Angewandte Chemie.

Luetz, Stephan (2013) Book review “Enzyme Catalysis in Organic Synthesis”, 3rd edition. Angewandte Chemie, 125. pp. 2-3. ISSN 0044-8249

Lukjanenko, Laura and Brachat, Sophie and Pierrel, Eliane and Trifilieff, Estelle and Feige, Jerome (2013) Genomic profiling reveals that transient adipogenic activation is a hallmark of mouse models of skeletal muscle regeneration. PLoS ONE, 8 (8). p. 71084. ISSN 1932-6203

Luksch, H and Romanowski, MJ and Chara, O and Tungler, V and Caffarena, ER and Heymann, MC and Lohse, P and Aksentijevich, I and Remmers, EF and Flecks, S and Quoos, N and Gramatte, J and Petzold, C and Hofmann, SR and Winkler, S and Pessler, F and Kallinich, T and Ganser, G and Nimtz-Talaska, A and Baumann, U and Runde, V and Grimbacher, B and Birmelin, J and Gahr, M and Roesler, J and Rosen-Wolff, A (2013) Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1beta. Human Mutation. pp. 122-131.


Mabrouk, OS and Mela, F and Calcagno, M and Budri, M and Viaro, R and Dekundy, A and Parsons, CG and Auberson, YP and Morari, M (2013) GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats. ACS Chemical Neuroscience. pp. 808-816.

Maclachlan, Timothy and McIntyre, Maritza and Jolly, Douglas and Mitrophanous, Kyriacos and Miskin, James and Holder, Julie and Cavagnaro, Joy (2013) Not reinventing the wheel – applying 3Rs concepts to viral vector gene therapy biodistribution studies. Human Gene Therapy Clinical Development, 24 (1). pp. 1-4.

Madden, JA and Hoyer, PB and Devine, Pj and Keating, AF (2013) Acute 7,12-dimethylbenz[a]anthracene exposure causes differential concentration dependent follicle depletion and gene expression in neonatal rat ovaries. Toxicology and Applied Pharmacology.

Maia, LF and Kaeser, SA and Reichwald, J and Hruscha, M and Martus, P and Staufenbiel, M and Jucker, M (2013) Changes in amyloid-beta and tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein. Science Translational Medicine.

Mainolfi, Nello and Powers, James and Amin, Jakal and Long, Debby and Lee, Wendy and Mclaughlin, Margaret and Jaffee, Bruce and Brain, Christopher and Elliott, Jason and Sivak, Jeremy (2013) An Effective Prodrug Strategy to Selectively Enhance Ocular Exposure of a Cannabinoid Receptor (CB1/2) Agonist. Journal of Medicinal Chemistry. ISSN 0022-2623

Majumdar, Dyuti and Chin, Donovan and Fortin, Pascal and Feng, Yun and Gould, Ty and Kirby, Christina and Shao, Wenlin and Stams, Travis and Waters, Nigel and Shultz, Michael (2013) Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases. Journal of Medicinal Chemistry, 56 (17). pp. 7049-7059. ISSN 0022-2623

Malherbe, DC and Sanders, RW and van Gils, MJ and Park, B and Gomes, MM and Schuitemaker, H and Barnett, S and Haigwood, NL (2013) HIV-1 Envelope Glycoprotein Resistance to Monoclonal Antibody 2G12 Is Subject-Specific and Context-Dependent in Macaques and Humans. PLoS One.

Manjunatha, Ujjini Havaldar and Rao, Srinivasa P.S. and Lakshminarayana, Suresh Bangalore and Kondreddi, Ravinder Reddy and Herve, Maxime Marcel and Bifani, Juan Pablo and Luis, Camacho and Jiricek, Jan and Sarath, Kalapala and Tan, Bee Huat and Nanjundappa, Mahesh Bangalore and Seow Hwee, Ng and Sindhu, Ravindran and Seah, Peck Gee and Thayalan, Pamela and Lee, Boon Heng and Barnes, Whitney and Anne, Goh and Arnab, Chatterjee and Kevin, Pethe and Kuhen, Kelli and Walker, John and Babu, Sreehari and Gu, Feng and Lijun, Zhang and Blasco, Francesca and Beer, David John and Weaver, Margaret and Veronique, Dartois and Glynne, Richard and Thomas, Dick and Smith, Paul William and Diagana, Thierry Tidiane and Vivian, Lim NITD and Ida, Ma (2013) Indolcarboxamide, a promising pre-clinical candidate for the treatment of multi drug resistant tuberculosis. Science Translational Medicine.

Manley, Paul W. and Blasco, Francesca and Mestan, Juergen and Aichholz, Reiner (2013) The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588. Bioorganic Medicinal Chemistry, 21 (11). pp. 3233-3239. ISSN 0968-0896

Manrique, J and Piatak, M and Lauer, W and Johnson, W and Mansfield, K and Lifson, J and Desrosiers, R (2013) Influence of mismatch of env sequences on vaccine protection by live attenuated simian immunodeficiency virus. Journal of Virology. pp. 7246-7254.

Marais, R and Sellers, W and Livingston, D and Mihich, E (2013) Twenty-fourth Annual Pezcoller Symposium: Molecular Basis for Resistance to Targeted Agents. CANCER RESEARCH. pp. 1046-1049.

Maresca, Marcello and Lin, Victor and Guo, Ning and Yang, Yi (2013) Obligate Ligation-Gated Recombination (ObLiGaRe): Custom designed nucleases mediated targeted integration through non-homologous end joining. Genome Research. pp. 1-8. ISSN 1088-9051

Margolin, AA and Bilal, E and Huang, E and Norman, TC and Ottestad, L and Mecham, BH and Sauerwine, B and Kellen, MR and Mangravite, LM and Furia, MD and Vollan, HKM and Rueda, OM and Guinney, J and Deflaux, NA and Hoff, B and Schildwachter, X and Russnes, HG and Park, D and Vang, VO and Pirtle, T and Youseff, L and Citro, C and Curtis, C and Kristensen, VN and Hellerstein, J and Friend, SH and Stolovitzky, G and Aparicio, S and Caldas, C and Borresen-Dale, A (2013) Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer. Science Translational Medicine.

Marsilje, Thomas and Pei, Wei and Lu, Wenshuo and Uno, Tetsuo and Jin, Yunho and Jiang, Tao and Kim, Sungjoon and Li, Nanxin and Sarkisova, Yelena and Steffy, Auzon and Culazzo, Annemarie and Kasibhatla, Shailaja and Joseph, Sean and Kim, Young and Tuntland, Tove and Cui, Xiaoming and Li, Jie and Gordon, William and Richmond, Wendy and Chang, Hsiao-Yen and Groessl, Todd and He, You-Qun and Liu, Bo and Fangxian, Sun and Phimister, Andrew and Aycinena, Juan and Bursulaya, Badry and Lee, Christian and Seidel, Martin and Harris, Jennifer and Michellys, Pierre (2013) Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl) phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. Journal of Medicinal Chemistry, 56 (14). pp. 5675-5690. ISSN 0022-2623

Martin, Eric and Tseng, Y. Jane and bologa, Cristian and Shelat, Anag (2013) A Mini-Series on the Cheminformatics Aspects of High Throughput Screening: from Robots to Models - Summary. Journal of Computer-aided Molecular Design.

Martin, Jeffrey and Rejtar, Tomas and Martin, Stephen (2013) Integrated microscale analysis system for targeted LC/MS proteomics on limited amounts of enriched cell populations. Analytical Chemistry.

Martin, P and Talabot-Ayer, D and Seemayer, CA and Vigne, S and Lamacchia, C and Rodriguez, E and Finckh, A and Smith, DE and Gabay, C and Palmer, G (2013) Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency - art. no. R13. ARTHRITIS RESEARCH & THERAPY.

Martina, Marzia and Comas, Tanya and Mealing, Geoffrey (2013) Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus. Journal of Neuroscience, 4. ISSN 1663-9812

Marzinzik, Andreas and Lewis, Ian (2013) KGF-SCS Senior Industrial Investigator Award 2013. Chimia, 67 (4). A302.

Marzinzik, Andreas and Vorherr, Thomas (2013) Towards intracellular delivery of peptides. Chimia.

Massacesi, C and Di, TE and Fretault, N and Hirawat, S (2013) Challenges in the clinical development of PI3K inhibitors. Annals of the New York Academy of Sciences. pp. 19-23.

Matos Coelho, Fernanda and Natale, Daniela and Soriano, Silvia and Hons, Swoger and Mayer, Jürgen and Danuser, Renzo and Scandella, Elke and Pieczyk, Markus and Zerwes, Hans-Guenter and Junt, Tobias and Sailer, Andreas and Ludewig, Burkhard and Sharpe, James and Figge, Marc Thilo and Stein, Jens (2013) Analyzing the in vivo contribution of G protein-coupled receptors and LFA-1 for naive B cell trafficking in lymph nodes. Blood, 121 (20). pp. 4101-4109. ISSN 0006-4971

Matthews, GM and Lefebure, M and Doyle, MA and Shortt, J and Ellul, J and Chesi, M and Banks, KM and Vidacs, E and Faulkner, D and Atadja, P and Bergsagel, PL and Johnstone, RW (2013) Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma - art. no. e798. CELL DEATH & DISEASE.

May, Andrew and Hazelhurst, Scott and Waldvogel, Marie and Eichenberger, Juerg and Norris, Shane A and Govind, Nimmisha and Tikly, Mohammed and Hon, Yee and Johnson, Keith and Hartmann, Nicole and Staedtler, Frank and Ramsay, Michèle (2013) Genetic diversity in black South Africans from Soweto. BMC Genomics, 14 (644).

McDonald, Michelle and Mikulec, Kathy and Peacock, Lauren and Morse, Alyson and Baldock, Paul Andrew and Kostenuik, Paul and Little, David G (2013) Osteoclasts are redundant during MMP-driven endochondral fracture repair. McDonald MM, Morse A, Mikulec K, Peacock L, Baldock P, Kostenuik PJ, Little DG. Osteoclasts are redundant during MMP driven endochondral fracture repair, but essential to hard callus remodelling. J Bone Miner Res. 2013 Jul;28(7):1550-60.

Mcnamara, Case and Lim, Chek Shik and Lim, Siau Hoi and Roland, Jason and Simon, Oliver and Yeung, Bryan King Sing and Kuhen, Kelli and Gagaring, Kerstin Mae and Nagle, Advait and Plouffe, David and Bursulaya, Badry and Trappe, Joerg and Haasen, Dorothea and Glynne, Richard and Bodenreider, Christophe and Diagana, Thierry Tidiane and Winzeler, Elizabeth A (2013) Targeting Plasmodium phosphatidylinositol-4 kinase for the treatment, prevention and elimination of malaria. Nature, 504 (7479). pp. 248-253. ISSN 0028-08361476-4687

Megison, Michael L. and Stewart, Jerry E. and Gillory, Lauren A. and Nabers, Hugh and Beierle, Elizabeth A. (2013) FAK Inhibition Decreases Neuroblastoma Cell Invasion, Migration and Metastasis. Clinical and Experimental Metastasis, 30 (5). pp. 555-568. ISSN 0262-0898

Mehling, M and Brinkmann, V and Burgener, AV and Gubser, P and Luster, AD and Kappos, L and Hess, C (2013) Homing frequency of human T cells inferred from peripheral blood depletion kinetics after sphingosine-1-phosphate receptor blockade. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1440-.

Meier, V and Geigy, C and Grosse, N and McSheehy, P and Bley, CR (2013) Use of Epothilone B (Patupilone) in Refractory Lymphoma and Advanced Solid Tumors in Dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE. pp. 120-125.

Meingassner, Josef and Aschauer, Heinrich and Winiski, Anthony and Dales, Natalie and Yowe, David and Winther, Michael and Zhang, Zahui and Stuetz, Anton and Billich, Andreas (2013) Pharmacological Inhibition of Stearoyl CoA Desaturase 1 in the Skin Induces Atrophy of the Sebaceous Glands. Journal of Investigative Dermatology, 133 (8). pp. 2091-2094. ISSN 0022-202X

Menon, Roopika and Deng, Mario and Rüenauver, Kerstin and Kunze, Friedrich and Diana, Boehm and Vogel, Wenzel and Scheble, Veit and Fend, Falko and Kristiansen, Glen and Wernert, Nicolas and Oberbeckmann, Nicole and Biskup, Saskia and Rubin, Mark A. and Shaikhibrahim, Zaki and Perner, Sven (2013) Somatic copy number alterations by whole exome sequencing implicates YWHAZ and PTK2 in castration resistant prostate cancer. The Journal of Pathology.

Merchant, M and Ma, X and Maun, HR and Zheng, Z and Peng, J and Romero, M and Huang, A and Yang, N and Nishimura, M and Greve, J and Santell, L and Zhang, Y and Su, Y and Kaufman, DW and Billeci, KL and Mai, E and Moffat, B and Lim, A and Duenas, ET and Phillips, HS and Xiang, H and Young, JC and Vande Woude, GF and Dennis, MS and Reilly, DE and Schwall, RH and Starovasnik, MA and Lazarus, RA and Yansura, DG (2013) Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. E2987-E2996.

Meredith, Erik and Burgis, Robin and Beil, Michael and Capparelli, Michael and Fu, Fumin and Hu, Chii-Whei and Hu, Qi-Ying and Jeng, Arco and Ksander, Gary and Lasala, Daniel and Liu, Qian and Miranda, Karl and Monovich, Lauren and Morris, Patrick and Papillon, Julien and Rao, Chang and Rigel, Dean and Singh, Alok (2013) Discovery and in vivo evaluation of potent dual CYP11B2 (aldosterone synthase) and CYP11B1 inhibitors. ACS Medicinal Chemistry Letters.

Michelle L, Frost and Amelia E, Moore and Musib, Siddique and Glen M, Blake and Laurent, Didier and Borah, Babul and Schramm, Ursula and Theodore, Pellas and Paul K, Marsden and Paul J, Schleyer and Ignac, Fogelman (2013) 18F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: A prospective, randomized, controlled clinical study. Journal of Bone and Mineral Research, 28 (6). pp. 1337-1347. ISSN 08840431

Micoli, Francesca and Romano, Maria Rosaria and Tontini, Marta and Cappelletti, Emilia and Gavini, Massimiliano and Proietti, Daniela and Rondini, Simona and Swennen, Erwin Frans and Santini, Laura and Filippini, Sara and Balocchi, Cristiana and Adamo, Roberto and Pluschke, Gert and Norheim, Gunnstein and Pollard, Andrew J. and Saul, Allan James and Rappuoli, Rino and Maclennan, Calman Alexander and Berti, Francesco and Costantino, Paolo (2013) The development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X. Proceedings of the National Academy of Sciences (PNAS).

Minetti, Giulia and feige, Jerome and Bombard, Florian and Heier, Annabelle and Morvan, Frederic and Nuerberg, Bernd and Leiss , Veronika and Birnbaumer, Lutz and Glass, David and Fornaro, Mara (2013) Gαi2 signaling is required for skeletal muscle growth, regeneration and satellite cell proliferation and differentiation. Mol Cell Biol.

Misof, Barbara M and Roschger, Paul and Paschalis, Eleftherios P and Eriksen, Erik F and Recker, Robert R and Gasser, Juerg Andreas and Klaushofer, Klaus (2013) Annual intraveneous zoledronic acid for three years increased cancellous bone matrix mineralization beyond normal values in the HORIZON biopsy cohort. Journal of Bone and Mineral Research.

Mochel, JP and Fink, M and Peyrou, M and Desevaux, C and Deurinck, M and Giraudel, JM and Danhof, M (2013) Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology. CHRONOBIOLOGY INTERNATIONAL. pp. 1144-1159.

Modur, V and Hailman, E and Barrett, JC (2013) Evidence-Based Laboratory Medicine in Oncology Drug Development: From Biomarkers to Diagnostics. CLINICAL CHEMISTRY. pp. 102-109.

Moggs, Jonathan and Kronenberg, Sven and Baumann, Andreas and de Haan, Lolke and Hinton, Heather J and Theil, Frank-Peter and Wakefield, Ian and Singer, Thomas (2013) Current challenges and opportunities in nonclinical safety testing of biologics. Drug Discovery Today, 18 (23-24). pp. 1138-1143. ISSN 1878-5832

Moggs, Jonathan and Satish, Jean and Sethu, Swaminathan and Bielsky, Marie-Christine and de Haan, Lolke and French, Neil and Govindappa, Karthik and Green, James and Griffiths, Christopher and Holgate, Stephen and Jones, David and Kimber, Ian and Naisbitt, Dean and Pirmohamed, Munir and Reichmann, Gabriele and Sims, Jennifer and Subramanyam, Meena and Todd, Marque and van der Laan, Jan Willem and Weaver, Richard and Park, Kevin (2013) Challenges and approaches for the development of safer immunomodulatory biologics. Nature Reviews Drug Discovery, 12. pp. 306-324.

Molina-Arcas, Miriam and Hancock, David / C and Sheridan, Clare and Kumar, Madhu / S and Downward, Julian (2013) Coordinate direct input of both KRAS and IGF1 receptor to activation of PI 3-kinase in KRAS mutant lung cancer. Cancer Discovery.

Moon, K and Six, DA and Lee, H and Raetz, CRH and Gottesman, S (2013) Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification. Molecular Microbiology. pp. 52-64.

Moreira Proenca, Catia and Stoehr, Natacha and Bernhard, Mario and Seger, Shanon and Genoud, Christel and Roscic, Ana and Paganetti, Paolo and Murphy, Leon and Kuhn, Rainer and Bouwmeester, Antonius and Galimberti, Ivan (2013) Atg4b-dependent Autophagic Flux Alleviates Huntington’s Disease Progression. PloS ONE, 8 (7). pp. 1-16.

Morin, N and Morissette, M and Gregoire, L and Gomez-Mancilla, B and Gasparini, F and Di Paolo, T (2013) Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys. NEUROPHARMACOLOGY. pp. 216-231.

Myers, AP (2013) New Strategies in Endometrial Cancer: Targeting the PI3K/mTOR Pathway-The Devil Is in the Details. CLINICAL CANCER RESEARCH. pp. 5264-5274.


Nakamura, Eri and Otsuka, Fumio and Inagaki, Kenichi and Miyoshi, Tomoko and Tsukamoto, Naoko and Ogura-Ochi, Kanako and Takeda, Masaya and Toma, Kishio and Makino, Hirofumi (2013) Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis. The Journal of steroid biochemistry and molecular biology, 134. pp. 67-74. ISSN 0960-0760

Ngaemthao, W and Suriyachadkun, C and Chunhametha, S and Tamura, T and Sanglier, JJ (2013) Planobispora siamensis sp nov., isolated from soil. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. pp. 2649-2654.

Nguyen, HP and Hubener, J and Weber, JJ and Grueninger, S and Riess, O and Weiss, A (2013) Cerebellar Soluble Mutant Ataxin-3 Level Decreases during Disease Progression in Spinocerebellar Ataxia Type 3 Mice. PLoS One.

Nguyen, THT and Guedj, J and Yu, J and Levi, M and Mentre, F (2013) Influence of a priori information, designs, and undetectable data on individual parameters estimation and prediction of hepatitis c treatment outcome. CPT: Pharmacometrics and Systems Pharmacology.

Nicholson, Thomas and Su, Hui and Hevi, Sarah and Bajko, Jeff and Wang, Jing and Valdez, Reginald and Loureiro, Joseph and Cheng, Xiaodong and Li, En and Kinzel, Bernd and Labow, Mark and Chen, Taiping (2013) Defective heart development in hypomorphic Lsd1 mice. PLoS One, 8 (4). ISSN 1932-6203

Nijmeijer, S and Vischer, H and Sirci, F and Schultes, S and Engelhardt, H and de Graaf, C and Rosethorne, Elizabeth and Charlton, Steven and Leurs, R (2013) Detailed analysis of biased histamine H4 receptor signalling by JNJ7777120 analogues. British Journal of Pharmacology, 170. pp. 78-88.

Nilar, Shahul Hameed and Ma, Ngai Ling and Keller, Thomas H. (2013) Incorporating Molecular Complexity in the Design of Screening Libraries. Journal of Computer Aided Molecular Design.

Noble, Christian Guy and Lim, Siew Pheng and Chen, Yen Liang and Shi, Pei-Yong (2013) Conformational flexibility of the dengue virus RNA dependent RNA polymerase revealed by a complex with an inhibitor. Journal of Virology, 87 (9). pp. 5291-5295. ISSN 0022-538X

Noble, Christian Guy and Shi, Pei-Yong (2013) Difficulties and advancements in developing drugs for the treatment of dengue fever. Expert Opinion on Orphan Drugs, 1 (12). pp. 947-949. ISSN 2167-8707

Noble, Christian Guy and Vasudevan, Dileep and Rao, Srinivasa P.S. (2013) Structural basis of mycobacterial inhibition by Cyclomarin A. Journal of Biological Chemistry, 288 (43). ISSN 0021-92581083-351X

Nordstrand, Annika and Lundholm, Marie and Larsson, Andreas and Lerner, Ulf H and Widmark, Anders and Wikström, Pernilla (2013) Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone. Cancer Microenvironment. ISSN 1875-2292


O'Connor, RM and Thakker, DR and Schmutz, Markus and Van Der Putten, P. Herman and Hoyer, Daniel and Flor, PJ and Cryan, JF (2013) Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse. Neuropharmacology, 72. pp. 66-73. ISSN 0028-3908

Ostermann, Nils and Ruedisser, Simon and Ehrhardt, Claus and Breitenstein, Werner and Marzinzik, Andreas and Jacoby, Edgar and Vangrevelinghe, Eric and Ottl, Johannes and Klumpp, Martin and Mueller-Hartwieg, Constanze and Cumin, Frederic and Hassiepen, Ulrich and Trappe, Joerg and Geisse, Sabine and Gerhartz, Bernd and Richert, Paul and Francotte, Eric and Wagner, Beatrix and Kosaka, Takatoshi and Webb, Randy and Maibaum, Juergen Klaus and Baeschlin, Daniel and Sedrani, Richard (2013) A novel class of oral direct renin inhibitors - highly potent 3,5-disubstituted piperidines bearing a tricyclic P3-P1 unit. Journal of medicinal chemistry, 56 (6). pp. 2196-2206. ISSN 0022-2623


Pan, Shifeng and Gray, Nathanael and Gao, Wenqi and Mi, Yuan and Fan, Yi and Wang, Xia and Tuntland, Tove and Che, Jianwei and Lefebvre, Sophie and Chen, Yu and Chu, Alan and Gardin, Anne and End, Peter and Heining, Peter and Bruns, Christian and Cooke, Nigel Graham and Nuesslein-Hildesheim, Barbara (2013) Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Medicinal Chemistry Letters, 4 (3). ISSN 1948-5875

Pantano, Serafino and Dubost, Valerie and Darribat, Katy and Couttet, Philippe and Grenet, Olivier and Busch, Steven and Moulin, Pierre (2013) Differential expression of dipeptidyl peptidase IV in human versus cynomolgus monkey skin eccrine sweat glands. Journal of Molecular Histology, 44 (6). pp. 733-747. ISSN 1567-2387

Pantano, Serafino and Dubost, Valerie and Darribat, Katy and Couttet, Philippe and Grenet, Olivier and Busch, Steven and Moulin, Pierre (2013) Differential expression of dipeptidyl peptidase IV in human versus cynomolgus monkey skin eccrine sweat glands. Journal of Molecular Histology, 44 (6). pp. 733-747. ISSN 1567-2379

Park, So Young and Mun, Hee-Chang and Eom, Young Sil and Jung, Tae Sik and Hong, Suntaek and Lee, Sihoon and Kim, Chul Hoon (2013) Identification and characterization of D410E, a novel mutation in the loop 3 domain of CaSR, in autosomal dominant hypocalcemia and therapeutic approaches with novel calcilytics, AXT914. Clinical Endocrinology, 78 (5). pp. 687-693. ISSN 0300-0664

Parker, C (2013) Antisense Drug Technology, Principles, Strategies and Applications, 2nd edition. JOURNAL OF BIOMOLECULAR SCREENING. 1-.

Parkinson, Scott James and Holway, Nicholas and Siddharth, Jay (2013) A western diet ecological module identified from the 'humanized' mouse microbiota predicts diet in adults and formula feeding in children. PLoS ONE, 8 (12). ISSN 1932-6203

Patrone, JD and Kennedy, JP and Frank, AO and Feldkamp, MD and Vangamudi, B and Pelz, NF and Rossanese, OW and Waterson, AG and Chazin, WJ and Fesik, SW (2013) Discovery of protein-protein interaction inhibitors of replication protein A. ACS Medicinal Chemistry Letters. pp. 601-605.

Pawar, PV and Gohil, SV and Jain, JP and Kumar, N (2013) Functionalized polymersomes for biomedical applications. POLYMER CHEMISTRY. pp. 3160-3176.

Pearlstein, Robert and Sherman, Woody and Abel, Robert (2013) Contributions of Water Transfer Energy to Protein-Ligand Association and Dissociation Barriers: WaterMap Analysis of a Series of p38α MAP Kinase Inhibitor. PROTEINS: Structure, Function, and Bioinformatics. ISSN 0887-3585

Pecchi, Sabina and Ni, Zhi-Jie and Han, Wooseok and Smith, Aaron and Jiong, Lan and Burger, Matthew and Merritt, Hanne and Wiesmann, Marion and Kaufman, Susan and Chan, John and Knapp, Mark and Jansen, Johanna and Hu, Kay and Voliva, Charles (2013) Structure Guided Optimization of a Fragment Hit to Imidazopyridine Inhibitors of PI3K. Bioorganic and Medicinal Chemistry Letters, 23 (16). pp. 4652-4656. ISSN 0960894X

Peille, A and Brouste, V and Kauffmann, A and Lagarde, P and Le, M and Coindre, J and Chibon, F and Bresson-Bepoldin, L (2013) Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas. PLoS One.

Penno, CA and Arsenijevic, D and Da Cunha, T and Kullak-Ublick, GA and Montani, JP and Odermatt, A (2013) Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry. ANALYTICAL METHODS. pp. 1155-1164.

Perez, EG and Ocampo, C and Feuerbach, D and Lopez, JJ and Morelo, GL and Tapia, RA and Arias, HR (2013) Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodides are competitive antagonists for the human alpha4beta2 and alpha7 nicotinic acetylcholine receptors. MedChemComm. pp. 1166-1170.

Perez-Schindler, J and Summermatter, S and Santos, G and Zorzato, F and Handschin, C (2013) The transcriptional coactivator PGC-1alpha is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 20314-20319.

Pethe, Kevin and Jang, Jichan and Kang, Sunhee and Park, Seijin and Ahn, Sujin and Jiricek, Jan and Jung, Juyoung and Jeon, Hee Kyoung and Cechetto, Jonathan and Christophe, Thierry and Kempf, Marie and Jackson, Mary and Lenaerts, Anne J. and Pham, Ha and Jones, Victoria and Seo, Min Jung and Lee, Saeyeon and Kim, Young and Seo, Mooyoung and Seo, Jeong Jea and Ko, Yoonae and Choi, Inhee and Kim, Ryangyeo and Kim, Seyeon and Lim, SeungBin and Yim, SeungAe and Jiyoun Nam, Jiyoun Nam and Hwankyu Kang, Hwankyu Kang and Chun-Taek Oh, Chun-Taek Oh and Yoojin Cho, Yoojin Cho and Yunhee Jang, Yunhee Jang and Junghwan Kim, Junghwan Kim and Chua, Adeline and Tan, Bee Huat and Nanjundappa, Mahesh Bangalore and Rao, Srinivasa P.S. and Barnes, Whitney and Wintjens, René and Walker, John and Alonso, Sylvie and Kim, Jungjun and Oh, Soohyun and Oh, Taegwon and Han, Sung-Jun and No, Zaesung and Lee, Jinhwa and Brodin, Priscille and Cho, Sang-Nae and Nam, Kiyean and Bifani, Juan Pablo and Kim, Jaeseung (2013) Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nature Medicine, 19 (9). pp. 1157-1160. ISSN 1078-8956

Petrone, Paula and Wassermann, Anne and Lounkine, Eugen and Kutchukian, Peter and Simms, Ben and Jenkins, Jeremy and Selzer, Paul and Glick, Meir (2013) Biodiversity of small molecules – a new perspective in screening set selection. Drug Discov Today, 18 (13-14). pp. 674-680. ISSN 13596446

Phong, Wai Yee and Lin, WenWei and Rao, Srinivasa P.S. and Dick, Thomas and Sylvie, Alonso and Pethe, Kevin (2013) Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia. PLOS One. ISSN 1932-6203

Pillai, Goonaseelan and Mirza, Fareed and Tadmor, Brigitta and Steimer, Jean-Louis and Davies, Geriant and Denti, Paolo and McIlleron, Helen and Holford, Nicholas H G (2013) Pharmacometrics – Opportunity for Reducing Disease Burden in the Developing World. Clinical Pharmacology and Therapeutics:Pharmacometrics & Systems Pharmacology, 2 (e69).

Pistorius, Dominik and Müller, Rolf (2013) Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining. ChemBioChem, 13 (3). pp. 416-426.

Poll, Chris and Verkuijl, Martin and Abbott Banner, Katharine (2013) Targeting TRP channels in airway disorders. Current Topics in Medicinal Chemistry, 13 (3). pp. 310-321. ISSN 1568-0266

Pyonteck, Stephanie M. and Schuhmacher, Alberto J. and Bowman, Robert L. and Akkari, Leila and Sevenich, Lisa and Olson, Oakley C. and Teijeiro, Virginia and Setty, Manu and Leslie, Christina and Huse, Jason T. and Oei, Yoko and Holland, Eric C. and Daniel, Dylan and Joyce, Johanna (2013) Hyperacetylation of α-tubulin correlates with starvation induced autophagy in tobacco BY-2 cells. Molecular Biology of the Cell, 24 (24). ISSN 1059-1524


Radimerski, Thomas and Bentires-Alj, Mohamed and Britschgi, Adrian (2013) Targeting PI3K, IL-8/JAK2 axis and HER2 in metastatic breast cancer: which combination makes the whole greater than the sum of its parts. Drug Resist Update, 16 (3-5). pp. 68-72.

Rath, CM and Yang, JY and Alexandrov, T and Dorrestein, PC (2013) Data-independent microbial metabolomics with ambient ionization mass spectrometry. Journal of the American Society for Mass Spectrometry. pp. 1167-1176.

Reilmann, Ralf and Saft, Carsten and Süssmuth, Sigurd and Priller, Joseph and Rosser, Anne and Rickards, Hugh and Schöls, Ludger and Pezous, Nicole and Landwehrmeyer,, Bernhard and Gomez-Mancilla, Baltazar and Rouzade-Dominguez, Marie-Laure and Gasparini, Fabrizio and Johns, Donald (2013) Efficacy, Safety and Tolerability of AFQ056 for the treatment of chorea in patients with Huntington’s disease. Movement DIsorders.

Reisen, Felix and Zhang, Xian and Gabriel, Daniela and Selzer, Paul (2013) Benchmarking of Multivariate Similarity Measures for High Content Screening Fingerprints in Phenotypic Drug Discovery. Journal of Biomolecular Screening, 18 (10). pp. 1284-1297. ISSN 1087-05711552-454X

Reisen, Felix and Zhang, Xian and Gabriel, Daniela and Selzer, Paul (2013) Benchmarking of Multivariate Similarity Measures for High Content Screening Fingerprints in Phenotypic Drug Discovery. Journal of Biomolecular Screening, 18 (10). pp. 1284-1297. ISSN 1087-05711552-454X

Renner, Steffen (2013) Past, Present, and Future of Chemogenomics. Molecular Informatics, 32 (11-12). pp. 877-879. ISSN 1868-1751

Rice, DS (2013) Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of Pain and Itch. Neuron, 78 (2). pp. 312-324. ISSN 0896-6273

Richie, Daryl and Thompson, Katherine and Studer, Christian and Aust, Thomas and Riedl, Ralph and Estoppey, David and Zabawa, Thomas and Drumm Iii, Joseph and Cotesta, Simona and Eichenberger, Juerg and Schuierer, Sven and Hartmann, Nicole and Movva, Rao and Tallarico, John and Ryder, Neil and Hoepfner, Dominic (2013) Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents. Antimicrobial Agents and Chemotherapy, 57 (5). pp. 2272-2280. ISSN 0066-4804

Riddick, DS and Ding, X and Wolf, CR and Porter, TD and Pandey, AV and Zhang, Q and Gu, J and Finn, RD and Ronseaux, S and McLaughlin, LA and Henderson, CJ and Zou, L and Fluck, CE (2013) NADPH-cytochrome P450 oxidoreductase: Roles in physiology, pharmacology, and toxicology. Drug Metabolism and Disposition. pp. 12-23.

Rinaldi, F and Clematide, S and Hafner, S and Schneider, G and Grigonyte, G and Romacker, M and Vachon, T (2013) Using the OntoGene pipeline for the triage task of BioCreative 2012. Database-the Journal of Biological Databases and Curation.

Riniker, Sereina and Fechner, Nikolas and Landrum, Gregory (2013) Heterogeneous Classifier Fusion for Ligand-Based Virtual Screening: Or, How Decision Making by Committee Can Be a Good Thing. Journal of Chemical Information and Modeling, 53. pp. 2829-2836.

Riniker, Sereina and Landrum, Gregory (2013) Open Source Platform to Benchmark Fingerprints for Ligand-Based Virtual Screening. Journal of Cheminformatics, 5 (1). pp. 26-43. ISSN 1758-2946

Riniker, Sereina and Landrum, Gregory (2013) Similarity maps - a visualization strategy for molecular fingerprints and machine-learning methods. Journal of Cheminformatics, 5. p. 43.

Ritter Iii, Robert and Senchyna, Michelle and Srinivasan, Sruthi and Heynen, Miriam L. and Martell, Elizabeth and Jones1, Lyndon (2013) Expression of MUC1 and MUC16 in tears and conjunctival epithelial cells collected from postmenopausal women. Molecular Vision, 19. pp. 970-979.

Rombach-Riegraf, Verena and Karle, Anette and Wolf, Babette and Sorde, Laetitia and Koepke, Stephan and Gottlieb, Sascha and Djidja, Marie-Claude and Baban, Aida and Spindeldreher, Sebastian and Koulov, Atanas and Kiessling, Andrea (2013) Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-cell Responses In Vitro. PLoS One.

Romero, V and Fert-Bober, J and Nigrovic, PA and Darrah, E and Haque, UJ and Lee, DM and Van, EJ and Rosen, A and Andrade, F (2013) Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Science Translational Medicine.

Rot, A and McKimmie, C and Burt, CL and Pallas, KJ and Jamieson, T and Pruenster, M and Horuk, R and Nibbs, RJB and Graham, GJ (2013) Cell-Autonomous Regulation of Neutrophil Migration by the D6 Chemokine Decoy Receptor. JOURNAL OF IMMUNOLOGY. pp. 6450-6456.

Rothenbacher, D and Hoffmann, MM and Breitling, LP and Rajman, I and Koenig, W and Brenner, H (2013) Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care - art. no. 61. BMC CARDIOVASCULAR DISORDERS. 61-.

Roubenoff, Ronenn (2013) The “Cytokine for Gerontologists” Has Some Company. Journal of Gerontology: Biological Sciences.

Rowe, Steven and Reeves, Ginger and Halthorne, Heather and Solomon, G Martin and Abbi, Smita and Renard, Didier and Lock, Ruth and Zhou, Ping and Danahay, Henry and Clancy, JP and Waltz, David (2013) Reduced Sodium Transport with Nasal Administration of the Prostasin Inhibitor Camostat in Cystic Fibrosis Subjects. Chest, 144 (1). pp. 200-207. ISSN None

Ruby, JG and Bellare, P and DeRisi, JL (2013) PRICE: Software for the targeted assembly of components of (Meta) genomic sequence data. G3: Genes, Genomes, Genetics. pp. 865-880.

Rueeger, Heinrich and Lueoend, Rainer Martin and Machauer, Rainer and Veenstra, Siem and Jacobson, Laura and Staufenbiel, Matthias and Desrayaud, Sandrine and Rondeau, Jean-Michel and Moebitz, Henrik and Neumann, Ulf (2013) Discovery of Cyclic Sulfoxide Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure Based Design and in Vivo Reduction of Amyloid β-Peptides. Bioorganic & Medicinal Chemistry Letters, 23. pp. 5300-5306.

Ruffner, Heinz (2013) Master thesis: Study of the Yap-Hippo and Wnt Pathways for Intestinal Regeneration in an Ex Vivo Small Intestinal 3D Organoid Model. Hochschule Mannheim. Master thesis, not published, presented to supervisor at Hochschule Mannheim under CDA..


Sadlish, Heather and Galicia-Vazquez, Gabriela and Paris, Greg and Aust, Thomas and Bhullar, Bhupinder and Chang, Lena and Helliwell, Stephen and Hoepfner, Dominic and Knapp, Britta and Paris, Charles and Riedl, Ralph and Roggo, Silvio and Schuierer, Sven and Studer, Christian and Pelletier, Jerry and Movva, Rao (2013) Evidence for a functionally relevant rocaglamide binding site on the eIF4A:RNA complex. ACS Chemical Biology. ISSN 1554-8929

San Sebastian, Eider and Zimmerman, Tahl and Zubia, Aizpea and Vara, Yosu and Martin, Elyette and Sirockin, Finton and Dejaegere, Annick and Stote, Roland H and Lopez, Xabier and Pantoja-Uceda, David and Varcarcel, Maria and Medoza, Lorea and Vidal-Vanaclocha, Fernando and Cossío, Fernando P. and Blanco, Francisco J. (2013) Design, Synthesis and Functional Evaluation of Leuko-cyte-Function Associated Antigen-1 (LFA-1) Antagonists in Early and Late Stages of Cancer Development. Journal of Medicinal Chemistry, 56 (3). pp. 735-747. ISSN 0022-2623

Sandham, David and Arnold, Nicola and Aschauer, Heinrich and Bala, Kamlesh and Barker, Lucy and Brown, Lyndon and Brown, Zarin and Budd, David and Cox, Brian and Dubois, Gerald and Docx, Cerys and Duggan, Nicholas and England, Karen and Everatt, Brian and Furegati, Markus and Hall, Edward and Kalthoff, Frank and King, Anna and Leblanc, Catherine and Manini, Jodie and Meingassner, Josef and Profit, Rachael and Stringer, Rowan and Schmidt, Alfred and Simmons, Jennifer and Sohal, Bindi and Thomas, Matthew and Turner, Katharine and Walker, Christoph and Watson, Simon and Westwick, John and Willis, Jennifer and Williams, Gareth and Wilson, Caroline (2013) Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorganic and Medicinal Chemistry.

Schluepen, Christina and Malito, Enrico and Marongiu, Ambra and Schirle, Markus and Mc Whinnie, Elizabeth and Lo Surdo, Paola and Biancucci, Marco and Falugi, Fabiana and Nardi Dei Da Filicaia Dotti, Vincenzo and Marchi, Sara and Fontana, Maria Rita and Lombardi, Benedetta and De Falco, Maria Grazia and Rinaudo, Daniela and Spraggon, Glen and Grandi, Guido and Nissum, Mikkel and Bagnoli, Fabio and Bottomley, Matthew James and Liberatori, Sabrina (2013) A novel family of highly conserved antigens that induce protective immunity against Staphylococcus aureus. Biochemical journal, 455 (3). pp. 273-284. ISSN 1470-8728; 0264-6021

Schoumacher, M and Glentis, A and Gurchenkov, VV and Vignjevic, DM (2013) Basement membrane invasion assays: Native basement membrane and chemoinvasion assay. Adhesion Protein Protocols. pp. 133-144.

Schutzius, G and Bleckmann, D and Kapps-Fouthier, S and di Giorgio, F and Gerhartz, B and Weiss, A (2013) A quantitative homogeneous assay for fragile X mental retardation 1 protein - art. no. 8. JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 5 (1). p. 8. ISSN 1866-1947

Schutzius, Gabi and Bleckmann, Dorothee and Kapps-Fouthier, Sandra and Di Giorgio, Francesco and Gerhartz, Bernd and Weiss, Andreas (2013) A high-throughput compatible quantitative homogenous assay for Fragile X Mental Retardation 1 Protein. Journal for Neurodevelopmental Disorders, 5 (1). p. 8. ISSN 1866-1947

Schwarz, Adam J and Hill, Derek G and Frisoni, Giovanni and Jack, Clifford and Maguire, Paul and Stephenson, Diane (2013) CAMD/EMA Biomarker Qualification of Hippocampal Volume for Patient Enrichment. Alzheimer’s and dementia.

Schweizer, D and Vostiar, I and Heier, A and Serno, T and Schoenhammer, K and Jahn, M and Jones, S and Piequet, A and Beerli, C and Gram, H and Goepferich, A (2013) Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation. JOURNAL OF CONTROLLED RELEASE. pp. 975-982.

Scuto, A and Kirschbaum, M and Buettner, R and Kujawski, M and Cermak, JM and Atadja, P and Jove, R (2013) SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-kappa B/STAT3 complex to its promoter in malignant lymphoid cells - art. no. e635. CELL DEATH & DISEASE.

Sen, A and Dimlich, DN and Guruharsha, KG and Kankel, MW and Hori, K and Yokokura, T and Brachat, S and Richardson, D and Loureiro, J and Sivasankaran, R and Curtis, D and Davidow, LS and Rubin, LL and Hart, AC and Van Vactor, D and Artavanis-Tsakonas, S (2013) Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. E2371-E2380.

Sharma, S. and deVries, E.G. and Infante, J.R. and Oldenhuis, C.N. and Gietema, J.A. and Yang, Lin and Bilic, Sanela and Parker, Kathryn and Goldbrunner, Michael and Scott, Jeffrey and Burris, H.A. (2013) Safety, Pharmacokinetics, and Pharmacodynamics of the DR5 Antibody LBY135 Alone and in Combination with Capecitabine in Patients with Advanced Solid Tumors. Investigational New Drugs. ISSN 0167-6997

Shcheglovitov, A and Shcheglovitova, O and Yazawa, M and Portmann, T and Shu, R and Sebastiano, V and Krawisz, A and Froehlich, W and Bernstein, JA and Hallmayer, JF and Dolmetsch, RE (2013) SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. NATURE. pp. 267-271.

Shi, Pei-Yong and Zhang, Bo (2013) Report of the fifth symposium on emerging viral diseases. Virologica Sinica, 28 (2). pp. 63-64. ISSN 1674-0769

Shidong, JIa and Massimo, Loda and Thomas, Roberts (2013) Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discovery, 3 (1). pp. 44-51. ISSN 2159-8274

Shieh, Mae Mae Yi Fong and Thompson, Corinne and My, Phan Vu Tra and Van, Thi Thuy Linh and Tediosi, Fabrizio and Merson, Laura and Farrar, Jeremy and Ha, Manh Tuan and Ho, Lu Viet and Pham, Thi Ngoc Tuyet and Baker, Stephen (2013) Policy of free healthcare for children under six in Vietnam: assessment of its non-usage during hospitalization for diarrhea in Ho Chi Minh City. Tropical Medicine & International Health.

Shimada, Kenji and Filipuzzi, Ireos and Helliwell, Stephen and Studer, Christian and Hoepfner, Dominic and Movva, Rao and Gasser, Susan and Stahl, Michael and Loewith, Robbie (2013) TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Molecular Cell, 51 (6). pp. 829-839. ISSN 1097-2765

Shinde, DD and Kim, H and Choi, J and Pan, W and Bae, SK and Yeo, C and Shon, J and Kim, D and Shin, JG (2013) Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects. Journal of Clinical Pharmacology. pp. 550-558.

Shou, Jianyong (2013) Inhibition of H3K9 Methyltransferase G9a/GLP Prevents Ototoxic and Ongoing Hair Cell Death. Cell Death and Diseases, 4 (e506). ISSN 2041-4889

Shultz, Michael (2013) Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters. Bioorganic and Medicinal Chemistry Letters, 23 (21). pp. 5980-5991. ISSN 0960-894X

Shultz, Michael (2013) The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations. Bioorganic and Medicinal Chemistry Letters, 23 (21). pp. 5992-6000. ISSN 0960-894X

Shultz, Michael and Kirby, Christina and Firestone, Brant and Fan, Jianmei and Chen, Christine and Chen, Zhuoliang and Cheung, Atwood and Chin, Donovan and DiPietro, Lucian and Fazal, Aleem and Feng, Yun and Fortin, Pascal and Gould, Ty and Huangshu, Lei and Lenoir, Francois and Majumdar, Dyuti and Ochala, Etienne and Palermo, Mark and Pham, Ly and Pu, Minying and Smith, Troy and Tomlinson, Ronald and Toure, Bakary-Barry and Visser, Michael and Wang, Run-Ming and Waters, Nigel and Shao, Wenlin (2013) Identification of NVP-TNKS656: The use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. Journal of Medicinal Chemistry, 56 (16). pp. 6495-6511. ISSN 0022-2623

Sitnick, MT and Basantani, MK and Cai, L and Schoiswohl, G and Yazbeck, CF and Distefano, G and Ritov, V and DeLany, JP and Schreiber, R and Stolz, DB and Gardner, NP and Kienesberger, PC and Pulinilkunnil, T and Zechner, R and Goodpaster, BH and Coen, P and Kershaw, EE (2013) Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. DIABETES. pp. 3350-3361.

Skora, Lukasz and Jahnke, Wolfgang and Mestan, Jürgen and Grzesiek, Stephan and Fabbro, Doriano (2013) NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors. PNAS, 110 (47). pp. 4437-4445. ISSN 0027-84241091-6490

Skvara, Hans and Burnett, Patrick and Jones, Julie and Plassmann, Peter and Thirion, Jean-Philippe (2013) Quantification of skin lesions with a 3D stereovision camera system: Validation and clinical applications. Skin Research and Technology, 19 (1). e182-190. ISSN 0909-752X

Slomianka, L and Drenth, T and Cavegn, N and Menges, D and Lazic, SE and Phalanndwa, M and Chimimba, CT and Amrein, I (2013) The hippocampus of the eastern rock sengi: Cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis. Frontiers in Neuroanatomy.

Smith, Nichola and Benito-Alifonso, David and Jones, Rachel A and Tran, Anh-Tuan and Woodward, Hannah and Galan, M Carmen (2013) Synthesis of mucin-type O-glycan probes ready to be immobilized to glycoarray platforms. Beilstein Journal of Organic Chemistry.

Song, Y and Lunde, CS and Benton, BM and Wilkinson, BJ (2013) Studies on the mechanism of telavancin decreased susceptibility in a laboratory-derived mutant. Microbial Drug Resistance. pp. 247-255.

Springer, Clayton and Sokolnicki, Katherine (2013) “A molecular matched pair analysis of hERG inhibition data”. Chemistry Central Journal, 7 (167). p. 167. ISSN 1752-153X

Spytek, Kimberly and Gualtieri, Giovanna (2013) Test project for OAK training videos. Marine Biology.

Sridar, C and Hanna, I and Hollenberg, PF (2013) Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches. XENOBIOTICA. pp. 336-345.

Staedtler, Frank and Hartmann, Nicole and Letzkus, Martin and Bongiovanni, Sandrine and Johnson, Keith and Schumacher, Martin (2013) Robust and tissue-independent gender-specific transcript biomarkers. Biomarkers, 18 (5). pp. 436-445.

Stalder, Lukas and Heusermann, Wolf and Hean, Justin and Pfanzagl, Vera and Aeschimann, Florian and Weiler, Jan and Gerace, Larry and Morrissey, David and Meisner Kober, Nicole-Claudia (2013) The rough endoplasmatic reticulum is the central site of siRNA-mediated RNA silencing. EMBO Journal, 32 (8). pp. 1115-1125. ISSN 0261-4189

Stegmeier, Frank and Jaffe, Jacob and Chan, Ho Man and Wang, Yan and Mcdonald Iii, Earl and Liu, Jun and Keen, Nicholas and Sellers, William and Livi, Garraway and Grigoriy, Kryukov and Hu, Min and Zhang, Jingui and Downing, James (2013) Global chromatin profiling reveals NSD2 mutation in pediastric acute lymphoblastic leukemia. Nature Genetics.

Stein, A and Bellmunt, J and Escudier, B and Kim, D and Stergiopoulos, SG and Mietlowski, W and Motzer, RJ (2013) Survival Prediction in Everolimus-treated Patients with Metastatic Renal Cell Carcinoma Incorporating Tumor Burden Response in the RECORD-1 Trial. EUROPEAN UROLOGY. pp. 994-1002.

Stein, AM and Martinelli, G and Hughes, TP and Mueller, MC and Beppu, L and Gottardi, E and Branford, S and Soverini, S and Woodman, RC and Hochhaus, A and Kim, DW and Saglio, G and Radich, JP (2013) Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia - art. no. 173. BMC CANCER. 173-.

Stein, Daniel and Ke, June and Uy, Grace and Bosheva, Miroslava and Yin, Qi and Praestgaard, Jens (2013) A Phase I, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics and Safety of Telbivudine in Children and Adolescents with Chronic Hepatitis B. Antimicrobial agents and chemotherapy, 57 (9). pp. 4128-4133. ISSN 1098-6596

Stevenson, CS and Sridhar, S and Phillips, JE (2013) Predicting drug efficacy using integrative models for chronic respiratory diseases. Inflammation and Allergy - Drug Targets. pp. 124-131.

Stevenson, CS and Yew-Booth, L (2013) Is intrinsic aerobic exercise capacity a determinant of COPD susceptibility? Pulmonary Pharmacology & Therapeutics. pp. 459-463.

Stoeckli, Markus and Staab, Dieter and Morandi, Gregory (2013) Mass Spectrometric Imaging Applied to Biomedical Research. Chimia, 57 (4).

Strober, B and Buonanno, M and Clark, JD and Kawabata, T and Tan, H and Wolk, R and Valdez, H and Langley, RG and Harness, J and Menter, A and Papp, K (2013) Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment. BRITISH JOURNAL OF DERMATOLOGY. pp. 992-999.

Subramony, JA (2013) Needle free parenteral drug delivery: Leveraging active transdermal technologies for pediatric use. INTERNATIONAL JOURNAL OF PHARMACEUTICS. pp. 14-18.

Sung, RK and Kim, AM and Tseng, ZH and Han, F and Inada, K and Tedrow, UB and Viswanathan, MN and Badhwar, N and Varosy, PD and Tanel, R and Olgin, JE and Stephenson, WG and Scheinman, M (2013) Diagnosis and Ablation of Multiform Fascicular Tachycardia. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. pp. 297-304.

Sunkara, Gangadhar and Bende, Girish and Mendonza, Anisha and Solar-Yohay, Susan and Biswal, Shibadas and Neelakantham, Srikanth and Wagner, Robert and Flarakos, Jimmy and Zhang, Yiming and Jarugula, Venkateswar (2013) BIOAVAILABILITY OF VALSARTAN LIQUID ORAL DOSAGE FORMS. Clinical Pharmacology in drug development, 3 (2). pp. 132-138. ISSN 2160763X

Suriyachadkun, C and Ngaemthao, W and Chunhametha, S and Tamura, T and Sanglier, JJ (2013) Kutzneria buriramensis sp nov., isolated from soil, and emended description of the genus Kutzneria. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. pp. 47-52.

Suriyachadkun, C and Ngaemthao, W and Chunhametha, S and Thawai, C and Sanglier, J (2013) Actinoplanes siamensis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology. pp. 3037-3042.

Szustakowski, Joseph and Yang, Fan and Linghu, Bolan and Damask, Amy and Klickstein, Lloyd and Duca, Jose and Chibout, Salah-Dine and Johnson, Keith and Boyer, Olivia and Woerner, Stephanie and Tête, Marie-Josèphe and Heibel, Françoise and Matignon, Marie and Beaudoin, Véronique and Chantrel, Francois and Champigneulle, Jacqueline and Nitschké, Patrick and Gubler, Marie-Claire and Antignac, Corinne and Oakeley, Edward James and Gribouval, Olvier (2013) LMX1B mutations as an unexpected cause of hereditary focal segmental glomerulosclerosis without extra-renal involvement. Journal of the American Society of Nephrology (JASN), 24 (8). pp. 1216-1222.


Takahashi, Tsuyoshi and Serada, Satoshi and Urase, Maiko and Fujimoto, Minoru and Miyazaki, Yasuaki and Ikezoe, Takayuki and Taguchi, Takahiro and Kurokawa, Yukinori and Yamasaki, Makoto and Miyata, Hiroshi and Takiguchi, Shuji and Mori, Masaki and Doki, Yuichirou and Naka, Tetsuji and Nishida, Toshirou (2013) New findings of kinase switch in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis. International Journal of Cancer.

Thomas, Matthew and Ciuclan, Loredana and Hussey, Martin and Press, Neil (2013) Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension. Pharmacology and Therapeutics, 138 (3). pp. 409-417. ISSN 0163-7258

Thomson, John P and Hunter, Jennifer M and Nestor, Colm E and Dunican, Donncha S and Terranova, Remi and Moggs, Jonathan and Meehan, Richard R (2013) Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques. Nucleic Acids Research, 41 (22). ISSN 0305-1048

Thudium, K and Bilic, S and Leipold, D and Mallet, W and Kaur, S and Meibohm, B and Erickson, H and Tibbitts, J and Zhao, H and Gupta, M (2013) American Association of Pharmaceutical Scientists National Biotechnology Conference short course: Translational challenges in developing antibody-drug conjugates. mAbs. pp. 5-12.

Tian, Li and Mukherjee, Prasenjit and Martin, Eric (2013) Kinase-Kernel Models: Accurate Chemogenomic Method for the Entire Human Kinome. Molecular Informatics.

Timmerman, LA and Holton, T and Yuneva, M and Louie, RJ and Padro, M and Daemen, A and Hu, M and Chan, DA and Ethier, SP and van 't Veer, LJ and Polyak, K and McCormick, F and Gray, JW (2013) Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target. CANCER CELL. pp. 450-465.

Tovar, Kenneth R and McGinley, Matthew J and Westbrookl, Gary L (2013) Triheteromeric NMDA Receptors at Hippocampal Synapses. Journal of Neuroscience.

Trompette, Aurelien and Gollwitzer, Eva and Yadava, Koshika and Sichelstiel, Anke K. and Sprenger, Norbert and Ngom-Bru, Catherine and Blanchart, Carine G. and Junt, Tobias and Nicod, Laurent P. and Harris, Nicola L. and Marsland, Benjamin J. (2013) Dietary fiber influences the severity of allergic airway inflammation through GPR41 mediated host-microbial-metabolite cross-talk. Nature Medicine.

Troxler, Thomas J. and Greenidge, Paulette and Zimmermann, Kaspar and Desrayaud, Sandrine and Drueckes, Peter and Schweizer, Tatjana and Stauffer, Daniela and Rovelli, Giorgio and Shimshek, Derya (2013) Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2. Bioorganic & Medicinal Chemistry Letters, 23 (14). pp. 4085-4090. ISSN 0960894X

True, Sarah (2013) Industrial Trainee dissertation report. To remain in-house and be reviewed by University lectures under CDA.

Tsao, J and Jiang, Y (2013) Hierarchical IDEAL: Fast, robust, and multiresolution separation of multiple chemical species from multiple echo times. MAGNETIC RESONANCE IN MEDICINE. pp. 155-159.

Tukulula, M and Njoroge, M and Abay, ET and Mugumbate, GC and Wiesner, L and Taylor, D and Gibhard, L and Norman, J and Swart, KJ and Gut, J and Rosenthal, PJ and Barteau, S and Streckfuss, J and Kameni-Tcheudji, J and Chibale, K (2013) Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds. ACS MEDICINAL CHEMISTRY LETTERS. pp. 1198-1202.

Tyagarajan, SK and Ghosh, H and Yevenes, GE and Imanishi, SY and Zeilhofer, HU and Gerrits, B and Fritschy, J (2013) Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. Journal of Biological Chemistry. pp. 9634-9647.


Uehara, T (2013) Cell wall shaping during bacterial morphogenesis. Japanese. The Journal of Japanese Biochemical Societ. pp. 349-353.

Uehara, Tsuyoshi (2013) Peptidoglycan Remodeling during Bacterial Development. Seikagaku.

Ula, N and Mulder, G.M and Vavrinec, P and Landheer, S.W. and Gurdal, H and Goris, Maaike and van Dokkum, R.P.E. and Buikema, H and van Goor, H and Henning, R.H. (2013) Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats. J Pharmacol Exp Ther, 345 (3). pp. 393-403. ISSN 1521-0103


Vacchi-Suzzi, Caterina and Hahne, Florian and Scheubel, Philippe and Marcellin, Magali and Dubost, Valerie and Kalteis, Magdalena and Boeglen, Catherine and Buechmann-Moller, Stine and Cheung, Nicole and Cordier, Andre and De Benedetto, Christopher and Deurinck, Mark and Frei, Moritz and Moulin, Pierre and Oakeley, Edward James and Grenet, Olivier and Grevot, Armelle and Stull, Robert and Theil, Diethilde and Moggs, Jonathan and Marrer, Estelle and Couttet, Philippe (2013) Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions. PLoS ONE, 8 (1). e52442. ISSN 1932-6203

Valtcheva, N and Primorac, A and Jurisic, G and Hollmen, M and Detmar, M (2013) The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. Journal of Biological Chemistry. pp. 35736-37548.

Van Der Putten, P. Herman and Lotz, Gregor (2013) Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseases. Neurotherapeutics, 10 (3). pp. 416-428.

Van Diepen, Michiel and Groot-Kormelink, Paulus (2013) Optimization of YFP fluorescence quench assay to functionally test TMEM16A random mutagenesis library in order to uncover novel or improved structure-function relationships. N/A.

Vellas, B and Pahor, M and Manini, T and Rooks, D and Guralnik, JM and Morley, J and Studenski, S and Evans, W and Asbrand, C and Fariello, R and Pereira, S and Rolland, Y and Van Kan, GA and Cesari, M and Chumlea, W and Fielding, R (2013) Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US task force recommendations. JOURNAL OF NUTRITION HEALTH & AGING. pp. 612-618.

Verpelli, Chiara and Galimberti, Ivan and Gomez-Mancilla, Baltazar and Sala, Carlo (2013) Molecular basis for prospective pharmacological treatment strategies in intellectual disability syndromes. Molecular basis for prospective pharmacological treatment strategies in intellectual syndromes. ISSN 1932-8451

Visser, Michael and Toure, Bakary-Barry and Porter, Dale and Herlihy, Kara and Perez, Lawrence and Springer, Clayton and Xie, Xiaoling (2013) The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein-Protein Interactions. ACS Medicinal Chemistry Letters, 4 (2). pp. 186-190.

Vitale, A and Thorne, N and Lovell, S and Battaile, KP and Hu, X and Shen, M and D'Auria, S and Auld, DS (2013) Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum. PLoS One.

Vorherr, Thomas and Kitas, Eric (2013) Discovery and Development of therapeutic Peptides. Drug Discovery International.

Vulpetti, Anna and Dalvit, Claudio (2013) Best practice and advices for designing and generating fluorinated libraries and for their efficient 19F-NMR Screening. ChemMedChem, 8. pp. 2057-2069.


Walker, John R and Pacoma, Reynand and Watson, James and Ou, Weijia and Alves, Juliano and Mason, Daniel E and Peters, Eric C and Urbina, Hugo D and Welzel, Gus and Althage, Alana and Liu, Bo and Tuntland, Tove and Jacobson, Laura H and Harris, Jennifer L and Schumacher, Andrew M (2013) Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 (6). pp. 2457-2464. ISSN 1529-2401

Wallecha, A and Singh, R and Malinina, I (2013) Listeria monocytogenes (Lm)-LLO Immunotherapies Reduce the Immunosuppressive Activity of Myeloid-derived Suppressor Cells and Regulatory T Cells in the Tumor Microenvironment. JOURNAL OF IMMUNOTHERAPY. pp. 468-476.

Walles, Markus and Wolf, Thierry and Jin, Yi and Ritzau, Michael and Gschwind, Hans-Peter and Krauser, Joel and Woessner, Ralph and Ufer, Mike and Swart, Pieter Jacob (2013) Absorption and Disposition of mavoglurant (AFQ056), a metabotropic glutamate receptor 5 antagonist (mGluR5), in healthy volunteers. Drug Metabolism and Disposition, 41 (9). pp. 1626-1643.

Wang, H and Gill, CJ and Lee, SH and Mann, P and Zuck, P and Meredith, TC and Murgolo, N and She, X and Kales, S and Liang, L and Liu, J and Wu, J and Maria, JS and Su, J and Pan, J and Hailey, J and Mcguinness, D and Tan, CM and Flattery, A and Walker, S and Black, T and Roemer, T (2013) Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA beta-Lactam Combination Agents. CHEMISTRY & BIOLOGY. pp. 272-284.

Wang, Q and Thanh, V and Bronson, R and Ruan, M and Mu, W and Huang, A and Maira, SM and Zhao, JJ (2013) Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome. GENES & DEVELOPMENT. pp. 1568-1580.

Wang, X and Magnuson, S and Pastor, R and Fan, E and Hu, H and Tsui, V and Deng, W and Murray, J and Steffek, M and Wallweber, H and Moffat, J and Drummond, J and Chan, G and Harstad, E and Ebens, AJ (2013) Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. pp. 3149-3153.

Wang, X and Zhang, J and Eberhart, D and Urban, R and Meda, K and Solorzano, C and Yamanaka, H and Rice, D and Basbaum, A (2013) Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of Pain and Itch. Neuron. pp. 312-324.

Wang, Y and Zhang, Y and Lin, JJ and Hallock, SJ and Yu, H and Shao, H and Yan, J and Huang, B and Zhang, XC and Cao, W and Xu, X and Lin, X (2013) Purification and characterization of mutant miniPlasmin for thrombolytic therapy. Thrombosis Journal.

Wassermann, Anne and Kutchukian, Peter and Lounkine, Eugen and Luethi, Tiffany and Bocker, Michael and Malik, Hasnain and Hamon, Jacques and Jacob, Sandra and Glick, Meir (2013) Efficient Search of Chemical Space: Navigating from Fragments to Structurally Diverse Chemotypes. Journal of Medicinal Chemistry, 56 (21). pp. 8879-8891. ISSN 0022-26231520-4804

Wassermann, Anne and Lounkine, Eugen and Glick, Meir (2013) Bioturbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules. Journal of Chemical Information and Modeling, 53 (3). pp. 692-703. ISSN 1549-95961549-960X

Wassermann, Anne and Lounkine, Eugen and Glick, Meir (2013) Bioturbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules. Journal of Chemical Information and Modeling, 53 (3). pp. 692-703. ISSN 1549-9596

Wassermann, Anne and Lounkine, Eugen and Glick, Meir (2013) Supplementary Information for Manuscript "Bio turbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules". J Chem Inf Model, 53 (3). pp. 692-703. ISSN 1549-95961549-960X

Wassermann, Anne and Lounkine, Eugen and Glick, Meir (2013) Supplementary Information for Manuscript "Bioturbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules". Journal of Chemical Information and Modeling, 53 (3). pp. 692-703. ISSN 1549-95961549-960X

Wassermann, Anne and Lounkine, Eugen and Whitebread, Steven and Chen, Shanni and Hughes, Kevin and Guo, Hongqiu and Kutlina, Elena and Fekete, Alexander and Urban, Laszlo and Klumpp, Martin and Glick, Meir (2013) Leaving the Lamp Post - A Fresh Perspective on the Targets of Natural Products and Marketed Drugs. Nature Chemical Biology.

Weisberg, Ellen and Liu, Qingsong and Zhang, Xin and Nelson, Eric and Sattler, Martin and Liu, Feiyang and Nicolais, Maria and Zhang, Jianming and Mitsiades, Constantine and Smith, Robert and Stone, Richard and Galinsky, Ilene and Nonami, Atsushi and Griffin, D. James and Gray, Nathanael and Carmeli, Yael (2013) Akt and p38 MAPK synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells. PLoS One. , 8 (2). e56473. .

Weiss, Markus and Gatlik, Ewa (2013) Equilibrium gel filtration to measure plasma protein binding of very highly bound drugs. Journal of Pharmaceutical Sciences.

Welt, Anja and Tewes, Mitra and Aktas, Bahriye and Wiesweg, Marcel and Ting, Saskia and Reis, Henning and Worm, Karl and Richly, Heike and Hense, Jörg and Peters, Malte and Schlegel, Robert and Lee, Benjamin and Palmer, Michael and Monahan, John and Scheulen, Max and Lehnerdt, Cathrin and Kohl, Marzena and Derks, Cordula and Skottky, Silke and Haus-Weiner, Ulrike and Schmid, Kurt and Kimmig, Rainer and Schuler, Martin and Kasper, Stefan (2013) Preemptive tumor profiling for biomarker-stratified early clinical drug development in metastatic breast cancer patients. Breast Cancer Research and Treatment, 142 (1). pp. 81-88. ISSN 0167-6806

White, Nicholas J and Pukrittayakamee, Sasithon and Phyo, Aung P and Rueangweerayut, Ronnatrai and Nosten, François and Jittmala, Podjanee and Jeeyapant , Atthanee and Jain, Jay Prakash and Lefevre, Gilbert and Li, Ruobing and Magnusson, Baldur and Diagana, Thierry Tidiane and Leong, Franz Joel Wen (2013) The novel spiroindolone KAE609 clears parasitemia rapidly in falciparum and vivax malaria. The Novel Spiroindolone KAE609 Clears Parasitemia Rapidly.

White, Nicholas J and Pukrittayakamee, Sasithon and Phyo, Aung P and Rueangweerayut, Ronnatrai and Nosten, François and Jittmala, Podjanee and Jeeyapant , Atthanee and Jain, Jay Prakash and Lefevre, Gilbert and Li, Ruobing and Magnusson, Baldur and Diagana, Thierry Tidiane and Leong, Franz Joel Wen (2013) The novel spiroindolone KAE609 clears parasitemia rapidly in falciparum and vivax malaria. The novel spiroindolone KAE609 clears parasitemia rapidly.

Williamson, Alice E. and Ylioja, Paul M. and Robertson, Murray N. and Antonova, Jenya and Avery, Vicky and Baell, Jonathan and Batchu, Harikrishna and Batra, Sanjay and Burrows, Jeremy N. and Bhattacharyya, Soumya and Calderon, Felix and Charman, Sue and Clark, Julie and Crespo, Benigno and Dean, Matin and Debbert, Stefan and Dennis, Adelaide S. M. and Deroose, Frederik and Duffy, Sandra and Fletcher, Sabine and Giaever, Guri and Hallyburton, Irene and Gamo, Francisco-Javier and Gebbia, Marinella and Guy, R. Kiplin and Hungerford, Zoe and Kirk, Kiaran and Lafuente-Monasterio, Maria J. and Lee, Anna and Meister, Stephan and Nislow, Corey and Overington, John P. and Papadatos, George and Patiny, Luc and Pham, James and Ralph, Stuart and Ryan, Eileen and Southan, Chris and Svrivastava, Kumkum and Swai, Chris and Tarnowski, Matthew J. and Thomson, Patrick and Turner, Peter and Wallace, Iain and Wells, Timothy N. C. and White, Karen and White, Laura and Willis, Paul and Winzeler, Elizabeth A. and Wittlin, Sergio and Todd, Matthew H. (2013) Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the GlaxoSmithKline Tres Cantos Arylpyrroles. PLoS Medicine.

Winter, M and Moser, MA and Meunier, D and Fischer, C and Machat, G and Mattes, K and Lichtenberger, BM and Brunmeir, R and Weissmann, S and Murko, C and Humer, C and Meischel, T and Brosch, G and Matthias, P and Sibilia, M and Seiser, C (2013) Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. EMBO Journal. pp. 3176-3191.

Woehrle, Simon and Thuery, Anne and Henninger, Christine and Olivier, Bonny and Beluch, Noemie and Studer, Anne and Ingold, Peter and Stamm, Christelle and Bohler, Bruno and Sterker, Dario and Hynes, Nancy and Guagnano, Vito and Sellers, William and Kneissel, Michaela and Hofmann, Francesco and Graus Porta, Diana (2013) Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. Journal of bone and mineral research., 28 (4). pp. 899-911. ISSN 08840431

Woehrle, Simon and Weiss, Andreas and Ito, Moriko and Kauffmann, Audrey and Murakami, Masato and Jagani, Zainab and Thuery, Anne and Bauer-Probst, Beatrice and Reimann, Flavia and Stamm, Christelle and Pornon, Astrid and Guagnano, Vito and Bruemmendorf, Thomas and Sellers, William and Hofmann, Francesco and Roberts, Charles W. M. and Graus Porta, Diana (2013) Fibroblast growth factor receptors as novel therapeutic targets in malignant rhabdoid tumors. PLoS ONE, 8 (10). e77652-e77652. ISSN 1932-6203

Wong, KA and Worth, A and Martin, R and Svarovskaia, E and Brainard, DM and Lawitz, E and Miller, MD and Mo, H (2013) Characterization of hepatitis C virus resistance from a multiple-dose clinical trial of the novel NS5A inhibitor GS-5885. Antimicrobial Agents and Chemotherapy. pp. 6333-6340.

Wong, Vanessa and Pickard, Derer and Barquist, Lars and Sivaraman, Karthikeyan and Hart, Peter and Arends, Mark and Holt, Kathryn and Kane, Leanne and Mottram, Lynda and Ellison, Louise and Kay, Sally and Wileman, Thomas and Kenny, Linda and Maclennan, Calman Alexander and Kingsley, Robert and Dougan, Gordon (2013) Characterization of the yehUT two-component regulatory system of Salmonella enterica serovar Typhi and Typhimurium. PLoS ONE, 8 (12). ISSN 1932-6203

Wood, DJ and Carlsson, L and Eklund, M and Norinder, U and Stalring, J (2013) QSAR with experimental and predictive distributions: an information theoretic approach for assessing model quality. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. pp. 203-219.

Wu, Xuping and Sooman, Linda and Wickström, Malin and Frynäs, Mårten and Dyrager, Christine and Lennartsson, Johan and Gullbo, Joachim (2013) Significant off-target effects of postulated IGF-1R inhibitor picropodophyllin (PPP) in vitro. Molecular Cancer Therapeutics.


Xie, Qian and Su, Yanli and Dykema, Karl and Johnson, Jennifer and Koeman, Julie and Giorgi, Valeria and Essenburg, Curt and Kang, Liang and Iwaya, Keiichi and Seki, Shuhji and Khoo, Sok and Zhang, Boheng and Buonaguro, Franco and Marincola, Francesco and Furge, Kyle and VandeWoude, George and Shinomiya, Nariyoshi (2013) HGF/MET axis drives hepatocellular carcinoma progression and determines sensitivity to MET-targeted therapy. Genes Cancer.

Xie, Xuping and Kang, Congbao and Gayen, Shovanlal and Yuan, Zhiming and Shi, Pei-Yong (2013) Membrane topology and function of dengue virus NS2A protein. Journal of Virology, 87 (8). pp. 4609-4622. ISSN 0022-538X

Xie, Yang and Avello, Monika and Feng, Yan and Schirle, Markus and Bric-Furlong, Eva and Wilson, Christopher and Nathans, Robin and Zhang, Jing and Kirschner, Marc W and Huang, Shih-Min and Cong, Feng (2013) Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. Journal of Biological Chemistry, 288 (5). pp. 2976-2985. ISSN 0021-9258

Xiong, X and Coombs, PJ and Martin, SR and Liu, J and Xiao, H and McCauley, JW and Locher, K and Walker, PA and Collins, PJ and Kawaoka, Y and Skehel, JJ and Gamblin, SJ (2013) Receptor binding by a ferret-transmissible H5 avian influenza virus. NATURE. pp. 392-396.


Yamaguchi, Masayuki and Saji, Takami and Nozaki, Sachiko and Kulmatycki, Kenneth and He, Yan-Ling and Kenichi, Furihata and Sekiguchi, Kaneo (2013) Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with type 2 diabetes. International Journal of Clinical Pharmacology and Therapeutics.

Yang, S and Wang, B and Cui, D and Kerwood, D and Wilkens, S and Han, J and Luk, YY (2013) Stereochemical Control of Nonamphiphilic Lyotropic Liquid Crystals: Chiral Nematic Phase of Assemblies Separated by Six Nanometers of Aqueous Solvents. JOURNAL OF PHYSICAL CHEMISTRY B. pp. 7133-7143.

Yang, Y and Fiskus, W and Yong, B and Atadja, P and Takahashi, Y and Pandita, TK and Wang, HG and Bhalla, KN (2013) Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 6841-6846.

Yang, ZF and Zhang, H and Ma, L and Peng, C and Chen, Y and Wang, J and Green, MR and Li, S and Rosmarin, AG (2013) GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 2312-2317.

Yin, OQP and Bedoucha, V and McCulloch, T and Zheng, C and Zhou, W and Hussaini, A and Novick, S (2013) Effects of famotidine or an antacid preparation on the pharmacokinetics of nilotinib in healthy volunteers. CANCER CHEMOTHERAPY AND PHARMACOLOGY. pp. 219-226.

Yokokawa, Fumiaki (2013) Recent progress on the discovery of non-peptidic direct renin inhibitors as antihypertensives. Expert Opinion on Drug Discovery. ISSN 1746-0441

Yokokawa, Fumiaki and Wang, Gang and Wong, Josephine and Rao, Srinivasa P.S. and Manjunatha, Ujjini Havaldar and Lakshminarayana, Suresh Bangalore and Herve, Maxime Marcel and Kounde, Cyrille Stephane and Tan, Bee Huat and Thayalan, Pamela and Ng, Seow Hwee and Nanjundappa, Mahesh Bangalore and Zhang, Chengzhi and Wagner, Beatrix and Dix, Ina and Kuhen, Kelli and Glynne, Richard and Smith, Paul William and Bifani, Juan Pablo and Jiricek, Jan and Seah, Peck Gee and Liu, Wei and Chen, Pei-Yu and Lee, Kok Sin and Chan, Wai Ling and Ma, Ida and Chatterjee, Arnab and Pethe, Kevin and Tan, Maria and Goh, Anne and Ang, Shi-Hua and Seah, Peck Gee (2013) Discovery of Tetrahydropyrazolopyrimidine Carboxamide De-rivatives as Potent and Orally Active Novel Anti-Tubercular Agents. ACS Medicinal Chemistry Letters, 4 (5). pp. 451-455. ISSN 1948-5875

Yrjola, S and Kalliokoski, T and Laitinen, T and Poso, A and Parkkari, T and Nevalainen, T (2013) Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists. European Journal of Pharmaceutical Sciences. pp. 9-20.


Zaglia, T and Milan, G and Franzoso, M and Bertaggia, E and Pianca, N and Piasentini, E and Voltarelli, VA and Chiavegato, D and Brum, PC and Glass, DJ and Schiaffino, S and Sandri, M and Mongillo, M (2013) Cardiac sympathetic neurons provide trophic signal to the heart via 2-adrenoceptor-dependent regulation of proteolysis. CARDIOVASCULAR RESEARCH. pp. 240-250.

Zhang, Ji and Auld, Douglas and Hill, William and Ardayfio, Ophelia and Kang, Zhao Bin and Smith, Thomas and Wallace, Iain and Bowes, Scott (2013) Applications of titration-based compound sets for use in rapid evaluation of high-throughput screening assays. Journal Biomolecular Screening, 19 (5). pp. 651-660. ISSN 1087-05711552-454X

Zhang, L and Zhou, F and GarciadeVinuesa, A and deKruijf, E and Mesker, W and Hui, L and Drabsch, Y and Li, Y and Bauer, A and Rousseau, A and Sheppard, K and Mickanin, C and Kuppen, P and Lu, C and tenDijke, P (2013) TRAF4 Promotes TGF-beta Receptor Signaling and Drives Breast Cancer Metastasis. MOLECULAR CELL. pp. 559-572.

Zhang, T and Li, Y and Zou, P and Yu, J and McEachern, D and Wang, S and Sun, D (2013) Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharmaceutics and Drug Disposition. pp. 348-359.

Zhang, Tao and Yanyan , Li and Zou, Peng and Yu, Jing-yu and McEachern, Donna and Wang, Shaomeng and Sun, Duxin (2013) Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharmaceutics and Drug Disposition, 34 (6). pp. 348-359. ISSN 0142-2782

Zhang, X and Boutros, M (2013) A novel phenotypic dissimilarity method for image-based high-throughput screens. BMC Bioinformatics.

Zhang, X and Zhang, J and Bauer, A and Zhang, L and Selinger, DW and Lu, CX and ten Dijke, P (2013) Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO JOURNAL. pp. 996-1007.

Zheng, Guishan and Schaefer, Michael and Karplus, Martin (2013) Hemoglobin Bohr Effects: Analysis of the Histidine Residue Contributions. Biochemistry.

Zhou, Wei (2013) Outsourcing in a bioanalytical laboratory. Bioanalysis, 5 (20).

Zhuang, G and Schmidt, M and Yao, J and Wu, X and Kaminker, JS and Jurinka, SS and Kolumam, G and Chung, AS and Jubb, A and Modrusan, Z and Ozawa, T and James, CD and Phillips, H and Haley, B and Tam, RNW and Clermont, AC and Cheng, JH and Yang, SX and Swain, SM and Chen, D and Scherer, SJ and Koeppen, H and Yeh, RF and Yue, P and Stephan, JP and Hegde, P and Ferrara, N and Singh, M and Bais, C (2013) Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies. CLINICAL CANCER RESEARCH. pp. 3681-3692.

Zimmerlin, Alfred Gilbert and Kiffe, Michael (2013) Fixing clearance as early as lead optimization using high throughput in-vitro incubations in combination with exact mass detection and automatic structure elucidation of metabolites. Drug Discovery Today, 10 (1). d191-E198. ISSN 1740-6749

Zitzmann, Kathrin and Vlotides, Galina Ailer and Auernhammer, Christoph J (2013) Potent antitumor activity of novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells. International Journal of Oncology, 43 (6). pp. 1824-1832. ISSN 1791-2423

Züst, Roland and Dong, Hongping and Li, Xiao-Feng and Chang, David and Zhang, Bo and Jiang, Tao and Li, Shi-Hua and Deng, Yong-Qiang and Ellis, Brett R and Ellis, Esther M and Qin, Cheng-Feng and Shi, Pei-Yong and Fink, Katja (2013) Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques. PLoS Pathogens, 9 (8). ISSN 1553-7366

This list was generated on Thu Jun 30 10:46:48 2022 UTC.


Email Alerts

Register with OAK to receive email alerts for saved searches.