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Items where Year is 2013

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Number of items: 513.

A

Abazeed, Mohamed E., Adams, Drew J., Hurov, Kristen, Tamayo, Pablo, Creighton, Chad J., Sonkin, Dmitriy, Giacomelli, Andrew O., Pashtan, Itai, Du, Charles, Fries, Daniel F., Wong, Kwok-Kin, Mesirov, Jill P., Loeffler, Jay S., Schreiber, Stuart L., Hammerman, Peter S. and Meyerson, Matthew (2013) Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Research, 73 (20). pp. 6289-6298. ISSN 0008-5472.CAN-13-1616

Adamo, Roberto, Proietti, Daniela, Gavini, Massimiliano, Romano, Maria Rosaria, Maclennan, Calman Alexander, Costantino, Paolo and Berti, Francesco (2013) Meningococcal X polysaccharide quantification by high-performance anion-exchange chromatography with pulsed amperometric detection using synthetic N-acetylglucosamine-4-phosphate as standard. Analytical Biochemistry, 44. pp. 259-261.

Alajati, A, Sausgruber, N, Aceto, N, Duss, S, Sarret, S, Voshol, H, Bonenfant, D and Bentires-Alj, M (2013) Mammary Tumor Formation and Metastasis Evoked by a HER2 Splice Variant. CANCER RESEARCH. pp. 5320-5327.

Alderton, WK, Anderson, RJ, Collingwood, SP and Pryde, DC (2013) THERAPEUTIC OPPORTUNITIES IN INFECTIOUS DISEASES HIGHLIGHTS FROM THE SOCIETY OF MEDICINES RESEARCH SYMPOSIUM, HELD ON MARCH 14TH 2013 AT THE NATIONAL HEART & LUNG INSTITUTE, LONDON, UK. DRUGS OF THE FUTURE. pp. 347-354.

Altstein, L and Li, G (2013) Latent Subgroup Analysis of a Randomized Clinical Trial through a Semiparametric Accelerated Failure Time Mixture Model. BIOMETRICS. pp. 52-61.

Anna-Lena, Gessler and Warncke, Max (2013) Master Thesis: Pathogenese und Keimzentrumsreaktion im Typ 1 Diabetes Mausmodell (Pathogenesis and germinal center reaction in the NOD T1D mouse model). University Freiburg.

Antoine, Daniel, Dear, James, Starkey-Lewis, Philip, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben, Gray, Alastair, Moggs, Jonathan, Bateman, Nicholas, Goldring, Christopher and Park, Kevin (2013) Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital. Journal of Hepatology, 58. ISSN 0168-8278

Antony, D, Becker-Heck, A, Zariwala, MA, Schmidts, M, Onoufriadis, A, Forouhan, M, Wilson, R, Taylor-Cox, T, Dewar, A, Jackson, C, Goggin, P, Loges, NT, Olbrich, H, Jaspers, M, Jorissen, M, Leigh, MW, Wolf, WE, Daniels, MLA, Noone, PG, Ferkol, TW, Sagel, SD, Rosenfeld, M, Rutman, A, Dixit, A, O'Callaghan, C, Lucas, JS, Hogg, C, Scambler, PJ, Emes, RD, Chung, EMK, Shoemark, A, Knowles, MR, Omran, H and Mitchison, HM (2013) Mutations in CCDC39 and CCDC40 are the Major Cause of Primary Ciliary Dyskinesia with Axonemal Disorganization and Absent Inner Dynein Arms. Human Mutation. pp. 462-472.

Arias, HR, Fedorov, NB, Benson, LC, Lippiello, PM, Gatto, GJ, Feuerbach, Dominik and Ortells, MC (2013) Functional and Structural Interaction of (-)-Reboxetine with the Human alpha4beta2 Nicotinic Acetylcholine Receptor. Journal of Pharmacology and experimental therapeutics, 344 (3). pp. 113-123. ISSN 112.197905

Arias, HR, Lopez, JJ, Feuerbach, D, Fierro, A, Ortells, MO and Perez, EG (2013) The International Journal of Biochemistry & Cell Biology. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. pp. 2420-2430.

Arias, HR, Ortells, MO and Feuerbach, Dominik (2013) Interaction of (-)-reboxetine with nicotinic acetylcholine receptors in different conformational states. International Journal of biochemistry and cell biology.

Assenberg, Rene, Wan, Paul, Geisse, Sabine and Mayr, Lorenz (2013) Advances in heterologous expression of recombinant proteins. Current opinion in Structural Biology, 23 (3). pp. 393-402. ISSN 0959-440X

Atassi, F, Behme, RJ and Patel, PJ (2013) Mesomorphous versus traces of crystallinity: The itraconazole example. THERMOCHIMICA ACTA. pp. 133-139.

Auclair, JR, Johnson, JL, Liu, Q, Salisbury, JP, Rotunno, MS, Petsko, GA, Ringe, D, Brown, J, Bosco, DA and Agar, JN (2013) Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage. Biochemistry. pp. 6137-6144.

Auld, D, Lea, W, Davis, MI and Simeonov, A (2013) Literature Search and Review: 3D Cocultures of Multiple Cell Types: What do they do and Where do they Go? Assay and Drug Development Technologies, 11 (8). pp. 457-467.

Auld, D, Lea, W, Davis, MI and Simeonov, A (2013) Literature Search and Review: BLI Coupled with DNA Tetrahedron. Assay and Drug Development Technologies, 11 (3). pp. 139-151. ISSN 1540-658X1557-8127

Auld, D, Lea, W, Davis, MI and Simeonov, A (2013) Literature Search and Review: Better Biosensors for FBDD. Assay and Drug Development Technologies, 11 (5). pp. 289-298. ISSN 1540-658X1557-8127

Auld, D, Lea, W, Davis, MI and Simeonov, A (2013) Literature Search and Review: Detected Through A Quick Glance. Assay and Drug Development Technologies, 11 (1). pp. 1-8. ISSN 1540-658X1557-8127

Auld, DS, Veith, H and Cali, JJ (2013) Bioluminescent assays for cytochrome P450 enzymes. Methods in Molecular Biology. pp. 1-9.

Auld, Douglas, Breault, Lyne, Pandey, Pramod, Ho, Pei-I, Harbinski, Fred and Hill, William (2013) Reporter enzyme inhibitor study to aid assembly of orthogonal reporter gene assays. ACS Chemical Biology, 8 (5). pp. 1009-1017. ISSN 1554-8929

Azzaoui, Kamal, Jacoby, Edgar, Senger, Stefan, Cuadrado Rodríguez, Emiliano, Loza, Mabel, Zdrazil, Barbara, Pinto, Marta, Williams, Antony J, de la Torre, Victor, Mestres, Jordi, Taboureau, Olivier, Rarey, Matthias and Ecker, Gerhard F (2013) Analysis of the scientific competency questions followed by the IMI OpenPHACTS consortium for the development of the semantic web-based molecular information system OPS. Drug Discovery Today, 18 (17-18). pp. 843-852. ISSN 1878-5832

B

Baba, Nobuyasu, Van, VuQuang, Wakahara, Keiko, Weckbecker, Gisbert, Kolbinger, Frank, Heusser, Christoph, Huber, Thomas, Welzenbach, Karl and Sarfati, Marika (2013) CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med..

Baeten, Dominique, Baraliakos, Xenofon, Braun, Juergen, Sieper, Joachim, Emery, Paul, Van der Heijde, Desiree, McInnes, Iain, Van Laar, Jacob, Landewé, Robert, Wordsworth, Paul, Wollenhaupt, Jürgen, Kellner, Herbert, Paramarta, Jacqueline, Wei, Jiawei, Brachat, Arndt Holger, Bek, Stephan, Laurent, Didier, Li, Yali, Bertolino, Arthur, Gsteiger, Sandro, Wright, Andrew and Hueber, Wolfgang (2013) Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial. The Lancet, 382 (9906). pp. 1705-1713. ISSN 01406736

Balibar, Carl, Mcguire, Dorothy and Dean, Charles (2013) Elongation Factor P is dispensable in Escherichia coli and Pseudomonas aeruginosa. Current Microbiology, 284. ISSN 0343-8651

Ballabeni, A, Zamponi, R, Moore, JK, Helin, K and Kirschner, MW (2013) Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. E2848-E2853.

Ballard, Sarah, Engeloch, Caroline and Baeschlin, Daniel (2013) Automated compound management evolves to meet the drug discovery demands of the future. Drug Discovery world.

Baltus, Christine, Press, Neil, Coles, Simon, Tizzard, Graham, Spencer, John, Chuckowree, Irina and Day, Iain (2013) Olefin cross-metathesis/Suzuki-Miyaura reactions on 4-vinylphenylboronic acid pinacol ester. Tetrahedron Letters, 54 (10). pp. 1211-1217. ISSN 0040-4039

Bardelli, M, Alleri, L, Angiolini, F, Buricchi, F, Tavarini, S, Sammicheli, C, Nuti, S, Degl'Innocenti, E, Isnardi, I, Fragapane, E, Del, GG, Castellino, F and Galli, G (2013) Ex Vivo Analysis of Human Memory B Lymphocytes Specific for A and B Influenza Hemagglutinin by Polychromatic Flow-Cytometry. PLoS One.

Barnes, David, Jain, Monish, Bell, Leslie, Ferreira, Suzie, Cohen, Scott, Chen, Xiao-Hui, Amin, Jakal, Snodgrass, Bradley and Hatsis, Panagiotis (2013) Metabolically Stable tert-Butyl Replacement. ACS Medicinal Chemistry Letters. ISSN 1948-5875

Barteau, Samuel, Heudi, Olivier, Kameni Tcheudji, Jacques, Streckfuss, Judith, Tukulula, Matshawandile, Njoroge, Mathew, Mugumbate, Grace, Little, Susan, Grut, Jiri, Rosenthal, Philip J, Wan, Baojie, Franzblau, Scott G and Chibale, Kelly (2013) Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial and antituberculosis agents. Journal of medicinal chemistry, 21 (17). pp. 4904-4913. ISSN 09680896

Bartels, Christian, Looby, Michael, Sechaud, Romain and Kaiser, Guenther (2013) Determination of the pharmacokinetics of glycopyrronium in the lung using a population pharmacokinetic modeling approach. Britisch Journal of Clinical Pharmacology. ISSN 0306-5251

Basu, A, Bodycombe, NE, Cheah, JH, Price, EV, Liu, K, Schaefer, GI, Ebright, RY, Stewart, ML, Ito, D, Wang, S, Bracha, AL, Liefeld, T, Wawer, M, Gilbert, JC, Wilson, AJ, Stransky, N, Kryukov, GV, Dancik, V, Barretina, J, Garraway, LA, Hon, CSY, Munoz, B, Bittker, JA, Stockwell, BR, Khabele, D, Stern, AM, Clemons, PA, Shamji, AF and Schreiber, SL (2013) An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. pp. 1151-1161.

Beck, Valerie, Leighton-Davies, Juliet, Beibel, Martin, Roma, Guglielmo, Oakeley, Edward James, Hamon, Jacques, Barbieri, Samuel, Preuss, Inga, Lasbennes-Eckerlen, Marie-Christine, Sailer, Andreas, Suply, Thomas, Seuwen, Klaus, Parker, Christian, Bassilana, Frederic, Lannoy, Vincent, bernard, Jerome and Hannedouche, Sebastien (2013) The identification of the C3a Receptor (C3AR1) as the target of the VGF derived peptide TLQP-21 in rodent cells. Journal of Biological Chemistry, 288 (38). pp. 27434-27443. ISSN 0021-9258

Beckett, Martin (2013) Book Review: Practical Process Research and Development, second edition by Neal G. Anderson, Elsevier, 2012. Chemistry and Industry, Januar. p. 49.

Beckett, Martin (2013) Book review: Organic Synthesis: State of the Art 2009-2011 by Douglass F Taber, Wiley, 2013. Chemistry and Industry, Septem (Septem). pp. 46-47.

Beckman, David, Schneider, Marilynn, Decristofaro, Marc, Samadfam, Rana, Smith, Susan and Pouliot, Louise (2013) Assessment of a nonsteroidal aromatase inhibitor, letrozole, in juvenile rats. Birth Defects Research, 98 (5). pp. 374-390. ISSN 1542-9741

Beckman, David, Youreneff, Maureen and Butt, Mark (2013) Neurotoxicity assessment of artemether in juvenile rats. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 98 (2). pp. 183-199. ISSN 1542-9741

Beckmann, N and Kaltashov, IA (2013) Delivery of biopharmaceuticals: advanced analytical and biophysical methods Preface. ADVANCED DRUG DELIVERY REVIEWS. 1001-.

Bentz, J, O'Connor, MP, Bednarczyk, D, Coleman, J, Lee, C, Palm, J, Pak, YA, Perloff, ES, Reyner, E, Balimane, P, Brannstrom, M, Chu, X, Funk, C, Guo, A, Hanna, I, Heredi-Szabo, K, Hillgren, K, Li, L, Hollnack-Pusch, E, Jamei, M, Lin, X, Mason, AK, Neuhoff, S, Patel, A, Podila, L, Plise, E, Rajaraman, G, Salphati, L, Sands, E, Taub, ME, Taur, JS, Weitz, D, Wortelboer, HM, Xia, CQ, Xiao, G, Yabut, J, Yamagata, T, Zhang, L and Ellens, H (2013) Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria. DRUG METABOLISM AND DISPOSITION. pp. 1347-1366.

Bereau, T, Kramer, C, Monnard, FW, Nogueira, ES, Ward, TR and Meuwly, M (2013) Scoring Multipole Electrostatics in Condensed-Phase Atomistic Simulations. JOURNAL OF PHYSICAL CHEMISTRY B. pp. 5460-5471.

Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Gee, Christine, Jacobson, Laura, Laue, Grit, Ofner, Silvio, Chaudhari, Vinod, Badiger, Sangamesh, Pandit, Chetan, Wagner, Juergen and Hoyer, Daniel (2013) Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia. Journal of Medicinal Chemistry.

Bian, X, Fu, J, Plaza, A, Herrmann, J, Pistorius, D, Stewart, AF, Zhang, Y and Muller, R (2013) In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation. ChemBioChem, 14 (10). pp. 1194-1197. ISSN 14394227

Bignon, Alexandre, Gaudin, Françoise, Hémon, Patrice, Tharinger, Hugo, Loetscher, Pius, Peuchmaur, Michel, Berrebi, Dominique and Balabanian, Karl (2013) Pivotal role of Ccr1 in murine lupus nephritis. Journal of Immunology.

Billedeau, RJ, Klein, KR, Kaplan, D and Lou, Y (2013) A New Pyrrole Synthesis via Silver(I)-Catalyzed Cycloaddition of Vinylogous Diazoester and Nitrile. ORGANIC LETTERS. pp. 1421-1423.

Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara and Kleylein-Sohn, Bernadette (2013) Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLOS ONE, 8 (3). e59630. ISSN 1932-6203

Billich, Andreas, Beerli, Christian, Bruns, Christian and Loetscher, Erika (2013) Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. Analytical Biochemistry, 434 (2). pp. 247-253. ISSN 0003-2697

Biukovic, Goran, Basak, Sandip, Manimekalai, Malathy Sony Subramanian, Rishikeshan, Sankaranarayanana, Roessle, Manfred, Dick, Thomas, Rao, Srinivasa, Hunke, Cornelia and Gruber, Gerhard (2013) Variations of subunit Varepsilon of the Mycobacterium tuberculosis F-1Fo ATP Synthase and Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207. Antimicrobial Agents and Chemotherapy, 57 (1). pp. 168-176. ISSN 0066-4804

Blache, U, Silvan, U, Plodinec, M, Suetterlin, R, Jakob, R, Klebba, I, Bentires-Alj, M, Aebi, U and Schoenenberger, CA (2013) A Tumorigenic Actin Mutant Alters Fibroblast Morphology and Multicellular Assembly Properties. CYTOSKELETON. pp. 635-650.

Bobardt, M, Hopkins, S, Baugh, J, Chatterji, U, Hernandez, F, Hiscott, J, Sluder, A, Lin, K and Gallay, PA (2013) HCV NS5A and IRF9 compete for CypA binding. JOURNAL OF HEPATOLOGY. pp. 16-23.

Bolton, SA, Sutton, JC, Anumula, R, Bisacchi, GS, Jacobson, B, Slusarchyk, WA, Treuner, UD, Wu, SC, Zhao, G, Pi, Z, Sheriff, S, Smirk, RA, Bisaha, S, Cheney, DL, Wei, A, Schumacher, WA, Hartl, KS, Liu, E, Zahler, R and Seiler, SM (2013) Discovery of nonbenzamidine factor VIla inhibitors using a biaryl acid scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. pp. 5239-5243.

Bouchez, Laure, Ruffner, Heinz, Spanka, Carsten and Patoor, Maude (2013) Synthesis of a Series of Promising Isobenzofurans for the Reduction of Acute Mucositis Risk after Chemo- and Radiotherapy. Synlett- special edition.

Boulton, C, David, OJ, Meiser, K and Schmouder, R (2013) Tolerability and pulmonary pharmacodynamic effects during treatment initiation of once-daily oral fingolimod in subjects with moderate asthma. Clinical Pharmacology in Drug Development. pp. 2-10.

Bowman, SK, Simon, MD, Deaton, AM, Tolstorukov, M, Borowsky, ML and Kingston, RE (2013) Multiplexed Illumina sequencing libraries from picogram quantities of DNA. BMC Genomics.

Brauchle, Michael, Yao, Zhiping, Arora, Rishi, Clay, Ieuan, Inverardi, Bruno, Gerrits, Bertran, Voshol, Johannes, Bauer, Andreas, Schuebeler, Dirk, Bouwmeester, Antonius, Ruffner, Heinz and Thigale, Sachin (2013) A systematic comparison of enzymatic activity and protein interaction analysis of the KDM3 histone demethylase subfamily. PLOS ONE, 8 (4). e60549. ISSN 1932-6203

Breckner, Anke, Gerwin, Nicole, Richter, Jens, Rausch, Martin, Marcellin, David and Ganz, Magdalena (2013) Effect of calstabin1 depletion on calcium transients and energy utilization in FDB muscle fibers and potential treatment opportunities based on RyR1 stabilizers. The Journal of Biological Chemistry, 8 (11). ISSN 1932-6203

Breitenstein, Werner, Cumin, Frederic, Ehrhardt, Claus, Jacoby, Edgar, Lorthiois, Edwige, Ostermann, Nils, Sellner, Holger, Kosaka, Takatoshi, Webb, Randy, Hassiepen, Ulrich, Wagner, Beatrix and Maibaum, Juergen Klaus (2013) Discovery from in silico 3D Pharmacophore Searches of Novel 3(R),4(S)-disubstituted Pyrrolidine Inhibitors of the Human Aspartyl Protease Renin. Journal of Medicinal Chemistry, 56 (6). pp. 2207-2217. ISSN 0022-2623

Bridges, James P., Ludwig, Marie-Gabrielle, Mueller, Matthias, Kinzel, Bernd, Sato, Atsuyasu, Xu, Yan, Whitsett, Jeffery A. and Ikegami, Machiko (2013) The Orphan G Protein-Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size. American Journal of Respiratory Cell and Molecular Biology. ISSN 1044-1549

Britschgi, Adrian, Bill, Anke, Brinkhaus, Heike, Rothwell, Christopher, Clay, Ieuan, Duss, Stephan, Rebhan, Michael, Raman, Pichai, Guy, Chantale, Wetzel, Kristie, George, Elizabeth, Popa, Oana, Lilley, Sarah, Choudhury, Hedaythul, Gosling, Martin, Wang, Louis, Fitzgerald, Stephanie, Borawski, Jason, Baffoe, Jonathan, Labow, Mark, Gaither, Larry and Bentires-Alj, Mohamed (2013) Inhibition of the 11q13 amplified calcium activated chloride channel ANO1 reduces Head and Neck and Breast cancer growth. PNAS, 110 (11). E1026-E1034. ISSN 0027-8424

Bulliard, Yannick, Jolicoeur, Rose, Windman, Maurice, Rue, Sarah M, Ettenberg, Seth, Knee, Deborah A, Wilson, Nicholas S, Dranoff, Glenn and Brogdon, Jennifer L (2013) Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. The Journal of Experimental Medicine, 210 (9). pp. 1685-1693. ISSN 1540-9538

Burger, Matthew, Han, Wooseok, Lan, Jiong, Nishiguchi, Gisele, Bellamacina, Cornelia, Lindvall, Mika, Atallah, Gordana, Ding, Yu, Mathur, Michelle, Mcbride, Christopher, Mieuli, Elizabeth, Muller, Kristine, Tamez Jr., Victoriano, Zhang, Yanchen, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Holash, Jocelyn, Langowski, John and Garcia, Pablo (2013) Structure Guided Optimization, In Vitro Activity and In Vivo Activity of Pan-PIM Kinase Inhibitors. American Chemical Society Medicinal Chemistry Letters, 4 (12). pp. 1193-1197.

Burmester, Gerd, Durez, Patrick, Shestakova, Galina, Genovese, Mark, Schulze-Koops, Hendrik, Li, Yue, Lewitzky, Steven, Koroleva, Irina, Agarwal, Anni, Lee, David and Hueber, Wolfgang (2013) Caspase 8 modulates the polarisome to prevent lung fibrosis in a murine SSC-like disease model. Arthritis and Rheumatism, 65 (Suppl.). S1171. ISSN 00043591

Butendeich, Heike, Pierret, Noelle and Numao, Shin (2013) Evaluation of a liquid dispenser for assay development and enzymology in 1536 well format. Journal of Laboratory Automation, 18 (3). pp. 245-250. ISSN 2211-0682

Byun, M, Ma, CS, Akcay, A, Pedergnana, V, Palendira, U, Myoung, J, Avery, DT, Liu, Y, Abhyankar, A, Lorenzo, L, Schmidt, M, Lim, HK, Cassar, O, Migaud, M, Rozenberg, F, Canpolat, N, Aydogan, G, Fleckenstein, B, Bustamante, J, Picard, C, Gessain, A, Jouanguy, E, Cesarman, E, Olivier, M, Gros, P, Abel, L, Croft, M, Tangye, SG and Casanova, JL (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. JOURNAL OF EXPERIMENTAL MEDICINE. pp. 1743-1759.

C

Cai, Mi and Yang, Yi (2013) Targeted genome editing tools for disease modeling and gene therapy. Current Gene Therapy.

Cai, Xinming, Xu, Yongyao, Cheung, Atwood, Tomlinson, Ronald, Alcazer-Roman, Abel, Murphy, Leon, Billich, Andreas, Feng, Yan, Zhang, Bailin, Klumpp, Martin, Rondeau, Jean-Michel, Fazal, Aleem, Wilson, Christopher, Myer, Vic, Joberty, Gerard, Bouwmeester, Antonius, Labow, Mark, Finan, Peter, Porter, Jeffrey, Ploegh, Hidde, Baird, Daniel, De Camilli, Pietro, Tallarico, John and Huang, Qian (2013) PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling. Chemistry & Biology, 20. pp. 912-921.

Callander, Gabrielle E., Olorunda, Morenike, Monna, Dominique, Schuepbach, Edi, Langenegger, Daniel, Betschart, Claudia, Hintermann, Samuel, Briard, Emmanuelle, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Laue, Grit, Ofner, Silvio, Gee, Christine, Jacobson, Laura and Hoyer, Daniel (2013) Kinetic properties of 'dual' orexin receptor antagonists at OX1 and Ox2 receptors. Frontiers in Neuroscience, Neuropharmacology., 7. p. 230. ISSN 1662-453X

Casado, P, Rodriguez-Prados, J, Cosulich, SC, Guichard, S, Vanhaesebroeck, B, Joel, S and Cutillas, PR (2013) Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Science Signaling. rs6-.

Castiello, MC, Bosticardo, M, Pala, F, Catucci, M, Chamberlain, N, van Zelm, MC, Driessen, GJ, Pac, M, Bernatowska, E, Scaramuzza, S, Aiuti, A, Sauer, AV, Traggiai, E, Meffre, E, Villa, A and van der Burg, M (2013) Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. Autoimmunity.

Catanese, MT, Loureiro, J, Jones, CT, Dorner, M, von, HT and Rice, MC (2013) Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission. Journal of Virology. pp. 8282-8293.

Chakraborty, Abhijit, Van, Linh, Skerjanec, Andrej, Floch, David, Klein, Ulf, Krammer, Gerhard, Sunkara, Gangadhar and Howard, Danny (2013) Pharmacokinetic and pharmacodynamic properties of canakinumab in patients with gouty arthritis. Journal of Clinical Pharmacology, 53 (12). pp. 1240-1251. ISSN 0091-2700

Chan, HCS, Kendrick, J, Neumann, MA and Leusen, FJJ (2013) Towards ab initio screening of co-crystal formation through lattice energy calculations and crystal structure prediction of nicotinamide, isonicotinamide, picolinamide and paracetamol multi-component crystals. CRYSTENGCOMM. pp. 3799-3807.

Chandriani, Sanjay, Skewes-Cox, Peter, Zhong, Weidong, Ganem, Donald, Divers, Thomas J., Tennant, Bud C., Van Blaricum, Anita J. and Kistler, Amy (2013) Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis. Proceedings of the National Academy of Sciences USA, 110 (15). E1407-1415. ISSN 0027-8424

Chang, Henry and Ganem, Donald (2013) A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity. Cell Host & Microbe, 13 (4). pp. 429-440. ISSN 1931-3128

Che, Jianwei, Guo, Zuojun, Li, Bo, Cheng, Li-Tien, Dzubiella, Joachim and McCammon, J. Andrew (2013) Evaluation of Hydration Free Energy by the Level-Set Variational Implicit-Solvent Model with the Coulomb-Field Approximation. Journal of chemical theory and computation. ISSN 1549-9618

Chen, Jinyun, Chung, Franklin, Yang, Guizhi, Pu, Minying, Gao, Hui, Jiang, Wei, Yin, Hong, Capka, Vladimir, Kasibhatla, Shailaja, Laffitte, Bryan, Pagliarini, Raymond, Chen, Yaoyu and Zhou, Wenlai (2013) Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget, 4 (12). pp. 2502-2511. ISSN 1949-2553

Chen, Y and Li, S (2013) Molecular signatures of chronic myeloid leukemia stem cells. Biomarker Research.

Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Megan, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale and Zhou, Wenlai (2013) Targeting HSF1 sensitizes cancer cells to HSP90 inhibitor. Oncotarget.

Cheng, CH, Leferovich, J, Zhang, XM, Bedelbaeva, K, Gourevitch, D, Hatcher, CJ, Basson, CT, Heber-Katz, E and Marx, KA (2013) Keratin gene expression profiles after digit amputation in C57BL/6 vs. regenerative MRL mice imply an early regenerative keratinocyte activated-like state. PHYSIOLOGICAL GENOMICS. pp. 409-421.

Cheng, DT, Kim, DK, Cockayne, DA, Belousov, A, Bitter, H, Cho, MH, Duvoix, A, Edwards, LD, Lomas, DA, Miller, BE, Reynaert, N, Tal-Singer, R, Wouters, EFM, Agusti, A, Fabbri, LM, Rames, A, Visvanathan, S, Rennard, SI, Jones, P, Parmar, H, MacNee, W, Wolff, G, Silverman, EK, Mayer, RJ and Pillai, SG (2013) Systemic Soluble Receptor for Advanced Glycation Endproducts Is a Biomarker of Emphysema and Associated with AGER Genetic Variants in Patients with Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. pp. 948-957.

Cheng, Tiewei, Roth, Beat, Woonyoung, Choi, Black, Peter, Dinney, Colin and McConkey, David J. (2013) Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: Implications for therapeutic targeting. PLoS ONE, 8 (2). e57284-e57284. ISSN 1932-6203

Chivers, Simon (2013) Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis. Birth Defects Research Part B - Developmental and Reproductive Toxicology, 98 (6). pp. 459-485. ISSN 1542-9733

Christensen, Jesper, Litherland, Karine, Van De Kerkhof, Esther, Natt, Francois, Hunziker, Juerg, Faller, Thomas, Krauser, Joel and Swart, Pieter Jacob (2013) Metabolism Studies of Unformulated Internally [3H]-labeled siRNAs in Mice. Drug metabolism Disposition, 41 (6). pp. 1211-1219. ISSN 0090-9556

Chung, LM, Ferguson, JP, Zheng, W, Qian, F, Bruno, V, Montgomery, RR and Zhao, HY (2013) Differential expression analysis for paired RNA-seq data. BMC Bioinformatics.

Cloutier, N, Tan, S, Boudreau, LH, Cramb, C, Subbaiah, R, Lahey, L, Albert, A, Shnayder, R, Gobezie, R, Nigrovic, PA, Farndale, RW, Robinson, WH, Brisson, A, Lee, DM and Boilard, E (2013) The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: The microparticle-associated immune complexes. EMBO Molecular Medicine. pp. 235-249.

Collman, Emilie, Bohnacker, Thomas, Marone, Romina, Dawson King, Janet, Rehburg, Markus, Stringer, Rowan, Krombach, Fritz, Burkhart, Christoph, Hirsch, Emilio, Hollingworth, Greg, Thomas, Matthew and Wymann, Matthias (2013) Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells’ route to allergy. Journal of Allergy and Clinical Immunology, 132 (4). pp. 959-968. ISSN 00916749

Corbin, AS, O'Hare, T, Gu, Z, Kraft, IL, Eiring, AM, Khorashad, JS, Pomicter, AD, Zhang, TY, Eide, CA, Manley, PW, Cortes, JE, Druker, BJ and Deininger, MW (2013) KIT Signaling Governs Differential Sensitivity of Mature and Primitive CML Progenitors to Tyrosine Kinase Inhibitors. CANCER RESEARCH. pp. 5775-5786.

Cotton, Graham, Bowen, Wayne, Grundy, Robert and Hassiepen, Ulrich (2013) Fluorescence Lifetime Assays. Drug Discovery World.

D

Dalvit, Claudio, Young Ko, Soo and Vulpetti, Anna (2013) Application of the rule of shielding in the design of novel fluorinated molecules and peptidomimetics. Journal of Fluorine Chemistry, 152. pp. 129-135. ISSN 0022-1139

Damiano, Jason and Wasserman, Ernesto (2013) Molecular Pathways: Blockade of the PRLR Signaling Pathway as a Novel Anti-hormonal Approach for the Treatment of Breast and Prostate Cancer. Clinical Cancer Research. ISSN 1078-0432

Dand , Nick, Weale, Michael, Schulz, Reiner, Oakey, Rebecca, Simpson, Michael and Schlitt, Thomas (2013) Network-informed gene ranking tackles genetic heterogeneity in exome-sequencing studies of monogenic disease. Human Mutation.

Das Thakur, Meghna and Stuart, Darrin (2013) The evolution of melanoma resistance reveals therapeutic opportunities. Cancer Research, 73 (20). pp. 6106-6110. ISSN 0008-5472

David, DeOrnellis (2013) An insurance policy (and more) for the animal care and use program. Lab Animal, 42 (11). ISSN 1548-4475

Davis, MI, Sasaki, AT, Shen, M, Emerling, BM, Thorne, N, Michael, S, Pragani, R, Boxer, M, Sumita, K, Takeuchi, K, Auld, DS, Li, Z, Cantley, LC and Simeonov, A (2013) A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation. PLoS One.

Day, ES, Capili, AD, Borysenko, CW, Zafari, M and Whitty, A (2013) Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore. Analytical Biochemistry. pp. 96-107.

De, N, Young, L, Lau, PW, Meisner, NC, Morrissey, DV and MacRae, IJ (2013) Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2. MOLECULAR CELL. pp. 344-355.

DeOrnellis, D (2013) An insurance policy (and more) for the animal care and use program. Lab Animal. 433-.

Deng, Y, Wang, Z, Wang, R, Zhang, X, Zhang, S, Wu, Y, Staufenbiel, M, Cai, F and Song, W (2013) Amyloid- protein (A) Glu11 is the major -secretase site of -site amyloid- precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to A Asp1 contributes to Alzheimer pathogenesis. EUROPEAN JOURNAL OF NEUROSCIENCE. pp. 1962-1969.

Deornellis, David, D'Anna, Amy and Astrofsky, Keith (2013) Techniques Training: Rat. American Association for Laboratory Animal Science, Memphis, TN.

Dhuria, Shyeilla, Einolf, Heidi, Mangold, James, Sen, Suman, Wang, Lai, Gu, Huiping and Cameron, John (2013) Time-dependent inhibition and induction of human cytochrome P450A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects. Journal of Clinical Pharmacology, 63 (6). pp. 642-653. ISSN 0091-2700

Didiot, Marie-Cecile, Agarinis, Claudia, Varin, Thibault, Wu, Hua, Nelson, Thomas, Selinger, Douglas, King, Frederick, Schuffenhauer, Ansgar and Parker, Christian (2013) Glucocorticoid receptor ligands modulate EMCV Internal Ribosome Entry Site Activity. ASSAY and Drug Development Technologies, 11 (6). pp. 355-366.

Dienstmann, Rodrigo, Rodon, Jordi, Barretina, Jordi and Tabernero, Josep (2013) The genomic medicine frontier in human solid tumors: prospects and challenges. Journal of Clinical Oncology, 31 (15). pp. 1874-1884. ISSN 0732-183X

Dincer, Zuhal, Schadt, Heiko, Junker Walker, Ursula, Piaia, Alessandro, Pognan, Francois, Cordier, Andre, Spence, Fiona and Chibout, Salah-Dine (2013) The effects of PKC (Protein Kinase C) inhibitors on steroid hormones: a 2-week rat oral (gavage) investigative study focusing on pathology and hormone analysis in plasma and tissues. ESTP 2013 Congress.

Doberentz, E, Schumacher, R, Gembruch, U, Gasser, JA and Mueller, AM (2013) Coronal Vertebral Clefts: A Radiological Indicator for Chromosomal Aberrations. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. pp. 1-6.

Dodd, RD, Mito, JK, Eward, WC, Chitalia, R, Sachdeva, M, Ma, Y, Barretina, J, Dodd, L and Kirsch, DG (2013) NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to mek inhibition. MOLECULAR CANCER THERAPEUTICS. pp. 1906-1917.

Doelemeyer, Arno, De Vera Mudry, Maria Christina, Kohler, Manfred and Schorsch, Frederic (2013) The CEPA* industry working group’s approach to image analysis based cell proliferation studies using electronic images. Toxicologic Pathology.

Doucet, Julie, Fu, Jean, Zhao, An and Avrameas, Alexandre (2013) Development and validation of an ELISA at acidic pH for the quantitative determination of IL-13 in human plasma and serum. Journal of Pharmaceutical and Biomedical Analysis, 35. pp. 465-474. ISSN 0278-02401875-8630

Dranchak, P, MacArthur, R, Guha, R, Zuercher, WJ, Drewry, DH, Auld, DS and Inglese, J (2013) Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays. PLoS One.

Dreier, Oliver, Brasse, Hannah, Ingles, Sara, Schweigler, Patrick and Melkko, Samu (2013) Accurate, Fast and Facile Preparation of Compound Dilution Series by Digital Dispensing. GEN Genetic Engineering & Biotechnology News, 33 (11).

Dumitras, Swati, Sechaud, Romain, Drollmann, Anton Franz, Pal, Parasar, Vaidyanathan, Sivakumar, Camenisch, Gian P. and Kaiser, Guenther (2013) Effect of cimetidine, a model drug for inhibition of the organic cation transport in the kidney, on the pharmacokinetics of glycopyrronium. International Journal of Clinical Pharmacology and Therapeutics, 51 (10). pp. 771-779.

d'Offay, JM, Eberle, R, Wolf, RF, Kosanke, SD, Doocy, KR, Ayalew, S, Mansfeild, KG and White, GL (2013) Simian T-lymphotropic Virus-Associated Lymphoma in 2 Naturally Infected Baboons: T-cell Clonal Expansion and Immune Response during Tumor Development. COMPARATIVE MEDICINE. pp. 288-294.

de Lichtervelde, L, Boitano, AE, Wang, Y, Krastel, P, Petersen, F, Cooke, MP and Schultz, PG (2013) Eupalinilide E Inhibits Erythropoiesis and Promotes the Expansion of Hematopoietic Progenitor Cells. ACS CHEMICAL BIOLOGY. pp. 866-870.

E

Egerman, Marc and Glass, David (2013) Signaling pathways controlling skeletal muscle mass. Critical Reviews in Biochemistry and Molecular Biology, 49 (1). pp. 59-68. ISSN 1040-9238

Egger, Christine, Cannet, Catherine, Gerard Sachot, Christelle, Jarman, Elizabeth, Jarai, Gabor, Feige, Agnes, Suply, Thomas, Dunbar, Andrew W., Tigani, Bruno and Beckmann, Nicolau (2013) Administration of Bleomycin via the Oropharyngeal Aspiration Route Leads to Sustained Lung Fibrosis in Mice and Rats as Quantified by UTE-MRI and Histology. PLoS ONE, 8 (5). ISSN 1932-6203

Einolf, Heidi, Chen, Liangfu, Fahmi, Odette, Gibson, Christopher, Obach, Scott, Shebley, Mohamad, Silva, Jose, Sinz, Michael, Unadkat, Jashvant, Zhang, Lei and Zhao, Ping (2013) Assessing modeling methods for predicting clinical CYP3A induction: A collaborative effort among academic, government regulatory, and pharmaceutical industry scientists. Clinical Pharmacology and Therapeutics, 95 (2). pp. 179-188. ISSN 1532-6535

Elkabets, Moshe, Vora, Sadhna, Juric, Dejan, Morse, Natasha, Mino-Kenudson, Mari, Muranen, Taru, Tao, Jessica, Bosch Campos, Ana, Rodon, Jordi, Ibrahim, Yasir, Rodrik-Outmezguine, Vanessa, Quadt, Cornelia, Huang, Alan, Brugge, Joan, Rosen, Neal, Engelman, Jeffrey A., Scaltriti, Maurizio and Baselga, Jose (2013) mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PI3CA-mutant breast cancer. Science Translational Medicine, 5 (196).

Ellens, H, Deng, S, Coleman, J, Bentz, J, Taub, ME, Ragueneau-Majlessi, I, Chung, SP, Heredi-Szabo, K, Neuhoff, S, Palm, J, Balimane, P, Zhang, L, Jamei, M, Hanna, I, O'Connor, M, Bednarczyk, D, Forsgard, M, Chu, X, Funk, C, Guo, A, Hillgren, KM, Li, L, Pak, AY, Perloff, ES, Rajaraman, G, Salphati, L, Taur, JS, Weitz, D, Wortelboer, HM, Xia, CQ, Xiao, G, Yamagata, T and Lee, CA (2013) Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions. DRUG METABOLISM AND DISPOSITION. pp. 1367-1374.

Erdemli, Gul (2013) Phenotypic screening in the 21st century. Frontiers in Pharmacology Research Topics, 5. p. 264. ISSN 1663-9812

Erdemli, Gul, Mikhailov, Dmitri and Kim, Albert (2013) Indirect modulation of cardiac ion channels and implications for preclinical safety assessment. European Pharmaceutical Review.

Ertl, Peter and Bienfait, Bruno (2013) JSME: a Free Molecule Editor in JavaScript. Journal of Cheminformatics, 5 (24). p. 24. ISSN 1758-2946

Erve, JCL, Gauby, S, Maynard, JW, Svensson, MA, Tonn, G and Quinn, KP (2013) Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry. Chemical Research in Toxicology. pp. 926-936.

Evensen, L, Odlo, K, Micklem, DR, Littlewood-Evans, A, Wood, J, Kuzniewski, C, Altmann, K, Hansen, TV and Lorens, JB (2013) Contextual compound screening for improved therapeutic discovery. ChemBioChem. pp. 2512-2518.

Evrot, Emeline, Ebel, Nicolas, Romanet, Vincent, Roelli, Claudia, Andraos-Rey, Rita, Qian, Zhiyan, Doelemeyer, Arno, Dammassa, Ernesta, Sterker, Dario, Hofmann, Francesco, Murakami, Masato, Baffert, Fabienne and Radimerski, Thomas (2013) JAK1/2 and pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease. Clinical Cancer Research.

Evrot, Emeline, Ebel, Nicolas, Romanet, Vincent, Roelli, Claudia, Andraos-Rey, Rita, Qian, Zhiyan, Doelemeyer, Arno, Dammassa, Ernesta, Sterker, Dario, Hofmann, Francesco, Murakami, Masato, Baffert, Fabienne and Radimerski, Thomas (2013) JAK1/2 and pan-deacetylase inhibitor combination therapy yields improved efficacy in preclinical mouse models of JAK2V617F-driven disease. Clinical Cancer Research.

F

Favret, Sandra, Rubic-Schneider, Tina, Carballido, Jose and Sapieha, Przemyslaw (2013) Deficiency in the Metabolite-Sensing Receptor SUCNR1 (GPR91) Leads to Outer Retinal Lesions akin to dry-Age-Related Macular Degeneration. Aging, 5 (6). pp. 427-444.

Feldkamp, MD, Frank, AO, Kennedy, JP, Patrone, JD, Vangamudi, B, Waterson, AG, Fesik, SW and Chazin, WJ (2013) Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein a interaction motif of ATR interacting protein. Biochemistry. pp. 6515-6524.

Feldman, David, Jin, Liang, Xuan, Hong, Mueller, Dominik, Persohn, Elke, Scheutz, Helmut, Luft, Frederich and Zhou, Wei (2013) The direct renin inhibitor aliskiren localizes and persists in rat kidneys. American Journal of Physiology - Renal Physiology, 305 (11). F1593-F1602. ISSN 0363-6127

Felice, Dana / L, El-Shennawy, Lamiaa, Zhao, Shuangping, Lantvit, Daniel / L, Shen, Qi, Unterman, Terry / G, Swanson, Steven / M and Frasor, Jonna (2013) Growth Hormone potentiates 17beta-estradiol-dependent breast cancer cell proliferation in an IGF-I-independent manner. Endocrinology.

Fendt, Markus, Imobersteg, Stefan, Peterlik, Daniel, Chaperon, Frederique, Olpe, Hans-Rudolf, Mosbacher, Johannes, Vranesic, Ivan-Toma, van der Putten, Herman, Mcallister, Kevin, Flor, Peter J. and Gee, Christine E. (2013) Differential roles of mGlu7 and mGlu8 in amygdala physiology and in amygdala-dependent behavior. Neuropharmacology.

Feuerbach, Dominik, Arias, Hugo and Ortells, Marcello (2013) (-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurochemistry International.

Feuerbach, Dominik, Arias, Hugo R, De Rosa, Maria Jose and Bouzat, Cecilia (2013) Differential Pharmacological Activity of JN403 At α7 and Muscle Nicotinic Acetylcholine Receptors. The International Journal of Biochemistry & Cell Biology.

Filipovic, Georg (2013) How many test series does a market-ready medication need? Tecan Annual Report 2012. pp. 10-11.

Fishman, Mark, Cross, Robert and Tadmor, Brigitta (2013) Better connected. Nature, 493 (7434). p. 709. ISSN 0028-0836

Fletcher, E, Raman, M, Huebner, P, Liu, A, Mungas, D, Carmichael, O and DeCarli, C (2013) Loss of fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals. JAMA Neurology. pp. 1389-1395.

Flowerdew, SE, Wick, D, Himmelein, S, Horn, AKE, Sinicina, I, Strupp, M, Brandt, T, Theil, D and Hufner, K (2013) Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection. PLoS One.

Fornaro, Mara, Hinken, Aaron C., Needle, Saul, Hu, Erding, Trendelenburg, Anne-Ulrike, Meyer, Angelika, Rosenstiel, Antonia, Chang, Calvin, Meier, Viktor, Billin, Andrew N., Becherer, J. David, Evans, William J., Glass, David and Russell, Alan J. (2013) Mechano Growth Factor peptide (MGF), the COOH terminus of unprocessed Insulin-like growth factor 1 (IGF-1), has no apparent effect on muscle myoblasts or primary muscle stem cells. American Journal of Physiology.

Frank, AO, Feldkamp, MD, Kennedy, JP, Waterson, AG, Pelz, NF, Patrone, JD, Vangamudi, B, Camper, DV, Rossanese, OW, Chazin, WJ and Fesik, SW (2013) Discovery of a potent inhibitor of replication protein A protein-protein interactions using a fragment-linking approach. Journal of Medicinal Chemistry. pp. 9242-9250.

Furegati, Markus, Ossola, Flavio, La Vecchia, Luigi, Kramer, Christian and Bakonyi, Bettina (2013) Concise synthesis of all four stereoisomers of 3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid. Journal of Organic Chemistry, 78 (18). pp. 9328-9339.

Furet, Pascal, Guagnano, Vito, Fairhurst, Robin, Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Doriano and Caravatti, Giorgio (2013) Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorganic and Medicinal Chemistry Letters, 23 (13). pp. 3741-3748. ISSN 0960-894X

fu, jun, koul, dimpy, wang, shuzhen, yao, jun, yuan, yin, sulman, erik p., lang, frederick f. and yung, alfred w.k. (2013) A Novel HSP90 inhibitor, NVP-HSP990 Targets the Cell Cycle Regulators to Produce Anti-glioma Effect in Olig2-expressing Glioma Stem Cells. Cancer Research, 73 (10). pp. 3062-3074.

fu, wei, chu, baoky and pledger, w.jack (2013) Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH 727965 and a heat shock protein 90 inhibitor. Cell Death and Disease, 4 (3). ISSN 2041-4889

G

Gadd, MS, Jacques, DA, Nisevic, I, Craig, VJ, Kwan, AH, Guss, JM and Matthews, JM (2013) A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. Journal of Biological Chemistry. pp. 21924-21935.

Ganesh, S, Iyer, AK, Gattacceca, F, Morrissey, DV and Amiji, MM (2013) In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles. JOURNAL OF CONTROLLED RELEASE. pp. 699-706.

Ganesh, S, Iyer, AK, Morrissey, DV and Amiji, MM (2013) Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors. BIOMATERIALS. pp. 3489-3502.

Ganesh, S, Iyer, AK, Weiler, J, Morrissey, DV and Amiji, MM (2013) Combination of siRNA-directed gene silencing with cisplatin reverses drug resistance in human non-small cell lung cancer. Molecular Therapy - Nucleic Acids.

Gantois, I., Pop, A.S., de Esch, C.E.F., Buijsen, R.A.M., Gasparini, Fabrizio, D'Hooge, R. and Willemsen, R. (2013) Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice. Behavioural Brain Research, 239 (1). pp. 72-79. ISSN 0166-4328

Garcia-Fortanet, J, Formentin, P, Diaz-Oltra, S, Murga, J, Carda, M and Alberto Marco, J (2013) Stereoselective synthesis of a C1-C18 fragment of amphidinolides G and H. TETRAHEDRON. pp. 3192-3196.

Garner, Andrew P., Bialucha, Carl, Sprague, Elizabeth, Garrett, Joan T., Sheng, Qing, Li, Xiao, Sineshchekova, Olga, Saxena, Parmita, Sutton, Cammie R., Chen, Dongshu, Chen, Yan, Wang, Hui-Qin, Liang, Jinsheng, Das, Rita, Mosher, Rebecca, Gu, Jian, Huang, Alan, Haubst, Nicole, Zehetmeier, Carol, Haberl, Manuela, Kunz, Christian, Ellis, Winfried, Heidt, Analeah, Herlihy, Kara, Murtie, Joshua, Schuller, Alwin, Arteaga, Carlos L., Sellers, William and Ettenberg, Seth (2013) LJM716, an anti-HER3 antibody that locks HER3 in the inactive conformation and inhibits both HER2 and neuregulin driven tumor growth. Cancer Research, 73 (19). pp. 6024-35. ISSN 1538-7445

Garofalo, AW, Adler, M, Aubele, DL, Bowers, S, Franzini, M, Goldbach, E, Lorentzen, C, Neitz, RJ, Probst, GD, Quinn, KP, Santiago, P, Sham, HL, Tam, D, Truong, AP, Ye, XM and Ren, Z (2013) Novel cinnoline-based inhibitors of LRRK2 kinase activity. Bioorganic and Medicinal Chemistry Letters. pp. 71-74.

Garon, Edward B., Finn, Richard S., Hamidi, Habib, Dering, Judy, Kamranpour, Naeimeh, Desai, Amrita J., Hosmer, Wylie, Dubinett, Steven M., Slamon, Dennis J., Ide, Susan, Avsar, Emin, Jensen, Michael Rugaard, Quadt, Cornelia and Liu, Manway (2013) The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth. Molecular cancer therapeutics, 12 (6). pp. 890-900. ISSN 1538-8514

Garrett, Joan T., Sutton, Cammie R., Kurupi, Richard, Bialucha, Carl, Ettenberg, Seth, Collins, Scott, Sheng, Qing, Wallweber, Jerry, DeFazio-Eli, Lisa and Arteaga, Carlos L. (2013) Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks pi3k signaling and growth of HER2+ breast cancers. Cancer Research, 73 (19). pp. 6013-6023. ISSN 0008-5472

Genick, Christine and Ottl, Johannes (2013) Applications of Biophysics in High Throughput Screening Hit Validation. Journal of Biomolecular Screening, 19 (5). pp. 707-714. ISSN 1087-05711552-454X

Genovino, Julien, Luetz, Stephan, Toure, Bakary-Barry and Sames, Dalibor (2013) Complementation of Biotransformations with Chemical C-H Oxidation: Copper-Catalyzed Oxidation of Tertiary Amines in Complex Pharmaceuticals. Journal of the American Chemical Society, 135 (33). pp. 12346-12355. ISSN 0002-7863

Glynne, Richard, Mcnamara, Peter, Laffitte, Bryan, Li, Jing, Wu, Tom, Jin, Qihui, Baaten, Janine, Cho, Charles, Kamireddy, Anwesh, Zhang, You-Qing, Harb, George, Filippi, Christophe, Shen, Weijun, Tremblay, Matthew, Deshmukh, Vishal, Wang, Weidong, Swoboda, Jonathan, Wu, Xu, Herman, Ann and Schultz, Peter (2013) A small molecule inducer of β cell proliferation identified by high-throughput screening. Journal of the American Chemical Society, 135 (5). pp. 1669-1672. ISSN 0002-7863

Gomez-Mancilla, Baltazar, Johns, Donald, Kalkman, Hans O., Hariry, Sam, Hans-Christoph, Diener, Brand, Ronald, Jürgens, Tim and Harmut, Göbel (2013) Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks. Cephalalgia.

Gong, C, Tang, Y and Maquat, LE (2013) mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. NATURE STRUCTURAL & MOLECULAR BIOLOGY. pp. 1214-1220.

Gong, Ting and Szustakowski, Joseph (2013) DeconRNA-Seq: A Statistical Framework for Deconvolution of He-terogeneous Tissue Samples Based on mRNA-Seq data. Bioinformatics.

Gubler, Hanspeter, Schopfer, Ulrich and Jacoby, Edgar (2013) Theoretical and Experimental Relationships between %-Inhibition and IC50 Data observed in HTS. Journal of Biomolecular Screening, 18 (1). pp. 1-13. ISSN 1087-0571

Gurumurthy, Meera, Rao, Srinivasa P.S., Manjunatha, Ujjini Havaldar, Rao, Martin, Mukharjee, Tathagata, Boshoff, Helena, Dick, Thomas and Barry, Clifton (2013) An F420 dependent anti-oxidant mechanism protects Mycobacterium against oxidative stress and bactericidal agents. Molecular Microbiology. ISSN 0950-382X

Guérard, Melanie, Marchand, Christine and Plappert Helbig, Ulla (2013) Influence of experimental conditions on data variability in the liver comet assay. Tox Letters.

gillis, j and butler, L (2013) Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors. Oncotarget, 4 (5). pp. 691-704. ISSN 1949-2553

H

Hall, Michelle, Jorgensen, William and Whitehead, Lewis (2013) Automated cheminformatics and structure-based protocol for in silico prediction of Human Serum Albumin binding. Journal of Chemical Information & Modeling, 53 (4). pp. 907-922. ISSN 1549-9596

Hamann, Lawrence, Bryan, Marian, Dillon, Barry, Hughes, Greg, Kopach, Michael, Manley, Julie, Peterson, Emily, Pourashraf, Mehrnaz, Raheem, Izzat, Richardson, Paul, Richter, Daniel and Sneddon, Helen (2013) Sustainable practices in medicinal chemistry: Current state and future directions. Journal of Medicinal Chemistry, 56 (15). pp. 6007-6021. ISSN 0022-2623

Hannemann, Holger, Sung, Po-Yu, Bird, Jim, Lim, Siew Pheng and Davidson, Andrew (2013) Serotype Specific Differences in Dengue Virus Non-Structural Protein 5 Nuclear Localisation. Journal of Biological Chemistry.

Hao, L, He, Q, Wang, Z, Craven, M, Newton, MA and Ahlquist, P (2013) Limited Agreement of Independent RNAi Screens for Virus-Required Host Genes Owes More to False-Negative than False-Positive Factors. PLoS Computational Biology.

Haq, R, Yokoyama, S, Hawryluk, EB, Jonssond, GB, Frederick, DT, McHenry, K, Porter, D, Tran, TN, Love, KT, Langer, R, Anderson, DG, Garraway, LA, Duncan, LM, Morton, DL, Hoon, DSB, Wargo, JA, Song, JS and Fisher, DE (2013) BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 4321-4326.

Hara, Hisanori, Sechaud, Romain, Uziel-Fusi, Susan, Drollmann, Anton Franz and winkle, peter (2013) Glycopyrronium does not affect QT interval in healthy subjects: a randomized, three-period, cross-over, placebo- and positive-controlled study. Glycopyrronium does not affect QT interval in healthy subjects: a randomized, three-period, cross-over, placebo- and positive-controlled study .

Harner, MJ, Frank, AO and Fesik, SW (2013) Fragment-based drug discovery using NMR spectroscopy. Journal of Biomolecular NMR. pp. 65-75.

Hatzivassiliou, G, Haling, JR, Chen, H, Song, K, Price, S, Heald, R, Hewitt, JFM, Zak, M, Peck, A, Orr, C, Merchant, M, Hoeflich, KP, Chan, J, Luoh, S, Anderson, DJ, Ludlam, MJC, Wiesmann, C, Ultsch, M, Friedman, LS, Malek, S and Belvin, M (2013) Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature, 501 (7466). pp. 232-236. ISSN 0028-08361476-4687

Hau, Jean-Christophe, Erdmann, Dirk, Mesrouze, Yannick, Furet, Pascal, Fontana, Patrizia, Zimmermann, Catherine, Schmelzle, Tobias, Hofmann, Francesco and Chene, Patrick (2013) The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. ChemBioChem, 14 (10). pp. 1218-1225. ISSN 1439-4227

He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Kelleher Iii, Joseph, Dorsch, Marion, Buonamici, Silvia, Maniara, Wieslawa, Peukert, Stefan, Bourret, Aaron, Ramamurthy, Arun, Williams, Juliet, Green, John, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing and Yusuff, Naeem (2013) Discovery of NVP-LEQ506, a second generation inhibitor of Smoothened. ChemMedChem, 8 (8). pp. 1261-1265. ISSN 1860-7179

He, YL, Foteinos, G, Neelakantham, S, Mattapalli, D, Kulmatycki, K, Forst, T and Taylor, A (2013) Differential effects of vildagliptin and glimepiride on glucose fluctuations in patients with type 2 diabetes mellitus assessed using continuous glucose monitoring. DIABETES OBESITY & METABOLISM. pp. 1111-1119.

He, Yan-Ling, Zhang, Yiming, Yan, Jing-He, Zhou, Wei, Komjathy, Steven and Taylor, Ann (2013) High-quality triplicate electrocardiogram monitoring in a first-in-man study: potential for early detection of drug-induced QT prolongation. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 51 (12). pp. 948-957. ISSN 0946-1965

Heimbach, Tycho, Xia, Binfeng, Lin, Tsu-han and He, Handan (2013) Case studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data. AAPS Journal, 15 (1). pp. 143-158. ISSN 1550-7416

Hellman, Maarit, Piirainen, Henni, Jaakola, Veli-Pekka and Permi, Perttu (2013) Bridge over troubled proline: assignment of intrinsically disordered proteins using (HCA)CON(CAN)H and (HCA)N(CA)CO(N)H experiments concomitantly with HNCO and i(HCA)CO(CA)NH. Journal of Biomolecular NMR, 58 (1). pp. 49-60. ISSN 0925-2738

Heudi, Olivier, Maganda, Betty, Cortinovis, Agnes, Picard, Franck and Kretz, Olivier (2013) A fast and reliable reversed phase high performance liquid chromatography method for simultaneous determination of selected anti-retroviral and lumefantrine in human plasma. Journal of Chromatography B, 919/92. pp. 52-60. ISSN 1570-0232

Heudi, Olivier, Van Baar, Ben, Rohde, Morten, Wieling, Jaap, Verhaeghe, Tom, Lüdtke, Silke, De Vries, Ronald, White, Steve, Cobb, Zoe and Timmerman, Philip (2013) Internal standard addition in bioanalysis of dried blood spots: results from the EBF DBS-microsampling consortium. Bioanalysis, 5 (17). pp. 2137-2145. ISSN 1757-6180

Hill, RJ, Lou, Y and Tan, SL (2013) B-Cell Antigen Receptor Signaling in Chronic Lymphocytic Leukemia: Therapeutic Targets and Translational Opportunities. INTERNATIONAL REVIEWS OF IMMUNOLOGY. pp. 377-396.

Hoffman, Gregory, Rahal, Rami, Buxton, Frank, Mcallister, Gregory, Xiang, Xiaoqin, Frias, Elizabeth, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Bagdasarian, Linda, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris, Meyer, Matthew, Saenz-Vash, Veronica, Zhai, Huili, Mclaughlin, Margaret, Charles, Roberts, Myer, Vic, Porter, Jeffrey, Keen, Nicholas, Mickanin, Craig, Stegmeier, Frank and Jagani, Zainab (2013) A functional screen of the epigenome identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Molecular Cancer Therapeutics, 12 (11). ISSN 15357163

Hoffmaster, Keith, Brouwer, Kim, Keppler, Dietrich, Bow, Daniel, Cheng, Yaofeng, Lai, Yurong, Palm, Johan, Stieger, Bruno and Evers, Raymond (2013) In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. Clinical Pharmacology and Experimental Therapeutics.

Holderfield, Matthew, Merritt, Hanne, Chan, John, Wallroth, Marco, Tandeske, Laura, Zhai, Huili, Hardy, Stephen, Hekmat-Nejad, Mohammad, Stuart, Darrin, McCormick, Frank and Nagel, Tobi (2013) RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation. Cancer Cell, 23 (5). pp. 594-602. ISSN 1535-6108

Hopkins, Neil (2013) test. test.

Horman, SR, Janas, MM, Litterst, C, Wang, B, MacRae, IJ, Sever, MJ, Morrissey, DV, Graves, P, Luo, B, Umesalma, S, Qi, HH, Miraglia, LJ, Novina, CD and Orth, AP (2013) Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets. MOLECULAR CELL. pp. 356-367.

Hortobagyi, GN, Piccart-Gebhart, MJ, Rugo, HS, Burris, HA, Campone, M, Noguchi, S, Perez, AT, Deleu, I, Shtivelband, M, Provencher, L, Masuda, N, Dakhil, SR, Anderson, I, Chen, D, Damask, A, Huang, A, McDonald, R, Taran, T, Sahmoud, T and Baselga, J (2013) Correlation of molecular alterations with efficacy of everolimus in hormone-receptor-positive (HR+), HER2-negative advanced breast Cancer: Preliminary results from BOLERO-2. Journal of Clinical Oncology.

Hoyer, D, Durst, T, Fendt, M, Jacobson, LH, Betschart, C, Hintermann, S, Behnke, D, Cotesta, S, Laue, G, Ofner, S, Legangneux, E and Gee, CE (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Frontiers in Neuroscience. 235-.

Hoyer, Daniel, Duerst, Thomas, Fendt, Markus, Jacobson, Laura, Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Laue, Grit, Ofner, Silvio, Legangneux, Eric and Gee, Christine (2013) Distinct effects of orexin 2 receptor antagonism and dual orexin 1,2 receptor antagonism on sleep architecture in mice. Frontiers in Neuroscience, Neuropharmacology..

Huang, G, Buckler-Pena, D, Nauta, T, Singh, M, Asmar, A, Shi, J, Kim, JY and Kandror, KV (2013) Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Molecular Biology of the Cell. pp. 3115-3122.

Huang, Zheng, Wu, Haiping, Chuai, Shannon, Xu, Fiona, Yan, Feng, Englund, Nathan, Wang, Zhaofu, Zhang, Hailong, Fang, Ming, Wang, Youzhen, Gu, Justin, Zhang, Maya, Yang, Teddy, Zhao, Kehao, Yu, Yanyan, Dai, Jingquan, Yi, Wei, Zhou, Shaolian, Li, Qian, Wu, Jing, Liu, Jun, Wu, Xu, Chan, Ho Man, Lu, Chris, Atadja, Peter, Li, En, Wang, Yan and Hu, Min (2013) The PHD domain targets NSD2 to oncogenic gene loci and drives tumorigenesis in multiple myeloma cells. Cancer Research, 73 (20). pp. 1-12.

Huebener, J, Weber, JJ, Richter, C, Honold, L, Weiss, A, Murad, F, Breuer, P, Wuellner, U, Bellstedt, P, Paquet-Durand, F, Takano, J, Saido, TC, Riess, O and Huu, PN (2013) Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). HUMAN MOLECULAR GENETICS. pp. 508-518.

Hutz, Janna, Nelson, Thomas, Wu, Hua, Mcallister, Gregory, Moutsatsos, Ioannis, Jaeger, Savina, Bandyopadhyay, Somnath, Nigsch, Florian, Cornett, Allen, Jenkins, Jeremy and Selinger, Douglas (2013) The multidimensional perturbation value: A single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. Journal of Biomolecular Screening, 18 (4). pp. 367-377. ISSN 1087-0571; 1552-454X

I

Imbert, Pierre-Eloi, Siebert, Daniela, Unterreiner, Vincent, Meyerhofer, Marco, Leder, Lukas, Mcallister, Kathryn, Gabriel, Daniela and Parker, Christian (2013) Development of an Image Based Assay to Detect C5a Receptor Occupancy. Abstracts for MipTec 2010.

Inta, D, Vogt, MA, Luoni, A, Filipovic, D, Lima-Ojeda, JM, Pfeiffer, N, Gasparini, F, Riva, MA and Gass, P (2013) Significant increase in anxiety during aging in mGlu5 receptor knockout mice. BEHAVIOURAL BRAIN RESEARCH. pp. 27-31.

Ioannou, Nikolaos, Seddon, Alan / M, Dalgleish, Angus, Mackintosh, David and Modjtahedi, Helmout (2013) Synergistic growth inhibition of human pancreatic cancer cells following treatment with a combination of ErbB family blocker afatinib and IGF-IR inhibitor NVP-AEW541. BMC Cancer, 13. pp. 41-52. ISSN 1471-2407

Iwata, H, Baselga, J, Campone, M, Arteaga, CL, Cortes, J, Jonat, W, De Laurentiis, M, Ciruelos, E, Janni, W, Bachelot, T, Lonning, PE, Ma, C, O'Regan, R, Di Tomaso, E, Bharani-Dharan, B, Duval, V, Lau, H, Germa, C, Urban, P and Di Leo, A (2013) Ph III randomized studies of the oral pan-PI3K inhibitor buparlisib (BKM120) with fulvestrant in postmenopausal women with HR+/HER2-locally advanced or metastatic breast cancer (BC) after aromatase inhibitor (AI; BELLE-2) or AI and mTOR inhibitor (BELLE-3) treatment. Journal of Clinical Oncology.

Iwata, N, Sekiguchi, M, Hattori, Y, Takahashi, A, Asai, M, Ji, B, Higuchi, M, Staufenbiel, M, Muramatsu, S and Saido, TC (2013) Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Scientific Reports.

infante, J, gerecitano, G, Chugh , r, cassier , P, ribrag, V, shapiro, G, witteveen, E, Matano, Alessandro, Chakraborty, Abhijit and Parasuraman, Sudha (2013) Phase 1 multicenter, open label, dose-escalation study of LEE011, an oral inhibitor of cyclin-dependent kinase 4/6, in patients with advanced solid tumors or lymphomas. Molecular Cancer Therapeutics, 12 (11). ISSN 1535-7163

J

Jaguva Vasudevan, AA, Mario, P, Bulliard, Y, Cichutek, K, Trono, D, Haussinger, D and Munk, C (2013) Prototype foamy virus bet impairs the dimerization and cytosolic solubility of human APOBEC3G. Journal of Virology. pp. 9030-9040.

Jain, Rishi and Beckwith, Rohan (2013) Recent advances in small molecule target identification methods. Annual Reports in Medicinal Chemistry, 48. pp. 301-315. ISSN 0065-7743

Jakab, Annamaria, Winter, Serge, Raccuglia, Marc, Picard, Franck, Dumitras, Swati, Woessner, Ralph, Mistry, Sanket, Chudasama, Jayraj, Guttikar, Swati and Kretz, Olivier (2013) Validation of an LC-MS/MS method for the quantitative determination of Mavoglurant (AFQ056) in human plasma. Analytical and Bioanalytical Chemistry, 405 (1). pp. 215-223. ISSN 1618-2642

Jalili, Ahmed, Mertz, Kirsten D, Romanov, Julia, Wagner, Christine, Kalthoff, Frank, Stuetz, Anton, Pathria, Gaurav, Gschaider, Melanie, Stingl, Georg and Wagner, Stephan N (2013) NVP-LDE225, a potent and selective smoothened antagonist possess anti-melanoma activity both in vitro and in vivo. PLoS One, 8 (7). pp. 1-10.

Jamontt, Joanna, Clark, Natalie, Petit, Stephanie, Parkinson, Scott James and Smith, Philip (2013) NOD2 signalling promotes hyper-responsive macrophages and colitis in IL-10 deficient mice. Journal of Immunology, 190. ISSN 0022-1767

Javaid, S, Zhang, J, Anderssen, E, Black, JC, Wittner, BS, Tajima, K, Ting, DT, Smolen, GA, Zubrowski, M, Desai, R, Maheswaran, S, Ramaswamy, S, Whetstine, JR and Haber, DA (2013) Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of snail-1. Cell Reports. pp. 1679-1689.

Jenkins, JL (2013) DRUG DISCOVERY Rethinking cellular drug response. NATURE CHEMICAL BIOLOGY. pp. 669-670.

Jimenez-Guri, E, Huerta-Cepas, J, Cozzuto, L, Wotton, KR, Kang, H, Himmelbauer, H, Roma, G, Gabaldon, T and Jaeger, J (2013) Comparative transcriptomics of early dipteran development. BMC Genomics.

Jurisic, G, Sundberg, JP and Detmar, M (2013) Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflammatory Bowel Diseases. pp. 1983-1989.

K

Kaendler, Kerstin, Warren, Andrew Paul, Lloyd, Peter, Sims, Jennifer and Sickert, Denise (2013) Evaluation of Dried Blood Spots for the Quantification of Therapeutic Monoclonal Antibodies and Detection of Anti-Drug Antibodies. Bioanalysis, 5 (5). pp. 613-622. ISSN 1757-6180

Kale, MG, Raichurkar, A, Shahul, HP, Waterson, D, McKinney, D, Manjunatha, MR, Kranthi, U, Koushik, K, Jena, LK, Shinde, V, Rudrapatna, S, Barde, S, Humnabadkar, V, Madhavapeddi, P, Basavarajappa, H, Ghosh, A, Ramya, V, Guptha, S, Sharma, S, Vachaspati, P, Kumar, KNM, Giridhar, J, Reddy, J, Panduga, V, Ganguly, S, Ahuja, V, Gaonkar, S, Kumar, CNN, Ogg, D, Tucker, JA, Boriack-Sjodin, PA, De Sousa, SM, Sambandamurthy, VK and Ghorpade, SR (2013) Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA gyrase B. Journal of Medicinal Chemistry. pp. 8834-8848.

Kalkeri, G, Lin, C, Gopilan, J, Sloan, K, Rijnbrand, R and Kwong, AD (2013) Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations. Antimicrobial Agents and Chemotherapy. pp. 4417-4426.

Kalliokoski, Tuomo, Kramer, Christian and Vulpetti, Anna (2013) Quality issues with public domain chemogenomics data. Molecular Informatics, 32 (11-12). pp. 898-905. ISSN 1868-1743

Kalliokoski, Tuomo, Kramer, Christian, Vulpetti, Anna and Gedeck, Peter (2013) Comparability of mixed IC50 data – A Statistical Analysis. PLOS ONE, 8 (4). e61007. ISSN 1932-6203

Kalliokoski, Tuomo, Olsson, Tjelvar and Vulpetti, Anna (2013) Sub-pocket analysis method for Fragment-Based Drug Discovery. Journal of Chemical Information and Modeling, 53 (1). pp. 131-141. ISSN 1549-9596

Kamel, A, Colizza, K and Obach, RS (2013) In vitro metabolism of the 5-hydroxytryptamine 1B receptor antagonist elzasonan. XENOBIOTICA. pp. 368-378.

Kammerer, M, Gutzwiller, S, Stauffer, D, Delhon, I, Seltenmeyer, Y and Fournier, B (2013) Estrogen Receptor alpha (ER alpha) and Estrogen Related Receptor alpha (ERR alpha) are both transcriptional regulators of the Runx2-I isoform. MOLECULAR AND CELLULAR ENDOCRINOLOGY. pp. 150-160.

Karkare, S, Chung, TTH, Collin, F, Mitchenall, LA, McKay, AR, Greive, SJ, Meyer, JJM, Lall, N and Maxwell, A (2013) The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. Journal of Biological Chemistry. pp. 5149-5156.

Kawanami, Toshio, Karns, Alexander, Adams, Christopher and Serrano-Wu, Michael (2013) Efficient preparation of Ellman’s imines from trifluoromethyl ketones promoted by zirconium tert-butoxide. Tetrahedron Letters.

Khokhlovich, Edward, Wahl, Daniel, Masiello, Anthony, Parisot, Pierre, Baumann, Stefan, Szustakowski, Joseph, Nirmala, Nanguneri and Tuch, David (2013) RAMP: A Bioinformatics Framework for Researching Imaging Agents through Molecular Pathways. Molecular Imaging, 12 (1). pp. 2-7. ISSN 1535-3508

Kim, H, Babu, CR and Burgess, DJ (2013) Quantification of protonation in organic solvents using solution NMR spectroscopy: Implication in salt formation. INTERNATIONAL JOURNAL OF PHARMACEUTICS. pp. 123-131.

Kim, SE, Patapoutian, A and Grandl, J (2013) Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations. PLoS One.

Kim, SG, Hoffman, GR, Poulogiannis, G, Buel, GR, Jang, YJ, Lee, KW, Kim, B, Erikson, RL, Cantley, LC, Choo, AY and Blenis, J (2013) Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex. MOLECULAR CELL. pp. 172-185.

Kim, Sunkyu, Caponigro, Giordano, Parasuraman, Sudha, Rader, JulieAnn, Maris, John, Russell, Mike, Hart, Lori, Nakazawa, Michael, Belcastro, Lili, Martinez, Daniel, Li, Yimei, Carpenter, Erica, Attiyeh, Edward, Schnepp, Robert, Wood, Andrew, Pawel, Bruce and Cole, Kristina (2013) Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clinical Cancer Research, 19 (22). pp. 6173-6182. ISSN 1078-0432

Kimmel, Dannielle W, Dole, William and Cliffel, David E (2013) Application of multianalyte microphysiometry to characterize macrophage metabolic responses to oxidized LDL and effects of an apoA-1 mimetic. Biochemical and Biophysical Research Communications, 431 (2). pp. 181-185. ISSN 0006291X

King, Daniel, Ma, Weilei, Yao, Danfeng and Tobias, Renee (2013) BLItz Application Note Instant Protein Analysis using BLItz for Faster, Easier Bioprocess Development and Production. Blitz Application Note.

Kinoshita, Katsuhiro, Aono, Yoshinori, Azuma, Momoyo, Kishi, Jun, Takezaki, Akio, Kishi, Masami, Makino, Hideki, Okazaki, Hiroyasu, Uehara, Hisanori, Izumi, Keisuke, Sone, Saburo and Nishioka, Yasuhiko (2013) Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-induced induced Pulmonary Fibrosis in Mice. American Journal of Respiratory Cell and Molecular Biology. ISSN 1044-1549

Kipp, Randy, Quinn, Christopher and Fortin, Pascal (2013) Enzyme-Dependent Lysine Deprotonation in EZH2 Catalysis. Biochemistry, 52 (39). pp. 6866-6878. ISSN 0006-2960

Kondreddi, Ravinder Reddy, Jiricek, Jan, Rao, Srinivasa P.S., Lakshminarayana, Suresh Bangalore, Rao, Ranga Rao K.R., Herve, Maxime Marcel, Bifani, Juan Pablo, Kuhen, Kelli, Manjunatha, Ujjini Havaldar, Smith, Paul William, Camacho, Luis, Ma, Ida, Goh, Anne and Chatterjee, Arnab (2013) Design, synthesis and biological evaluation of indole-2-carboxamides, a promising class of anti-tuberculosis agents. J. med Chem, 56. pp. 8849-8859.

Koromilas, AE and Mounir, Z (2013) Control of oncogenesis by eIF2alpha phosphorylation: Implications in PTEN and PI3K-Akt signaling and tumor treatment. Future Oncology. pp. 1005-1015.

Korpal, Manav, Korn, Joshua, Ruddy, David, Doshi, Shivang, Yuan, Jing, Kim, Sunkyu, Cooke, Vesselina, Stegmeier, Frank, Roberts, Thomas, Sellers, William, Zhou, Wenlai and Zhu, Ping (2013) An F876l mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (Enzalutamide). Cancer Discovery, 3 (9). pp. 1030-1043. ISSN 2159-8274

Kovarik, Jiri (2013) From Immunosuppression to Immunomodulation: Current Principles and Future Strategies. Pathobiology, 80 (6). pp. 275-281. ISSN PMID: 24013771

Kramer, Christian, Bereau, Tristan, Spinn, Alexander, Liedl, Klaus R., Gedeck, Peter and Meuwly, Markus (2013) Deriving Static Atomic Multipoles from the Electrostatic Potential. Journal of Chemical Information and Modeling, 53. pp. 3410-3417.

Krauser, Joel (2013) A perspective on tritium versus carbon-14: ensuring optimal label selection in pharmaceutical research and development. Journal of Labelled Compounds and Radiopharmaceuticals. ISSN 0362-4803

Krumova, P and Weishaupt, JH (2013) Sumoylation in neurodegenerative diseases. CELLULAR AND MOLECULAR LIFE SCIENCES. pp. 2123-2138.

Kustermann, S, Boess, F, Buness, A, Schmitz, M, Watzele, M, Weiser, T, Singer, T, Suter, L and Roth, A (2013) A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects. Toxicology in Vitro. pp. 1589-1595.

Kutchukian, Peter, Lindvall, Mika, Wright, Kirk, Ottl, Johannes, Jacob, Jaison, Scheufler, Clemens, Marzinzik, Andreas, Natasja, Brooijmans and Glick, Meir (2013) Beyond Consensus: Leveraging Inherent Biases in Fragment Based Screening Technologies. Journal of medicinal chemistry.

kittan, nicolai, allen, ronald, dhaliwal, abhay, cavassani, karen, schaller, matthew, Jarai, Gabor, Westwick, John, kunkel, steven and hogaboam, cory (2013) Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes. PLoS ONE, 8 (10). ISSN 1932-6203

L

Lallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther and Wright, Amy (2013) The Marine Natural Product Manzamine A targets Vacuolar ATPases and Autophagy in Pancreatic Cancer Cells. Marine Drugs, 12 (4). pp. 3500-3516. ISSN None

Lamacchia, C, Palmer, G, Rodriguez, E, Martin, P, Vigne, S, Seemayer, CA, Talabot-Ayer, D, Towne, JE and Gabay, C (2013) The severity of experimental arthritis is independent of IL-36 receptor signaling - art. no. R38. ARTHRITIS RESEARCH & THERAPY.

Laurent, Didier, Yerby, Brittany, Zhang, Bailin, Chen, Xiao-Hui, Gounarides, John, Gao, Jiaping and Duttaroy, Alokesh (2013) Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960. European Journal Of Pharmacology, 715 (1-3). pp. 89-95.

Lazic, SE (2013) Comment on 'Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice'. SCIENCE. 1-.

Lazic, SE and Essioux, L (2013) Improving basic and translational science by accounting for litter-to-litter variation in animal models. BMC Neuroscience.

Leary, Beth A., Lawrence-Henderson, Rosemary, Mallozzi, Carolyn, Fernandez Ocana, Mireia, Duriga, Nicole, O'Hara, Denise, Kavosi, Mania, Qiang, Qu and Joyce, Alison (2013) Bioanalytical platform comparison using a generic human IgG PK assay format. Journal of Immunological Methods, 397 (1-2). pp. 28-36. ISSN 0022-1759

Leary, RJ, Sausen, M, Diaz, J and Velculescu, VE (2013) Cancer detection using whole-genome sequencing of cell free DNA. ONCOTARGET. pp. 1119-1120.

Lee, ACY, Epe, C and Bowman, DD (2013) Comparison of Ancylostoma caninum worm counts acquired by endoscopy and necropsy. Veterinary Parasitology. pp. 538-540.

Lee, David and Andrade, Felipe (2013) Cytotoxic cells induce cellular hypercitrullination and citrullinated autoantigen production via perforin. Science Translational Medicine.

Lee, JH, Gao, J, Kosinski, PA, Elliman, SJ, Hughes, TE, Gromada, J and Kemp, DM (2013) Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. pp. 1109-1113.

Leeds, Jennifer, Sachdeva, Meena, Mullin, Steve, Barnes, Whitney and Ruzin, Alexey (2013) In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin. Journal of Antimicrobial Chemotherapy. ISSN 0305-7453

Lefevre, Gilbert, Bhad, Prafulla, Jain, Jay Prakash, Kalluri, Sampath, Cheng, Yi, Dave, Hardik and Stein, Daniel (2013) Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem®) for bioequivalence in a randomized, open-label, two-period study. Malaria Journal, 12 (1). p. 312. ISSN 1475-2875

Leino, MS, Loxham, M, Blume, C, Swindle, EJ, Jayasekera, NP, Dennison, PW, Shamji, BWH, Edwards, MJ, Holgate, ST, Howarth, PH and Davies, DE (2013) Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors. PLoS One.

Lemmerer, Martin, London, Anne, Pannicucci, Alexandra, Gutierrez-Vargas, Cristina and Lihon, Michael (2013) Coupled Affinity and Sizing Chromatography: A novel in-process analytical tool to measure titer and trend Fc-protein aggregation. Journal of Immunological Methods, 393 (1/2). pp. 81-85. ISSN 0022-1759

Lepist, EI, Damaraju, VL, Zhang, J, Gati, WP, Yao, SYM, Smith, KM, Karpinski, E, Young, JD, Leung, KH and Cass, CE (2013) Transport of A(1) Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1. DRUG METABOLISM AND DISPOSITION. pp. 916-922.

Levy, JR, Campbell, KP and Glass, DJ (2013) MG53's new identity. Skeletal Muscle. 25-.

Lex, Alexander, Partl, Christian, Kalkofen, Denis, Streit, Marc, Gratzl, Samuel, Wassermann, Anne, Schmalstieg, Dieter and Pfister, Hanspeter (2013) Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets. IEEE Transactions on Visualization and Computer Graphics, 19 (12). pp. 2536-2545. ISSN 1077-2626

Li, C, Liu, B, Chang, J, Groessl, T, Zimmerman, M, He, YQ, Isbell, J and Tuntland, T (2013) A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery. DRUG DISCOVERY TODAY. pp. 71-78.

Li, D, Jin, L, Alesi, GN, Kim, YM, Fan, J, Seo, JH, Wang, D, Tucker, M, Gu, TL, Lee, BH, Taunton, J, Magliocca, KR, Chen, ZG, Shin, DM, Khuri, FR and Kang, S (2013) The Prometastatic Ribosomal S6 Kinase 2-cAMP Response Element-binding Protein (RSK2-CREB) Signaling Pathway Up-regulates the Actin-binding Protein Fascin-1 to Promote Tumor Metastasis. JOURNAL OF BIOLOGICAL CHEMISTRY. pp. 32528-32538.

Li, Q, Korzan, WJ, Ferrero, DM, Chang, RB, Roy, DS, Buchi, M, Lemon, JK, Kaur, AW, Stowers, L, Fendt, M and Liberles, SD (2013) Synchronous Evolution of an Odor Biosynthesis Pathway and Behavioral Response. CURRENT BIOLOGY. pp. 11-20.

Li, Shi-Hua, Dong, Hongping, Li, Xiao-Feng, Xie, Xuping, Zhao, Hui, Deng, Yong-Qiang, Wang, Xiao-Yu, Ye, Qing, Zhu, Shun-Ya, Wang, Hong-Jiang, Zhang, Bo, Qin, E-De, Qin, Cheng-Feng and Shi, Pei-Yong (2013) Rational design of a flavivirus vaccine through abolishing viral RNA 2′-O methylation. Journal of virology, 87 (10). pp. 5812-5819. ISSN 1098-5514; 0022-538X

Li, Shu, Gu, Justin, Hao, Qin, Fan, Hong, Li, Ling, Zhou, Shaolian, Zhao, Kehao, Chan, Ho Man and Wang, Yingqi (2013) A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases. Analytical Biochemistry, 443 (2). pp. 214-221. ISSN 0003-2697

Li, Wenkui, Lin, Hui, Flarakos, Jimmy and Tse, Francis (2013) Practical Approaches to Incurred Sample LC-MS/MS Reanalysis: Confirming Unexpected Results. Analytical Chemistry.

Li, Y and Zhang, T (2013) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts. Future Oncology. pp. 1097-1103.

Li, ZZ, Gilbert, JA, Zhang, Y, Zhang, M, Qiu, Q, Ramanujan, K, Shavlakadze, T, Eash, JK, Scaramozza, A, Goddeeris, MM, Kirsch, DG, Campbell, KP, Brack, AS and Glass, DJ (2013) An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis (vol 23, pg 1176, 2012). Developmental Cell. p. 112.

Li, Zhizhong, Glass, David and Zhang, Yunyu (2013) The HMGA2-IGF2BP2 Pathway Maintains Controls Mutated N-Ras Levels in Rhabdomyosarcoma. Cancer Research.

Liang, Y, Quenelle, D, Vogel, JL, Mascaro, C, Ortega, A and Kristie, TM (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio.

Liao, Rijing, Wu, Haiping, Deng, Haibing, Yu, Yanyan, Hu, Min, Zhai, Huili, Yang, Pengyuan, Zhou, Shaolian and Yi, Wei (2013) Specific and Efficient N-propionylation of histones with Propionic acid N-hydroxysuccinimide Ester for Histone Marks Characterization by LC-MS. Analytical Chemistry, 85 (4). pp. 2253-2259. ISSN 0003-2700

Lim, Siew Pheng, Koh, Hong Kiew Jolene, Seh, Cheah Chen, Liew, Chong Wai, Davidson, Andrew D, Chua, leng Shiew, Chandrasekaran, Ramya, Cornvik, Tobias, Shi, Pei-Yong and Lescar, Julien (2013) A novel crystal structure of the Dengue virus NS5 polymerase delineates inter-domain amino acids residues that enhance its thermostability and de novo initiation activities. Journal of Biological Chemistry.

Lim, Siew Pheng and Shi, Pei-Yong (2013) West Nile virus drug discovery. Viruses.

Lim, Siew Pheng, Shi, Pei-Yong, Soh, Sherryl, Zhao, Yongqian, Zheng , Jie , Phoo , Wint Wint , Swaminathan, Kunchithapadam , Cornvik , Tobias C., Lescar , Julien , Vasudevan , Subhash G. and Luo , Dahai (2013) A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication. PLOS Pathogens.

Lim, Siew Pheng, Wang, Qingyin, Noble, Christian Guy, Chen, Yen Liang, Dong, Hongping, Zou, Bin, Yokokawa, Fumiaki, Nilar, Shahul Hameed, Smith, Paul William, Beer, David John, julien, lescar and Shi, Pei-Yong (2013) Ten years of dengue drug discovery: progress and prospects. Anti-viral Research Journal.

Linghu, B, Franzosa, EA and Xia, Y (2013) Construction of functional linkage gene networks by data integration. Data Mining for Systems Biology: Methods and Protocols. pp. 215-232.

Liu, Jun, Pan, Shifeng, Ng, Nicholas, Kasibhatla, Shailaja, Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, Annemarie, Steffy, Auzon, Kowal, Colleen, Wang, Yan, Li, Chun, Wang, Tao, Mcnamara, Peter, Sellers, William, Petruzzelli, Lilli, Boral, Anthony, Seidel, Martin, Mclaughlin, Margaret, Che, Jianwei, Vanasse, K. Gary, Sun, Frank, Schuller, Alwin, Li, Allen, Cheng, Jane, Phung, Van, Guo, Guirong, Graham, Martin, Brenner, J. Chad, Villarroel, Maria, Schultz, Peter, Wu, Xu, Carey, Thomas and Hsieh, Hsin-I (2013) Targeting Wnt-driven Cancer Through the inhibition of Porcupine by LGK974. Proceedings of the National Academy of Sciences of the United States of America PNAS., 110 (50). pp. 20224-20229. ISSN 1091-6490; 0027-8424

Liu, LN, Wang, G, Hendricks, K, Lee, K, Bohnlein, E, Junker, Uwe and Mosca, JD (2013) Comparison of drug and cell-based delivery: engineered adult mesenchymal stem cells expressing soluble tumor necrosis factor receptor II prevent arthritis in mouse and rat animal models. Stem Cells Translational Medicine, 2 (5). pp. 362-375. ISSN 2157-6564

Liu, W, Collins, CM, Smith, MB and Yang, QX (2013) On consideration of radiated power in RF field simulations for MRI. MAGNETIC RESONANCE IN MEDICINE. pp. 290-294.

Liu, XH, Ide, JL, Norton, I, Marchionni, MA, Ebling, MC, Wang, LY, Davis, E, Sauvageot, CM, Kesari, S, Kellersberger, KA, Easterling, ML, Santagata, S, Stuart, DD, Alberta, J, Agar, JN, Stiles, CD and Agar, NYR (2013) Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Scientific Reports.

Liu, Yahua (2013) Fluorescent Probes for the Detection of Hydrogen Peroxide in Biological Systems. Current Organic Chemistry, 17 (6). pp. 654-669. ISSN 1385-2728

Lloyd, Peter (2013) Biological Therapeutics. Textbook of Pharmaceutical Medicine.

Loetscher, Erika, Beerli, Christian, Schneider, Karolina and Billich, Andreas (2013) Assay to measure the secretion of S1P from cells induced by S1P lyase inhibitors. Biochemical Biophysical Research Communications, 433 (3). pp. 345-348.

Lombardo, Franco, Waters, Nigel, Argikar, Upendra, Dennehy, Michelle, Zhan, Yu, Gunduz, Mithat, Harriman, Shawn, Berellini, Giuliano, Liric Rajlic, Ivana and Obach, R. Scott (2013) Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: Volume of distribution at steady state. Journal of Clinical Pharmacology, 53 (2). pp. 167-177. ISSN 0091-2700

Lombardo, Franco, Waters, Nigel, Argikar, Upendra, Dennehy, Michelle, Zhan, Yu, Gunduz, Mithat, Harriman, Shawn, Berellini, Giuliano, Liric Rajlic, Ivana and Obach, Scott (2013) Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: Clearance. Journal of Clinical Pharmacology, 53 (2). pp. 178-191. ISSN 0091-2700

Lomniczi, A, Loche, A, Castellano, JM, Ronnekleiv, OK, Bosch, M, Kaidar, G, Knoll, JG, Wright, H, Pfeifer, GP and Ojeda, SR (2013) Epigenetic control of female puberty. Nature Neuroscience. pp. 281-289.

Lotz, Gregor and Legleiter, Justin (2013) The role of amyloidogenic protein oligomerization in neurodegenerative disease. Neurotherapeutics. ISSN 1878-7479; 1933-7213

Lu, Boxun, Al-Ramahi, Ismael, Antonio, Valencia, Berenshteyn, Frada, Yang, Haidi, Gallego-Flores, Tatiana, Ichcho, Salah, Lacoste, Arnaud, Marian, Difiglia, Hild, Marc, Botas, Juan, Palacino, James and Wang, Qiong (2013) Identification of NUB1 as a Suppressor of Mutant Huntingtin Toxicity via Enhanced Protein Clearance. Nature Neuroscience. ISSN 1097-6256

Lu, Boxun and Palacino, James (2013) A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration. FASEB Journal. ISSN 0892-6638

Lu, Jing, Zavorotinskaya, Tatiana, Dai, Yumin, Niu, Xiaohong, Castillo, Joseph, Sim, Janet, Yu, Jianjun, Wang, Yingyun, Langowski, John, Holash, Jocelyn, Shannon, Kevin and Garcia, Pablo (2013) Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood, 122 (9). pp. 1610-1620. ISSN 1528-0020

Lu, Yang, Hongjing, Niu, Xianjun, Gao, Qingsong, Wang, Gang, Han, Liming, Cao, Chunquan, Cai, Weiler, Jan and Yin, HaiFang (2013) Effective Exon Skipping and Dystrophin Restoration by 2′-O-Methoxyethyl Antisense Oligonucleotide in Dystrophin-Deficient Mice. PLoS ONE, 8 (4). ISSN 1932-6203

Luetz, Stephan (2013) Book Review "Biocatalyst and Enzyme Technology", 2nd edition. Angewandte Chemie.

Luetz, Stephan (2013) Book review “Enzyme Catalysis in Organic Synthesis”, 3rd edition. Angewandte Chemie, 125. pp. 2-3. ISSN 0044-8249

Lukjanenko, Laura, Brachat, Sophie, Pierrel, Eliane, Trifilieff, Estelle and Feige, Jerome (2013) Genomic profiling reveals that transient adipogenic activation is a hallmark of mouse models of skeletal muscle regeneration. PLoS ONE, 8 (8). p. 71084. ISSN 1932-6203

Luksch, H, Romanowski, MJ, Chara, O, Tungler, V, Caffarena, ER, Heymann, MC, Lohse, P, Aksentijevich, I, Remmers, EF, Flecks, S, Quoos, N, Gramatte, J, Petzold, C, Hofmann, SR, Winkler, S, Pessler, F, Kallinich, T, Ganser, G, Nimtz-Talaska, A, Baumann, U, Runde, V, Grimbacher, B, Birmelin, J, Gahr, M, Roesler, J and Rosen-Wolff, A (2013) Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1beta. Human Mutation. pp. 122-131.

M

Mabrouk, OS, Mela, F, Calcagno, M, Budri, M, Viaro, R, Dekundy, A, Parsons, CG, Auberson, YP and Morari, M (2013) GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats. ACS Chemical Neuroscience. pp. 808-816.

Maclachlan, Timothy, McIntyre, Maritza, Jolly, Douglas, Mitrophanous, Kyriacos, Miskin, James, Holder, Julie and Cavagnaro, Joy (2013) Not reinventing the wheel – applying 3Rs concepts to viral vector gene therapy biodistribution studies. Human Gene Therapy Clinical Development, 24 (1). pp. 1-4.

Madden, JA, Hoyer, PB, Devine, Pj and Keating, AF (2013) Acute 7,12-dimethylbenz[a]anthracene exposure causes differential concentration dependent follicle depletion and gene expression in neonatal rat ovaries. Toxicology and Applied Pharmacology.

Maia, LF, Kaeser, SA, Reichwald, J, Hruscha, M, Martus, P, Staufenbiel, M and Jucker, M (2013) Changes in amyloid-beta and tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein. Science Translational Medicine.

Mainolfi, Nello, Powers, James, Amin, Jakal, Long, Debby, Lee, Wendy, Mclaughlin, Margaret, Jaffee, Bruce, Brain, Christopher, Elliott, Jason and Sivak, Jeremy (2013) An Effective Prodrug Strategy to Selectively Enhance Ocular Exposure of a Cannabinoid Receptor (CB1/2) Agonist. Journal of Medicinal Chemistry. ISSN 0022-2623

Majumdar, Dyuti, Chin, Donovan, Fortin, Pascal, Feng, Yun, Gould, Ty, Kirby, Christina, Shao, Wenlin, Stams, Travis, Waters, Nigel and Shultz, Michael (2013) Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases. Journal of Medicinal Chemistry, 56 (17). pp. 7049-7059. ISSN 0022-2623

Malherbe, DC, Sanders, RW, van Gils, MJ, Park, B, Gomes, MM, Schuitemaker, H, Barnett, S and Haigwood, NL (2013) HIV-1 Envelope Glycoprotein Resistance to Monoclonal Antibody 2G12 Is Subject-Specific and Context-Dependent in Macaques and Humans. PLoS One.

Manjunatha, Ujjini Havaldar, Rao, Srinivasa P.S., Lakshminarayana, Suresh Bangalore, Kondreddi, Ravinder Reddy, Herve, Maxime Marcel, Bifani, Juan Pablo, Luis, Camacho, Jiricek, Jan, Sarath, Kalapala, Tan, Bee Huat, Nanjundappa, Mahesh Bangalore, Seow Hwee, Ng, Sindhu, Ravindran, Seah, Peck Gee, Thayalan, Pamela, Lee, Boon Heng, Barnes, Whitney, Anne, Goh, Arnab, Chatterjee, Kevin, Pethe, Kuhen, Kelli, Walker, John, Babu, Sreehari, Gu, Feng, Lijun, Zhang, Blasco, Francesca, Beer, David John, Weaver, Margaret, Veronique, Dartois, Glynne, Richard, Thomas, Dick, Smith, Paul William, Diagana, Thierry Tidiane, Vivian, Lim NITD and Ida, Ma (2013) Indolcarboxamide, a promising pre-clinical candidate for the treatment of multi drug resistant tuberculosis. Science Translational Medicine.

Manley, Paul W., Blasco, Francesca, Mestan, Juergen and Aichholz, Reiner (2013) The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588. Bioorganic Medicinal Chemistry, 21 (11). pp. 3233-3239. ISSN 0968-0896

Manrique, J, Piatak, M, Lauer, W, Johnson, W, Mansfield, K, Lifson, J and Desrosiers, R (2013) Influence of mismatch of env sequences on vaccine protection by live attenuated simian immunodeficiency virus. Journal of Virology. pp. 7246-7254.

Marais, R, Sellers, W, Livingston, D and Mihich, E (2013) Twenty-fourth Annual Pezcoller Symposium: Molecular Basis for Resistance to Targeted Agents. CANCER RESEARCH. pp. 1046-1049.

Maresca, Marcello, Lin, Victor, Guo, Ning and Yang, Yi (2013) Obligate Ligation-Gated Recombination (ObLiGaRe): Custom designed nucleases mediated targeted integration through non-homologous end joining. Genome Research. pp. 1-8. ISSN 1088-9051

Margolin, AA, Bilal, E, Huang, E, Norman, TC, Ottestad, L, Mecham, BH, Sauerwine, B, Kellen, MR, Mangravite, LM, Furia, MD, Vollan, HKM, Rueda, OM, Guinney, J, Deflaux, NA, Hoff, B, Schildwachter, X, Russnes, HG, Park, D, Vang, VO, Pirtle, T, Youseff, L, Citro, C, Curtis, C, Kristensen, VN, Hellerstein, J, Friend, SH, Stolovitzky, G, Aparicio, S, Caldas, C and Borresen-Dale, A (2013) Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer. Science Translational Medicine.

Marsilje, Thomas, Pei, Wei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Sarkisova, Yelena, Steffy, Auzon, Culazzo, Annemarie, Kasibhatla, Shailaja, Joseph, Sean, Kim, Young, Tuntland, Tove, Cui, Xiaoming, Li, Jie, Gordon, William, Richmond, Wendy, Chang, Hsiao-Yen, Groessl, Todd, He, You-Qun, Liu, Bo, Fangxian, Sun, Phimister, Andrew, Aycinena, Juan, Bursulaya, Badry, Lee, Christian, Seidel, Martin, Harris, Jennifer and Michellys, Pierre (2013) Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl) phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. Journal of Medicinal Chemistry, 56 (14). pp. 5675-5690. ISSN 0022-2623

Martin, Eric, Tseng, Y. Jane, bologa, Cristian and Shelat, Anag (2013) A Mini-Series on the Cheminformatics Aspects of High Throughput Screening: from Robots to Models - Summary. Journal of Computer-aided Molecular Design.

Martin, Jeffrey, Rejtar, Tomas and Martin, Stephen (2013) Integrated microscale analysis system for targeted LC/MS proteomics on limited amounts of enriched cell populations. Analytical Chemistry.

Martin, P, Talabot-Ayer, D, Seemayer, CA, Vigne, S, Lamacchia, C, Rodriguez, E, Finckh, A, Smith, DE, Gabay, C and Palmer, G (2013) Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency - art. no. R13. ARTHRITIS RESEARCH & THERAPY.

Martina, Marzia, Comas, Tanya and Mealing, Geoffrey (2013) Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus. Journal of Neuroscience, 4. ISSN 1663-9812

Marzinzik, Andreas and Lewis, Ian (2013) KGF-SCS Senior Industrial Investigator Award 2013. Chimia, 67 (4). A302.

Marzinzik, Andreas and Vorherr, Thomas (2013) Towards intracellular delivery of peptides. Chimia.

Massacesi, C, Di, TE, Fretault, N and Hirawat, S (2013) Challenges in the clinical development of PI3K inhibitors. Annals of the New York Academy of Sciences. pp. 19-23.

Matos Coelho, Fernanda, Natale, Daniela, Soriano, Silvia, Hons, Swoger, Mayer, Jürgen, Danuser, Renzo, Scandella, Elke, Pieczyk, Markus, Zerwes, Hans-Guenter, Junt, Tobias, Sailer, Andreas, Ludewig, Burkhard, Sharpe, James, Figge, Marc Thilo and Stein, Jens (2013) Analyzing the in vivo contribution of G protein-coupled receptors and LFA-1 for naive B cell trafficking in lymph nodes. Blood, 121 (20). pp. 4101-4109. ISSN 0006-4971

Matthews, GM, Lefebure, M, Doyle, MA, Shortt, J, Ellul, J, Chesi, M, Banks, KM, Vidacs, E, Faulkner, D, Atadja, P, Bergsagel, PL and Johnstone, RW (2013) Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma - art. no. e798. CELL DEATH & DISEASE.

May, Andrew, Hazelhurst, Scott, Waldvogel, Marie, Eichenberger, Juerg, Norris, Shane A, Govind, Nimmisha, Tikly, Mohammed, Hon, Yee, Johnson, Keith, Hartmann, Nicole, Staedtler, Frank and Ramsay, Michèle (2013) Genetic diversity in black South Africans from Soweto. BMC Genomics, 14 (644).

McDonald, Michelle, Mikulec, Kathy, Peacock, Lauren, Morse, Alyson, Baldock, Paul Andrew, Kostenuik, Paul and Little, David G (2013) Osteoclasts are redundant during MMP-driven endochondral fracture repair. McDonald MM, Morse A, Mikulec K, Peacock L, Baldock P, Kostenuik PJ, Little DG. Osteoclasts are redundant during MMP driven endochondral fracture repair, but essential to hard callus remodelling. J Bone Miner Res. 2013 Jul;28(7):1550-60.

Mcnamara, Case, Lim, Chek Shik, Lim, Siau Hoi, Roland, Jason, Simon, Oliver, Yeung, Bryan King Sing, Kuhen, Kelli, Gagaring, Kerstin Mae, Nagle, Advait, Plouffe, David, Bursulaya, Badry, Trappe, Joerg, Haasen, Dorothea, Glynne, Richard, Bodenreider, Christophe, Diagana, Thierry Tidiane and Winzeler, Elizabeth A (2013) Targeting Plasmodium phosphatidylinositol-4 kinase for the treatment, prevention and elimination of malaria. Nature, 504 (7479). pp. 248-253. ISSN 0028-08361476-4687

Megison, Michael L., Stewart, Jerry E., Gillory, Lauren A., Nabers, Hugh and Beierle, Elizabeth A. (2013) FAK Inhibition Decreases Neuroblastoma Cell Invasion, Migration and Metastasis. Clinical and Experimental Metastasis, 30 (5). pp. 555-568. ISSN 0262-0898

Mehling, M, Brinkmann, V, Burgener, AV, Gubser, P, Luster, AD, Kappos, L and Hess, C (2013) Homing frequency of human T cells inferred from peripheral blood depletion kinetics after sphingosine-1-phosphate receptor blockade. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1440-.

Meier, V, Geigy, C, Grosse, N, McSheehy, P and Bley, CR (2013) Use of Epothilone B (Patupilone) in Refractory Lymphoma and Advanced Solid Tumors in Dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE. pp. 120-125.

Meingassner, Josef, Aschauer, Heinrich, Winiski, Anthony, Dales, Natalie, Yowe, David, Winther, Michael, Zhang, Zahui, Stuetz, Anton and Billich, Andreas (2013) Pharmacological Inhibition of Stearoyl CoA Desaturase 1 in the Skin Induces Atrophy of the Sebaceous Glands. Journal of Investigative Dermatology, 133 (8). pp. 2091-2094. ISSN 0022-202X

Menon, Roopika, Deng, Mario, Rüenauver, Kerstin, Kunze, Friedrich, Diana, Boehm, Vogel, Wenzel, Scheble, Veit, Fend, Falko, Kristiansen, Glen, Wernert, Nicolas, Oberbeckmann, Nicole, Biskup, Saskia, Rubin, Mark A., Shaikhibrahim, Zaki and Perner, Sven (2013) Somatic copy number alterations by whole exome sequencing implicates YWHAZ and PTK2 in castration resistant prostate cancer. The Journal of Pathology.

Merchant, M, Ma, X, Maun, HR, Zheng, Z, Peng, J, Romero, M, Huang, A, Yang, N, Nishimura, M, Greve, J, Santell, L, Zhang, Y, Su, Y, Kaufman, DW, Billeci, KL, Mai, E, Moffat, B, Lim, A, Duenas, ET, Phillips, HS, Xiang, H, Young, JC, Vande Woude, GF, Dennis, MS, Reilly, DE, Schwall, RH, Starovasnik, MA, Lazarus, RA and Yansura, DG (2013) Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. E2987-E2996.

Meredith, Erik, Burgis, Robin, Beil, Michael, Capparelli, Michael, Fu, Fumin, Hu, Chii-Whei, Hu, Qi-Ying, Jeng, Arco, Ksander, Gary, Lasala, Daniel, Liu, Qian, Miranda, Karl, Monovich, Lauren, Morris, Patrick, Papillon, Julien, Rao, Chang, Rigel, Dean and Singh, Alok (2013) Discovery and in vivo evaluation of potent dual CYP11B2 (aldosterone synthase) and CYP11B1 inhibitors. ACS Medicinal Chemistry Letters.

Michelle L, Frost, Amelia E, Moore, Musib, Siddique, Glen M, Blake, Laurent, Didier, Borah, Babul, Schramm, Ursula, Theodore, Pellas, Paul K, Marsden, Paul J, Schleyer and Ignac, Fogelman (2013) 18F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: A prospective, randomized, controlled clinical study. Journal of Bone and Mineral Research, 28 (6). pp. 1337-1347. ISSN 08840431

Micoli, Francesca, Romano, Maria Rosaria, Tontini, Marta, Cappelletti, Emilia, Gavini, Massimiliano, Proietti, Daniela, Rondini, Simona, Swennen, Erwin Frans, Santini, Laura, Filippini, Sara, Balocchi, Cristiana, Adamo, Roberto, Pluschke, Gert, Norheim, Gunnstein, Pollard, Andrew J., Saul, Allan James, Rappuoli, Rino, Maclennan, Calman Alexander, Berti, Francesco and Costantino, Paolo (2013) The development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X. Proceedings of the National Academy of Sciences (PNAS).

Minetti, Giulia, feige, Jerome, Bombard, Florian, Heier, Annabelle, Morvan, Frederic, Nuerberg, Bernd, Leiss , Veronika, Birnbaumer, Lutz, Glass, David and Fornaro, Mara (2013) Gαi2 signaling is required for skeletal muscle growth, regeneration and satellite cell proliferation and differentiation. Mol Cell Biol.

Misof, Barbara M, Roschger, Paul, Paschalis, Eleftherios P, Eriksen, Erik F, Recker, Robert R, Gasser, Juerg Andreas and Klaushofer, Klaus (2013) Annual intraveneous zoledronic acid for three years increased cancellous bone matrix mineralization beyond normal values in the HORIZON biopsy cohort. Journal of Bone and Mineral Research.

Mochel, JP, Fink, M, Peyrou, M, Desevaux, C, Deurinck, M, Giraudel, JM and Danhof, M (2013) Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology. CHRONOBIOLOGY INTERNATIONAL. pp. 1144-1159.

Modur, V, Hailman, E and Barrett, JC (2013) Evidence-Based Laboratory Medicine in Oncology Drug Development: From Biomarkers to Diagnostics. CLINICAL CHEMISTRY. pp. 102-109.

Moggs, Jonathan, Kronenberg, Sven, Baumann, Andreas, de Haan, Lolke, Hinton, Heather J, Theil, Frank-Peter, Wakefield, Ian and Singer, Thomas (2013) Current challenges and opportunities in nonclinical safety testing of biologics. Drug Discovery Today, 18 (23-24). pp. 1138-1143. ISSN 1878-5832

Moggs, Jonathan, Satish, Jean, Sethu, Swaminathan, Bielsky, Marie-Christine, de Haan, Lolke, French, Neil, Govindappa, Karthik, Green, James, Griffiths, Christopher, Holgate, Stephen, Jones, David, Kimber, Ian, Naisbitt, Dean, Pirmohamed, Munir, Reichmann, Gabriele, Sims, Jennifer, Subramanyam, Meena, Todd, Marque, van der Laan, Jan Willem, Weaver, Richard and Park, Kevin (2013) Challenges and approaches for the development of safer immunomodulatory biologics. Nature Reviews Drug Discovery, 12. pp. 306-324.

Molina-Arcas, Miriam, Hancock, David / C, Sheridan, Clare, Kumar, Madhu / S and Downward, Julian (2013) Coordinate direct input of both KRAS and IGF1 receptor to activation of PI 3-kinase in KRAS mutant lung cancer. Cancer Discovery.

Moon, K, Six, DA, Lee, H, Raetz, CRH and Gottesman, S (2013) Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification. Molecular Microbiology. pp. 52-64.

Moreira Proenca, Catia, Stoehr, Natacha, Bernhard, Mario, Seger, Shanon, Genoud, Christel, Roscic, Ana, Paganetti, Paolo, Murphy, Leon, Kuhn, Rainer, Bouwmeester, Antonius and Galimberti, Ivan (2013) Atg4b-dependent Autophagic Flux Alleviates Huntington’s Disease Progression. PloS ONE, 8 (7). pp. 1-16.

Morin, N, Morissette, M, Gregoire, L, Gomez-Mancilla, B, Gasparini, F and Di Paolo, T (2013) Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys. NEUROPHARMACOLOGY. pp. 216-231.

Myers, AP (2013) New Strategies in Endometrial Cancer: Targeting the PI3K/mTOR Pathway-The Devil Is in the Details. CLINICAL CANCER RESEARCH. pp. 5264-5274.

N

Nakamura, Eri, Otsuka, Fumio, Inagaki, Kenichi, Miyoshi, Tomoko, Tsukamoto, Naoko, Ogura-Ochi, Kanako, Takeda, Masaya, Toma, Kishio and Makino, Hirofumi (2013) Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis. The Journal of steroid biochemistry and molecular biology, 134. pp. 67-74. ISSN 0960-0760

Ngaemthao, W, Suriyachadkun, C, Chunhametha, S, Tamura, T and Sanglier, JJ (2013) Planobispora siamensis sp nov., isolated from soil. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. pp. 2649-2654.

Nguyen, HP, Hubener, J, Weber, JJ, Grueninger, S, Riess, O and Weiss, A (2013) Cerebellar Soluble Mutant Ataxin-3 Level Decreases during Disease Progression in Spinocerebellar Ataxia Type 3 Mice. PLoS One.

Nguyen, THT, Guedj, J, Yu, J, Levi, M and Mentre, F (2013) Influence of a priori information, designs, and undetectable data on individual parameters estimation and prediction of hepatitis c treatment outcome. CPT: Pharmacometrics and Systems Pharmacology.

Nicholson, Thomas, Su, Hui, Hevi, Sarah, Bajko, Jeff, Wang, Jing, Valdez, Reginald, Loureiro, Joseph, Cheng, Xiaodong, Li, En, Kinzel, Bernd, Labow, Mark and Chen, Taiping (2013) Defective heart development in hypomorphic Lsd1 mice. PLoS One, 8 (4). ISSN 1932-6203

Nijmeijer, S, Vischer, H, Sirci, F, Schultes, S, Engelhardt, H, de Graaf, C, Rosethorne, Elizabeth, Charlton, Steven and Leurs, R (2013) Detailed analysis of biased histamine H4 receptor signalling by JNJ7777120 analogues. British Journal of Pharmacology, 170. pp. 78-88.

Nilar, Shahul Hameed, Ma, Ngai Ling and Keller, Thomas H. (2013) Incorporating Molecular Complexity in the Design of Screening Libraries. Journal of Computer Aided Molecular Design.

Noble, Christian Guy, Lim, Siew Pheng, Chen, Yen Liang and Shi, Pei-Yong (2013) Conformational flexibility of the dengue virus RNA dependent RNA polymerase revealed by a complex with an inhibitor. Journal of Virology, 87 (9). pp. 5291-5295. ISSN 0022-538X

Noble, Christian Guy and Shi, Pei-Yong (2013) Difficulties and advancements in developing drugs for the treatment of dengue fever. Expert Opinion on Orphan Drugs, 1 (12). pp. 947-949. ISSN 2167-8707

Noble, Christian Guy, Vasudevan, Dileep and Rao, Srinivasa P.S. (2013) Structural basis of mycobacterial inhibition by Cyclomarin A. Journal of Biological Chemistry, 288 (43). ISSN 0021-92581083-351X

Nordstrand, Annika, Lundholm, Marie, Larsson, Andreas, Lerner, Ulf H, Widmark, Anders and Wikström, Pernilla (2013) Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone. Cancer Microenvironment. ISSN 1875-2292

O

O'Connor, RM, Thakker, DR, Schmutz, Markus, Van Der Putten, P. Herman, Hoyer, Daniel, Flor, PJ and Cryan, JF (2013) Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse. Neuropharmacology, 72. pp. 66-73. ISSN 0028-3908

Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Mueller-Hartwieg, Constanze, Cumin, Frederic, Hassiepen, Ulrich, Trappe, Joerg, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Beatrix, Kosaka, Takatoshi, Webb, Randy, Maibaum, Juergen Klaus, Baeschlin, Daniel and Sedrani, Richard (2013) A novel class of oral direct renin inhibitors - highly potent 3,5-disubstituted piperidines bearing a tricyclic P3-P1 unit. Journal of medicinal chemistry, 56 (6). pp. 2196-2206. ISSN 0022-2623

P

Pan, Shifeng, Gray, Nathanael, Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xia, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel Graham and Nuesslein-Hildesheim, Barbara (2013) Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Medicinal Chemistry Letters, 4 (3). ISSN 1948-5875

Pantano, Serafino, Dubost, Valerie, Darribat, Katy, Couttet, Philippe, Grenet, Olivier, Busch, Steven and Moulin, Pierre (2013) Differential expression of dipeptidyl peptidase IV in human versus cynomolgus monkey skin eccrine sweat glands. Journal of Molecular Histology, 44 (6). pp. 733-747. ISSN 1567-2387

Pantano, Serafino, Dubost, Valerie, Darribat, Katy, Couttet, Philippe, Grenet, Olivier, Busch, Steven and Moulin, Pierre (2013) Differential expression of dipeptidyl peptidase IV in human versus cynomolgus monkey skin eccrine sweat glands. Journal of Molecular Histology, 44 (6). pp. 733-747. ISSN 1567-2379

Park, So Young, Mun, Hee-Chang, Eom, Young Sil, Jung, Tae Sik, Hong, Suntaek, Lee, Sihoon and Kim, Chul Hoon (2013) Identification and characterization of D410E, a novel mutation in the loop 3 domain of CaSR, in autosomal dominant hypocalcemia and therapeutic approaches with novel calcilytics, AXT914. Clinical Endocrinology, 78 (5). pp. 687-693. ISSN 0300-0664

Parker, C (2013) Antisense Drug Technology, Principles, Strategies and Applications, 2nd edition. JOURNAL OF BIOMOLECULAR SCREENING. 1-.

Parkinson, Scott James, Holway, Nicholas and Siddharth, Jay (2013) A western diet ecological module identified from the 'humanized' mouse microbiota predicts diet in adults and formula feeding in children. PLoS ONE, 8 (12). ISSN 1932-6203

Patrone, JD, Kennedy, JP, Frank, AO, Feldkamp, MD, Vangamudi, B, Pelz, NF, Rossanese, OW, Waterson, AG, Chazin, WJ and Fesik, SW (2013) Discovery of protein-protein interaction inhibitors of replication protein A. ACS Medicinal Chemistry Letters. pp. 601-605.

Pawar, PV, Gohil, SV, Jain, JP and Kumar, N (2013) Functionalized polymersomes for biomedical applications. POLYMER CHEMISTRY. pp. 3160-3176.

Pearlstein, Robert, Sherman, Woody and Abel, Robert (2013) Contributions of Water Transfer Energy to Protein-Ligand Association and Dissociation Barriers: WaterMap Analysis of a Series of p38α MAP Kinase Inhibitor. PROTEINS: Structure, Function, and Bioinformatics. ISSN 0887-3585

Pecchi, Sabina, Ni, Zhi-Jie, Han, Wooseok, Smith, Aaron, Jiong, Lan, Burger, Matthew, Merritt, Hanne, Wiesmann, Marion, Kaufman, Susan, Chan, John, Knapp, Mark, Jansen, Johanna, Hu, Kay and Voliva, Charles (2013) Structure Guided Optimization of a Fragment Hit to Imidazopyridine Inhibitors of PI3K. Bioorganic and Medicinal Chemistry Letters, 23 (16). pp. 4652-4656. ISSN 0960894X

Peille, A, Brouste, V, Kauffmann, A, Lagarde, P, Le, M, Coindre, J, Chibon, F and Bresson-Bepoldin, L (2013) Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas. PLoS One.

Penno, CA, Arsenijevic, D, Da Cunha, T, Kullak-Ublick, GA, Montani, JP and Odermatt, A (2013) Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry. ANALYTICAL METHODS. pp. 1155-1164.

Perez, EG, Ocampo, C, Feuerbach, D, Lopez, JJ, Morelo, GL, Tapia, RA and Arias, HR (2013) Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodides are competitive antagonists for the human alpha4beta2 and alpha7 nicotinic acetylcholine receptors. MedChemComm. pp. 1166-1170.

Perez-Schindler, J, Summermatter, S, Santos, G, Zorzato, F and Handschin, C (2013) The transcriptional coactivator PGC-1alpha is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 20314-20319.

Pethe, Kevin, Jang, Jichan, Kang, Sunhee, Park, Seijin, Ahn, Sujin, Jiricek, Jan, Jung, Juyoung, Jeon, Hee Kyoung, Cechetto, Jonathan, Christophe, Thierry, Kempf, Marie, Jackson, Mary, Lenaerts, Anne J., Pham, Ha, Jones, Victoria, Seo, Min Jung, Lee, Saeyeon, Kim, Young, Seo, Mooyoung, Seo, Jeong Jea, Ko, Yoonae, Choi, Inhee, Kim, Ryangyeo, Kim, Seyeon, Lim, SeungBin, Yim, SeungAe, Jiyoun Nam, Jiyoun Nam, Hwankyu Kang, Hwankyu Kang, Chun-Taek Oh, Chun-Taek Oh, Yoojin Cho, Yoojin Cho, Yunhee Jang, Yunhee Jang, Junghwan Kim, Junghwan Kim, Chua, Adeline, Tan, Bee Huat, Nanjundappa, Mahesh Bangalore, Rao, Srinivasa P.S., Barnes, Whitney, Wintjens, René, Walker, John, Alonso, Sylvie, Kim, Jungjun, Oh, Soohyun, Oh, Taegwon, Han, Sung-Jun, No, Zaesung, Lee, Jinhwa, Brodin, Priscille, Cho, Sang-Nae, Nam, Kiyean, Bifani, Juan Pablo and Kim, Jaeseung (2013) Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nature Medicine, 19 (9). pp. 1157-1160. ISSN 1078-8956

Petrone, Paula, Wassermann, Anne, Lounkine, Eugen, Kutchukian, Peter, Simms, Ben, Jenkins, Jeremy, Selzer, Paul and Glick, Meir (2013) Biodiversity of small molecules – a new perspective in screening set selection. Drug Discov Today, 18 (13-14). pp. 674-680. ISSN 13596446

Phong, Wai Yee, Lin, WenWei, Rao, Srinivasa P.S., Dick, Thomas, Sylvie, Alonso and Pethe, Kevin (2013) Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia. PLOS One. ISSN 1932-6203

Pillai, Goonaseelan, Mirza, Fareed, Tadmor, Brigitta, Steimer, Jean-Louis, Davies, Geriant, Denti, Paolo, McIlleron, Helen and Holford, Nicholas H G (2013) Pharmacometrics – Opportunity for Reducing Disease Burden in the Developing World. Clinical Pharmacology and Therapeutics:Pharmacometrics & Systems Pharmacology, 2 (e69).

Pistorius, Dominik and Müller, Rolf (2013) Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining. ChemBioChem, 13 (3). pp. 416-426.

Poll, Chris, Verkuijl, Martin and Abbott Banner, Katharine (2013) Targeting TRP channels in airway disorders. Current Topics in Medicinal Chemistry, 13 (3). pp. 310-321. ISSN 1568-0266

Pyonteck, Stephanie M., Schuhmacher, Alberto J., Bowman, Robert L., Akkari, Leila, Sevenich, Lisa, Olson, Oakley C., Teijeiro, Virginia, Setty, Manu, Leslie, Christina, Huse, Jason T., Oei, Yoko, Holland, Eric C., Daniel, Dylan and Joyce, Johanna (2013) Hyperacetylation of α-tubulin correlates with starvation induced autophagy in tobacco BY-2 cells. Molecular Biology of the Cell, 24 (24). ISSN 1059-1524

R

Radimerski, Thomas, Bentires-Alj, Mohamed and Britschgi, Adrian (2013) Targeting PI3K, IL-8/JAK2 axis and HER2 in metastatic breast cancer: which combination makes the whole greater than the sum of its parts. Drug Resist Update, 16 (3-5). pp. 68-72.

Rath, CM, Yang, JY, Alexandrov, T and Dorrestein, PC (2013) Data-independent microbial metabolomics with ambient ionization mass spectrometry. Journal of the American Society for Mass Spectrometry. pp. 1167-1176.

Reilmann, Ralf, Saft, Carsten, Süssmuth, Sigurd, Priller, Joseph, Rosser, Anne, Rickards, Hugh, Schöls, Ludger, Pezous, Nicole, Landwehrmeyer,, Bernhard, Gomez-Mancilla, Baltazar, Rouzade-Dominguez, Marie-Laure, Gasparini, Fabrizio and Johns, Donald (2013) Efficacy, Safety and Tolerability of AFQ056 for the treatment of chorea in patients with Huntington’s disease. Movement DIsorders.

Reisen, Felix, Zhang, Xian, Gabriel, Daniela and Selzer, Paul (2013) Benchmarking of Multivariate Similarity Measures for High Content Screening Fingerprints in Phenotypic Drug Discovery. Journal of Biomolecular Screening, 18 (10). pp. 1284-1297. ISSN 1087-05711552-454X

Reisen, Felix, Zhang, Xian, Gabriel, Daniela and Selzer, Paul (2013) Benchmarking of Multivariate Similarity Measures for High Content Screening Fingerprints in Phenotypic Drug Discovery. Journal of Biomolecular Screening, 18 (10). pp. 1284-1297. ISSN 1087-05711552-454X

Renner, Steffen (2013) Past, Present, and Future of Chemogenomics. Molecular Informatics, 32 (11-12). pp. 877-879. ISSN 1868-1751

Rice, DS (2013) Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of Pain and Itch. Neuron, 78 (2). pp. 312-324. ISSN 0896-6273

Richie, Daryl, Thompson, Katherine, Studer, Christian, Aust, Thomas, Riedl, Ralph, Estoppey, David, Zabawa, Thomas, Drumm Iii, Joseph, Cotesta, Simona, Eichenberger, Juerg, Schuierer, Sven, Hartmann, Nicole, Movva, Rao, Tallarico, John, Ryder, Neil and Hoepfner, Dominic (2013) Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents. Antimicrobial Agents and Chemotherapy, 57 (5). pp. 2272-2280. ISSN 0066-4804

Riddick, DS, Ding, X, Wolf, CR, Porter, TD, Pandey, AV, Zhang, Q, Gu, J, Finn, RD, Ronseaux, S, McLaughlin, LA, Henderson, CJ, Zou, L and Fluck, CE (2013) NADPH-cytochrome P450 oxidoreductase: Roles in physiology, pharmacology, and toxicology. Drug Metabolism and Disposition. pp. 12-23.

Rinaldi, F, Clematide, S, Hafner, S, Schneider, G, Grigonyte, G, Romacker, M and Vachon, T (2013) Using the OntoGene pipeline for the triage task of BioCreative 2012. Database-the Journal of Biological Databases and Curation.

Riniker, Sereina, Fechner, Nikolas and Landrum, Gregory (2013) Heterogeneous Classifier Fusion for Ligand-Based Virtual Screening: Or, How Decision Making by Committee Can Be a Good Thing. Journal of Chemical Information and Modeling, 53. pp. 2829-2836.

Riniker, Sereina and Landrum, Gregory (2013) Open Source Platform to Benchmark Fingerprints for Ligand-Based Virtual Screening. Journal of Cheminformatics, 5 (1). pp. 26-43. ISSN 1758-2946

Riniker, Sereina and Landrum, Gregory (2013) Similarity maps - a visualization strategy for molecular fingerprints and machine-learning methods. Journal of Cheminformatics, 5. p. 43.

Ritter Iii, Robert, Senchyna, Michelle, Srinivasan, Sruthi, Heynen, Miriam L., Martell, Elizabeth and Jones1, Lyndon (2013) Expression of MUC1 and MUC16 in tears and conjunctival epithelial cells collected from postmenopausal women. Molecular Vision, 19. pp. 970-979.

Rombach-Riegraf, Verena, Karle, Anette, Wolf, Babette, Sorde, Laetitia, Koepke, Stephan, Gottlieb, Sascha, Djidja, Marie-Claude, Baban, Aida, Spindeldreher, Sebastian, Koulov, Atanas and Kiessling, Andrea (2013) Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-cell Responses In Vitro. PLoS One.

Romero, V, Fert-Bober, J, Nigrovic, PA, Darrah, E, Haque, UJ, Lee, DM, Van, EJ, Rosen, A and Andrade, F (2013) Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Science Translational Medicine.

Rot, A, McKimmie, C, Burt, CL, Pallas, KJ, Jamieson, T, Pruenster, M, Horuk, R, Nibbs, RJB and Graham, GJ (2013) Cell-Autonomous Regulation of Neutrophil Migration by the D6 Chemokine Decoy Receptor. JOURNAL OF IMMUNOLOGY. pp. 6450-6456.

Rothenbacher, D, Hoffmann, MM, Breitling, LP, Rajman, I, Koenig, W and Brenner, H (2013) Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care - art. no. 61. BMC CARDIOVASCULAR DISORDERS. 61-.

Roubenoff, Ronenn (2013) The “Cytokine for Gerontologists” Has Some Company. Journal of Gerontology: Biological Sciences.

Rowe, Steven, Reeves, Ginger, Halthorne, Heather, Solomon, G Martin, Abbi, Smita, Renard, Didier, Lock, Ruth, Zhou, Ping, Danahay, Henry, Clancy, JP and Waltz, David (2013) Reduced Sodium Transport with Nasal Administration of the Prostasin Inhibitor Camostat in Cystic Fibrosis Subjects. Chest, 144 (1). pp. 200-207. ISSN None

Ruby, JG, Bellare, P and DeRisi, JL (2013) PRICE: Software for the targeted assembly of components of (Meta) genomic sequence data. G3: Genes, Genomes, Genetics. pp. 865-880.

Rueeger, Heinrich, Lueoend, Rainer Martin, Machauer, Rainer, Veenstra, Siem, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Moebitz, Henrik and Neumann, Ulf (2013) Discovery of Cyclic Sulfoxide Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure Based Design and in Vivo Reduction of Amyloid β-Peptides. Bioorganic & Medicinal Chemistry Letters, 23. pp. 5300-5306.

Ruffner, Heinz (2013) Master thesis: Study of the Yap-Hippo and Wnt Pathways for Intestinal Regeneration in an Ex Vivo Small Intestinal 3D Organoid Model. Hochschule Mannheim. Master thesis, not published, presented to supervisor at Hochschule Mannheim under CDA..

S

Sadlish, Heather, Galicia-Vazquez, Gabriela, Paris, Greg, Aust, Thomas, Bhullar, Bhupinder, Chang, Lena, Helliwell, Stephen, Hoepfner, Dominic, Knapp, Britta, Paris, Charles, Riedl, Ralph, Roggo, Silvio, Schuierer, Sven, Studer, Christian, Pelletier, Jerry and Movva, Rao (2013) Evidence for a functionally relevant rocaglamide binding site on the eIF4A:RNA complex. ACS Chemical Biology. ISSN 1554-8929

San Sebastian, Eider, Zimmerman, Tahl, Zubia, Aizpea, Vara, Yosu, Martin, Elyette, Sirockin, Finton, Dejaegere, Annick, Stote, Roland H, Lopez, Xabier, Pantoja-Uceda, David, Varcarcel, Maria, Medoza, Lorea, Vidal-Vanaclocha, Fernando, Cossío, Fernando P. and Blanco, Francisco J. (2013) Design, Synthesis and Functional Evaluation of Leuko-cyte-Function Associated Antigen-1 (LFA-1) Antagonists in Early and Late Stages of Cancer Development. Journal of Medicinal Chemistry, 56 (3). pp. 735-747. ISSN 0022-2623

Sandham, David, Arnold, Nicola, Aschauer, Heinrich, Bala, Kamlesh, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Cox, Brian, Dubois, Gerald, Docx, Cerys, Duggan, Nicholas, England, Karen, Everatt, Brian, Furegati, Markus, Hall, Edward, Kalthoff, Frank, King, Anna, Leblanc, Catherine, Manini, Jodie, Meingassner, Josef, Profit, Rachael, Stringer, Rowan, Schmidt, Alfred, Simmons, Jennifer, Sohal, Bindi, Thomas, Matthew, Turner, Katharine, Walker, Christoph, Watson, Simon, Westwick, John, Willis, Jennifer, Williams, Gareth and Wilson, Caroline (2013) Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorganic and Medicinal Chemistry.

Schluepen, Christina, Malito, Enrico, Marongiu, Ambra, Schirle, Markus, Mc Whinnie, Elizabeth, Lo Surdo, Paola, Biancucci, Marco, Falugi, Fabiana, Nardi Dei Da Filicaia Dotti, Vincenzo, Marchi, Sara, Fontana, Maria Rita, Lombardi, Benedetta, De Falco, Maria Grazia, Rinaudo, Daniela, Spraggon, Glen, Grandi, Guido, Nissum, Mikkel, Bagnoli, Fabio, Bottomley, Matthew James and Liberatori, Sabrina (2013) A novel family of highly conserved antigens that induce protective immunity against Staphylococcus aureus. Biochemical journal, 455 (3). pp. 273-284. ISSN 1470-8728; 0264-6021

Schoumacher, M, Glentis, A, Gurchenkov, VV and Vignjevic, DM (2013) Basement membrane invasion assays: Native basement membrane and chemoinvasion assay. Adhesion Protein Protocols. pp. 133-144.

Schutzius, G, Bleckmann, D, Kapps-Fouthier, S, di Giorgio, F, Gerhartz, B and Weiss, A (2013) A quantitative homogeneous assay for fragile X mental retardation 1 protein - art. no. 8. JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 5 (1). p. 8. ISSN 1866-1947

Schutzius, Gabi, Bleckmann, Dorothee, Kapps-Fouthier, Sandra, Di Giorgio, Francesco, Gerhartz, Bernd and Weiss, Andreas (2013) A high-throughput compatible quantitative homogenous assay for Fragile X Mental Retardation 1 Protein. Journal for Neurodevelopmental Disorders, 5 (1). p. 8. ISSN 1866-1947

Schwarz, Adam J, Hill, Derek G, Frisoni, Giovanni, Jack, Clifford, Maguire, Paul and Stephenson, Diane (2013) CAMD/EMA Biomarker Qualification of Hippocampal Volume for Patient Enrichment. Alzheimer’s and dementia.

Schweizer, D, Vostiar, I, Heier, A, Serno, T, Schoenhammer, K, Jahn, M, Jones, S, Piequet, A, Beerli, C, Gram, H and Goepferich, A (2013) Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation. JOURNAL OF CONTROLLED RELEASE. pp. 975-982.

Scuto, A, Kirschbaum, M, Buettner, R, Kujawski, M, Cermak, JM, Atadja, P and Jove, R (2013) SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-kappa B/STAT3 complex to its promoter in malignant lymphoid cells - art. no. e635. CELL DEATH & DISEASE.

Sen, A, Dimlich, DN, Guruharsha, KG, Kankel, MW, Hori, K, Yokokura, T, Brachat, S, Richardson, D, Loureiro, J, Sivasankaran, R, Curtis, D, Davidow, LS, Rubin, LL, Hart, AC, Van Vactor, D and Artavanis-Tsakonas, S (2013) Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. E2371-E2380.

Sharma, S., deVries, E.G., Infante, J.R., Oldenhuis, C.N., Gietema, J.A., Yang, Lin, Bilic, Sanela, Parker, Kathryn, Goldbrunner, Michael, Scott, Jeffrey and Burris, H.A. (2013) Safety, Pharmacokinetics, and Pharmacodynamics of the DR5 Antibody LBY135 Alone and in Combination with Capecitabine in Patients with Advanced Solid Tumors. Investigational New Drugs. ISSN 0167-6997

Shcheglovitov, A, Shcheglovitova, O, Yazawa, M, Portmann, T, Shu, R, Sebastiano, V, Krawisz, A, Froehlich, W, Bernstein, JA, Hallmayer, JF and Dolmetsch, RE (2013) SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. NATURE. pp. 267-271.

Shi, Pei-Yong and Zhang, Bo (2013) Report of the fifth symposium on emerging viral diseases. Virologica Sinica, 28 (2). pp. 63-64. ISSN 1674-0769

Shidong, JIa, Massimo, Loda and Thomas, Roberts (2013) Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discovery, 3 (1). pp. 44-51. ISSN 2159-8274

Shieh, Mae Mae Yi Fong, Thompson, Corinne, My, Phan Vu Tra, Van, Thi Thuy Linh, Tediosi, Fabrizio, Merson, Laura, Farrar, Jeremy, Ha, Manh Tuan, Ho, Lu Viet, Pham, Thi Ngoc Tuyet and Baker, Stephen (2013) Policy of free healthcare for children under six in Vietnam: assessment of its non-usage during hospitalization for diarrhea in Ho Chi Minh City. Tropical Medicine & International Health.

Shimada, Kenji, Filipuzzi, Ireos, Helliwell, Stephen, Studer, Christian, Hoepfner, Dominic, Movva, Rao, Gasser, Susan, Stahl, Michael and Loewith, Robbie (2013) TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Molecular Cell, 51 (6). pp. 829-839. ISSN 1097-2765

Shinde, DD, Kim, H, Choi, J, Pan, W, Bae, SK, Yeo, C, Shon, J, Kim, D and Shin, JG (2013) Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects. Journal of Clinical Pharmacology. pp. 550-558.

Shou, Jianyong (2013) Inhibition of H3K9 Methyltransferase G9a/GLP Prevents Ototoxic and Ongoing Hair Cell Death. Cell Death and Diseases, 4 (e506). ISSN 2041-4889

Shultz, Michael (2013) Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters. Bioorganic and Medicinal Chemistry Letters, 23 (21). pp. 5980-5991. ISSN 0960-894X

Shultz, Michael (2013) The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations. Bioorganic and Medicinal Chemistry Letters, 23 (21). pp. 5992-6000. ISSN 0960-894X

Shultz, Michael, Kirby, Christina, Firestone, Brant, Fan, Jianmei, Chen, Christine, Chen, Zhuoliang, Cheung, Atwood, Chin, Donovan, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal, Gould, Ty, Huangshu, Lei, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, Mark, Pham, Ly, Pu, Minying, Smith, Troy, Tomlinson, Ronald, Toure, Bakary-Barry, Visser, Michael, Wang, Run-Ming, Waters, Nigel and Shao, Wenlin (2013) Identification of NVP-TNKS656: The use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. Journal of Medicinal Chemistry, 56 (16). pp. 6495-6511. ISSN 0022-2623

Sitnick, MT, Basantani, MK, Cai, L, Schoiswohl, G, Yazbeck, CF, Distefano, G, Ritov, V, DeLany, JP, Schreiber, R, Stolz, DB, Gardner, NP, Kienesberger, PC, Pulinilkunnil, T, Zechner, R, Goodpaster, BH, Coen, P and Kershaw, EE (2013) Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. DIABETES. pp. 3350-3361.

Skora, Lukasz, Jahnke, Wolfgang, Mestan, Jürgen, Grzesiek, Stephan and Fabbro, Doriano (2013) NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors. PNAS, 110 (47). pp. 4437-4445. ISSN 0027-84241091-6490

Skvara, Hans, Burnett, Patrick, Jones, Julie, Plassmann, Peter and Thirion, Jean-Philippe (2013) Quantification of skin lesions with a 3D stereovision camera system: Validation and clinical applications. Skin Research and Technology, 19 (1). e182-190. ISSN 0909-752X

Slomianka, L, Drenth, T, Cavegn, N, Menges, D, Lazic, SE, Phalanndwa, M, Chimimba, CT and Amrein, I (2013) The hippocampus of the eastern rock sengi: Cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis. Frontiers in Neuroanatomy.

Smith, Nichola, Benito-Alifonso, David, Jones, Rachel A, Tran, Anh-Tuan, Woodward, Hannah and Galan, M Carmen (2013) Synthesis of mucin-type O-glycan probes ready to be immobilized to glycoarray platforms. Beilstein Journal of Organic Chemistry.

Song, Y, Lunde, CS, Benton, BM and Wilkinson, BJ (2013) Studies on the mechanism of telavancin decreased susceptibility in a laboratory-derived mutant. Microbial Drug Resistance. pp. 247-255.

Springer, Clayton and Sokolnicki, Katherine (2013) “A molecular matched pair analysis of hERG inhibition data”. Chemistry Central Journal, 7 (167). p. 167. ISSN 1752-153X

Spytek, Kimberly and Gualtieri, Giovanna (2013) Test project for OAK training videos. Marine Biology.

Sridar, C, Hanna, I and Hollenberg, PF (2013) Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches. XENOBIOTICA. pp. 336-345.

Staedtler, Frank, Hartmann, Nicole, Letzkus, Martin, Bongiovanni, Sandrine, Johnson, Keith and Schumacher, Martin (2013) Robust and tissue-independent gender-specific transcript biomarkers. Biomarkers, 18 (5). pp. 436-445.

Stalder, Lukas, Heusermann, Wolf, Hean, Justin, Pfanzagl, Vera, Aeschimann, Florian, Weiler, Jan, Gerace, Larry, Morrissey, David and Meisner Kober, Nicole-Claudia (2013) The rough endoplasmatic reticulum is the central site of siRNA-mediated RNA silencing. EMBO Journal, 32 (8). pp. 1115-1125. ISSN 0261-4189

Stegmeier, Frank, Jaffe, Jacob, Chan, Ho Man, Wang, Yan, Mcdonald Iii, Earl, Liu, Jun, Keen, Nicholas, Sellers, William, Livi, Garraway, Grigoriy, Kryukov, Hu, Min, Zhang, Jingui and Downing, James (2013) Global chromatin profiling reveals NSD2 mutation in pediastric acute lymphoblastic leukemia. Nature Genetics.

Stein, A, Bellmunt, J, Escudier, B, Kim, D, Stergiopoulos, SG, Mietlowski, W and Motzer, RJ (2013) Survival Prediction in Everolimus-treated Patients with Metastatic Renal Cell Carcinoma Incorporating Tumor Burden Response in the RECORD-1 Trial. EUROPEAN UROLOGY. pp. 994-1002.

Stein, AM, Martinelli, G, Hughes, TP, Mueller, MC, Beppu, L, Gottardi, E, Branford, S, Soverini, S, Woodman, RC, Hochhaus, A, Kim, DW, Saglio, G and Radich, JP (2013) Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia - art. no. 173. BMC CANCER. 173-.

Stein, Daniel, Ke, June, Uy, Grace, Bosheva, Miroslava, Yin, Qi and Praestgaard, Jens (2013) A Phase I, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics and Safety of Telbivudine in Children and Adolescents with Chronic Hepatitis B. Antimicrobial agents and chemotherapy, 57 (9). pp. 4128-4133. ISSN 1098-6596

Stevenson, CS, Sridhar, S and Phillips, JE (2013) Predicting drug efficacy using integrative models for chronic respiratory diseases. Inflammation and Allergy - Drug Targets. pp. 124-131.

Stevenson, CS and Yew-Booth, L (2013) Is intrinsic aerobic exercise capacity a determinant of COPD susceptibility? Pulmonary Pharmacology & Therapeutics. pp. 459-463.

Stoeckli, Markus, Staab, Dieter and Morandi, Gregory (2013) Mass Spectrometric Imaging Applied to Biomedical Research. Chimia, 57 (4).

Strober, B, Buonanno, M, Clark, JD, Kawabata, T, Tan, H, Wolk, R, Valdez, H, Langley, RG, Harness, J, Menter, A and Papp, K (2013) Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment. BRITISH JOURNAL OF DERMATOLOGY. pp. 992-999.

Subramony, JA (2013) Needle free parenteral drug delivery: Leveraging active transdermal technologies for pediatric use. INTERNATIONAL JOURNAL OF PHARMACEUTICS. pp. 14-18.

Sung, RK, Kim, AM, Tseng, ZH, Han, F, Inada, K, Tedrow, UB, Viswanathan, MN, Badhwar, N, Varosy, PD, Tanel, R, Olgin, JE, Stephenson, WG and Scheinman, M (2013) Diagnosis and Ablation of Multiform Fascicular Tachycardia. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. pp. 297-304.

Sunkara, Gangadhar, Bende, Girish, Mendonza, Anisha, Solar-Yohay, Susan, Biswal, Shibadas, Neelakantham, Srikanth, Wagner, Robert, Flarakos, Jimmy, Zhang, Yiming and Jarugula, Venkateswar (2013) BIOAVAILABILITY OF VALSARTAN LIQUID ORAL DOSAGE FORMS. Clinical Pharmacology in drug development, 3 (2). pp. 132-138. ISSN 2160763X

Suriyachadkun, C, Ngaemthao, W, Chunhametha, S, Tamura, T and Sanglier, JJ (2013) Kutzneria buriramensis sp nov., isolated from soil, and emended description of the genus Kutzneria. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. pp. 47-52.

Suriyachadkun, C, Ngaemthao, W, Chunhametha, S, Thawai, C and Sanglier, J (2013) Actinoplanes siamensis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology. pp. 3037-3042.

Szustakowski, Joseph, Yang, Fan, Linghu, Bolan, Damask, Amy, Klickstein, Lloyd, Duca, Jose, Chibout, Salah-Dine, Johnson, Keith, Boyer, Olivia, Woerner, Stephanie, Tête, Marie-Josèphe, Heibel, Françoise, Matignon, Marie, Beaudoin, Véronique, Chantrel, Francois, Champigneulle, Jacqueline, Nitschké, Patrick, Gubler, Marie-Claire, Antignac, Corinne, Oakeley, Edward James and Gribouval, Olvier (2013) LMX1B mutations as an unexpected cause of hereditary focal segmental glomerulosclerosis without extra-renal involvement. Journal of the American Society of Nephrology (JASN), 24 (8). pp. 1216-1222.

T

Takahashi, Tsuyoshi, Serada, Satoshi, Urase, Maiko, Fujimoto, Minoru, Miyazaki, Yasuaki, Ikezoe, Takayuki, Taguchi, Takahiro, Kurokawa, Yukinori, Yamasaki, Makoto, Miyata, Hiroshi, Takiguchi, Shuji, Mori, Masaki, Doki, Yuichirou, Naka, Tetsuji and Nishida, Toshirou (2013) New findings of kinase switch in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis. International Journal of Cancer.

Thomas, Matthew, Ciuclan, Loredana, Hussey, Martin and Press, Neil (2013) Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension. Pharmacology and Therapeutics, 138 (3). pp. 409-417. ISSN 0163-7258

Thomson, John P, Hunter, Jennifer M, Nestor, Colm E, Dunican, Donncha S, Terranova, Remi, Moggs, Jonathan and Meehan, Richard R (2013) Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques. Nucleic Acids Research, 41 (22). ISSN 0305-1048

Thudium, K, Bilic, S, Leipold, D, Mallet, W, Kaur, S, Meibohm, B, Erickson, H, Tibbitts, J, Zhao, H and Gupta, M (2013) American Association of Pharmaceutical Scientists National Biotechnology Conference short course: Translational challenges in developing antibody-drug conjugates. mAbs. pp. 5-12.

Tian, Li, Mukherjee, Prasenjit and Martin, Eric (2013) Kinase-Kernel Models: Accurate Chemogenomic Method for the Entire Human Kinome. Molecular Informatics.

Timmerman, LA, Holton, T, Yuneva, M, Louie, RJ, Padro, M, Daemen, A, Hu, M, Chan, DA, Ethier, SP, van 't Veer, LJ, Polyak, K, McCormick, F and Gray, JW (2013) Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target. CANCER CELL. pp. 450-465.

Tovar, Kenneth R, McGinley, Matthew J and Westbrookl, Gary L (2013) Triheteromeric NMDA Receptors at Hippocampal Synapses. Journal of Neuroscience.

Trompette, Aurelien, Gollwitzer, Eva, Yadava, Koshika, Sichelstiel, Anke K., Sprenger, Norbert, Ngom-Bru, Catherine, Blanchart, Carine G., Junt, Tobias, Nicod, Laurent P., Harris, Nicola L. and Marsland, Benjamin J. (2013) Dietary fiber influences the severity of allergic airway inflammation through GPR41 mediated host-microbial-metabolite cross-talk. Nature Medicine.

Troxler, Thomas J., Greenidge, Paulette, Zimmermann, Kaspar, Desrayaud, Sandrine, Drueckes, Peter, Schweizer, Tatjana, Stauffer, Daniela, Rovelli, Giorgio and Shimshek, Derya (2013) Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2. Bioorganic & Medicinal Chemistry Letters, 23 (14). pp. 4085-4090. ISSN 0960894X

True, Sarah (2013) Industrial Trainee dissertation report. To remain in-house and be reviewed by University lectures under CDA.

Tsao, J and Jiang, Y (2013) Hierarchical IDEAL: Fast, robust, and multiresolution separation of multiple chemical species from multiple echo times. MAGNETIC RESONANCE IN MEDICINE. pp. 155-159.

Tukulula, M, Njoroge, M, Abay, ET, Mugumbate, GC, Wiesner, L, Taylor, D, Gibhard, L, Norman, J, Swart, KJ, Gut, J, Rosenthal, PJ, Barteau, S, Streckfuss, J, Kameni-Tcheudji, J and Chibale, K (2013) Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds. ACS MEDICINAL CHEMISTRY LETTERS. pp. 1198-1202.

Tyagarajan, SK, Ghosh, H, Yevenes, GE, Imanishi, SY, Zeilhofer, HU, Gerrits, B and Fritschy, J (2013) Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. Journal of Biological Chemistry. pp. 9634-9647.

U

Uehara, T (2013) Cell wall shaping during bacterial morphogenesis. Japanese. The Journal of Japanese Biochemical Societ. pp. 349-353.

Uehara, Tsuyoshi (2013) Peptidoglycan Remodeling during Bacterial Development. Seikagaku.

Ula, N, Mulder, G.M, Vavrinec, P, Landheer, S.W., Gurdal, H, Goris, Maaike, van Dokkum, R.P.E., Buikema, H, van Goor, H and Henning, R.H. (2013) Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats. J Pharmacol Exp Ther, 345 (3). pp. 393-403. ISSN 1521-0103

V

Vacchi-Suzzi, Caterina, Hahne, Florian, Scheubel, Philippe, Marcellin, Magali, Dubost, Valerie, Kalteis, Magdalena, Boeglen, Catherine, Buechmann-Moller, Stine, Cheung, Nicole, Cordier, Andre, De Benedetto, Christopher, Deurinck, Mark, Frei, Moritz, Moulin, Pierre, Oakeley, Edward James, Grenet, Olivier, Grevot, Armelle, Stull, Robert, Theil, Diethilde, Moggs, Jonathan, Marrer, Estelle and Couttet, Philippe (2013) Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions. PLoS ONE, 8 (1). e52442. ISSN 1932-6203

Valtcheva, N, Primorac, A, Jurisic, G, Hollmen, M and Detmar, M (2013) The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. Journal of Biological Chemistry. pp. 35736-37548.

Van Der Putten, P. Herman and Lotz, Gregor (2013) Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseases. Neurotherapeutics, 10 (3). pp. 416-428.

Van Diepen, Michiel and Groot-Kormelink, Paulus (2013) Optimization of YFP fluorescence quench assay to functionally test TMEM16A random mutagenesis library in order to uncover novel or improved structure-function relationships. N/A.

Vellas, B, Pahor, M, Manini, T, Rooks, D, Guralnik, JM, Morley, J, Studenski, S, Evans, W, Asbrand, C, Fariello, R, Pereira, S, Rolland, Y, Van Kan, GA, Cesari, M, Chumlea, W and Fielding, R (2013) Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US task force recommendations. JOURNAL OF NUTRITION HEALTH & AGING. pp. 612-618.

Verpelli, Chiara, Galimberti, Ivan, Gomez-Mancilla, Baltazar and Sala, Carlo (2013) Molecular basis for prospective pharmacological treatment strategies in intellectual disability syndromes. Molecular basis for prospective pharmacological treatment strategies in intellectual syndromes. ISSN 1932-8451

Visser, Michael, Toure, Bakary-Barry, Porter, Dale, Herlihy, Kara, Perez, Lawrence, Springer, Clayton and Xie, Xiaoling (2013) The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein-Protein Interactions. ACS Medicinal Chemistry Letters, 4 (2). pp. 186-190.

Vitale, A, Thorne, N, Lovell, S, Battaile, KP, Hu, X, Shen, M, D'Auria, S and Auld, DS (2013) Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum. PLoS One.

Vorherr, Thomas and Kitas, Eric (2013) Discovery and Development of therapeutic Peptides. Drug Discovery International.

Vulpetti, Anna and Dalvit, Claudio (2013) Best practice and advices for designing and generating fluorinated libraries and for their efficient 19F-NMR Screening. ChemMedChem, 8. pp. 2057-2069.

W

Walker, John R, Pacoma, Reynand, Watson, James, Ou, Weijia, Alves, Juliano, Mason, Daniel E, Peters, Eric C, Urbina, Hugo D, Welzel, Gus, Althage, Alana, Liu, Bo, Tuntland, Tove, Jacobson, Laura H, Harris, Jennifer L and Schumacher, Andrew M (2013) Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 (6). pp. 2457-2464. ISSN 1529-2401

Wallecha, A, Singh, R and Malinina, I (2013) Listeria monocytogenes (Lm)-LLO Immunotherapies Reduce the Immunosuppressive Activity of Myeloid-derived Suppressor Cells and Regulatory T Cells in the Tumor Microenvironment. JOURNAL OF IMMUNOTHERAPY. pp. 468-476.

Walles, Markus, Wolf, Thierry, Jin, Yi, Ritzau, Michael, Gschwind, Hans-Peter, Krauser, Joel, Woessner, Ralph, Ufer, Mike and Swart, Pieter Jacob (2013) Absorption and Disposition of mavoglurant (AFQ056), a metabotropic glutamate receptor 5 antagonist (mGluR5), in healthy volunteers. Drug Metabolism and Disposition, 41 (9). pp. 1626-1643.

Wang, H, Gill, CJ, Lee, SH, Mann, P, Zuck, P, Meredith, TC, Murgolo, N, She, X, Kales, S, Liang, L, Liu, J, Wu, J, Maria, JS, Su, J, Pan, J, Hailey, J, Mcguinness, D, Tan, CM, Flattery, A, Walker, S, Black, T and Roemer, T (2013) Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA beta-Lactam Combination Agents. CHEMISTRY & BIOLOGY. pp. 272-284.

Wang, Q, Thanh, V, Bronson, R, Ruan, M, Mu, W, Huang, A, Maira, SM and Zhao, JJ (2013) Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome. GENES & DEVELOPMENT. pp. 1568-1580.

Wang, X, Magnuson, S, Pastor, R, Fan, E, Hu, H, Tsui, V, Deng, W, Murray, J, Steffek, M, Wallweber, H, Moffat, J, Drummond, J, Chan, G, Harstad, E and Ebens, AJ (2013) Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. pp. 3149-3153.

Wang, X, Zhang, J, Eberhart, D, Urban, R, Meda, K, Solorzano, C, Yamanaka, H, Rice, D and Basbaum, A (2013) Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of Pain and Itch. Neuron. pp. 312-324.

Wang, Y, Zhang, Y, Lin, JJ, Hallock, SJ, Yu, H, Shao, H, Yan, J, Huang, B, Zhang, XC, Cao, W, Xu, X and Lin, X (2013) Purification and characterization of mutant miniPlasmin for thrombolytic therapy. Thrombosis Journal.

Wassermann, Anne, Kutchukian, Peter, Lounkine, Eugen, Luethi, Tiffany, Bocker, Michael, Malik, Hasnain, Hamon, Jacques, Jacob, Sandra and Glick, Meir (2013) Efficient Search of Chemical Space: Navigating from Fragments to Structurally Diverse Chemotypes. Journal of Medicinal Chemistry, 56 (21). pp. 8879-8891. ISSN 0022-26231520-4804

Wassermann, Anne, Lounkine, Eugen and Glick, Meir (2013) Bioturbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules. Journal of Chemical Information and Modeling, 53 (3). pp. 692-703. ISSN 1549-95961549-960X

Wassermann, Anne, Lounkine, Eugen and Glick, Meir (2013) Bioturbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules. Journal of Chemical Information and Modeling, 53 (3). pp. 692-703. ISSN 1549-9596

Wassermann, Anne, Lounkine, Eugen and Glick, Meir (2013) Supplementary Information for Manuscript "Bio turbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules". J Chem Inf Model, 53 (3). pp. 692-703. ISSN 1549-95961549-960X

Wassermann, Anne, Lounkine, Eugen and Glick, Meir (2013) Supplementary Information for Manuscript "Bioturbo Similarity Searching: Combining Chemical and Biological Similarity to Discover Structurally Diverse Bioactive Molecules". Journal of Chemical Information and Modeling, 53 (3). pp. 692-703. ISSN 1549-95961549-960X

Wassermann, Anne, Lounkine, Eugen, Whitebread, Steven, Chen, Shanni, Hughes, Kevin, Guo, Hongqiu, Kutlina, Elena, Fekete, Alexander, Urban, Laszlo, Klumpp, Martin and Glick, Meir (2013) Leaving the Lamp Post - A Fresh Perspective on the Targets of Natural Products and Marketed Drugs. Nature Chemical Biology.

Weisberg, Ellen, Liu, Qingsong, Zhang, Xin, Nelson, Eric, Sattler, Martin, Liu, Feiyang, Nicolais, Maria, Zhang, Jianming, Mitsiades, Constantine, Smith, Robert, Stone, Richard, Galinsky, Ilene, Nonami, Atsushi, Griffin, D. James, Gray, Nathanael and Carmeli, Yael (2013) Akt and p38 MAPK synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells. PLoS One. , 8 (2). e56473. .

Weiss, Markus and Gatlik, Ewa (2013) Equilibrium gel filtration to measure plasma protein binding of very highly bound drugs. Journal of Pharmaceutical Sciences.

Welt, Anja, Tewes, Mitra, Aktas, Bahriye, Wiesweg, Marcel, Ting, Saskia, Reis, Henning, Worm, Karl, Richly, Heike, Hense, Jörg, Peters, Malte, Schlegel, Robert, Lee, Benjamin, Palmer, Michael, Monahan, John, Scheulen, Max, Lehnerdt, Cathrin, Kohl, Marzena, Derks, Cordula, Skottky, Silke, Haus-Weiner, Ulrike, Schmid, Kurt, Kimmig, Rainer, Schuler, Martin and Kasper, Stefan (2013) Preemptive tumor profiling for biomarker-stratified early clinical drug development in metastatic breast cancer patients. Breast Cancer Research and Treatment, 142 (1). pp. 81-88. ISSN 0167-6806

White, Nicholas J, Pukrittayakamee, Sasithon, Phyo, Aung P, Rueangweerayut, Ronnatrai, Nosten, François, Jittmala, Podjanee, Jeeyapant , Atthanee, Jain, Jay Prakash, Lefevre, Gilbert, Li, Ruobing, Magnusson, Baldur, Diagana, Thierry Tidiane and Leong, Franz Joel Wen (2013) The novel spiroindolone KAE609 clears parasitemia rapidly in falciparum and vivax malaria. The Novel Spiroindolone KAE609 Clears Parasitemia Rapidly.

White, Nicholas J, Pukrittayakamee, Sasithon, Phyo, Aung P, Rueangweerayut, Ronnatrai, Nosten, François, Jittmala, Podjanee, Jeeyapant , Atthanee, Jain, Jay Prakash, Lefevre, Gilbert, Li, Ruobing, Magnusson, Baldur, Diagana, Thierry Tidiane and Leong, Franz Joel Wen (2013) The novel spiroindolone KAE609 clears parasitemia rapidly in falciparum and vivax malaria. The novel spiroindolone KAE609 clears parasitemia rapidly.

Williamson, Alice E., Ylioja, Paul M., Robertson, Murray N., Antonova, Jenya , Avery, Vicky, Baell, Jonathan, Batchu, Harikrishna, Batra, Sanjay, Burrows, Jeremy N., Bhattacharyya, Soumya, Calderon, Felix, Charman, Sue, Clark, Julie, Crespo, Benigno, Dean, Matin, Debbert, Stefan, Dennis, Adelaide S. M., Deroose, Frederik, Duffy, Sandra, Fletcher, Sabine, Giaever, Guri, Hallyburton, Irene, Gamo, Francisco-Javier, Gebbia, Marinella, Guy, R. Kiplin, Hungerford, Zoe, Kirk, Kiaran, Lafuente-Monasterio, Maria J., Lee, Anna, Meister, Stephan, Nislow, Corey, Overington, John P., Papadatos, George, Patiny, Luc, Pham, James, Ralph, Stuart, Ryan, Eileen, Southan, Chris, Svrivastava, Kumkum, Swai, Chris, Tarnowski, Matthew J., Thomson, Patrick, Turner, Peter, Wallace, Iain, Wells, Timothy N. C., White, Karen, White, Laura, Willis, Paul, Winzeler, Elizabeth A., Wittlin, Sergio and Todd, Matthew H. (2013) Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the GlaxoSmithKline Tres Cantos Arylpyrroles. PLoS Medicine.

Winter, M, Moser, MA, Meunier, D, Fischer, C, Machat, G, Mattes, K, Lichtenberger, BM, Brunmeir, R, Weissmann, S, Murko, C, Humer, C, Meischel, T, Brosch, G, Matthias, P, Sibilia, M and Seiser, C (2013) Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. EMBO Journal. pp. 3176-3191.

Woehrle, Simon, Thuery, Anne, Henninger, Christine, Olivier, Bonny, Beluch, Noemie, Studer, Anne, Ingold, Peter, Stamm, Christelle, Bohler, Bruno, Sterker, Dario, Hynes, Nancy, Guagnano, Vito, Sellers, William, Kneissel, Michaela, Hofmann, Francesco and Graus Porta, Diana (2013) Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. Journal of bone and mineral research., 28 (4). pp. 899-911. ISSN 08840431

Woehrle, Simon, Weiss, Andreas, Ito, Moriko, Kauffmann, Audrey, Murakami, Masato, Jagani, Zainab, Thuery, Anne, Bauer-Probst, Beatrice, Reimann, Flavia, Stamm, Christelle, Pornon, Astrid, Guagnano, Vito, Bruemmendorf, Thomas, Sellers, William, Hofmann, Francesco, Roberts, Charles W. M. and Graus Porta, Diana (2013) Fibroblast growth factor receptors as novel therapeutic targets in malignant rhabdoid tumors. PLoS ONE, 8 (10). e77652-e77652. ISSN 1932-6203

Wong, KA, Worth, A, Martin, R, Svarovskaia, E, Brainard, DM, Lawitz, E, Miller, MD and Mo, H (2013) Characterization of hepatitis C virus resistance from a multiple-dose clinical trial of the novel NS5A inhibitor GS-5885. Antimicrobial Agents and Chemotherapy. pp. 6333-6340.

Wong, Vanessa, Pickard, Derer, Barquist, Lars, Sivaraman, Karthikeyan, Hart, Peter, Arends, Mark, Holt, Kathryn, Kane, Leanne, Mottram, Lynda, Ellison, Louise, Kay, Sally, Wileman, Thomas, Kenny, Linda, Maclennan, Calman Alexander, Kingsley, Robert and Dougan, Gordon (2013) Characterization of the yehUT two-component regulatory system of Salmonella enterica serovar Typhi and Typhimurium. PLoS ONE, 8 (12). ISSN 1932-6203

Wood, DJ, Carlsson, L, Eklund, M, Norinder, U and Stalring, J (2013) QSAR with experimental and predictive distributions: an information theoretic approach for assessing model quality. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. pp. 203-219.

Wu, Xuping, Sooman, Linda, Wickström, Malin, Frynäs, Mårten, Dyrager, Christine, Lennartsson, Johan and Gullbo, Joachim (2013) Significant off-target effects of postulated IGF-1R inhibitor picropodophyllin (PPP) in vitro. Molecular Cancer Therapeutics.

X

Xie, Qian, Su, Yanli, Dykema, Karl, Johnson, Jennifer, Koeman, Julie, Giorgi, Valeria, Essenburg, Curt, Kang, Liang, Iwaya, Keiichi, Seki, Shuhji, Khoo, Sok, Zhang, Boheng, Buonaguro, Franco, Marincola, Francesco, Furge, Kyle, VandeWoude, George and Shinomiya, Nariyoshi (2013) HGF/MET axis drives hepatocellular carcinoma progression and determines sensitivity to MET-targeted therapy. Genes Cancer.

Xie, Xuping, Kang, Congbao, Gayen, Shovanlal, Yuan, Zhiming and Shi, Pei-Yong (2013) Membrane topology and function of dengue virus NS2A protein. Journal of Virology, 87 (8). pp. 4609-4622. ISSN 0022-538X

Xie, Yang, Avello, Monika, Feng, Yan, Schirle, Markus, Bric-Furlong, Eva, Wilson, Christopher, Nathans, Robin, Zhang, Jing, Kirschner, Marc W, Huang, Shih-Min and Cong, Feng (2013) Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. Journal of Biological Chemistry, 288 (5). pp. 2976-2985. ISSN 0021-9258

Xiong, X, Coombs, PJ, Martin, SR, Liu, J, Xiao, H, McCauley, JW, Locher, K, Walker, PA, Collins, PJ, Kawaoka, Y, Skehel, JJ and Gamblin, SJ (2013) Receptor binding by a ferret-transmissible H5 avian influenza virus. NATURE. pp. 392-396.

Y

Yamaguchi, Masayuki, Saji, Takami, Nozaki, Sachiko, Kulmatycki, Kenneth, He, Yan-Ling, Kenichi, Furihata and Sekiguchi, Kaneo (2013) Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with type 2 diabetes. International Journal of Clinical Pharmacology and Therapeutics.

Yang, S, Wang, B, Cui, D, Kerwood, D, Wilkens, S, Han, J and Luk, YY (2013) Stereochemical Control of Nonamphiphilic Lyotropic Liquid Crystals: Chiral Nematic Phase of Assemblies Separated by Six Nanometers of Aqueous Solvents. JOURNAL OF PHYSICAL CHEMISTRY B. pp. 7133-7143.

Yang, Y, Fiskus, W, Yong, B, Atadja, P, Takahashi, Y, Pandita, TK, Wang, HG and Bhalla, KN (2013) Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 6841-6846.

Yang, ZF, Zhang, H, Ma, L, Peng, C, Chen, Y, Wang, J, Green, MR, Li, S and Rosmarin, AG (2013) GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. pp. 2312-2317.

Yin, OQP, Bedoucha, V, McCulloch, T, Zheng, C, Zhou, W, Hussaini, A and Novick, S (2013) Effects of famotidine or an antacid preparation on the pharmacokinetics of nilotinib in healthy volunteers. CANCER CHEMOTHERAPY AND PHARMACOLOGY. pp. 219-226.

Yokokawa, Fumiaki (2013) Recent progress on the discovery of non-peptidic direct renin inhibitors as antihypertensives. Expert Opinion on Drug Discovery. ISSN 1746-0441

Yokokawa, Fumiaki, Wang, Gang, Wong, Josephine, Rao, Srinivasa P.S., Manjunatha, Ujjini Havaldar, Lakshminarayana, Suresh Bangalore, Herve, Maxime Marcel, Kounde, Cyrille Stephane, Tan, Bee Huat, Thayalan, Pamela, Ng, Seow Hwee, Nanjundappa, Mahesh Bangalore, Zhang, Chengzhi, Wagner, Beatrix, Dix, Ina, Kuhen, Kelli, Glynne, Richard, Smith, Paul William, Bifani, Juan Pablo, Jiricek, Jan, Seah, Peck Gee, Liu, Wei, Chen, Pei-Yu, Lee, Kok Sin, Chan, Wai Ling, Ma, Ida, Chatterjee, Arnab, Pethe, Kevin, Tan, Maria, Goh, Anne, Ang, Shi-Hua and Seah, Peck Gee (2013) Discovery of Tetrahydropyrazolopyrimidine Carboxamide De-rivatives as Potent and Orally Active Novel Anti-Tubercular Agents. ACS Medicinal Chemistry Letters, 4 (5). pp. 451-455. ISSN 1948-5875

Yrjola, S, Kalliokoski, T, Laitinen, T, Poso, A, Parkkari, T and Nevalainen, T (2013) Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists. European Journal of Pharmaceutical Sciences. pp. 9-20.

Z

Zaglia, T, Milan, G, Franzoso, M, Bertaggia, E, Pianca, N, Piasentini, E, Voltarelli, VA, Chiavegato, D, Brum, PC, Glass, DJ, Schiaffino, S, Sandri, M and Mongillo, M (2013) Cardiac sympathetic neurons provide trophic signal to the heart via 2-adrenoceptor-dependent regulation of proteolysis. CARDIOVASCULAR RESEARCH. pp. 240-250.

Zhang, Ji, Auld, Douglas, Hill, William, Ardayfio, Ophelia, Kang, Zhao Bin, Smith, Thomas, Wallace, Iain and Bowes, Scott (2013) Applications of titration-based compound sets for use in rapid evaluation of high-throughput screening assays. Journal Biomolecular Screening, 19 (5). pp. 651-660. ISSN 1087-05711552-454X

Zhang, L, Zhou, F, GarciadeVinuesa, A, deKruijf, E, Mesker, W, Hui, L, Drabsch, Y, Li, Y, Bauer, A, Rousseau, A, Sheppard, K, Mickanin, C, Kuppen, P, Lu, C and tenDijke, P (2013) TRAF4 Promotes TGF-beta Receptor Signaling and Drives Breast Cancer Metastasis. MOLECULAR CELL. pp. 559-572.

Zhang, T, Li, Y, Zou, P, Yu, J, McEachern, D, Wang, S and Sun, D (2013) Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharmaceutics and Drug Disposition. pp. 348-359.

Zhang, Tao, Yanyan , Li, Zou, Peng, Yu, Jing-yu, McEachern, Donna, Wang, Shaomeng and Sun, Duxin (2013) Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharmaceutics and Drug Disposition, 34 (6). pp. 348-359. ISSN 0142-2782

Zhang, X and Boutros, M (2013) A novel phenotypic dissimilarity method for image-based high-throughput screens. BMC Bioinformatics.

Zhang, X, Zhang, J, Bauer, A, Zhang, L, Selinger, DW, Lu, CX and ten Dijke, P (2013) Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO JOURNAL. pp. 996-1007.

Zheng, Guishan, Schaefer, Michael and Karplus, Martin (2013) Hemoglobin Bohr Effects: Analysis of the Histidine Residue Contributions. Biochemistry.

Zhou, Wei (2013) Outsourcing in a bioanalytical laboratory. Bioanalysis, 5 (20).

Zhuang, G, Schmidt, M, Yao, J, Wu, X, Kaminker, JS, Jurinka, SS, Kolumam, G, Chung, AS, Jubb, A, Modrusan, Z, Ozawa, T, James, CD, Phillips, H, Haley, B, Tam, RNW, Clermont, AC, Cheng, JH, Yang, SX, Swain, SM, Chen, D, Scherer, SJ, Koeppen, H, Yeh, RF, Yue, P, Stephan, JP, Hegde, P, Ferrara, N, Singh, M and Bais, C (2013) Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies. CLINICAL CANCER RESEARCH. pp. 3681-3692.

Zimmerlin, Alfred Gilbert and Kiffe, Michael (2013) Fixing clearance as early as lead optimization using high throughput in-vitro incubations in combination with exact mass detection and automatic structure elucidation of metabolites. Drug Discovery Today, 10 (1). d191-E198. ISSN 1740-6749

Zitzmann, Kathrin, Vlotides, Galina Ailer and Auernhammer, Christoph J (2013) Potent antitumor activity of novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells. International Journal of Oncology, 43 (6). pp. 1824-1832. ISSN 1791-2423

Züst, Roland, Dong, Hongping, Li, Xiao-Feng, Chang, David, Zhang, Bo, Jiang, Tao, Li, Shi-Hua, Deng, Yong-Qiang, Ellis, Brett R, Ellis, Esther M, Qin, Cheng-Feng, Shi, Pei-Yong and Fink, Katja (2013) Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques. PLoS Pathogens, 9 (8). ISSN 1553-7366

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