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Is intrinsic aerobic exercise capacity a determinant of COPD susceptibility?

Stevenson, CS and Yew-Booth, L (2013) Is intrinsic aerobic exercise capacity a determinant of COPD susceptibility? Pulmonary Pharmacology & Therapeutics. pp. 459-463.


Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality, which is most commonly associated with smoking or exposure to environmental pollutants. Unfortunately, there is an inadequate understanding of the molecular and physiological determinants governing one's susceptibility for developing COPD. Here, we describe a novel hypothesis: Individuals with intrinsically low aerobic exercise capacity are more likely to develop COPD after exposure to key risk factors. The hypothesis is based on observations that aerobic exercise capacity is tightly associated with mortality across many complex diseases. The premise is supported by recent studies demonstrating that smokers who exercise regularly are less likely to develop or be hospitalized for COPD. Herein, we describe the evolutionary and molecular basis for this hypothesis and how it is a natural extension of previous theories explaining COPD susceptibility. (c) 2013 Elsevier Ltd. All rights reserved

Item Type: Article
Additional Information: pubid: 127 nvp_institute: NIBR contributor_address: Novartis Inst Biomed Res, Resp Dis Area, Horsham RH12 5AB, W Sussex, UK.
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12


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