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Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts

Li, Y and Zhang, T (2013) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts. Future Oncology. pp. 1097-1103.


Many studies have supported the protective effects of broccoli and broccoli sprouts against cancer. The chemopreventive properties of sulforaphane, which is derived from the principal glucosinolate of broccoli and broccoli sprouts, have been extensively studied. Recent research into the effects of sulforaphane on cancer stem cells (CSCs) has drawn lots of interest. CSCs are suggested to be responsible for initiating and maintaining cancer, and to contribute to recurrence and drug resistance. A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-B, SHH, epithelial-mesenchymal transition and Wnt/beta-catenin pathways. Combination therapy with sulforaphane and chemotherapy in preclinical settings has shown promising results. In this article, we focus on the effects of sulforaphane on CSCs and self-renewal pathways, as well as giving a brief review of recent human studies using broccoli sprout preparations. 2013 Future Medicine Ltd

Item Type: Article
Additional Information: pubid: 214 nvp_institute: NIBR contributor_address: (Li) Department of Health and Nutrition Sciences, Montclair State University, University Hall 4190, 1 Normal Avenue, Montclair, NJ 07043, United States (Zhang) Drug Metabolism and Pharmacokinetics, Novartis Institute for Biomedical Research, Novartis Pharmaceutical Corporation, East Hanover, NJ 07936, United States
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12


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