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The hippocampus of the eastern rock sengi: Cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis

Slomianka, L and Drenth, T and Cavegn, N and Menges, D and Lazic, SE and Phalanndwa, M and Chimimba, CT and Amrein, I (2013) The hippocampus of the eastern rock sengi: Cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis. Frontiers in Neuroanatomy.

Abstract

The brains of sengis (elephant shrews, order Macroscelidae) have long been known to contain a hippocampus that in terms of allometric progression indices is larger than that of most primates and equal in size to that of humans. In this report, we provide descriptions of hippocampal cytoarchitecture in the eastern rock sengi (Elephantulus myurus), of the distributions of hippocampal calretinin, calbindin, parvalbumin, and somatostatin, of principal neuron numbers, and of cell numbers related to proliferation and neuronal differentiation in adult hippocampal neurogenesis. Sengi hippocampal cytoarchitecture is an amalgamation of characters that are found in CA1 of, e.g., guinea pig and rabbits and in CA3 and dentate gyrus of primates. Correspondence analysis of total cell numbers and quantitative relations between principal cell populations relate this sengi to macaque monkeys and domestic pigs, and distinguish the sengi from distinct patterns of relations found in humans, dogs, and murine rodents. Calretinin and calbindin are present in some cell populations that also express these proteins in other species, e.g., interneurons at the stratum oriens/alveus border or temporal hilar mossy cells, but neurons expressing these markers are often scarce or absent in other layers. The distributions of parvalbumin and somatostatin resemble those in other species. Normalized numbers of PCNA+ proliferating cells and doublecortin-positive (DCX+) differentiating cells of neuronal lineage fall within the overall ranges of murid rodents, but differed from three murid species captured in the same habitat in that fewer DCX+ cells relative to PCNA+ were observed. The large and well-differentiated sengi hippocampus is not accompanied by correspondingly sized cortical and subcortical limbic areas that are the main hippocampal sources of afferents and targets of efferents. This points to intrinsic hippocampal information processing as the selective advantage of the large sengi hippocampus. 2013 Slomianka, Drenth, Cavegn, Menges, Lazic, Phalanndwa, Chimimba and Amrein

Item Type: Article
Additional Information: pubid: 219 nvp_institute: NIBR contributor_address: (Slomianka, Drenth, Cavegn, Menges, Amrein) Institute of Anatomy, University of Zurich, Zurich, Switzerland (Lazic) In Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, Switzerland (Phalanndwa, Chimimba) Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa (Phalanndwa) Western Cape Nature Conservation Board (CapeNature), Cape Town, South Africa (Chimimba) Department of Science and Technology-National Research Foundation, Centre of Excellence for Invasion Biology, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/22034

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