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Signaling pathways controlling skeletal muscle mass

Egerman, Marc and Glass, David (2013) Signaling pathways controlling skeletal muscle mass. Critical Reviews in Biochemistry and Molecular Biology, 49 (1). pp. 59-68. ISSN 1040-9238


The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed "atrophy", is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. Cachexia increases the likelihood of death from these already serious diseases. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce differentiation and post-injury regeneration, which are also essential for the maintenance of skeletal muscle mass. In this review, we summarize and discuss the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle. © 2014 Informa Healthcare USA, Inc.

Item Type: Article
Additional Information: This is a review of the published literature; there are no new disclosures
Keywords: Cachexia IGF-1 MuRF1 Muscle atrophy Muscle hypertrophy Myostatin Sarcopenia Skeletal muscle
Date Deposited: 25 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:46


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