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Pharmacometrics – Opportunity for Reducing Disease Burden in the Developing World

Pillai, Goonaseelan, Mirza, Fareed, Tadmor, Brigitta, Steimer, Jean-Louis, Davies, Geriant, Denti, Paolo, McIlleron, Helen and Holford, Nicholas H G (2013) Pharmacometrics – Opportunity for Reducing Disease Burden in the Developing World. Clinical Pharmacology and Therapeutics:Pharmacometrics & Systems Pharmacology, 2 (e69).


Pharmacometricians are virtually non-existent in Africa and the developing world. The unrelenting burden of neglected infectious diseases, which are often treated using medicines with narrow effectiveness – safety dose windows, and the growing prevalence of non-communicable diseases represents a significant burden for the patients while affording an opportunity for advancing science. Pharmacometrics is (still) an emerging discipline in the developed world which struggles to integrate into the established ways of conducting drug discovery and development. In Africa, the science and infrastructure is being built without a legacy system representing opportunity amid a need to better define and/or optimize dosing in local populations, or patients with co-morbidities. This paper outlines the business case for pharmacometricians to re-direct their expertise to focus on the disease burden affecting the developing world.

Item Type: Article
Date Deposited: 03 May 2016 23:45
Last Modified: 03 May 2016 23:45