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In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

Bian, X and Fu, J and Plaza, A and Herrmann, J and Pistorius, D and Stewart, AF and Zhang, Y and Muller, R (2013) In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation. ChemBioChem, 14 (10). pp. 1194-1197. ISSN 14394227

Abstract

Releasing the cytopath: We have identified an N-myristoyl-D-asparagine (1) as the free N-terminal prodrug scaffold in cytopathogenic Escherichia coli strains expressing the colibactin gene cluster. Colibactin is released in vivo upon cleavage of precolibactin. We provide for the first time in vivo evidence of the prodrug-like release mechanism of colibactin. 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Item Type: Article
Additional Information: pubid: 121 nvp_institute: NIBR contributor_address: (Bian, Plaza, Herrmann, Pistorius, Muller) Department of Microbial Natural Products, Helmholtz Centre for Infection Research (HZI), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Department of Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrucken, Germany (Bian, Zhang) Shandong University-Helmholtz Joint Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Shanda Nanlu 27, 250100 Jinan, China (Fu, Stewart) Department of Genomics, BioInnovationsZentrum, Technische Universitat Dresden, Tatzberg 47-51, 01307 Dresden, Germany (Pistorius) Natural Products Unit, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056 Basel, Switzerland
Date Deposited: 13 Oct 2015 13:12
Last Modified: 06 Jul 2016 23:45
URI: https://oak.novartis.com/id/eprint/21958

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