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Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of Pain and Itch

Wang, X and Zhang, J and Eberhart, D and Urban, R and Meda, K and Solorzano, C and Yamanaka, H and Rice, D and Basbaum, A (2013) Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of Pain and Itch. Neuron. pp. 312-324.

Abstract

To what extent dorsal horn interneurons contribute to the modality specific processing of pain and itch messages is not known. Here, we report that loxp/cre-mediated CNS deletion of TR4, a testicular orphan nuclear receptor, results in loss of many excitatory interneurons in the superficial dorsal horn but preservation of primary afferents and spinal projection neurons. The interneuron loss is associated with a near complete absence of supraspinally integrated pain and itch behaviors, elevated mechanical withdrawal thresholds and loss of nerve injury-induced mechanical hypersensitivity, but reflex responsiveness to noxious heat, nerve injury-induced heat hypersensitivity, and tissue injury-induced heat and mechanical hypersensitivity are intact. We conclude that different subsets of dorsal horn excitatory interneurons contribute to tissue and nerve injury-induced heat and mechanical pain and that the full expression of supraspinally mediated pain and itch behaviors cannot be generated solely by nociceptor and pruritoceptor activation of projection neurons; concurrent activation of excitatory interneurons is essential

Item Type: Article
Additional Information: pubid: 93 nvp_institute: NIBR contributor_address: (Wang, Zhang, Urban, Meda, Solorzano, Yamanaka, Basbaum) Departments of Anatomy and Physiology, University of California, San Francisco, San Francisco, CA 94158, United States (Eberhart, Rice) Lexicon Pharmaceuticals, Inc., The Woodlands, TX 77381, United States (Eberhart) University of Georgia, Athens, GA 30602, United States (Rice) Novartis Institutes for BioMedical Research, Cambridge, MA 02139, United States
Date Deposited: 13 Oct 2015 13:13
Last Modified: 13 Oct 2015 13:13
URI: https://oak.novartis.com/id/eprint/21934

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