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Predicting drug efficacy using integrative models for chronic respiratory diseases

Stevenson, CS and Sridhar, S and Phillips, JE (2013) Predicting drug efficacy using integrative models for chronic respiratory diseases. Inflammation and Allergy - Drug Targets. pp. 124-131.

Abstract

Animal models are vital instruments of the drug discovery process. In addition to assessing the efficacy of candidate molecules, in vivo disease models also help validate the therapeutic potential of molecular targets. Over recent years, several molecules that have shown efficacy in preclinical models of respiratory diseases have failed to translate into new medicines for chronic respiratory conditions such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. As such, many scientists have argued that these systems are of limited value; however, we propose that a more careful and thorough approach to the characterization of these models and the interpretation of data generated using these systems would improve their translational utility. Herein, we describe two key elements of our strategy aiming to improve the predictive nature of these models: 1) Novel bioinformatics methods that can be used to identify animal models that best represent specific patient populations; and 2) Innovative physiological techniques that will improve our ability to discover drugs that can restore the functional capacity of lungs damaged during the course of the disease. 2013 Bentham Science Publishers

Item Type: Article
Additional Information: pubid: 179 nvp_institute: NIBR contributor_address: (Stevenson, Phillips) DTA Inflammation, Hoffmann-La Roche Inc., pRED, Pharma Research and Early Development, 340 Kingsland Street, Nutley, 07110, United States (Sridhar) Translational Research Sciences, Hoffmann-La Roche Inc., pRED, Pharma Research and Early Development, 340 Kingsland Street, Nutley, 07110, United States (Stevenson) Pharmacology and Toxicology Section, National Heart and Lung Institute, Centre for Integrative Mammalian Physiology and Pharmacology, Centre for Respiratory Infections, Imperial College London, SW7 2AZ, United Kingdom (Stevenson) University of Southern Denmark, Institute for Medical Biology, DK-5000 Odense C, Denmark (Stevenson) Respiratory Diseases, Novartis Institutes for Biomedical Research, Horsham, RH12 5AB, United Kingdom
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/22001

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