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In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

Hoffmaster, Keith and Brouwer, Kim and Keppler, Dietrich and Bow, Daniel and Cheng, Yaofeng and Lai, Yurong and Palm, Johan and Stieger, Bruno and Evers, Raymond (2013) In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development. Clinical Pharmacology and Experimental Therapeutics.

Abstract

This whitepaper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition in humans. Discussion focuses on in vitro tools to address key questions in drug development, including vesicle and cell-based systems. How these methods can be used to assess the liability of compounds for transporter-based DDIs in vivo also is explored. Existing challenges and approaches to examine the involvement of transporters in drug disposition are discussed.

Item Type: Article
Keywords: Drug Transporters
Date Deposited: 26 Apr 2016 23:46
Last Modified: 26 Apr 2016 23:46
URI: https://oak.novartis.com/id/eprint/9756

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