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Targeting PI3K, IL-8/JAK2 axis and HER2 in metastatic breast cancer: which combination makes the whole greater than the sum of its parts

Radimerski, Thomas and Bentires-Alj, Mohamed and Britschgi, Adrian (2013) Targeting PI3K, IL-8/JAK2 axis and HER2 in metastatic breast cancer: which combination makes the whole greater than the sum of its parts. Drug Resist Update, 16 (3-5). pp. 68-72.

Abstract

The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a pivotal role in cellular growth, proliferation, metabolism and survival. Not surprisingly, inappropriate activation of this pathway is very frequent in human cancers and transgenic expression of mutant PI3K in mice causes tumors. Extensive efforts have been made in the development of PI3K-pathway inhibitors but single agent therapy mostly yields limited antitumor activity in the clinical setting due to the rapid emergence of adaptive resistance

Item Type: Article
Additional Information: Thomas Radimerski is the requestor on behalf of M. Bentires-Alj
Date Deposited: 08 May 2016 23:45
Last Modified: 08 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/10063

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