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Synthesis of a Series of Promising Isobenzofurans for the Reduction of Acute Mucositis Risk after Chemo- and Radiotherapy.

Bouchez, Laure and Ruffner, Heinz and Spanka, Carsten and Patoor, Maude (2013) Synthesis of a Series of Promising Isobenzofurans for the Reduction of Acute Mucositis Risk after Chemo- and Radiotherapy. Synlett- special edition.

Abstract

Mycophenolate mofelite (MMF), an immunosuppressant and prodrug of mycophenolic acid (MPA), is used extensively in transplant medicine and more specifically after bone marrow transplantation to prevent acute rejection and other severe complications such as mucositis. Despite extensive research, a mucositis-specific pain treatment has yet to be developed in order to improve the conditions of patients treated by chemo- and radiotherapy. Herein, we present the synthesis of a small series of isobenzofuran analogues identified during a screening campaign as possible mucositis mediators.

Item Type: Article
Date Deposited: 17 May 2016 23:45
Last Modified: 17 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/10968

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