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Fragment-based drug discovery using NMR spectroscopy

Harner, MJ, Frank, AO and Fesik, SW (2013) Fragment-based drug discovery using NMR spectroscopy. Journal of Biomolecular NMR. pp. 65-75.


Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool for fragment-based drug discovery over the last two decades. While NMR has been traditionally used to elucidate the three-dimensional structures and dynamics of biomacromolecules and their interactions, it can also be a very valuable tool for the reliable identification of small molecules that bind to proteins and for hit-to-lead optimization. Here, we describe the use of NMR spectroscopy as a method for fragment-based drug discovery and how to most effectively utilize this approach for discovering novel therapeutics based on our experience. 2013 Springer Science+Business Media Dordrecht

Item Type: Article
Additional Information: pubid: 98 nvp_institute: NIBR contributor_address: (Harner, Frank, Fesik) Department of Biochemistry, Vanderbilt University School of Medicine, 607 Light Hall, 2215 Garland Ave, Nashville, TN 37232-0146, United States (Frank) Novartis Institutes for BioMedical Research (NIBR), Global Discovery Chemistry, Emeryville, CA, United States
Date Deposited: 13 Oct 2015 13:13
Last Modified: 13 Oct 2015 13:13