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Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension

Thomas, Matthew, Ciuclan, Loredana, Hussey, Martin and Press, Neil (2013) Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension. Pharmacology and Therapeutics, 138 (3). pp. 409-417. ISSN 0163-7258


As we uncover the complex pathophysiology underlying idiopathic and familial pulmonary arterial hypertension, multiple disease associated pathways, cell types and processes reveal links to elements of the serotonin system. Beyond the original 'serotonin hypothesis' observed with anorexigens, and the latterly demonstrated association with vascular tone and pulmonary artery smooth muscle cell proliferation, recent studies suggest links to BMPR2, PDGF and RhoK pathways, as well as an impact upon more complex lesion formation and pathologic bone marrow progenitor mobilization. Clinical experience with antagonists targeting the various elements of the serotonin pathway has been unsatisfactory, yet perhaps this is less than surprising given our expanding knowledge around serotonin production and signaling biology, which indicate opportunities for novel therapeutic options. © 2012 Elsevier Inc.

Item Type: Article
Keywords: Disease mechanisms Pulmonary arterial hypertension Serotonin Therapies
Date Deposited: 25 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:46