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The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action

Karkare, S and Chung, TTH and Collin, F and Mitchenall, LA and McKay, AR and Greive, SJ and Meyer, JJM and Lall, N and Maxwell, A (2013) The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. Journal of Biological Chemistry. pp. 5149-5156.

Abstract

Background: New antibacterial compounds are urgently needed; DNA gyrase is a well-validated target. Results: Diospyrin and other naphthoquinones inhibit DNA gyrase by binding to a novel site in the B subunit. Conclusion: Naphthoquinones are inhibitors of gyrase with a novel mechanism of action. Significance: Naphthoquinones have potential as antibacterial compounds against TB. 2013 by The American Society for Biochemistry and Molecular Biology, Inc

Item Type: Article
Additional Information: pubid: 222 nvp_institute: NIBR contributor_address: (Karkare, Chung, Collin, Mitchenall, Greive, Maxwell) Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom (McKay) Department of Chemistry, University College London, London WC1H 0AJ, United Kingdom (Meyer, Lall) Department of Plant Science, University of Pretoria, Pretoria 0002, South Africa (Karkare) Novartis Institute of Biomedical Research, Basel 4056, Switzerland (Greive) Inspiralis Ltd., Norwich Bioincubator, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/22036

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