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Mesomorphous versus traces of crystallinity: The itraconazole example

Atassi, F and Behme, RJ and Patel, PJ (2013) Mesomorphous versus traces of crystallinity: The itraconazole example. THERMOCHIMICA ACTA. pp. 133-139.

Abstract

Characterizing disordered pharmaceutical materials can be challenging, especially materials with partially disordered structures that lose one or two directional order (mesophases) and do not fit the traditional characterization categories of amorphous, crystalline or a combination of the two. Itraconazole, an antifungal agent, was chosen as a model compound that, when quench cooled, exhibits atypical disordered structure. Five different analytical tools were used to map out the molecular structure of this material and how it changes with changing temperature. X-ray diffraction showed some remnant crystallinity while dielectric analysis, dynamic mechanical analysis, DSC and hot stage microscopy gave more detailed molecular structure of the disordered material and explained all temperature related structural changes.The characterization of mesomorphous Itraconazole described here will help characterize a wide range of pharmaceuticals that exhibit thermotropic (temperature induced) mesomorphism at the molecular level. (C) 2013 Elsevier B.V. All rights reserved

Item Type: Article
Additional Information: pubid: 144 nvp_institute: NIBR contributor_address: Eli Lilly & Co, Lilly Res Labs, Pharmaceut Sci R&D, Indianapolis, IN 46285 USA fatassi@yahoo.com; Eli Lilly & Co, Lilly Res Labs, Pharmaceut Sci R&D, Indianapolis, IN 46285 USA; Atassi, F; Novartis Inst Biomed Res, Cambridge, MA USA
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/21978

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