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Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment

Strober, B and Buonanno, M and Clark, JD and Kawabata, T and Tan, H and Wolk, R and Valdez, H and Langley, RG and Harness, J and Menter, A and Papp, K (2013) Effect of tofacitinib, a Janus kinase inhibitor, on haematological parameters during 12 weeks of psoriasis treatment. BRITISH JOURNAL OF DERMATOLOGY. pp. 992-999.

Abstract

BackgroundThe Janus kinase (JAK) inhibitor, tofacitinib, has shown efficacy for the treatment of psoriasis in a phase IIb trial (A3921047; NCT00678210).ObjectivesTo report haematology data from the phase IIb trial, given the importance of JAK-dependent signalling in haematopoiesis.MethodsPatients with moderate-to-severe chronic plaque psoriasis were randomized to receive tofacitinib 2, 5 or 15mg, or placebo, twice daily over 12weeks. Blood samples were collected at screening, baseline, weeks 2, 4, 8 and 12 during treatment, and weeks 14 and 16 during off-treatment follow-up.ResultsBaseline haematology was similar across patients receiving tofacitinib 2mg (n=49), 5mg (n=49) or 15mg (n=49), or placebo (n=50). Tofacitinib conferred dose-dependent decreases in haemoglobin, haematocrit and red blood cell counts, while reticulocyte counts initially declined, before recovering by week 8, and exceeding baseline levels after treatment cessation. With regard to white blood cells, tofacitinib had no clear dose-dependent effects on basophils or monocytes, but appeared to be associated with transient or reversible dose-dependent decreases in neutrophil and eosinophil counts and transient increases in lymphocyte counts, which were primarily attributable to increases in B-cell counts. Natural killer cell counts declined with tofacitinib.ConclusionsTofacitinib conferred tolerable, dose-dependent changes in haematological parameters during short-term administration in patients with psoriasis. The effects did not appear to be progressive, and were often transient or reversible

Item Type: Article
Additional Information: pubid: 85 nvp_institute: NIBR contributor_address: Univ Connecticut, Sch Med, Dept Dermatol, Farmington, CT 06032 USA, Prob Med Res, Waterloo, ON, Canada strober@uchc.edu; Pfizer Inc, Groton, CT 06340 USA ; Pfizer Inc, Cambridge, MA USA ; Pfizer Inc, New York, NY USA ; Dalhousie Univ, Dept Med, Div Dermatol, Halifax, NS, Canada ; Novartis Inst Biomed Res, Basel, Switzerland ; Baylor Psoriasis Res Inst, Dallas, TX USA ; Prob Med Res, Waterloo, ON, Canada ; Univ Connecticut, Sch Med, Dept Dermatol, Farmington, CT 06032 USA; Prob Med Res, Waterloo, ON, Canada; Strober, B; Univ Connecticut, Sch Med, Dept Dermatol, Farmington, CT 06032 USA
Date Deposited: 13 Oct 2015 13:13
Last Modified: 13 Oct 2015 13:13
URI: https://oak.novartis.com/id/eprint/21927

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