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Synthesis of mucin-type O-glycan probes ready to be immobilized to glycoarray platforms.

Smith, Nichola and Benito-Alifonso, David and Jones, Rachel A and Tran, Anh-Tuan and Woodward, Hannah and Galan, M Carmen (2013) Synthesis of mucin-type O-glycan probes ready to be immobilized to glycoarray platforms. Beilstein Journal of Organic Chemistry.

Abstract

The chemical synthesis of a series of mucin-type oligosaccharide fragments 2-7 containing an αlinked amino-propyl spacer ready for glyco-array attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields

Item Type: Article
Date Deposited: 26 Apr 2016 23:46
Last Modified: 26 Apr 2016 23:46
URI: https://oak.novartis.com/id/eprint/10560

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