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Accart Gris, Nathalie and Genoud, Christel (2019) Un premier pas vers l’étude du collagène du cartilage articulaire en microscopie électronique. Revue Française d'Histotechnologie, 31 (1). pp. 85-92. ISSN 0997-6434

Adams, Christopher and Stacy, Rebecca and Rangaswamy, Nalini and Bigelow, Chad and Grosskreutz, Cyndy and Prasanna, Ganesh (2019) Glaucoma - Next Generation Therapeutics: Impossible to Possible. Pharmaceutical Research, 36 (2). ISSN 1573904X

Aeffner, Famke and Zarella, Mark and Buchbinder, Nathan and Bui, Marilyn and Goodman, Matthew and Hartman, Douglas and Lujan, Giovanni and Molani, Mariam and Parwani, Anil and Tunstall, kate and Turner, Oliver and Vemuri, Venkata and Yuil-Valdes, Ana and Bowman, Douglas (2019) Introduction to Digital Image Analysis in Whole-Slide Imaging: A White Paper from the Digital Pathology Association. Journal of Pathology Informatics, 10 (9). pp. 1-17.

Aeschlimann, Samuel and Graf, Christian and Mayilo, Dmytro and Munschy, Helene and Urda, Lorena and Kappes, Nora and Simonis, Marieke and Splinter, Erik and van Min, Max and Laux, Holger (2019) Shortened abstract for Enhanced CHO clone screening using Next-Generation Sequencing and Targeted Locus Amplification publication. Enhanced CHO clone screening: Applying Targeted Locus Amplification and Next-Generation Sequencing technologies during cell line development.

Aguilar-de-Leyva, Ángela and Campiñez, Maria Dolores and Jost, Flavia and Gavira, Miguel and Caraballo, Isidoro (2019) Study of the critical points in combined matrix tablets containing both inert and swelling excipients. Journal of Drug Delivery Science and Technology, 52. pp. 885-894. ISSN 17732247

Aho, Erin R and Wang, Jing and Gogliotti, Rocco D and Howard, Gregory C and Phan, Jason and Acharya, Pankaj and Macdonald, Jonathan D and Cheng, Ken and Lorey, Shelly L and Lu, Bin and Wenzel, Sabine and Foshage, Audra M and Alvarado, Joseph and Wang, Feng and Shaw, J Grace and Zhao, Bin and Weissmiller, April M and Thomas, Lance R and Vakoc, Christopher R and Hall, Matthew D and Hiebert, Scott W and Liu, Qi and Stauffer, Shaun R and Fesik, Stephen W and Tansey, William P (2019) Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell reports, 26 (11). 2916-2928.e13. ISSN 2211-1247

Albiol, Laia and Büttner, Alexander and Pflanz, David and Mikolajewicz , Nicholas and Birkhold, Annette I. and Kramer, Ina and Kneissel, Michaela and Duda, Georg and Checa, Sara and Willie, Bettina M. (2019) Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice. Calcified tissue international.

Alexander, Schuhmacher and Oliver, Gassmann and Michael, Kuss and Hinder, Markus (2019) The Art of Virtualizing Pharma R&D. Drug Discovery Today. pp. 1-2. ISSN 18785832

Altshuler, Bob (2019) Research summary for postdoc program mentor profile. NIBR Postdoc Program.

Ando, Yuichi and Iwasa, Satoru and Takahashi, Shunji and Saka, Hideo and KAKIZUME, TOMOYUKI and NATSUME, KAZUTO and NOUMI, NAOKO and Quadt, Cornelia and Yamada, Yasuhide (2019) Phase I study of alpelisib (BYL719), an α-specific PI3K inhibitor, in Japanese patients with advanced solid tumors. Cancer Science. ISSN 13497006

Arias, HR and Jin, X-T and Peng, C and Feuerbach, Dominik and Ortells, MO and Elgoyhen, AB and Drenan, RM (2019) Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes. Neurochemistry international.

Arias, Hugo R and Ortells, Marcelo O and Feuerbach, Dominik and Burgos, Viviana and Paz, Cristian (2019) Alkaloids purified from the Aristotelia chilensis tree inhibit the human α3β4 nicotinic acetylcholine receptor with higher potency compared to human α4β2 and α7 subtypes. Journal of natural products.

Arista, Luca and Ullrich, Thomas and Riela, Serena and Massaro, Marina and Buscemi, Gabriella and Biddeci, Giuseppa and Cavallaro, Giuseppe and D'Anna, Francesca and Di Blasi, Francesco and Ferrante, Angelo and Lazzara, Giuseppe and Rizzo, Carla and Spinelli, Gaetano (2019) Multifunctional carrier based on halloysite/laponite hybrid hydrogel for kartogenin delivery. ACS Medicinal Chemistry Letters, 2019 (10). pp. 419-424. ISSN 1948-58751948-5875

Arora, Rishi and Nimonkar, Amitabh and Baird, Daniel and Wang, Chunhua and Chiu, Chun-Hao and Horton, Patricia and Hanrahan, Susan and Cubbon, Rose and Weldon, Stephen and Tschantz, Bill and Mueller, Sascha and Brunner, Reto and Lehr, Philipp and Meier, Peter and Ottl, Johannes and Voznesensky, Andrei and Pandey, Pramod and Smith, Thomas and Stojanovic, Aleksandar and Flyer, Alec and Benson, Timothy and Romanowski, Michael and Trauger, John (2019) Structure of lipoprotein lipase in complex with GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America, 116 (21). pp. 10360-10365. ISSN 10916490

Arora, Rishi and Nimonkar, Amitabh V and Baird, Daniel and Wang, Chunhua and Chiu, Chun-Hao and Horton, Patricia A and Hanrahan, Susan and Cubbon, Rose and Weldon, Stephen and Tschantz, William R and Mueller, Sascha and Brunner, Reto and Lehr, Philipp and Meier, Peter and Ottl, Johannes and Voznesensky, Andrei and Pandey, Pramod and Smith, Thomas M and Stojanovic, Aleksandar and Flyer, Alec and Benson, Timothy E and Romanowski, Michael J and Trauger, John W (2019) Structure of lipoprotein lipase in complex with GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America. ISSN 1091-6490

Arora, Rishi and Nimonkar, Amitabh V and Baird, Daniel and Wang, Chunhua and Chiu, Chun-Hao and Horton, Patricia A and Hanrahan, Susan and Cubbon, Rose and Weldon, Stephen and Tschantz, William R and Mueller, Sascha and Brunner, Reto and Lehr, Philipp and Meier, Peter and Ottl, Johannes and Voznesensky, Andrei and Pandey, Pramod and Smith, Thomas M and Stojanovic, Aleksandar and Flyer, Alec and Benson, Timothy E and Romanowski, Michael J and Trauger, John W (2019) Structure of lipoprotein lipase in complex with GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America, 116 (21). pp. 10360-10365. ISSN 1091-6490

Artim, Stephen C and Sheh, Alexander and Burns, Monika A and Fox, James G (2019) Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus). PloS one, 14 (11). e0224950. ISSN 1932-6203

Auberson, Yves (2019) An Element of Community: EFMC, the European Federation for Medicinal Chemistry. Chimia..


Babrak, Lmar M. and Menetski, Joseph and Rebhan, Michael and Nisato, Giovanni and Zinggeler, Marc and Brasier, Noe and Baerenfaller, Katja and Brenzikofer, Thomas and Baltzer, Laurenz and Vogler, Christian and Gschwind, Leo and Schneider, Cornelia and Streiff, Fabian and Groenen, Peter M.A. and Miho, Enkelejda (2019) Traditional and digital biomarkers - two worlds apart? Digital Biomarkers, 3 (2). pp. 92-102. ISSN 2504-110X

Baenziger, Markus and Eswaran, Sumesh and Kanasithan, Gopu and Jiang, Yifan (2019) Selective ortho -Metalation of a Fluoroarene with Knochel-Hauser Base and Reactions with Various Electrophiles. Synthesis (Germany), 51 (7). pp. 1649-1654. ISSN 1437210X

Baenziger, Markus and Pachinger, Werner and Stauffer, Frederic and Zaugg, Werner (2019) Development of the synthesis of BEZ235 on ton scale. Organic Process Research & Development, 23 (9). pp. 1908-1917. ISSN 1083-61601520-586X

Bagdanoff, Jeffrey and Acker, Michael and Chan, Ho Man and Dore, Michael and Firestone, Brant and Fodor, Michelle and Garcia Fortanet, Jorge and Hentemann, Martin and Kato, Mitsunori and Koenig, Robert and La Bonte, Laura and Liu, Shumei and Chen, Zhuoliang and Chen, Ying-Nan and Mohseni, Mori and Ntaganda, Rukundo and Sarver, Patrick and Smith, Troy and Sendzik, Martin and Stams, Travis and Spence, Stan and Towler, Christopher and Wang, Hongyun and Wang, Ping and Williams, Sarah (2019) Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. Journal of Medicinal Chemistry, 62 (4). pp. 1781-1792. ISSN 15204804

Baltschukat, Sabrina and Schacher Engstler, Barbara and Huang, Alan and Hao, Huaixiang and Tam, Angela and Wang, Hui-Qin and Liang, Jinsheng and Dimare, Matt and Bhang, Hyo-Eun and Wang, Youzhen and Furet, Pascal and Sellers, William and Hofmann, Francesco and Schoepfer, Joseph and Tiedt, Ralph (2019) Capmatinib (INC280) is active against models of non–small cell lung cancer and other cancer types with defined mechanisms of MET activation. Clinical Cancer Research, 25 (10). pp. 3164-3175. ISSN 15573265

Bassilana, Frederic and Nash, Mark and Ludwig, Marie-Gabrielle (2019) Adhesion G protein-coupled receptors: opportunities for drug discovery. Nature reviews drug discovery.

Beck, Katharina R. and Kanagaratnam, Sharavan and Kratschmar, Denise V. and Birk, Julia and Yamaguchi, Hideaki and Sailer, Andreas and Seuwen, Klaus and Odermatt, Alex (2019) Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2. Journal of steroid biochemistry and molecular biology, 190. pp. 19-28. ISSN 1879-1220

Bednarczyk, Dallas and Sanghvi, Menaka (2019) The impact of assay recovery on the apparent permeability, a function of lysosomal trapping. Xenobiotica; the fate of foreign compounds in biological systems. pp. 1-22. ISSN 13665928

Bernink, Jochem H and Ohne, Yoichiro and Teunissen, Marcel BM and wang, Jingya and wu, Jincheng and krabbendam, lisette and Guntermann, Christine and volckmann, richard and koster, jan and van Tol, sophie and ramirez, ivan and shrestha, yashaswi and de rie, menno a and spits, hergen and ros, xavier romero and humbles, alison a (2019) c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Nature immunology. ISSN 1529-2916

Berrien-Elliott, Melissa M. and Sun, Yaping and Neal, Carly and Ireland, Aaron and Trissal, Maria C. and Sullivan, Ryan and Wagner, Julia A. and Leong, Jeffrey W. and Wong, Pamela and Mah-Som, Annelise Y. and Wong, Terrence N. and Schappe, Timothy and Keppel, Catherine R. and Cortez, Victor S. and Stamatiades, Efstathios G. and Li, Ming O. and Colonna, Marco and Link, Daniel C. and French, Anthony R. and Cooper, Megan A. and Wang, Wei-Le and Boldin, Mark P. and Reddy, Pavan and Fehniger, Todd A. (2019) MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells. Immunity. ISSN 10747613

Bhhatarai, Barun and Walters, Patrick and Hop, Cornelis and Lanza, Guido and Ekins, Sean (2019) Opportunities and Challenges Using Artificial Intelligence (AI) in ADME/Tox. Nature materials., 18. pp. 418-422. ISSN 1476-1122

Bill, Anke and Yeboah, Fred and Kim, Tae-Eu and Dettmer, Ulf (2019) Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiology of Disease, 132. ISSN 1095953X

Borsari, Chiara and Rageot, Denise and Dall’Asen, Alix and Bohnacker, Thomas and Melone, Anna and Sele, Alexander M. and Jackson, Eileen and Langlois, Jean-Baptiste and Beaufils, Florent and Hebeisen, Paul and Fabbro, Doriano and Hillmann, Petra and Wymann, Matthias P. (2019) A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. Journal of Medicinal Chemistry, 62 (18). pp. 8609-8630. ISSN 0022-2623

Bova, Kaitlin (2019) USP 800: Protecting Site Staff from Hazardous Drugs. Clinical Trial Supply Handbook .

Braun , Marie-Gabrielle and Díaz-Rodríguez, Alba and Diorazio, Louis and Fraunhoffer, Kenneth and Hayler, John and Hickey, Matthew and Lovelle, Lucie and McLaws, Mark and Parsons, Andrew and Richardson, Paul and Roiban, Doru and Steven, Alan and Terrett, Jack and White , Timothy and Yin, Jingjun (2019) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development, 23 (11). pp. 2287-2301. ISSN 1083-61601520-586X

Briard, Emmanuelle and joshi, Aniket and Shanmukhappa, Shiva and Ilovich, Olav and Auberson, Yves (2019) [18F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor‐Bearing Mice. ChemMedChem.

Brock, Ansgar and Venable, John and Steckler, Caitlin and Park, In Hee (2019) Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab fragment of NISTmAb. Analytical chemistry. ISSN 0003-2700

Bruch, Richard and Baaske, Julia and Chatelle, Claire and Meirich, Mailin and Madlener, Sibylle and Weber, Wilfried and Dincer, Can and Urban, Gerald Anton (2019) CRISPR/Cas13a‐powered electrochemical microfluidic biosensor for nucleic acid amplification‐free miRNA diagnostics. Advanced Materials. p. 1905311. ISSN 0935-9648

Bruin, Gerardus and Hasselberg, Anke and Korolova, Irena and Milojevic, Julie and Calonder, Claudio and Soon, Rachel and Woessner, Ralph and Pariser, David and Boutouyrie-Dumont, Bruno (2019) Secukinumab treatment does not alter the pharmacokinetics of the CYP3A4 substrate midazolam in patients with moderate to severe psoriasis – results from an open label disease-drug-drug interaction study. Clinical pharmacology and therapeutics, Early (Early ).

Burger, Matthew and Aversa, Robert and Taft, Benjamin and La Bonte, Laura and Cooke, Vesselina and Polyakov, Valery and Mishina, Yuji and Haling, Jake and Tellew, John and Iyer, Raman and Tian, Hung and Mathews Griner, Lesley and Mamo, Mulugeta and Huang, Shenlin and Gampa, Kalyani and Feng, Fei (2019) Design and Discovery of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254), A selective, efficacious, well-tolerated RAF inhibitor targeting RAS mutant cancers: The path to the clinic. Journal of medicinal chemistry, 63 (5). pp. 2013-2027.

Burns, Michael and Ott, Martin and Teasdale, Andrew and Stalford, Susanne and Antonucci, Vincent and Baumann, Jens-Christoph and Brown, Roland and Covey-Crump, Elisabeth and Elder, David and Elliott, Eric and Fennell, Jarred and Gallou, Fabrice and Ide, Nathan and Itoh, Tetsuji and Jordine, Guido and Kallemeyn, Jeffrey and Lauwers, Dick and Looker, Adam and Lovelle, Lucie and Molzahn, Robert and Schills, Didier and Schulte Oestrich, Rolf and Sluggett, Gregory and Stevenson, Neil and Talavera, Pere and Urquhart, Michael and Varie, David and Welch, Dennie (2019) A New Semi-Automated Computer-Based System for Assessing the Purge of Mutagenic Impurities. Organic process research & development.

Bussiere, Dirksen and Beckwith, Rohan and Be, Celine and Burke, Ashley and Carte, Nathalie and Cobb, Jennifer and Fazal, Aleem and Frank, Andreas and Frommlet, Alexandra and Godbole, Adarsh and Graff, Patrick and Hornak, Viktor and King, Daniel and Knapp, Mark and Paulk, Josh and Shu, Wei and Solomon, Jonathan and Srinivas, Honnappa and Voshol, Johannes and Wiesmann, Christian and Xie, Lili and Xu, Fangmin and Zhao, Junping and Okram, Barun and Jiang, Songchun and Michellys, Pierre and Karki, Rajeshri (2019) Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nature chemical biology. ISSN 1552-4469; 1552-4450


Cadena, Samuel and Choi, Sungshin and Saravia-Butler, Amanda and Shirazi-Fard, Yasaman and Leveson-Gower, Dennis and Stodieck, Louis and Beegle, Janet and Solis, Stephanie and Ronca, April and Globus, Ruth (2019) Behavior of mice aboard the International Space Station. Scientific reports, 9 (1). ISSN 20452322

Cadena, Samuel and Zhang, Yunyu and Lemire, Sophie and Kuss, Pia and Giorgetti, Elisa and Kneissel, Michaela and Glass, David and Stodieck, Louis (2019) Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space. Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space , 9 (1). p. 9397. ISSN 2045-2322


Canham, Steve and Russ, Carsten and Reece-Hoyes, John and Sigoillot, Frederic (2019) Bile acid analogues are activators of pyrin inflammasome. Journal of Biological Chemistry, 294 (10). pp. 3359-3366. ISSN 0021-92581083-351X

Carballido, Jose and Santamaria, Pere (2019) Taming autoimmunity: Translating antigen-specific approaches to induce immune tolerance. The Journal of Experimental Medicine. ISSN 0022-10071540-9538

Chapeau, Emilie and Mandon, Emeline and Romanet, Vincent and Ebel, Nicolas and Gill , Jason and Powajbo, Violetta and Andraos-Rey, Rita and Qian, Zhiyan and Kininis, Miltiadis and Zumstein-Mecker, Sabine and Ito, Moriko and Hynes, Nancy and Hofmann, Francesco and Tiedt, Ralph and Eshkind, Leonid and Bockamp, Ernesto and Kinzel, Bernd and Mueller, Matthias and Murakami, Masato and Baffert, Fabienne and Radimerski, Thomas (2019) A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression. PLoS ONE, 14 (10). ISSN 1932-6203

Chen, Kaiwen and Demarco, Benjamin and Shkarina, Kateryna and Boettcher, Andreas and Farady, Christopher and Heilig, Rosalie and Broz, Petr and Pelzcar, P (2019) Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly. EMBO Journal. ISSN 14602075

Chen, Lieyang and Cruz, Anthony and Ramsey, Steven and Dickson, Callum and Duca, Jose and Hornak, Viktor and Koes, David and Kurtzman, Tom (2019) Hidden bias in the DUD-E dataset leads to misleading performance of deep learning in structure-based virtual screening. PLoS ONE, 14 (8). ISSN 19326203

Chen1, Lisa S. and Keating, Michael J. and Wierda, William G. and Gandhi, Varsha V. (2019) Induction of apoptosis by MCL-1 inhibitors in chronic lymphocytic leukemia cells. Leukemia & lymphoma, 60. pp. 3063-3066. ISSN 1029-2403

Chiang, Derek and Leary, Rebecca and Wong, Connie and Singh, Angad and Charette, LaSalette (2019) A community-based lung cancer rapid tissue donation protocol provides high-quality drug-resistant specimens for proteogenomic analyses. Cancer Medicine. ISSN 20457634

Christian, Alec H and Jia, Shang and Zhang, Patricia and Tena Meza, Arismel and Sigman, Matthew S and Chang, Christopher J and Toste, F Dean (2019) A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation. Journal of the American Chemical Society JACS., 141 (32). pp. 12657-12662. ISSN 0002-78631520-5126

Clavaud, Matthieu and Lema-Martinez, Carmen and Roggo, Yves and Bigalke, Michael and Guillemain, Aurélie and Hubert, Philippe and Ziemons, Eric and Allmendinger, Andrea (2019) Near-infrared spectroscopy to determine residual moisture in freeze-dried products: model generation by statistical design of experiments. Journal of Pharmaceutical Sciences. ISSN 00223549

Cooner, Freda and Gamalo-Siebers, Margaret and Xia, Amy and Aijun, Gao and Ruan, Shiling and Tony, Jiang and Laura, Thompson (2019) Use of Alternative Designs and Data Sources for Pediatric Trials. Statistics in Biopharmaceutical Research. ISSN 19466315

Costa, Carlotta and Ly, Amy and Walmsley, Charlotte S. and Huynh, Tiffany and Healy, Christopher and Peterson, Rachel and Jakubik, Charles T. and Henderson, Laura E. and Ho, Jeffrey and Timotina, Daria and Sanidas, Ioannis and Veloso, Artur and Mino-Kenudson, Mari and Stone, James R. and Dyson, Nick and Benes, Cyril H. and Engelman, Jeffrey and Dejan, Juric (2019) PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer. Cancer discovery. ISSN 21598290

Cryer, Alexander M and Chan, Cheuk and Eftychidou, Anastasia and Maksoudian, Christy and Mahesh, Mohan and Tetley, Teresa D and Spivey, Alan C and Thorley, Andrew J (2019) Tyrosine Kinase Inhibitor Gold Nanoconjugates for the Treatment of Non-Small Cell Lung Cancer. ACS applied materials & interfaces, 11 (18). pp. 16336-16346. ISSN 1944-8252

Cryer, Alexander M and Thorley, Andrew J (2019) Nanotechnology in the diagnosis and treatment of lung cancer. Pharmacology & therapeutics, 198. pp. 189-205. ISSN 1879-016X


D'Alessandro, Pier Luca and Hollingworth, Greg and Vorherr, Thomas (2019) Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo. ACS Chemical Biology, 14 (10). pp. 2197-2205. ISSN 15548937

D'Alessandro, Pier Luca and Hollingworth, Greg and Vorherr, Thomas (2019) Real-time imaging and quantification of peptide uptake in vitro and in vivo. ACS Chemical Biology. ISSN 1554-89291554-8937

Dalvit, Claudio and Vulpetti, Anna (2019) Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects. Journal of Medicinal Chemistry, 62. pp. 2218-2244. ISSN 15204804

Daniela, Mercatelli and Bolognesi, Paolo and Frassineti, Martina and Clarissa, Pisanò and Francesco, Longo and Shimshek, Derya and Michele, Morari (2019) Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes. Pharmacology Research & Perspectives, 7 (3). ISSN 2052-17072052-1707

Darpo, B and Benson, C and Dota, C and Jarugula, Venkateswar (2019) Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ-CSRC Study. Journal of Clinical Pharmacology. ISSN 15524604

Deodato, Giacomo and Ball, Christopher and Zhang, Xian (2019) Bayesian Neural Networks for Cellular Image Classification and Uncertainty Analysis.

Diaz Verdugo, Carmen and Sun, Gerald and Fawcett, Caroline and Zhu, Peixin and Fishman, Mark (2019) Mating suppresses alarm response in zebrafish. Current biology. ISSN 1879-0445

Diaz Verdugo, Carmen and Sun, Gerald and Fawcett, Caroline and Zhu, Peixin and Fishman, Mark (2019) Mating suppresses alarm response in zebrafish. Current biology, 29. p. 2541. ISSN 1879-0445

Dickson, Callum and Velez-Vega, Camilo and Duca, Jose (2019) Revealing molecular determinants of hERG blocker and activator binding. Journal of chemical information and modeling. ISSN 1549960X

Dierich, Marlen and Hartmann, Stephanie and Dietrich, Nadine and Moeser, Philip and Tziridis, Konstantin and Schilling, Achim and Krauss , Patrick and Brede, Franziska and Hessler, Sabine and Karch, Sandra and Oliver, Dominik and Moser, Tobias and Schultze, Holger and Alzheimer, Christian and Leitner, Michael and Huth, Tobias (2019) β-secretase BACE1 is required for normal cochlear function. The journal of neuroscience. ISSN 1529-2401

Dodd, Stephanie and Kollipara, Sivacharan and Heimbach, Tycho and Beato, Stefania and Sanchez-Felix, Manuel and Meng, Qingshuo (2019) Prediction of ARA/PPI Drug-Drug Interactions at the Drug Discovery and Development Interface. Journal of Pharmaceutical Sciences, 108 (1). pp. 87-101. ISSN 15206017

Dodge, Robert (2019) Gene Therapy: Bioanalytical Support and Strategies. AAPS Training webinar, NA (NA). NA-NA. ISSN NA

Doerning, Carolyn M and Thurston, Sarah E and Villano, Jason S and Kaska, Carian L and Vozheiko, Tracy D and Soleimanpour, Scott A and Lofgren, Jennifer L (2019) Assessment of Mouse Handling Techniques During Cage Changing. Journal of the American Association for Laboratory Animal Science : JAALAS. ISSN 1559-6109

Dranoff, Glenn and Dougan, Michael and Dougan, Stephanie (2019) GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity, 50 (4). pp. 796-811. ISSN 10974180

Duca, Jose and Jansen, Hanneke and Schneider, Petra and Walters, W. Patrick and Plowright, Alleyn T. and Sieroka, Norman and Fisher, Jasmin and Listgarten, Jennifer and Goodnow, Jr., Robert A. and Rush, Thomas S. and Zentgraf, Matthias and Hill, John Edward and Krutoholow, Elizabeth and Kohler, Matthias and Luebkemann, Chris and Blaney, Jeff and Funatsu, Kimito and Schneider, Gisbert (2019) Rethinking drug design in the artificial intelligence era. Nature Reviews Drug Discovery. ISSN 14741784

Duvadie, Rohit and Robinson, Richard and Altinoglu, Erhan and Jensen, Klavs and Pomberger, Alexander and Mo, Yiming and Nandiwale, Kakasaheb and Schultz, Victor (2019) A Continuous Stirred-Tank Reactor (CSTR) Cascade for Handling Solid-Containing Photochemical Reactions. Organic process research & development, 23 (12). pp. 2699-2706.

Dörner, Thomas and Posch, Maximilian and Li, Yue and Petricoul, Olivier and Cabanski, Maciej and Valentin, Marie-Anne and Simonett, Claudia and Mooney, Louise and Gram, Hermann and Wagner, Frank and Oliver, Stephen (2019) Treatment of primary Sjögren’s syndrome with ianalumab (VAY736) Targeting B cells by BAFF receptor-blockade coupled with enhanced, antibody-dependent cellular cytotoxicity. Annals of the rheumatic diseases., 78 (5). pp. 641-647.

D’ATRI, Valentina and Pell, Reinhard and Clarke, Adrian and GUILLARME, Davy and FEKETE, Szabolcs (2019) Is hydrophobic interaction chromatography the most suitable technique to characterize site-specific antibody-drug conjugates? Journal of Chromatography A, 1586. pp. 149-153. ISSN 0021-9673

de Oliveira Mann, Carina and Orzalli, Megan and King, David and Kagan, Jonathan and Lee, Amy and Kranzusch, Philip (2019) Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation. Cell reports. ISSN 2211-1247


Ecoeur, Florence and Weiss, Jessica and Kaupmann, Klemens and Hintermann, Samuel and Orain, David and Guntermann, Christine (2019) Antagonizing Retinoic acid-related-orphan receptor gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses. Frontiers in Immunology, 10 (Front.).

Edge, Stephen and Morrical, Bradley and Singh, Dilraj and Lewis, David and Rouse, Tim and Shur, Jagdeep (2019) Defining the Dosage Strength for Labelling of DPIs: Use, Limitations and Relevance of in-vitro Data. Inhalation Magazine, 13 (Februa). pp. 7-13.

Emilsson, Valur and Gudnason, Vilmundur and Jennings, Lori (2019) Predicting health and life span with the deep plasma proteome. Nature Medicine, 25 (12). pp. 1815-1816. ISSN 1546170X

Erlanson, Daniel A. and Davis, Ben J. and Jahnke, Wolfgang (2019) Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures. Cell Chemical Biology, 26 (1). pp. 9-15. ISSN 24519448

Ertl, Peter and van Deursen, Ruud and Tetko, Igor V and Godin, Guillaume (2019) GEN: Highly Efficient SMILES Explorer Using Autodidactic Generative Examination Networks. arXiv.


Faller, Bernard and Winiwarter, Susanne and Chang, George and Desai, Prashant and Menzel, Carsten and Rieko, Arimoto and Keefer, Christopher and Broccatelli, Fabio (2019) Prediction of fraction unbound in microsomal and hepatocyte incubations – a comparison of methods across industry data sets (by the IQ in silico ADME working group). Molecular pharmaceutics, 16 (9). pp. 4077-4085. ISSN 1543-8392; 1543-8384

Filipponi, Paolo and Guelat, Bertrand and Haber, Julien and Mostarda, Serena and O Meadhra, Ruairi and Piccioni, Lorenzo and Polenk, Jutta and Schenkel, Berthold and Schoenebeck, Silke and Streit, Alexander and Suremann, Roger and Venturoni, Francesco and Wegmann, Stefan (2019) Fouling of Flow Reactors in Organolithium Mediated Transformations: Experience on Scale-up and Proposed Solution. Chimia.

Flannery, Erika and Markus, Miles and Vaughan, Ashley (2019) Parasite of the Month: Plasmodium vivax. Trends in Parasitology.

Flannery, Erika and Vaughan, Ashley (2019) Parasite of the Month: Plasmodium vivax. Trends in Parasitology.

Fleming, Margaret and Grant, Sarah (2019) COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, 6 (5). pp. 384-399. ISSN 2372952X

Fukami, Shigemi and TOMIOKA, DAISAKU and Murakami, Yutaka and Honda, Toshiyuki and Hatakeyama, Shinji (2019) Pharmacological profiling of a dual FAK/IGF-1R kinase inhibitor TAE226 in cellular and in vivo models. BMC research notes, 12. p. 347. ISSN 1756-0500


Gallou, Fabrice (2019) Bridging the gap between transition metal and biocatalysis. Nature, 10. p. 2169.

Gallou, Fabrice (2019) C,N-Disubstituted Biarylpalladacycles as Pre-catalysts for ppm Level Cross Couplings in Water Under Mild Conditions. ACS Catalysis, 9 (12). pp. 11647-11657.

Gallou, Fabrice (2019) Coolade. A Low-Foaming Surfactant for Organic Synthesis in Water. ChemSusChem.

Gallou, Fabrice (2019) Fe-Catalyzed Reductive Couplings of Terminal (Hetero)Aryl Alkenes and Alkyl Halides under Aqueous Micellar Conditions. Journal of the American Chemical Society JACS., 141. pp. 17117-17124. ISSN

Gallou, Fabrice (2019) Reactivity of Carbenes in the Aqueous Micelles Containing Palladium Nanoparticles. ACS Catalysis, 9 (12). pp. 10963-10970.

Gallou, Fabrice (2019) Site selective amide reduction of cyclosporine A yields derivatives of an important cyclic peptide. organic letters, 21 (9). pp. 3451-3455.

Gallou, Fabrice (2019) Sustainability challenges in peptide synthesis and purification: from R&D to production. The journal of organic chemistry : JOC, 84 (8). pp. 4615-4628.

Gallou, Fabrice (2019) Sustainable ppm Level Palladium-Catalyzed Aminations Under Mild, Aqueous Nanomicellar Conditions. chemical science, 2019.

Gallou, Fabrice and Onken, Ulrich and Koettgen, Agnieszka and Scheidat, Holger (2019) Environmental metrics to drive a cultural change: our green eco-label. Chimia, 73 (9). pp. 730-736.

Gallou, Fabrice and Parmentier, Michael (2019) Interface-rich Aqueous Systems for Sustainable Chemical Synthesis. Chimia., 73 (9). pp. 714-719.

Gallou, Fabrice and Plummer, Scott (2019) Insights on Heterogeneous Bimetallic Micellar Nanocatalysis for Buchwald-Hartwig Aminations. ACS Catal, 9 (11). pp. 10389-10397.

Gallou, Fabrice and Reilly, John (2019) A micellar-friendly, HandaPhos palladacycle pre-catalyst for ppm level Suzuki-Miyaura cross couplings in water under mild conditions. Chemical science, 10. pp. 8825-8831. ISSN 2041-6539; 2041-6520

Garrison, Catherine and Guan, Wendy and Kato, Mitsunori and Tamsett, Thomas and Patel, Tej and Sun, Yishan and Pathak, Tejas (2019) SAR evaluation of wasp toxin -PMTX leads to analogs with superior efficacy for human neuronal sodium channels. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Gill, Jonathan and Delezie, Julien and McGuirk, Shawn and Schnyder, Svenia and Gesa, Santos and Frank, Stephan and Rausch, Martin and Handschin, Christoph (2019) PGC-1α regulates mitochondrial-sarcoplasmic reticulum (SR)-mediated calcium exchange, SR stress and cell death to mitigate skeletal muscle aging. Aging cell. ISSN 1474-9726; 1474-9718

Giorgetti, Elisa and Obrecht, Michael and Ronco, Marie and Panesar, Moh and Lambert, Christian and Accart Gris, Nathalie and Doelemeyer, Arno and Nash, Mark and Bidinosti, Michael and Beckmann, Nicolau (2019) Magnetization Transfer Ratio (MTR) as a Non-Invasive Biomarker in Small Rodent Peripheral Nerve Injury Models. Scientific reports, 9 (1). p. 13508. ISSN 2045-2322

Giorgetti, Elisa and Panesar, Moh and Zhang, Yunyu and Joller, Stefanie and Ronco, Marie and Obrecht, Michael and Lambert, Christian and Accart Gris, Nathalie and Beckmann, Nicolau and Doelemeyer, Arno and Perrot, Ludovic and Fruh, Isabelle and Mueller, Matthias and Pierrel, Eliane and Summermatter, Serge and Bidinosti, Michael and Shimshek, Derya and Lemire, Sophie and Nash, Mark (2019) Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. Cell reports, 29 (6). p. 1539. ISSN 22111247

Giorgetti, Elisa and Panesar, Moh and Zhang, Yunyu and Joller, Stefanie and Ronco, Marie and Obrecht, Michael and Lambert, Christian and Accart Gris, Nathalie and Beckmann, Nicolau and Doelemeyer, Arno and Perrot, Ludovic and Fruh, Isabelle and Mueller, Matthias and Pierrel, Eliane and Summermatter, Serge and Bidinosti, Michael and Shimshek, Derya and Lemire, Sophie and Nash, Mark (2019) Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. Cell Reports, 29 (6). 1539-1554.e7. ISSN 22111247

Glowienke, Susanne (2019) Genetic toxicology in silico protocol. Regulatory Toxicology and Pharmacology, 107. ISSN 10960295

Glowienke, Susanne and Parenty, Alexis (2019) Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses. Regulatory toxicology and pharmacology.

Glueck, Anton and Hueber, Wolfgang and Schlitt, Thomas and Hasselberg, Anke and Flannery, Brian and Wharton, Keith and Krueger, James and Suarez-Farinas, Mayte (2019) CAIN457A2223 12 week microarray data for upload to dbGaP. Journal of Allergy and Clinical Immunology.

Gobbi, Luca and Mercier, Joel and Bang-Andersen, Benny and Nicolas, Jean-Marie and Reilly, John and Wagner, Björn and Whitehead, David and Briard, Emmanuelle and Maguire, Ralf Paul and borroni, Edilio and Auberson, Yves (2019) A comparative study of in vitro assays for predicting the non-specific binding of PET imaging agents in vivo. ChemMedChem : chemistry enabling drug discovery, 15 (7). pp. 585-592. ISSN 1860-71791860-7187

Golding-Ochsenbein, Alexandra and Vidal, Solange and Wilmering Wetter, Barbara and Guibourdenche, Christel and Beerli, Christian and Chang, Lena and Leonhard, Sabine and Holway, Nicholas and Seuwen, Klaus and Jurisic Snijder, Giorgia (2019) S1P-S1PR1 activity controls VEGF-A signaling during lymphatic vessel development. bioRxiv. ISSN 10.1101/845396

Gomes, Luis and Hipp, Silvia and Upadhaya, Ajeet and Balakrishnan, Karthikeyan and Koper, Marta and Reichwald, Julia and Rabe, Sabine and Vandenberghe, Rik and von Arnim, Christine and Tousseyn, Thomas and Staufenbiel, Matthias and Thal, Dietmar Rudolf (2019) Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein. Acta Neuropathologica. ISSN 14320533

Gorovits, Boris and Palmer, Rachel and Milton, Mark (2019) 2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62). Bioanalysis, 11 (24). pp. 2207-2244. ISSN 17576199

Gram, Hermann (2019) The long and winding road in pharmaceutical development of canakinumab, a human anti-IL-1 antibody. Pharmacological Research.

Granger, Anne (2019) Postdoc program external website.

Greenidge, Paulette and Blommers, Marcel J.J. and Priestle, John Peter and Hunziker, Juerg (2019) How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for De Novo siRNA Guide Strand Surrogate Selection. Journal of chemical information and modeling, 59. pp. 1897-1908. ISSN 1549960X

Growcott, Ellena and Cariaga, Taryn and Morris, Laura and Zang, Richard and Lopez, Sara and Ansaldi, Dan and Gold, Josh and Gamboa, Luis and Roth, Theresa and Simmons, Bob and Osborne, Colin (2019) Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection. Journal of Antimicrobial Chemotherapy, 74 (1). pp. 108-116. ISSN 14602091

Gudmundsdottir , Valborg and Emilsson, Valur and Aspelund, Thor and Ilkov, Marjan and Gudmundsson, Elias F and Zilhao, Nuno and Lamb, John and Jennings, Lori and Gudnason, Vilmundur (2019) Deep serum proteomics reveals biomarkers for prevalent and incident T2DM. Nature communications.


Haffke, Matthias and Duckely, Myriam and Bergsdorf, Christian and Jaakola, Veli-Pekka and Shrestha, Binesh (2019) Development of a biochemical and biophysical suite for integral membrane protein targets: A review. Protein expression and purification. ISSN 10960279

Haffke, Matthias and Fehlmann, Dominique and Rummel, Gabriele and Boivineau, Jacques and Duckely, Myriam and Gommermann, Nina and Cotesta, Simona and Sirockin, Finton and Freuler, Felix and Littlewood-Evans, Amanda and Kaupmann, Klemens and Jaakola, Veli-Pekka (2019) Structural basis of species-selective antagonist binding to the succinate receptor. Nature, 574. pp. 581-585.

Haiser, Henry and Porter, Jeffrey and Reinker, Stefan (2019) Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4 (2). pp. 293-305. ISSN 20585276

Handa, Sachin and Gallou, Fabrice (2019) Organopolymer with dual chromophores and fast charge-transfer properties for sustainable photocatalysis. Nature Communications, 10 (1). pp. 1837-1841. ISSN 20411723

Hao, Huaixiang and Wang, Hongyun and Liu, Chen and Kovats, Steven and Velazquez, Roberto and Lu, Henry and Pant, Bhavesh and Shirley, Matthew and Meyer, Matthew and Pu, Minying and Lim, Joanne and Fleming, Michael and Alexander, Leigh Ann and Farsidjani, Alireza and LaMarche, Matthew and Moody, Susan and Silver-Brown, Serena and Caponigro, Giordano and Stuart, Darrin and Abrams, Tinya and Hammerman, Peter and Williams, Juliet and Engelman, Jeffrey and Goldoni, Silvia and Mohseni, Mori (2019) Tumor intrinsic efficacy by SHP2 and RTK inhibitors in KRAS mutant cancers. Molecular cancer therapeutics.

Hardman, Clare and Chen, Wentao and Luo, Jian and Batty, Paul and Chen, Li-Ying and Nahler, Janina and Wu, Yianqui and Erpenbeck, Veit and Sandham, David and Xue, Luzheng and Ogg, Graham (2019) Fevipiprant, a selective prostaglandin-D2 receptor-2 antagonist, inhibits human group-2 innate lymphoid cell aggregation and function. Journal of Allergy and Clinical Immunology. ISSN 00916749

Harris, Emily and Bova, Kaitlin (2019) Patient engagement throughout drug development: understanding the role of patients and best practices for engagement. SOCRA Source, 101. pp. 28-31.

Harrison, Tyler and Bauer, Daniel and Berdichevsky, Alina and Chen, Xin and Duvadie, Rohit and Gilmore, Thomas and Hoogheem, Benjamin and Hatsis, Panagiotis and Liu, Qian and Mao, Justin and Rajaraman, Vasumathy and Rocheford, Erik and Zecri, Frederic and Zessis, Richard and Zheng, Rui and Streeper, Ryan and Patel, Sejal and Zhu, Qingming (2019) Successful strategies for mitigation of a preclinical signal for phototoxicity in a dgat1 inhibitor. ACS Medicinal Chemistry Letters, 10 (8). pp. 1128-1133. ISSN 19485875

Hayashi, Takahiro and Ligibel, Mathieu and Sager, Emine and Schroer, Kirsten and Snajdrova, Radka and Buller, Rebecca and Hunziker, Juerg (2019) Evolved Aliphatic Halogenases Enable Regiocomplementary C-H Functionalization of an Added-Value Chemical. Angewandte Chemie (International ed. in English). ISSN 15213773

Heimbach, Tycho and Kesisoglou, Filippos and Suarez, Sharp and Kakhi, Maziar and Holmstock, Nico and Olivares-Morales, Andres and Pepin, Xavier and Sjögren, Erik and Tsakalozou, Eleftheria and Seo, Paul and Li, Min and Zhang, Xinyuan and Lin, Ho-Pi and Montague, Timothy and Mitra, Amitava and Morris, Denise and Patel, Nikunjkumar (2019) Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report. AAPS Journal, 21 (2). ISSN 15507416

Hernandez, Eloy and Zheng, Lianxing and Kim, Young and Fang, Bin and Valdez, Reginald and Dietrich, Bill and Rucker, Paul and Chianelli, Donatella and Schmeits, James and Bao, Dingjiu and Zoll, Jocelyn and Dubois, Claire and Federe, Glenn and Chen, Lihao and Joseph, Sean and Klickstein, Lloyd and Walker, John and Molteni, Valentina and McNamara, Peter and Meeusen, Shelly and Tully, David and Badman, Michael and Xu, Jie and Laffitte, Bryan (2019) Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With Antioxidative Gene Expression Profile in Rodents. Hepatology Communications, 3 (8). pp. 1085-1097. ISSN 2471-254X2471-254X

Hernandez, Eloy and Zheng, Lianxing and Kim, Young and Fang, Bin and Valdez, Reginald and Dietrich, Bill and Rucker, Paul and Chianelli, Donatella and Schmeits, James and Bao, Dingjiu and Zoll, Jocelyn and Dubois, Claire and Federe, Glenn and Chen, Lihao and Joseph, Sean and Klickstein, Lloyd and Walker, John and Molteni, Valentina and McNamara, Peter and Meeusen, Shelly and Tully, David and Badman, Michael and Xu, Jie and Laffitte, Bryan (2019) Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents. Hepatology Communications, 3 (8). pp. 1085-1097. ISSN 2471254X

Herrmann, Amanda C. and Im, Jin S. and Pareek, Sumedha and Ruiz-Vasquez, Wilfredo and Lu, Sijie and Sergeeva, Anna and Mehrens, Jennifer and He, Hong and Alatrash, Gheath and Sukhumalchandra, Pariya and St. John, Lisa and Clise-Dwyer, Karen and Zha, Dongxing and Molldrem, Jeffrey J. (2019) A Novel T-Cell Engaging Bi-specific Antibody Targeting the Leukemia Antigen PR1/HLA-A2. Frontiers in Immunology, 9. ISSN 1664-3224

Hijazi, Sara and Heistek, Tim S and Scheltens, Philip and Neumann, Ulf and Shimshek, Derya and Mansvelder, Huibert D and Smit, August D and van Kesteren, Ronald E (2019) Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease. Biological psychiatry.

Himmel, Herbert and Delaunois, Annie and Deurinck, Mark and Dinklo, Theo and Errikson-Fälkler, Therese and Habermann, Christoph and Heers, Cara and Hempel, Katja and Lorenz, Helga and Schauerte, Heike and Teuns, Greet and Traebert, Martin and van Amsterdam, Christoph and van der Linde, Henk (2019) Variability of non-clinical behavioral CNS safety assessment: An intercompany comparison. Journal of Pharmacological and Toxicological Methods. ISSN 1873488X

Ho, Julie and Peters, Thomas and Dickson, Brendan and Swanson, David and Fernandez, Anita and Frova-Seguin, Aurelie and Valentin, Marie-Anne and Schramm-Franz, Ursula and Sultan, Marc and Nielsen, Torsten and Demicco, Elizabeth (2019) Detection of CSF1 rearrangements deleting the 3′ UTR in tenosynovial giant cell tumors. Genes Chromosomes and Cancer. ISSN 10982264

Hoegenauer, Klemens and Kallen, Joerg and Jimenez-Nunez, Eloisa and Strang, Ross and Ertl, Peter and Cooke, Nigel Graham and Hintermann, Samuel and Voegtle, Markus and Betschart, Claudia and McKay, Daniel and Wagner, Juergen and Ottl, Johannes and Beerli, Christian and Billich, Andreas and Dawson King, Janet and Kaupmann, Klemens and Streiff, Markus and Gobeau, Nathalie and Harlfinger, Stephanie and Stringer, Rowan and Guntermann, Christine (2019) Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors. Journal of medicinal chemistry, 62 (23). pp. 10816-10832. ISSN 1520-4804; 0022-2623

Huang, Zhihong and Molteni, Valentina and Liu, Yahu and Hao, Xueshi and Baaten, Janine and Hill, Robert and Meeusen, Shelly and Zou, Yefen and Yan, Shanshan and Jia, Yong and Tremblay, Matthew and Wu, Tom Y.-H. and Ding, Qiang and Liu, Bo and Nguyen-Tran, Van and Shen, Weijun and Bhat, Ganesh and Glynne, Richard and Laffitte, Bryan and Jing, Li (2019) Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes. ACS Omega, 4. pp. 3571-3581.

Huck, Catherine and Leppert, David and Wegert, Vanessa and Schmid, Cindy and Dunn, Bob and Weckbecker, Gisbert and Smith, Paul (2019) Low-dose subcutaneous anti-CD20 treatment depletes disease relevant B-cell subsets and attenuates neuroinflammation. Journal of neuroimmune pharmacology., 14 (1557-1). pp. 1-11. ISSN 1557-1904; 1557-1890

Huth, Felix and Gardin, Anne and Umehara, Ken-Ichi and He, Handan (2019) Prediction of the impact of CYP2C9 genotypes on the drug-drug interaction potential of siponimod with PBPK modeling: a comprehensive approach for drug label recommendations. Clinical Pharmacology & Therapeutics, 106 (5). pp. 1113-1124. ISSN 0009-92361532-6535

Hyrina, Anastasia and Holdorf, Meghan and Jones, Christopher (2019) ZCCHC14 is a novel host factor that is required for Hepatitis B virus RNA polyadenylation. Cell reports, 29 (10). pp. 2970-2978. ISSN 2211-1247

Hyrina, Anastasia and Jones, Christopher and Chen, Darlene and Clarkson, Scott and Cochran, Nadire and Feucht, Paul and Hoffman, Greg and Lindeman, Alicia and Russ, Carsten and Sigoillot, Frederic and Tsang, Tiffany and Uehara, Kyoko and Xie, Lili and Ganem, Donald and Holdorf, Meghan (2019) A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Cell Reports, 29 (10). 2970-2978.e6. ISSN 22111247

Hyrina, Anastasia and Jones, Christopher and Chen, Darlene and Clarkson, Scott and Cochran, Nadire and Feucht, Paul and Hoffman, Greg and Lindeman, Alicia and Russ, Carsten and Sigoillot, Frederic and Uehara, Kyoko and Xie, Lili and Ganem, Donald and Holdorf, Meghan (2019) A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Cell Reports, 29 (10). 2970-2978.e6. ISSN 22111247

Hyrina, Anastasia and Jones, Christopher and Chen, Darlene and Clarkson, Scott and Cochran, Nadire and Feucht, Paul and Hoffman, Greg and Lindeman, Alicia and Russ, Carsten and Sigoillot, Frederic and Uehara, Kyoko and Xie, Lili and Holdorf, Meghan (2019) A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Cell Reports, 29 (10). 2970-2978.e6. ISSN 22111247


Ian, Harrow and Rana, Balakrishnan and Ernesto, Jimenez-Ruiz and Simon, Jupp and Jane, Lomax and Jane, Reed and Martin, Romacker and Christian, Senger and Splendiani, Andrea and Jabe, Wilson and Peter, Wollard (2019) Ontology mapping for semantically enabled applications. Drug Discovery Today. ISSN 18785832

Imenez Silva, Pedro H and Benabbas, Chahira and Chan, Kessara and Ludwig, Marie-Gabrielle and Gasser, Juerg Andreas and Arnett, Timothy and Bonny, Olivier and Seuwen, Klaus and Wagner, Carsten A. (2019) The H+-Activated Ovarian Cancer G Protein-Coupled Receptor 1 (OGR1) is responsible for Renal Calcium Loss during Acidosis. Kidney international. ISSN 1523-1755; 0085-2538

Isobe, Yosuke and Okumura, Mikiko and White, Ross and McGregor, Lynn and McKenna, Jeffrey and Tallarico, John and Schirle, Markus and Maimone, Thomas and Nomura, Daniel (2019) Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity. BioRXiv.

Iyer, Shwetha and Malyala, Padma (2019) Long-Acting Intraocular Delivery Strategies for Biological Therapy of Age-Related Macular Degeneration- A Review Article. Journal of controlled release.


JENSEN, Poul Erik Hyldgaard and Warnke, Clemens and Ingenhoven, Kathleen and Piccoli, Luca and Gasis, Marcia and Hermanrud, Christina and Fernandez-Rodriguez, Blanca and Ryner, Malin and Kramer, Daniel and Link, Jenny and Ramanujam, Ryan and Auer, Michael and Buck, Dorothea and Grummel, Verena and Bertotti, Elisa and Fissolo, Nicolas and Oliver-Martos, Begoña and Nytrova, Petra and Khalil, Michael and Guger, Michael and Rathmaier, Sandra and Sievers, Claudia and Lindberg, Raija and Hässler, Signe and Bachelet, Delphine and Aktas, Orhan and Donnellan, Naoimh and Lawton, Andy and Hemmer, Bernhard and Havrdova, Eva Kubala and Kieseier, Bernd and Hartung, Hans-Peter and Comabella, Manuel and Montalban, Xavier and Derfuss, Tobias and Sellebjerg, Finn and Dönnes, Pierre and Pallardy, Marc and Spindeldreher, Sebastian and Broët, Philippe and Deisenhammer, Florian and Fogdell-Hahn, Anna and Sorensen, Per Soelberg (2019) Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study. Journal of neuroimmunology, 326. pp. 19-27. ISSN 01655728

Jackson, Samual J and Authier, Simon and Brohmann, Henning and Goody, Susan MG and Jones, David and Prior, Helen and Rosch, Anke and Traebert, Martin and Tse, Karen and Valentin, Jean Pierre and Milne, Aileen (2019) Neurofunctional test batteries in safety pharmacology – Current and emerging considerations for the drug development process. Journal of pharmacological and toxicological methods, 100. ISSN 10568719

Jansen, Hanneke and De Pascale, Gianfranco and Lindvall, Mika and Moser, Heinz and Pfister, Keith and Wartchow, Charles and Fong, Susan and Warne, Bob (2019) Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns. Journal of chemical information and modeling, 59 (5). pp. 1709-1714. ISSN 1549960X

Jaskelioff, Mariela (2019) Postdoc Mentor Profile.

Jensen, Michael Rugaard and Cadapa Prahallad, Anirudh and Chapeau, Emilie (2019) Deciphering mechanisms of response and resistance in large-scale mouse cancer screens. Current Opinion in Genetics and Development, 54. pp. 48-54. ISSN 18790380

Jenul, Christian and Sieber, Simon and Daeppen, Christophe and Lardi, Martina and Pessi, Gabriela and Hoepfner, Dominic and Neuburger, Markus and Linden, Anthony and Gademann, Karl and Eberl, Leo (2019) Biosynthesis of fragin is controlled by a novel quorum sensing signal. Nature communications. ISSN 2041-1723

Jimenez, Jose and Sabbadin, Davide and Cuzzolin, Alberto and Martinez-Rosell, Gerard and Gora, Jacob and Manchester, John and Duca, Jose and DeFabritiis, Gianni (2019) PathwayMap: Molecular Pathway Association with Self-Normalizing Neural Networks. Journal of chemical information and modeling, 59 (3). pp. 1172-1181. ISSN 1549960X

John, Wise and Ian, Harrow and Rafael, Jimenez and Eric, Little and Kees, van Bochove and Gaspare, Mellino and Victoria, Hedley and Splendiani, Andrea and Alexandra, Grebe de Barron and Peter, Walgemond and Vibhor, Gupta and Jan, Taubert and Tom, Plasterer and Rainer, Winnenberg and Beeta, Balali-Mood and Drashiti, Vasant and Ian, Smith (2019) Implementation and Relevance of FAIR Data Principles in Biopharmaceutical Research and Development. Drug discovery today. ISSN 13596446

Joseph, Giselle and Shavlakadze, Tea and Glass, David and Wang, Sharon and Zhou, Weihua and Tse, Herman and Jacobs, Cody and Eash, John and Kimble, Garrett (2019) Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia. Molecular and Cellular Biology, 39 (19). ISSN 10985549

Jourdain, Marie and Hatakeyama, Shinji (2019) A novel tissue-selective β2-adrenoceptor agonist with minimized cardiovascular effects, 5-HOB, attenuates neuropathic pain in mice. BMC research notes, 12. ISSN 1756-0500

Jumani, Rajiv Satish and Spector, Jonathan and Diagana, Thierry and Manjunatha, Ujjini and Rasa, Izadnegahdar and Paul, Kelly (2019) Innovations in addressing pediatric diarrhea in low resource settings. ACS infectious diseases. ISSN 23738227

Juras, Vladimir and Schreiner, Markus and Laurent, Didier and Zbýň, Štefan and Mlynarik, Vladimir and Szomolanyi, Pavol and Hager, Benedikt and Scotti, Celeste and Goldhahn, Jörg and Heule, Rahel and Bieri, Oliver and Trattnig, Siegfried (2019) The comparison of the performance of 3 T and 7 T T mapping for untreated low-grade cartilage lesions. Magnetic resonance imaging, 55. pp. 86-92. ISSN 1873-5894


Kallen, Joerg and Izaac, Aude and Chau, Suzanne and Wirth, Emmanuelle and Schoepfer, Joseph and Mah, Robert and Schlapbach, Achim and Stutz, Stefan and Vaupel, Andrea and Guagnano, Vito and Masuya, Keiichi and Stachyra, Therese-Marie and Salem, Bahaa and Chene, Patrick and Gessier, Francois and Holzer, Philipp and Furet, Pascal (2019) Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes. ChemMedChem, 14 (14). pp. 1305-1314. ISSN DOI: 10.1002/cmdc.201900201

Kane, Joshua and Fong, Susan and Shaul, Jacob and Frommlet, Alexandra and Frank, Andreas and Knapp, Mark and Bussiere, Dirksen and Kim, Peter and Ornelas, Elizabeth and Ceullar, Carlos and Abend, Johanna and Wartchow, Charles (2019) A VP2/3-derived peptide exhibits potent antiviral activity against BK and JC polyomaviruses by targeting a novel VP1 binding site. bioRxiv.

Karki, Rajeshri and Powers, James and Mainolfi, Nello and Anderson, Karen and Belanger, David and Liu, Donglei and Ji, Nan and Jendza, Keith and Gelin, Christine and Solovay, Catherine and Sweeney, Aengus and Delgado, Omar and Crowley, Maura and Liao, Sha-Mei and Argikar, Upendra and Flohr, Stefanie and La Bonte, Laura and Lorthiois, Edwige and Vulpetti, Anna and Cumin, Frederic and Brown, Ann and Adams, Christopher and Jaffee, Bruce and Mogi, Muneto (2019) Design, synthesis and pre-clinical characterization of selective Factor D inhibitors targeting the alternative complement pathway. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Karpov, Alexei and Nieto-Oberhuber, Cristina and Grotzfeld, Robert and Abrams, Tinya and Beng-Louka, Edwige and Chamoin, Sylvie and Chene, Patrick and Clark, Suzy and Dacquignies, Isabelle and Doumampouom Metoul, Lionel and Furegati, Markus and Granda, Brian and Joly, Emilie and Jones, Darryl and Lacaud-Baumlin, Marion and Guerro-Lagasse, Stephanie and Lorenzana, Edward and Martyniuk, Piotr and Marzinzik, Andreas and Mesrouze, Yannick and Nocito, Sandro and Oei, Yoko and Perruccio, Francesca and Richard, Etienne and Schindler, Patrick and Velay, Melanie and Venstrom, Kristine and Lafrance, Marc and Blanco, Enrique and Daniel, Dylan and Dillon, Michael and Drosos, Nikolaos and Fedoseev, Pavel and Mallet, William and Piizzi, Grazia and Wang, Peiyin and Zurini, Mauro and Rudewicz, Patrick (2019) Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

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Roth, Hans-Joerg and Fouche, Marianne and Blatter, Markus and Witek, Jagna and Wang, Shuzhe and Lingwood, Robin and Dounas, Andreas and Lemke, Oliver and Keller, Bettina and Riniker, Sereina (2019) Rationalization of the Membrane Permeability Differences in a Series of Analogue Cyclic Decapeptides. Journal of chemical information and modeling, 59 (1). pp. 294-308. ISSN 1549960X

Ruggiu, Fiorella and Yang, Shengtian and Robert, Simmons and Anthony, Casarez and Adriana, Jones and Cindy, Li and Jansen, Hanneke and Moser, Heinz and Charles, Dean and Folkert, Reck and Lindvall, Mika (2019) Size matters – and how you measure it: a gram-negative antibacterial example exceeding typical molecular weight limits. ACS Infectious Diseases. ISSN 2373-82272373-8227

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SATO, MASAHIKO and MORIYA, ATSUKO (2019) Phase I study of BGT226, a pan-PI3K and mTOR inhibitor, in Japanese patients with advanced solid cancers. Cancer Chemotherapy and Pharmacology, 84 (2). pp. 337-343. ISSN 14320843

Sacher, Christian and Blume, Tanja and Beyer, Leonie and Peters, Finn and Eckenweber, Floria and Sgobio, Carmelo and Deussing, Maximilian and Albert, Nathalie and Unterrainer, Marcus and Lindner, Simon and Gildehaus, Franz-Joseph and von Ungern-Sternberg, Barbara and Brzak, Irena and Neumann, Ulf and Saito, Takashi and Saido, Takomi and Bartenstein, Peter and Rominger, Axel and Herms, Jochen and Brendel, Matthias (2019) Longitudinal in vivo PET assessment of cerebral β-Amyloid deposition and glial activation in knock-in mice non-overexpressing β-Amyloid precursor protein. Journal of nuclear medicine : JNM, 58 (2). ISSN 1535-5667; 0161-5505

Sager, Maximilian and Grimm, Michael and Jedamzik, Philipp and Merdivan, Simon and Kromrey, Marie-Luise and Hasan, Mahmoud and Koziolek, Mirko and Tzvetkov, Mladen V. and Weitschies, Werner (2019) Validation of the salivary tracer technique for the determination of the in vivo disintegration of hard gelatin capsules. Molecular Pharmaceutics. ISSN 1543-83841543-8392

Salazar, Valerie S and Capelo, Luciane P and Cantù, Claudio and Zimmerli, Dario and Gosalia, Nehal and Pregizer, Steven and Cox, Karen and Ohte, Satoshi and Feigenson, Marina and Gamer, Laura and Nyman, Jeffry S and Carey, David J and Economides, Aris and Basler, Konrad and Rosen, Vicki (2019) Reactivation of a developmental signaling center is required for therapeutic control of the murine periosteal niche. eLife, 8. ISSN 2050-084X

Sanderlin, Edward J. and Marie, Mona and Velcicky, Juraj and Loetscher, Pius and Yang, Li V. (2019) Pharmacological Inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model. European journal of pharmacology, 852. pp. 218-230. ISSN 00142999

Santa Maria, John (2019) Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space. SLAS Discovery. p. 2472555219885373. ISSN 2472-5560

Sarver, Patrick and Acker, Michael and Bagdanoff, Jeffrey and Chen, Zhuoliang and Chen, Ying-Nan and Chan, Ho Man and Firestone, Brant and Fodor, Michelle and Garcia Fortanet, Jorge and Hao, Huaixiang and Hentemann, Martin and Kato, Mitsunori and Koenig, Robert and La Bonte, Laura and Liu, Gang and Liu, Shumei and Liu, Chen and McNeill, Eric and Mohseni, Mori and Sendzik, Martin and Stams, Travis and Spence, Stan and Tamez Jr., Victoriano and Tichkule, Ritesh and Towler, Christopher and Wang, Hongyun and Wang, Ping and Williams, Sarah and Yu, Bing (2019) 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. Journal of Medicinal Chemistry, 62 (4). pp. 1793-1802. ISSN 15204804

Saunders, Ruth and Kaul, Himanshu and Berair, Rachid and Gonem, Sherif and Singapuri, Amisha and Sutcliffe, Amanda and Latifa, Chachi and Biddle, Michael and Kaur, Davinder and Bourne, Michelle and Pavord, Ian and Wardlaw, Andrew and Siddiqui, Salman and Brook, Bindi and Smallwood, Rod and Brightling, Christopher (2019) Prostaglandin D2 type 2 receptor antagonism reduces airway smooth muscle mass in asthma: mechanistic insights from in vitro and computational models. Science Translational Medicine, 11 (479). ISSN 1946-62341946-6242

Schelle, Juliane and Wegenast-Braun, Bettina and Fritschi, Sarah and Kaeser, Stephan A and Häsler, Lisa M and Wolfer, David and Mueggler, Thomas and Shimshek, Derya and Neumann, Ulf and Dodt, Hans-Ulrich and Staufenbiel, Matthias and Jucker, Mathias (2019) Aβ reduction at early disease stages prevents progression of cerebral amyloid angiopathy in a mouse model of hereditary cerebral hemorrhage with amyloidosis - Dutch type. Annals of Neurology. ISSN 0364-51341531-8249

Schoeberl, Birgit (2019) Quantitative Systems Pharmacology models as a key to translational medicine. Current Opinion in Systems Biology, 16. pp. 25-31. ISSN 24523100

Schubart Wellensiek, Anna (2019) The next-generation sphingosine 1 receptor modulator BAF312 (siponimod) improves cortical network functionality in autoimmune neurodegeneration. Neural Regeneration Research, 14 (11). pp. 1950-1960. ISSN doi: 10.4103/1673-5374.259622

Schubart Wellensiek, Anna and Anderson, Karen and Mainolfi, Nello and Sellner, Holger and ehara, Takeru and Adams, Christopher and Mac Sweeney, Aengus and Liao, Sha-Mei and Crawley, Maura and Littlewood-Evans, Amanda and Sarret, Sophie and Wieczorek, Grazyna and Perrot, Ludovic and Dubost, Valerie and Flandre, Thierry and Zhang, Yuzhou and Smith, Richard and Risitano, Antonio and Karki, Rajeshri and Zhang, Chun and Valeur, Eric and Sirockin, Finton and Gerhartz, Bernd and Erbel, Paulus and Aubin, Nicola and Smith, Thomas and Cumin, Frederic and Argikar, Upendra and Haraldsson, Boerje and Mogi, Muneto and Sedrani, Richard and Wiesmann, Christian and Jaffee, Bruce and Maibaum, Juergen Klaus and Flohr, Stefanie and Harrison, Richard (2019) Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proceedings of the National Academy of Sciences of the United States of America, 116 (16). pp. 7926-7931. ISSN 10916490

Schuepp, Patrick (2019) Green Chemistry Benchmarking and improvement proposals for the CHAD Green Chemistry Scorecard Process. MS Thesis from UZH.

Schwizer, Natascha (2019) Stereo-controlled lithiation-methylation and subsequent aminolysis of a chiral epoxide in continuous flow. Masters Thesis for the University of Applied Sciences NW-Switzerland.

Sedrani, Richard and Cottens, Sylvain and Schuler, Walter and Kallen, Jörg (2019) Derivation of Rapamycin: Adventures in Natural Product Chemistry. Chimia., 73 (7). pp. 581-590. ISSN 0009-4293

Shukui, Qin and Stephen, Lam Chan and Wattana, Sukeepaisarnjaroen and Guohong, Han and Su Pin , Choo and Virote , Sriuranpong and Hongming, Pan and Thomas , Yau and Yabing , Guo and Minshan , Chen and Zhenggang, Ren and Jianming, Xu and Chia-Jui , Yen and Zhong-Zhe , Lin and Gu, Gary and Sun, Yongjian and Tiedt, Ralph and Hao, Lu and Song, Vicky and Tanwandee, Tawesak and Manenti, Luigi (2019) A Phase II Study of the Efficacy and Safety of the MET Inhibitor Capmatinib (INC280) in Patients with Advanced Hepatocellular Carcinoma. Therapeutic Advances in Medical Oncology, 11 (2019 D). ISSN 1758-83591758-8359

Shultz, Michael (2019) Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs. Journal of Medicinal Chemistry, 62 (4). pp. 1701-1714. ISSN 15204804

Shutinoski, Bojan and Hakimi, Mansoureh and Harmsen, Irene and Lunn, Michaela and Rocha, Juliana and Lengacher, Nathalie and Zhou, Yi Yuan and Khan, Jasmine and Nguyen, Angela and Hage-Volling, Quinton and El-Kodsi, Daniel and Li, Juan and Alikashani, Azadeh and Beauchamp, Claudine and Majithia, Jay and Coombs, Kevin and Marcogliese, Paul C. and Park, David S. and Rioux, John D. and Philpott, Dana and Woulfe, John M. and Hayley, Shawn and Sad, Subash and Tomlinson, Julianna J. and Brown, Earl G. and Schlossmacher, Michael G. (2019) Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner. Science Translational Medicine, 11 (511). ISSN 1946-62341946-6242

Sijbesma, Eline and Hallenbeck, Kenneth and Leysen, Seppe and de Vink, Pim and Jahnke, Wolfgang and Brunsveld, Luc and Arkin, Michelle and Ottmann, Christian (2019) Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society, 141 (8). pp. 3524-3531. ISSN 15205126

Singh, Ajeet and Sosa, Maria and Fang, Jian and Shanmukhappa, Shiva and Hubaud, Alexis and Fawcett, Caroline and Molind, Gregory and Tsai, Ting and Capodieci, Paola and Wetzel, Kristie and Sanchez, Ellen and Wang, Guangliang and Coble, Matthew and Tang, Wenlong and Cadena, Samuel and Fishman, Mark and Glass, David (2019) α-Klotho regulates age-associated vascular mineralization and lifespan in zebrafish. Cell reports, 28 (11). pp. 2767-2776. ISSN 22111247

Singh, Nathan and Xu, Jun and Binder, Zev and Collins, McKensie and O'Rourke, Donald and Melenhorst, J. Joseph (2019) Mechanisms of resistance to CAR T cell therapies. Seminars in cancer biology. ISSN 1044579X

Smith, Brian (2019) Where Will Statistical Sciences for Clinical Pharmacology Be in 2030? Clinical Pharmacology & Therapeutics, 107 (1). pp. 17-21. ISSN 0009-92361532-6535

Spiegel, Stephan and Hossain, Imtiaz and Ball, Christopher and Zhang, Xian (2019) Metadata-Guided Visual Representation Learning for Biomedical Images. BioRxiv.

Spradlin, Jessica N. and Hu, Xirui and Ward, Carl C. and Brittain, Scott and Jones, Michael and Ou, Lisha and To, Milton and Proudfoot, Andrew and Ornelas, Elizabeth and Woldegiorgis, Mikias and Olzmann, James A. and Bussiere, Dirksen and Thomas, Jason and Tallarico, John and McKenna, Jeffrey and Schirle, Markus and Maimone, Thomas J. and Nomura, Daniel K. (2019) Harnessing the anti-cancer natural product nimbolide for targeted protein degradation. Nature Chemical Biology, 15 (7). pp. 747-755. ISSN 15524469

Stauffer, Frederic and Weiss, Andreas and Scheufler, Clemens and Moebitz, Henrik and Ragot, Christian and Beyer, Kim and Calkins, Keith and Guthy, Daniel Alexander and Kiffe, Michael and Van Eerdenbrugh, Bernard and Tiedt, Ralph and Gaul, Christoph (2019) New potent DOT1L inhibitors for in vivo evaluation in mouse. ACS medicinal chemistry letters.

Studer, Christian and Hoepfner, Dominic and Roggo, Silvio and Helliwell, Stephen and Snyder, Nathan and Kim, Adam and Kester, Louis and Gale, Andrew and Cunningham, Kyle (2019) Auxin-inducible depletion of the essentialome suggests inhibition of TORC1 by auxins and inhibition of Vrg4 by SDZ 90-215, a natural antifungal cyclopeptide. G3: Genes, Genomes, Genetics, 9 (3). pp. 829-840. ISSN 21601836


Takase, Ryuta and Hino, Shinjiro and Nagaoka, Katsuya and Anan, Kotaro and Kohrogi, Kensaku and Araki, Hirotaka and Sakamoto, Akihisa and Nicholson, Thomas and Chen, Taiping and Nakao, Mitsuyoshi (2019) Lysine-specific demethylase-2 is distinctively involved in brown and beige adipogenic differentiation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (4). pp. 5300-5311. ISSN 15306860

Tan, Mario A. and Zueger, Patrik and Roggo, Silvio (2019) Total synthesis of diaportheone A. Tetrahedron Letters, 60 (1). pp. 52-54. ISSN 18733581

Tang, Cong and Ksiazek, Iwona and Siccardi, Noemie and Gapp, Berangere and Weber, Delphine and Wirsching, Johann and Beck, Valerie and Reist, Matthias and Gaudet, Laurent and Beibel, Martin and Roma, Guglielmo and Gubser Keller, Caroline and Bassilana, Frederic (2019) UTS2B defines a novel enteroendocrine cell population and regulates GLP-1 secretion through SSTR5 in male mice. Endocrinology. ISSN 1945-7170

Tang, Wenlong and Fulk, George and Zeigler, Stacey and Zhang, Ting and Sazonov , Edward (2019) Estimating Berg Balance Scale and Mini Balance Evaluation System Test Scores by Using Wearable Shoe Sensors. Engineering in Medicine and Biology Society, Annual international confrerence of the IEEE.

Tarselli, Mike and Potier, Yohann and Fletcher, Allan (2019) Automating Automation – How Close are We to Artificial Intelligence Impact? Drug Discovery World -

Tatrai, Peter and Schweigler, Patrick and Poller, Birk and Domange, Norbert and Hanna, Imad and Gaborik, Zsuzsanna and Huth, Felix (2019) A systematic in vitro investigation of the inhibitor preincubation effect on multiple classes of uptake transporters. Drug Metabolism and Disposition. ISSN 1521-009X

Thakare, Vivek and Mayr, Bettina and Artenjak, Andrej and Nianios, Dimitrios and Sest, Maike and Müller, Martin and Maltsev, Oleg V and Nowicki, Kajetan and Mischo, Andre and Ehrenstrasser, Christian and Fink, Matthias and Thanhaeuser, Silvia and Cerreti, Alessandra (2019) Investigation of drug product and container-closure interactions: A case study of diluent containing prefilled syringe. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 140. pp. 67-77. ISSN 1873-3441

Thangavelu, Govindarajan and Du, Jing and Paz, Katelyn and Loschi, Michael and Flynn, Ryan and Taylor, Patricia and Kirchmeier, Andrew and Zaiken, Micheal and Panoskaltsis-Mortari, Angela and Luznik, Leo and MacDonald, Kelli and Hill, Geoffrey and Maillard, Ivan and Munn, David and Serody, Jonathan and Murphy, William and Miklos, David and Cutler, Corey and Koreth, John and Antin, Joseph and Soiffer, Robert and Ritz, Jerome and Dahlberg-Bohl, Carol and Miller, Andrew and Blazar, Bruce (2019) Inhibition of Inositol kinase B controls acute and chronic graft-versus-host disease. Blood. ISSN 15280020

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Tlili, Anis and Ghiazza, Clement and Thierry, Billard (2019) Chalcogen OCF3-isosteres Modulate Drug Properties without Introducing Inherent Liabilities. ChemMedChem : chemistry enabling drug discovery, 14 (17). pp. 1586-1589. ISSN 1860-71791860-7187

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Troxler, Thomas J. and Feuerbach, Dominik and Zhang, Xuechun and Yang, Charles and Lagu, Bharat and Perrone, Mark and Wang, Tie-Lin and Briner, Karin and bock, Mark and Auberson, Yves (2019) The discovery of LML134, a histamine H3 receptor inverse agonist for the clinical treatment of excessive sleep disorders. ChemMedChem. ISSN 18607187

Tulli, Ludovico and Pintassilgo Miranda, Daniela and Lee, Cameron and Sullivan, Yang and Grotzfeld, Robert and Hollingworth, Greg and Kneuer, Rainer and Karpov, Alexei (2019) Modular synthesis and post-modification of novel bifunctional dendrons. Organic and biomolecular chemistry. ISSN 1477-0539; 1477-0520

Turner, Oliver and Janardhan, Kyathanahalli and Kohnken, Rebecca and Channabasavaiah, Gurumurthy and Kovi, Ramesh (2019) Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future. Toxicologic Pathology, 47 (8). pp. 1082-1087. ISSN 15331601

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Turner, Patricia V and Pang, Daniel Sj and Lofgren, Jennifer Ls (2019) A Review of Pain Assessment Methods in Laboratory Rodents. Comparative medicine, 69 (6). pp. 451-467. ISSN 1532-0820


Uluckan, Ozge and Roediger, Ben (2019) Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1. Cell Reports, 29 (4). 844-859.e3. ISSN 22111247

Umehara, Ken-Ichi and Huth, Felix and Schiller, Hilmar and Jin, Yi and Aslanis, Vassilios and Heimbach, Tycho and He, Handan (2019) Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions. Drug Metabolism and Personalized Therapy, 34 (2). ISSN 23638915

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Vilgelm, Anna E. and Saleh, Nabil and Riemenschneider, Kelsie and Slesur, Lauren and Chen, Sheau-Chian and Johnston, C. Andrew and Yang, Jinming and Johnson, Douglas B. and Al-rohil, Rami Nayef and Halilovic, Ensar and Kauffmann, Rondi M. and Hooks, Mary and Kelley, Mark and Ayers, Gregory D. and Richmond, Ann (2019) MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21. Science Translational Medicine, 11 (505). ISSN 19466242

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Vorherr, Thomas and Lewis, Ian and Schaefer, Michael (2019) Late-stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents. Angewandte Chemie, 58. pp. 1-5.

Voshol, Johannes and Trojer, Dominic and Corso, Guilia and Heusermann, Wolf and Görgens, Andre and Steib, Emmanuelle and Graff, Alexandra and Genoud, Christel and Lee, Yi and Hean, Justin and Nordin, Joel and Wiklander, Oskar and El Andaloussi, Samir and Meisner-Kober, Nicole (2019) Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging. Journal of Extracellular Vesicles, 8 (1). ISSN 2001-3078

van Keulen, Danielle and Pouwer, Marianne G. and Emilsson, Valur and Aldi, Silvia and Perisic Matic, Ljubica and Hedin, Ulf and Gudnason, Vilmundur and Jennings, Lori and Holstrom, Kim and Schnack Nielson, Boye and Pasterkamp, Gerard and Lindeman, Jan H.N. and van Gool, Alain J. and Sollewijn Gelpke, Maarten D. and Princen, Hans M.G. and Tempel, Dennie (2019) Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humans. PLoS ONE, 14 (8). pp. 1-22. ISSN 19326203

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Wang, Yang and Zhong, Yang and Zhou, Yingyao and Tanaseichuk, Olga and Wilkinson, Jeremy and Li, Zhizhong and Zhao, Jing Crystal (2019) Identification of a Xist silencing domain 1 by Tiling CRISPR. Scientific Reports.

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Weckbecker, Gisbert and Kneuer, Rainer and Migotto, Mary-Anne and Mardon, Karine and Orian, Jacqueline and Bhalla, Rajiv and Reutens, David C. (2019) Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice. Frontiers in Immunology, 10. ISSN 16643224

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Withers, Nikki and Mellman, James (2019) European Pharmaceutical Review James Mellman. European pharmaceutical review : The quarterly review of pharmaceutical business & technology.. ISSN 1360-8608

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Wyss, Annika and Rasseli, Tina and Perkins, Nathan and Ruiz, Florian and Schmelczer, Gerard and Klinke, Glynis and Moncsek, Anja and Roth, Rene and Spalinger, Marianne and Hering, Larissa and Atrott, Kirstin and Lang, Silvia and Frey-Wagner, Isabelle and Mertens, Joachim and Scharl, Michael and Sailer, Andreas and Pabst, Oliver and Hersberger, Martin and Pot, Caroline and Rogler, Gerhard and Misselwitz, Benjamin (2019) The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis. Mucosal immunology. ISSN 1935-3456

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Yamaura, Takeshi and Kasaoka, Tatsuhiko and KANEKO, NAOKO and Kimura, Masaaki and Hatakeyama, Shinji (2019) Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis. BMC research notes, 12. p. 200. ISSN 1756-0500

Yeyinmen, Karen and Stacey, Mary (2019) Team Coaching at Scale: Creating conditions for the emergence of adaptive leadership cultures. The Practitioner's Handbook of Team Coaching. pp. 405-419. ISSN 978-1-351-13055-4


Zerbi, Valerio and Markicevic, Marija and Gasparini, Fabrizio and Rudin, Markus and Wenderoth, Nicole (2019) Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice. NeuroImage, 191. pp. 392-402. ISSN 10959572

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This list was generated on Mon Nov 30 21:52:31 2020 UTC.


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