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Mechanisms of resistance to CAR T cell therapies

Singh, Nathan and Xu, Jun and Binder, Zev and Collins, McKensie and O'Rourke, Donald and Melenhorst, J. Joseph (2019) Mechanisms of resistance to CAR T cell therapies. Seminars in cancer biology. ISSN 1044579X

Abstract

Chimeric antigen receptor (CAR)-engineered T cells have demonstrated remarkable success in the treatment of B cell malignancies. FDA approval of these therapies represents a watershed moment in the development of therapies for cancer. Despite the successes of the last decade, many patients will unfortunately not experience durable responses to CAR therapy. Emerging research has shed light on the biology responsible for these failures, and further highlighted the hurdles to broader success. Here, we review the recent research identifying how interactions between cancer cells and engineered immune cells result in resistance to CAR therapies.

Item Type: Article
Date Deposited: 14 Apr 2020 00:45
Last Modified: 14 Apr 2020 00:45
URI: https://oak.novartis.com/id/eprint/41329

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