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The dark side of fluorine

Pan, Yue (2019) The dark side of fluorine. ACS Medicinal Chemistry Letters. pp. 1016-1019. ISSN 19485875


Despite the perceived stability of the C-F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists' attention.

Item Type: Article
Keywords: CYP TDI defluorination Fluorine reactive metabolite
Date Deposited: 27 Aug 2019 00:45
Last Modified: 27 Aug 2019 00:45


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