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5,5- and 5,5-Membered Spirocyclic Indoline-pyrrolidinone Hit Finding Libraries

Meier, Peter and Battaglia, Nicole and Ertl, Peter and Pirard, Bernard (2019) 5,5- and 5,5-Membered Spirocyclic Indoline-pyrrolidinone Hit Finding Libraries. ACS Combinatorial Science, 21 (7). pp. 528-536. ISSN 2156-89522156-8944

Abstract

The production of two libraries based on spirocyclic indolinepyrrolidinones is described. These libraries were selected from numerous spirocyclic indolinepyrrolidinone scaffolds by following the library evaluation procedure we introduced in 2005, based on virtual values as well as on measured properties of prototype compounds. The library production yielded in 176 and 428 compounds respectively, which could be isolated in sufficient amounts and purities.

Item Type: Article
Keywords: spirocyclic compounds, combinatorial chemistry, hit finding libraries
Date Deposited: 01 Aug 2019 00:45
Last Modified: 01 Aug 2019 00:45
URI: https://oak.novartis.com/id/eprint/38740

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