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One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2–Sp3 Cross-Coupling

Koyanagi, Takaoki and Loren, Jon and Herath, Ananda and Chong, Ashley and Ratnikov, Max and Valiere, Andrew and Chang, Jim and Molteni, Valentina (2019) One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2–Sp3 Cross-Coupling. Organic Letters, 21 (3). pp. 816-820. ISSN 1523-70601523-7052

Abstract

A one-pot electrochemical nickel-catalyzed decarboxylative sp2–sp3 cross-coupling reaction has been developed using redox-active esters prepared in situ from alkyl carboxylates and N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (PITU). This undivided cell one-pot method enables C–C bond formation using inexpensive, benchtop-stable reagents with isolated yields up to 95% with good functional group tolerance, which includes nitrile, ketone, ester, alkene and selectivity over other aromatic halogens.

Item Type: Article
Date Deposited: 16 Feb 2019 00:45
Last Modified: 16 Feb 2019 00:45
URI: https://oak.novartis.com/id/eprint/38541

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