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Bridging the gap between transition metal and biocatalysis

Gallou, Fabrice (2019) Bridging the gap between transition metal and biocatalysis. Nature, 10. p. 2169.


In our quest to attain synergistic processes involving chemo- and bio-catalysis, it has been discovered that aqueous solutions containing 2 wt % of the designer surfactant TPGS-750-M not only is compatible with enzymes, but also enhances their activity. Indeed, the lipophilic core of the micelles is suspected to act as a reservoir for substrates/products, avoiding noncompetitive inhibition of the enzyme. Numerous examples of cross-coupling reactions followed by asymmetric ketone reductions mediated by alcohol dehydrogenases (ADH) are reported, all run in 1-pot under mild conditions. Various transition metal catalysts based on Pd, Cu, Rh, and Au proved to be innocuous towards enzymatic activity, making this process suitable for a broad range of tandem organic transformations.

Item Type: Article
Date Deposited: 16 Jul 2019 00:45
Last Modified: 16 Jul 2019 00:45


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