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Natural product drug delivery: A special challenge?

Press, Neil and Joly, Emilie and Ertl, Peter (2019) Natural product drug delivery: A special challenge? Progress in Medicinal Chemistry, 58. pp. 157-187. ISSN 18757863

Abstract

Natural products have a long-standing and critical role in drug development and medical use. The structural and physicochemical properties of natural products, while derived evolutionarily to be effective in living systems, may create challenges in translation to a pharmaceutical product. Molecular complexity, low solubility, functional group reactivity and general instability are among the challenges that typically need to be overcome. This review looks at some of the ways that natural products have been formulated and delivered to enable the successful application of these vitally important medicines to patients.

Item Type: Article
Keywords: Drug delivery Drug development Formulation Natural products Solubility
Date Deposited: 29 Mar 2019 00:45
Last Modified: 29 Mar 2019 00:45
URI: https://oak.novartis.com/id/eprint/37316

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