Accart Gris, Nathalie and Genoud, Christel (2019) Un premier pas vers l’étude du collagène du cartilage articulaire en microscopie électronique. Revue Française d'Histotechnologie, 31 (1). pp. 85-92. ISSN 0997-6434

Adams, Christopher, Stacy, Rebecca, Rangaswamy, Nalini, Bigelow, Chad, Grosskreutz, Cyndy and Prasanna, Ganesh (2019) Glaucoma - Next Generation Therapeutics: Impossible to Possible. Pharmaceutical Research, 36 (2). ISSN 1573904X

Aeffner, Famke, Zarella, Mark, Buchbinder, Nathan, Bui, Marilyn, Goodman, Matthew, Hartman, Douglas, Lujan, Giovanni, Molani, Mariam, Parwani, Anil, Tunstall, kate, Turner, Oliver, Vemuri, Venkata, Yuil-Valdes, Ana and Bowman, Douglas (2019) Introduction to Digital Image Analysis in Whole-Slide Imaging: A White Paper from the Digital Pathology Association. Journal of Pathology Informatics, 10 (9). pp. 1-17.

Aeschlimann, Samuel, Graf, Christian, Mayilo, Dmytro, Munschy, Helene, Urda, Lorena, Kappes, Nora, Simonis, Marieke, Splinter, Erik, van Min, Max and Laux, Holger (2019) Shortened abstract for Enhanced CHO clone screening using Next-Generation Sequencing and Targeted Locus Amplification publication. Enhanced CHO clone screening: Applying Targeted Locus Amplification and Next-Generation Sequencing technologies during cell line development.

Aguilar-de-Leyva, Ángela, Campiñez, Maria Dolores, Jost, Flavia, Gavira, Miguel and Caraballo, Isidoro (2019) Study of the critical points in combined matrix tablets containing both inert and swelling excipients. Journal of Drug Delivery Science and Technology, 52. pp. 885-894. ISSN 17732247

Aho, Erin R, Wang, Jing, Gogliotti, Rocco D, Howard, Gregory C, Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D, Cheng, Ken, Lorey, Shelly L, Lu, Bin, Wenzel, Sabine, Foshage, Audra M, Alvarado, Joseph, Wang, Feng, Shaw, J Grace, Zhao, Bin, Weissmiller, April M, Thomas, Lance R, Vakoc, Christopher R, Hall, Matthew D, Hiebert, Scott W, Liu, Qi, Stauffer, Shaun R, Fesik, Stephen W and Tansey, William P (2019) Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell reports, 26 (11). 2916-2928.e13. ISSN 2211-1247

Albiol, Laia, Büttner, Alexander, Pflanz, David, Mikolajewicz , Nicholas, Birkhold, Annette I., Kramer, Ina, Kneissel, Michaela, Duda, Georg, Checa, Sara and Willie, Bettina M. (2019) Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice. Calcified tissue international.

Alexander, Schuhmacher, Oliver, Gassmann, Michael, Kuss and Hinder, Markus (2019) The Art of Virtualizing Pharma R&D. Drug Discovery Today. pp. 1-2. ISSN 18785832

Altshuler, Bob (2019) Research summary for postdoc program mentor profile. NIBR Postdoc Program.

Ando, Yuichi, Iwasa, Satoru, Takahashi, Shunji, Saka, Hideo, KAKIZUME, TOMOYUKI, NATSUME, KAZUTO, NOUMI, NAOKO, Quadt, Cornelia and Yamada, Yasuhide (2019) Phase I study of alpelisib (BYL719), an α-specific PI3K inhibitor, in Japanese patients with advanced solid tumors. Cancer Science. ISSN 13497006

Arias, HR, Jin, X-T, Peng, C, Feuerbach, Dominik, Ortells, MO, Elgoyhen, AB and Drenan, RM (2019) Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes. Neurochemistry international.

Arias, Hugo R, Ortells, Marcelo O, Feuerbach, Dominik, Burgos, Viviana and Paz, Cristian (2019) Alkaloids purified from the Aristotelia chilensis tree inhibit the human α3β4 nicotinic acetylcholine receptor with higher potency compared to human α4β2 and α7 subtypes. Journal of natural products.

Arista, Luca, Ullrich, Thomas, Riela, Serena, Massaro, Marina, Buscemi, Gabriella, Biddeci, Giuseppa, Cavallaro, Giuseppe, D'Anna, Francesca, Di Blasi, Francesco, Ferrante, Angelo, Lazzara, Giuseppe, Rizzo, Carla and Spinelli, Gaetano (2019) Multifunctional carrier based on halloysite/laponite hybrid hydrogel for kartogenin delivery. ACS Medicinal Chemistry Letters, 2019 (10). pp. 419-424. ISSN 1948-58751948-5875

Arora, Rishi, Nimonkar, Amitabh, Baird, Daniel, Wang, Chunhua, Chiu, Chun-Hao, Horton, Patricia, Hanrahan, Susan, Cubbon, Rose, Weldon, Stephen, Tschantz, Bill, Mueller, Sascha, Brunner, Reto, Lehr, Philipp, Meier, Peter, Ottl, Johannes, Voznesensky, Andrei, Pandey, Pramod, Smith, Thomas, Stojanovic, Aleksandar, Flyer, Alec, Benson, Timothy, Romanowski, Michael and Trauger, John (2019) Structure of lipoprotein lipase in complex with GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America, 116 (21). pp. 10360-10365. ISSN 10916490

Arora, Rishi, Nimonkar, Amitabh V, Baird, Daniel, Wang, Chunhua, Chiu, Chun-Hao, Horton, Patricia A, Hanrahan, Susan, Cubbon, Rose, Weldon, Stephen, Tschantz, William R, Mueller, Sascha, Brunner, Reto, Lehr, Philipp, Meier, Peter, Ottl, Johannes, Voznesensky, Andrei, Pandey, Pramod, Smith, Thomas M, Stojanovic, Aleksandar, Flyer, Alec, Benson, Timothy E, Romanowski, Michael J and Trauger, John W (2019) Structure of lipoprotein lipase in complex with GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America. ISSN 1091-6490

Arora, Rishi, Nimonkar, Amitabh V, Baird, Daniel, Wang, Chunhua, Chiu, Chun-Hao, Horton, Patricia A, Hanrahan, Susan, Cubbon, Rose, Weldon, Stephen, Tschantz, William R, Mueller, Sascha, Brunner, Reto, Lehr, Philipp, Meier, Peter, Ottl, Johannes, Voznesensky, Andrei, Pandey, Pramod, Smith, Thomas M, Stojanovic, Aleksandar, Flyer, Alec, Benson, Timothy E, Romanowski, Michael J and Trauger, John W (2019) Structure of lipoprotein lipase in complex with GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America, 116 (21). pp. 10360-10365. ISSN 1091-6490

Artim, Stephen C, Sheh, Alexander, Burns, Monika A and Fox, James G (2019) Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus). PloS one, 14 (11). e0224950. ISSN 1932-6203

Auberson, Yves (2019) An Element of Community: EFMC, the European Federation for Medicinal Chemistry. Chimia..

Babrak, Lmar M., Menetski, Joseph, Rebhan, Michael, Nisato, Giovanni, Zinggeler, Marc, Brasier, Noe, Baerenfaller, Katja, Brenzikofer, Thomas, Baltzer, Laurenz, Vogler, Christian, Gschwind, Leo, Schneider, Cornelia, Streiff, Fabian, Groenen, Peter M.A. and Miho, Enkelejda (2019) Traditional and digital biomarkers - two worlds apart? Digital Biomarkers, 3 (2). pp. 92-102. ISSN 2504-110X

Baenziger, Markus, Eswaran, Sumesh, Kanasithan, Gopu and Jiang, Yifan (2019) Selective ortho -Metalation of a Fluoroarene with Knochel-Hauser Base and Reactions with Various Electrophiles. Synthesis (Germany), 51 (7). pp. 1649-1654. ISSN 1437210X

Baenziger, Markus, Pachinger, Werner, Stauffer, Frederic and Zaugg, Werner (2019) Development of the synthesis of BEZ235 on ton scale. Organic Process Research & Development, 23 (9). pp. 1908-1917. ISSN 1083-61601520-586X

Bagdanoff, Jeffrey, Acker, Michael, Chan, Ho Man, Dore, Michael, Firestone, Brant, Fodor, Michelle, Garcia Fortanet, Jorge, Hentemann, Martin, Kato, Mitsunori, Koenig, Robert, La Bonte, Laura, Liu, Shumei, Chen, Zhuoliang, Chen, Ying-Nan, Mohseni, Mori, Ntaganda, Rukundo, Sarver, Patrick, Smith, Troy, Sendzik, Martin, Stams, Travis, Spence, Stan, Towler, Christopher, Wang, Hongyun, Wang, Ping and Williams, Sarah (2019) Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. Journal of Medicinal Chemistry, 62 (4). pp. 1781-1792. ISSN 15204804

Baltschukat, Sabrina, Schacher Engstler, Barbara, Huang, Alan, Hao, Huaixiang, Tam, Angela, Wang, Hui-Qin, Liang, Jinsheng, Dimare, Matt, Bhang, Hyo-Eun, Wang, Youzhen, Furet, Pascal, Sellers, William, Hofmann, Francesco, Schoepfer, Joseph and Tiedt, Ralph (2019) Capmatinib (INC280) is active against models of non–small cell lung cancer and other cancer types with defined mechanisms of MET activation. Clinical Cancer Research, 25 (10). pp. 3164-3175. ISSN 15573265

Bassilana, Frederic, Nash, Mark and Ludwig, Marie-Gabrielle (2019) Adhesion G protein-coupled receptors: opportunities for drug discovery. Nature reviews drug discovery.

Beck, Katharina R., Kanagaratnam, Sharavan, Kratschmar, Denise V., Birk, Julia, Yamaguchi, Hideaki, Sailer, Andreas, Seuwen, Klaus and Odermatt, Alex (2019) Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2. Journal of steroid biochemistry and molecular biology, 190. pp. 19-28. ISSN 1879-1220

Bednarczyk, Dallas and Sanghvi, Menaka (2019) The impact of assay recovery on the apparent permeability, a function of lysosomal trapping. Xenobiotica; the fate of foreign compounds in biological systems. pp. 1-22. ISSN 13665928

Bernink, Jochem H, Ohne, Yoichiro, Teunissen, Marcel BM, wang, Jingya, wu, Jincheng, krabbendam, lisette, Guntermann, Christine, volckmann, richard, koster, jan, van Tol, sophie, ramirez, ivan, shrestha, yashaswi, de rie, menno a, spits, hergen, ros, xavier romero and humbles, alison a (2019) c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Nature immunology. ISSN 1529-2916

Berrien-Elliott, Melissa M., Sun, Yaping, Neal, Carly, Ireland, Aaron, Trissal, Maria C., Sullivan, Ryan, Wagner, Julia A., Leong, Jeffrey W., Wong, Pamela, Mah-Som, Annelise Y., Wong, Terrence N., Schappe, Timothy, Keppel, Catherine R., Cortez, Victor S., Stamatiades, Efstathios G., Li, Ming O., Colonna, Marco, Link, Daniel C., French, Anthony R., Cooper, Megan A., Wang, Wei-Le, Boldin, Mark P., Reddy, Pavan and Fehniger, Todd A. (2019) MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells. Immunity. ISSN 10747613

Bhhatarai, Barun, Walters, Patrick, Hop, Cornelis, Lanza, Guido and Ekins, Sean (2019) Opportunities and Challenges Using Artificial Intelligence (AI) in ADME/Tox. Nature materials., 18. pp. 418-422. ISSN 1476-1122

Bill, Anke, Yeboah, Fred, Kim, Tae-Eu and Dettmer, Ulf (2019) Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiology of Disease, 132. ISSN 1095953X

Borsari, Chiara, Rageot, Denise, Dall’Asen, Alix, Bohnacker, Thomas, Melone, Anna, Sele, Alexander M., Jackson, Eileen, Langlois, Jean-Baptiste, Beaufils, Florent, Hebeisen, Paul, Fabbro, Doriano, Hillmann, Petra and Wymann, Matthias P. (2019) A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor. Journal of Medicinal Chemistry, 62 (18). pp. 8609-8630. ISSN 0022-2623

Bova, Kaitlin (2019) USP 800: Protecting Site Staff from Hazardous Drugs. Clinical Trial Supply Handbook .

Braun , Marie-Gabrielle , Díaz-Rodríguez, Alba , Diorazio, Louis , Fraunhoffer, Kenneth , Hayler, John , Hickey, Matthew , Lovelle, Lucie, McLaws, Mark , Parsons, Andrew , Richardson, Paul , Roiban, Doru , Steven, Alan , Terrett, Jack , White , Timothy and Yin, Jingjun (2019) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development, 23 (11). pp. 2287-2301. ISSN 1083-61601520-586X

Briard, Emmanuelle, joshi, Aniket, Shanmukhappa, Shiva, Ilovich, Olav and Auberson, Yves (2019) [18F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor‐Bearing Mice. ChemMedChem.

Brock, Ansgar, Venable, John, Steckler, Caitlin and Park, In Hee (2019) Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab fragment of NISTmAb. Analytical chemistry. ISSN 0003-2700

Bruch, Richard, Baaske, Julia, Chatelle, Claire, Meirich, Mailin, Madlener, Sibylle, Weber, Wilfried, Dincer, Can and Urban, Gerald Anton (2019) CRISPR/Cas13a‐powered electrochemical microfluidic biosensor for nucleic acid amplification‐free miRNA diagnostics. Advanced Materials. p. 1905311. ISSN 0935-9648

Bruin, Gerardus, Hasselberg, Anke, Korolova, Irena, Milojevic, Julie, Calonder, Claudio, Soon, Rachel, Woessner, Ralph, Pariser, David and Boutouyrie-Dumont, Bruno (2019) Secukinumab treatment does not alter the pharmacokinetics of the CYP3A4 substrate midazolam in patients with moderate to severe psoriasis – results from an open label disease-drug-drug interaction study. Clinical pharmacology and therapeutics, Early (Early ).

Burger, Matthew, Aversa, Robert, Taft, Benjamin, La Bonte, Laura, Cooke, Vesselina, Polyakov, Valery, Mishina, Yuji, Haling, Jake, Tellew, John, Iyer, Raman, Tian, Hung, Mathews Griner, Lesley, Mamo, Mulugeta, Huang, Shenlin, Gampa, Kalyani and Feng, Fei (2019) Design and Discovery of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254), A selective, efficacious, well-tolerated RAF inhibitor targeting RAS mutant cancers: The path to the clinic. Journal of medicinal chemistry, 63 (5). pp. 2013-2027.

Burns, Michael, Ott, Martin, Teasdale, Andrew, Stalford, Susanne, Antonucci, Vincent, Baumann, Jens-Christoph, Brown, Roland, Covey-Crump, Elisabeth, Elder, David, Elliott, Eric, Fennell, Jarred, Gallou, Fabrice, Ide, Nathan, Itoh, Tetsuji, Jordine, Guido, Kallemeyn, Jeffrey, Lauwers, Dick, Looker, Adam, Lovelle, Lucie, Molzahn, Robert, Schills, Didier, Schulte Oestrich, Rolf, Sluggett, Gregory, Stevenson, Neil, Talavera, Pere, Urquhart, Michael, Varie, David and Welch, Dennie (2019) A New Semi-Automated Computer-Based System for Assessing the Purge of Mutagenic Impurities. Organic process research & development.

Bussiere, Dirksen, Beckwith, Rohan, Be, Celine, Burke, Ashley, Carte, Nathalie, Cobb, Jennifer, Fazal, Aleem, Frank, Andreas, Frommlet, Alexandra, Godbole, Adarsh, Graff, Patrick, Hornak, Viktor, King, Daniel, Knapp, Mark, Paulk, Josh, Shu, Wei, Solomon, Jonathan, Srinivas, Honnappa, Voshol, Johannes, Wiesmann, Christian, Xie, Lili, Xu, Fangmin, Zhao, Junping, Okram, Barun, Jiang, Songchun, Michellys, Pierre and Karki, Rajeshri (2019) Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nature chemical biology. ISSN 1552-4469; 1552-4450

Cadena, Cristhian, Ahmad, Sadeem, Xavier, Audrey, Willemsen, Joschka, Park, Sehoon, Park, Ji Woo, Oh, Seong-Wook, Fujita, Takashi, Hou, Fajian, Binder, Marco and Hur, Sun (2019) Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity. Cell, 177 (5). 1187-1200.e16. ISSN 1097-4172

Cadena, Samuel, Choi, Sungshin, Saravia-Butler, Amanda, Shirazi-Fard, Yasaman, Leveson-Gower, Dennis, Stodieck, Louis, Beegle, Janet, Solis, Stephanie, Ronca, April and Globus, Ruth (2019) Behavior of mice aboard the International Space Station. Scientific reports, 9 (1). ISSN 20452322

Cadena, Samuel, Zhang, Yunyu, Lemire, Sophie, Kuss, Pia, Giorgetti, Elisa, Kneissel, Michaela, Glass, David and Stodieck, Louis (2019) Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space. Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space , 9 (1). p. 9397. ISSN 2045-2322

Camenisch, Gian P. (2019) DRUG-INDUCED LIVER INJURY PREDICTIONS: EXTENDED CLEARANCE MODEL AND ITS USE FOR PROPSPECTIVE TRANSPORTER- AND ENZYME-BASED HEPATIC CELL STRESS GRADING. International Journal of Pharmacy and Chemistry, 5 (2). pp. 15-19. ISSN 2575-5730

Canham, Steve, Russ, Carsten, Reece-Hoyes, John and Sigoillot, Frederic (2019) Bile acid analogues are activators of pyrin inflammasome. Journal of Biological Chemistry, 294 (10). pp. 3359-3366. ISSN 0021-92581083-351X

Carballido, Jose and Santamaria, Pere (2019) Taming autoimmunity: Translating antigen-specific approaches to induce immune tolerance. The Journal of Experimental Medicine. ISSN 0022-10071540-9538

Chapeau, Emilie, Mandon, Emeline, Romanet, Vincent, Ebel, Nicolas, Gill , Jason, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltiadis, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy, Hofmann, Francesco, Tiedt, Ralph, Eshkind, Leonid , Bockamp, Ernesto , Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne and Radimerski, Thomas (2019) A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression. PLoS ONE, 14 (10). ISSN 1932-6203

Chen, Kaiwen, Demarco, Benjamin, Shkarina, Kateryna, Boettcher, Andreas, Farady, Christopher, Heilig, Rosalie, Broz, Petr and Pelzcar, P (2019) Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly. EMBO Journal. ISSN 14602075

Chen, Lieyang, Cruz, Anthony, Ramsey, Steven, Dickson, Callum, Duca, Jose, Hornak, Viktor, Koes, David and Kurtzman, Tom (2019) Hidden bias in the DUD-E dataset leads to misleading performance of deep learning in structure-based virtual screening. PLoS ONE, 14 (8). ISSN 19326203

Chen1, Lisa S., Keating, Michael J., Wierda, William G. and Gandhi, Varsha V. (2019) Induction of apoptosis by MCL-1 inhibitors in chronic lymphocytic leukemia cells. Leukemia & lymphoma, 60. pp. 3063-3066. ISSN 1029-2403

Chiang, Derek, Leary, Rebecca, Wong, Connie, Singh, Angad and Charette, LaSalette (2019) A community-based lung cancer rapid tissue donation protocol provides high-quality drug-resistant specimens for proteogenomic analyses. Cancer Medicine. ISSN 20457634

Christian, Alec H, Jia, Shang, Zhang, Patricia, Tena Meza, Arismel, Sigman, Matthew S, Chang, Christopher J and Toste, F Dean (2019) A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation. Journal of the American Chemical Society JACS., 141 (32). pp. 12657-12662. ISSN 0002-78631520-5126

Clavaud, Matthieu, Lema-Martinez, Carmen, Roggo, Yves, Bigalke, Michael, Guillemain, Aurélie, Hubert, Philippe, Ziemons, Eric and Allmendinger, Andrea (2019) Near-infrared spectroscopy to determine residual moisture in freeze-dried products: model generation by statistical design of experiments. Journal of Pharmaceutical Sciences. ISSN 00223549

Cooner, Freda, Gamalo-Siebers, Margaret, Xia, Amy, Aijun, Gao, Ruan, Shiling, Tony, Jiang and Laura, Thompson (2019) Use of Alternative Designs and Data Sources for Pediatric Trials. Statistics in Biopharmaceutical Research. ISSN 19466315

Costa, Carlotta, Ly, Amy, Walmsley, Charlotte S., Huynh, Tiffany, Healy, Christopher, Peterson, Rachel, Jakubik, Charles T., Henderson, Laura E., Ho, Jeffrey, Timotina, Daria, Sanidas, Ioannis, Veloso, Artur, Mino-Kenudson, Mari, Stone, James R., Dyson, Nick, Benes, Cyril H., Engelman, Jeffrey and Dejan, Juric (2019) PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer. Cancer discovery. ISSN 21598290

Cryer, Alexander M, Chan, Cheuk, Eftychidou, Anastasia, Maksoudian, Christy, Mahesh, Mohan, Tetley, Teresa D, Spivey, Alan C and Thorley, Andrew J (2019) Tyrosine Kinase Inhibitor Gold Nanoconjugates for the Treatment of Non-Small Cell Lung Cancer. ACS applied materials & interfaces, 11 (18). pp. 16336-16346. ISSN 1944-8252

Cryer, Alexander M and Thorley, Andrew J (2019) Nanotechnology in the diagnosis and treatment of lung cancer. Pharmacology & therapeutics, 198. pp. 189-205. ISSN 1879-016X

D'Alessandro, Pier Luca, Hollingworth, Greg and Vorherr, Thomas (2019) Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo. ACS Chemical Biology, 14 (10). pp. 2197-2205. ISSN 15548937

D'Alessandro, Pier Luca, Hollingworth, Greg and Vorherr, Thomas (2019) Real-time imaging and quantification of peptide uptake in vitro and in vivo. ACS Chemical Biology. ISSN 1554-89291554-8937

Dalvit, Claudio and Vulpetti, Anna (2019) Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects. Journal of Medicinal Chemistry, 62. pp. 2218-2244. ISSN 15204804

Daniela, Mercatelli, Bolognesi, Paolo, Frassineti, Martina, Clarissa, Pisanò, Francesco, Longo, Shimshek, Derya and Michele, Morari (2019) Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes. Pharmacology Research & Perspectives, 7 (3). ISSN 2052-17072052-1707

Darpo, B, Benson, C, Dota, C and Jarugula, Venkateswar (2019) Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ-CSRC Study. Journal of Clinical Pharmacology. ISSN 15524604

Deodato, Giacomo, Ball, Christopher and Zhang, Xian (2019) Bayesian Neural Networks for Cellular Image Classification and Uncertainty Analysis. www.biorxiv.org.

Desjardins, Pascale, Couture, Camille, Germain, Lucie and Guérin, Sylvain (2019) Contribution of the WNK1 kinase to corneal wound healing using the tissue-engineered human cornea as an in vitro model. Biomaterials.

Diaz Verdugo, Carmen, Sun, Gerald, Fawcett, Caroline, Zhu, Peixin and Fishman, Mark (2019) Mating suppresses alarm response in zebrafish. Current biology. ISSN 1879-0445

Diaz Verdugo, Carmen, Sun, Gerald, Fawcett, Caroline, Zhu, Peixin and Fishman, Mark (2019) Mating suppresses alarm response in zebrafish. Current biology, 29. p. 2541. ISSN 1879-0445

Dickson, Callum, Velez-Vega, Camilo and Duca, Jose (2019) Revealing molecular determinants of hERG blocker and activator binding. Journal of chemical information and modeling. ISSN 1549960X

Dierich, Marlen, Hartmann, Stephanie, Dietrich, Nadine, Moeser, Philip, Tziridis, Konstantin, Schilling, Achim, Krauss , Patrick, Brede, Franziska, Hessler, Sabine, Karch, Sandra, Oliver, Dominik, Moser, Tobias, Schultze, Holger, Alzheimer, Christian, Leitner, Michael and Huth, Tobias (2019) β-secretase BACE1 is required for normal cochlear function. The journal of neuroscience. ISSN 1529-2401

Dodd, Stephanie, Kollipara, Sivacharan, Heimbach, Tycho, Beato, Stefania, Sanchez-Felix, Manuel and Meng, Qingshuo (2019) Prediction of ARA/PPI Drug-Drug Interactions at the Drug Discovery and Development Interface. Journal of Pharmaceutical Sciences, 108 (1). pp. 87-101. ISSN 15206017

Dodge, Robert (2019) Gene Therapy: Bioanalytical Support and Strategies. AAPS Training webinar, NA (NA). NA-NA. ISSN NA

Doerning, Carolyn M, Thurston, Sarah E, Villano, Jason S, Kaska, Carian L, Vozheiko, Tracy D, Soleimanpour, Scott A and Lofgren, Jennifer L (2019) Assessment of Mouse Handling Techniques During Cage Changing. Journal of the American Association for Laboratory Animal Science : JAALAS. ISSN 1559-6109

Dranoff, Glenn, Dougan, Michael and Dougan, Stephanie (2019) GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity, 50 (4). pp. 796-811. ISSN 10974180

Duca, Jose, Jansen, Hanneke, Schneider, Petra, Walters, W. Patrick, Plowright, Alleyn T., Sieroka, Norman , Fisher, Jasmin , Listgarten, Jennifer , Goodnow, Jr., Robert A. , Rush, Thomas S. , Zentgraf, Matthias , Hill, John Edward , Krutoholow, Elizabeth , Kohler, Matthias , Luebkemann, Chris, Blaney, Jeff , Funatsu, Kimito and Schneider, Gisbert (2019) Rethinking drug design in the artificial intelligence era. Nature Reviews Drug Discovery. ISSN 14741784

Duvadie, Rohit, Robinson, Richard, Altinoglu, Erhan, Jensen, Klavs, Pomberger, Alexander, Mo, Yiming, Nandiwale, Kakasaheb and Schultz, Victor (2019) A Continuous Stirred-Tank Reactor (CSTR) Cascade for Handling Solid-Containing Photochemical Reactions. Organic process research & development, 23 (12). pp. 2699-2706.

Dörner, Thomas, Posch, Maximilian, Li, Yue, Petricoul, Olivier, Cabanski, Maciej, Valentin, Marie-Anne, Simonett, Claudia, Mooney, Louise, Gram, Hermann, Wagner, Frank and Oliver, Stephen (2019) Treatment of primary Sjögren’s syndrome with ianalumab (VAY736) Targeting B cells by BAFF receptor-blockade coupled with enhanced, antibody-dependent cellular cytotoxicity. Annals of the rheumatic diseases., 78 (5). pp. 641-647.

D’ATRI, Valentina , Pell, Reinhard, Clarke, Adrian, GUILLARME, Davy and FEKETE, Szabolcs (2019) Is hydrophobic interaction chromatography the most suitable technique to characterize site-specific antibody-drug conjugates? Journal of Chromatography A, 1586. pp. 149-153. ISSN 0021-9673

Ecoeur, Florence, Weiss, Jessica, Kaupmann, Klemens, Hintermann, Samuel, Orain, David and Guntermann, Christine (2019) Antagonizing Retinoic acid-related-orphan receptor gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses. Frontiers in Immunology, 10 (Front.).

Edge, Stephen, Morrical, Bradley, Singh, Dilraj, Lewis, David, Rouse, Tim and Shur, Jagdeep (2019) Defining the Dosage Strength for Labelling of DPIs: Use, Limitations and Relevance of in-vitro Data. Inhalation Magazine, 13 (Februa). pp. 7-13.

Emilsson, Valur, Gudnason, Vilmundur and Jennings, Lori (2019) Predicting health and life span with the deep plasma proteome. Nature Medicine, 25 (12). pp. 1815-1816. ISSN 1546170X

Erlanson, Daniel A., Davis, Ben J. and Jahnke, Wolfgang (2019) Fragment-Based Drug Discovery: Advancing Fragments in the Absence of Crystal Structures. Cell Chemical Biology, 26 (1). pp. 9-15. ISSN 24519448

Ertl, Peter and Schuhmann, Tim (2019) A Systematic Cheminformatics Analysis of Functional Groups Occurring in Natural Products. Journal of natural products, 82 (5). pp. 1258-1263. ISSN 1520-6025

Ertl, Peter, van Deursen, Ruud, Tetko, Igor V and Godin, Guillaume (2019) GEN: Highly Efficient SMILES Explorer Using Autodidactic Generative Examination Networks. arXiv.

Faller, Bernard, Winiwarter, Susanne, Chang, George, Desai, Prashant, Menzel, Carsten, Rieko, Arimoto, Keefer, Christopher and Broccatelli, Fabio (2019) Prediction of fraction unbound in microsomal and hepatocyte incubations – a comparison of methods across industry data sets (by the IQ in silico ADME working group). Molecular pharmaceutics, 16 (9). pp. 4077-4085. ISSN 1543-8392; 1543-8384

Filipponi, Paolo, Guelat, Bertrand, Haber, Julien, Mostarda, Serena, O Meadhra, Ruairi, Piccioni, Lorenzo, Polenk, Jutta, Schenkel, Berthold, Schoenebeck, Silke, Streit, Alexander , Suremann, Roger, Venturoni, Francesco and Wegmann, Stefan (2019) Fouling of Flow Reactors in Organolithium Mediated Transformations: Experience on Scale-up and Proposed Solution. Chimia.

Flannery, Erika, Markus, Miles and Vaughan, Ashley (2019) Parasite of the Month: Plasmodium vivax. Trends in Parasitology.

Flannery, Erika and Vaughan, Ashley (2019) Parasite of the Month: Plasmodium vivax. Trends in Parasitology.

Fleming, Margaret and Grant, Sarah (2019) COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, 6 (5). pp. 384-399. ISSN 2372952X

Fukami, Shigemi, TOMIOKA, DAISAKU, Murakami, Yutaka, Honda, Toshiyuki and Hatakeyama, Shinji (2019) Pharmacological profiling of a dual FAK/IGF-1R kinase inhibitor TAE226 in cellular and in vivo models. BMC research notes, 12. p. 347. ISSN 1756-0500

Gallou, Fabrice and Plummer, Scott (2019) Insights on Bimetallic Micellar Nanocatalysis for Buchwald-Hartwig Aminations. ACS Catal., 9 (11). pp. 10389-10397.

Gallou, Fabrice (2019) Bridging the gap between transition metal and biocatalysis. Nature, 10. p. 2169.

Gallou, Fabrice (2019) C,N-Disubstituted Biarylpalladacycles as Pre-catalysts for ppm Level Cross Couplings in Water Under Mild Conditions. ACS Catalysis, 9 (12). pp. 11647-11657.

Gallou, Fabrice (2019) Coolade. A Low-Foaming Surfactant for Organic Synthesis in Water. ChemSusChem.

Gallou, Fabrice (2019) Fe-Catalyzed Reductive Couplings of Terminal (Hetero)Aryl Alkenes and Alkyl Halides under Aqueous Micellar Conditions. Journal of the American Chemical Society JACS., 141. pp. 17117-17124. ISSN https://pubs.acs.org/doi/pdf/10.1021/jacs.9b04510

Gallou, Fabrice (2019) Reactivity of Carbenes in the Aqueous Micelles Containing Palladium Nanoparticles. ACS Catalysis, 9 (12). pp. 10963-10970.

Gallou, Fabrice (2019) Site selective amide reduction of cyclosporine A yields derivatives of an important cyclic peptide. organic letters, 21 (9). pp. 3451-3455.

Gallou, Fabrice (2019) Sustainability challenges in peptide synthesis and purification: from R&D to production. The journal of organic chemistry : JOC, 84 (8). pp. 4615-4628.

Gallou, Fabrice (2019) Sustainable ppm Level Palladium-Catalyzed Aminations Under Mild, Aqueous Nanomicellar Conditions. chemical science, 2019.

Gallou, Fabrice, Onken, Ulrich, Koettgen, Agnieszka and Scheidat, Holger (2019) Environmental metrics to drive a cultural change: our green eco-label. Chimia, 73 (9). pp. 730-736.

Gallou, Fabrice and Parmentier, Michael (2019) Interface-rich Aqueous Systems for Sustainable Chemical Synthesis. Chimia., 73 (9). pp. 714-719.

Gallou, Fabrice and Plummer, Scott (2019) Insights on Heterogeneous Bimetallic Micellar Nanocatalysis for Buchwald-Hartwig Aminations. ACS Catal, 9 (11). pp. 10389-10397.

Gallou, Fabrice and Reilly, John (2019) A micellar-friendly, HandaPhos palladacycle pre-catalyst for ppm level Suzuki-Miyaura cross couplings in water under mild conditions. Chemical science, 10. pp. 8825-8831. ISSN 2041-6539; 2041-6520

Garrison, Catherine, Guan, Wendy, Kato, Mitsunori, Tamsett, Thomas, Patel, Tej, Sun, Yishan and Pathak, Tejas (2019) SAR evaluation of wasp toxin -PMTX leads to analogs with superior efficacy for human neuronal sodium channels. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Gill, Jonathan, Delezie, Julien, McGuirk, Shawn, Schnyder, Svenia, Gesa, Santos, Frank, Stephan, Rausch, Martin and Handschin, Christoph (2019) PGC-1α regulates mitochondrial-sarcoplasmic reticulum (SR)-mediated calcium exchange, SR stress and cell death to mitigate skeletal muscle aging. Aging cell. ISSN 1474-9726; 1474-9718

Giorgetti, Elisa, Obrecht, Michael, Ronco, Marie, Panesar, Moh, Lambert, Christian, Accart Gris, Nathalie, Doelemeyer, Arno, Nash, Mark, Bidinosti, Michael and Beckmann, Nicolau (2019) Magnetization Transfer Ratio (MTR) as a Non-Invasive Biomarker in Small Rodent Peripheral Nerve Injury Models. Scientific reports, 9 (1). p. 13508. ISSN 2045-2322

Giorgetti, Elisa, Panesar, Moh, Zhang, Yunyu, Joller, Stefanie, Ronco, Marie, Obrecht, Michael, Lambert, Christian, Accart Gris, Nathalie, Beckmann, Nicolau, Doelemeyer, Arno, Perrot, Ludovic, Fruh, Isabelle, Mueller, Matthias, Pierrel, Eliane, Summermatter, Serge, Bidinosti, Michael, Shimshek, Derya, Lemire, Sophie and Nash, Mark (2019) Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. Cell reports, 29 (6). p. 1539. ISSN 22111247

Giorgetti, Elisa, Panesar, Moh, Zhang, Yunyu, Joller, Stefanie, Ronco, Marie, Obrecht, Michael, Lambert, Christian, Accart Gris, Nathalie, Beckmann, Nicolau, Doelemeyer, Arno, Perrot, Ludovic, Fruh, Isabelle, Mueller, Matthias, Pierrel, Eliane, Summermatter, Serge, Bidinosti, Michael, Shimshek, Derya, Lemire, Sophie and Nash, Mark (2019) Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units. Cell Reports, 29 (6). 1539-1554.e7. ISSN 22111247

Glowienke, Susanne (2019) Genetic toxicology in silico protocol. Regulatory Toxicology and Pharmacology, 107. ISSN 10960295

Glowienke, Susanne and Parenty, Alexis (2019) Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses. Regulatory toxicology and pharmacology.

Glueck, Anton, Hueber, Wolfgang, Schlitt, Thomas, Hasselberg, Anke, Flannery, Brian, Wharton, Keith, Krueger, James and Suarez-Farinas, Mayte (2019) CAIN457A2223 12 week microarray data for upload to dbGaP. Journal of Allergy and Clinical Immunology.

Gobbi, Luca, Mercier, Joel, Bang-Andersen, Benny, Nicolas, Jean-Marie, Reilly, John, Wagner, Björn, Whitehead, David, Briard, Emmanuelle, Maguire, Ralf Paul, borroni, Edilio and Auberson, Yves (2019) A comparative study of in vitro assays for predicting the non-specific binding of PET imaging agents in vivo. ChemMedChem : chemistry enabling drug discovery, 15 (7). pp. 585-592. ISSN 1860-71791860-7187

Golding-Ochsenbein, Alexandra, Vidal, Solange, Wilmering Wetter, Barbara, Guibourdenche, Christel, Beerli, Christian, Chang, Lena, Leonhard, Sabine, Holway, Nicholas, Seuwen, Klaus and Jurisic Snijder, Giorgia (2019) S1P-S1PR1 activity controls VEGF-A signaling during lymphatic vessel development. bioRxiv. ISSN 10.1101/845396

Gomes, Luis, Hipp, Silvia, Upadhaya, Ajeet, Balakrishnan, Karthikeyan, Koper, Marta, Reichwald, Julia, Rabe, Sabine, Vandenberghe, Rik, von Arnim, Christine, Tousseyn, Thomas, Staufenbiel, Matthias and Thal, Dietmar Rudolf (2019) Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein. Acta Neuropathologica. ISSN 14320533

Gorovits, Boris, Palmer, Rachel and Milton, Mark (2019) 2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62). Bioanalysis, 11 (24). pp. 2207-2244. ISSN 17576199

Gram, Hermann (2019) The long and winding road in pharmaceutical development of canakinumab, a human anti-IL-1 antibody. Pharmacological Research.

Granger, Anne (2019) Postdoc program external website. Novartis.com.

Greenidge, Paulette, Blommers, Marcel J.J., Priestle, John Peter and Hunziker, Juerg (2019) How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for De Novo siRNA Guide Strand Surrogate Selection. Journal of chemical information and modeling, 59. pp. 1897-1908. ISSN 1549960X

Growcott, Ellena, Cariaga, Taryn, Morris, Laura, Zang, Richard, Lopez, Sara, Ansaldi, Dan, Gold, Josh, Gamboa, Luis, Roth, Theresa, Simmons, Bob and Osborne, Colin (2019) Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection. Journal of Antimicrobial Chemotherapy, 74 (1). pp. 108-116. ISSN 14602091

Gudmundsdottir , Valborg, Emilsson, Valur, Aspelund, Thor, Ilkov, Marjan, Gudmundsson, Elias F, Zilhao, Nuno, Lamb, John, Jennings, Lori and Gudnason, Vilmundur (2019) Deep serum proteomics reveals biomarkers for prevalent and incident T2DM. Nature communications.

Haffke, Matthias, Duckely, Myriam, Bergsdorf, Christian, Jaakola, Veli-Pekka and Shrestha, Binesh (2019) Development of a biochemical and biophysical suite for integral membrane protein targets: A review. Protein expression and purification. ISSN 10960279

Haffke, Matthias, Fehlmann, Dominique, Rummel, Gabriele, Boivineau, Jacques, Duckely, Myriam, Gommermann, Nina, Cotesta, Simona, Sirockin, Finton, Freuler, Felix, Littlewood-Evans, Amanda, Kaupmann, Klemens and Jaakola, Veli-Pekka (2019) Structural basis of species-selective antagonist binding to the succinate receptor. Nature, 574. pp. 581-585.

Haider, Ahmed, Müller Herde, Adrienne, Krämer, Stefanie D., Varisco, Jasmine, Keller, Claudia, Frauenknech, Katrin, Auberson, Yves, Temme, Louisa, Robaa, Dina, Sippl, Wolfgang, Schibli, Roger, Wünsch, Bernhard, Mu, Linjing and Ametamey, Simon (2019) Preclinical Evaluation of Benzazepine-Based PET Radioligands ( R)- and ( S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging. Journal of nuclear medicine : JNM, 60 (8). pp. 1167-1173. ISSN 1535-5667; 0161-5505

Haiser, Henry, Porter, Jeffrey and Reinker, Stefan (2019) Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology, 4 (2). pp. 293-305. ISSN 20585276

Handa, Sachin and Gallou, Fabrice (2019) Organopolymer with dual chromophores and fast charge-transfer properties for sustainable photocatalysis. Nature Communications, 10 (1). pp. 1837-1841. ISSN 20411723

Hao, Huaixiang, Wang, Hongyun, Liu, Chen, Kovats, Steven, Velazquez, Roberto, Lu, Henry, Pant, Bhavesh, Shirley, Matthew, Meyer, Matthew, Pu, Minying, Lim, Joanne, Fleming, Michael, Alexander, Leigh Ann, Farsidjani, Alireza, LaMarche, Matthew, Moody, Susan, Silver-Brown, Serena, Caponigro, Giordano, Stuart, Darrin, Abrams, Tinya, Hammerman, Peter, Williams, Juliet, Engelman, Jeffrey, Goldoni, Silvia and Mohseni, Mori (2019) Tumor intrinsic efficacy by SHP2 and RTK inhibitors in KRAS mutant cancers. Molecular cancer therapeutics.

Hardman, Clare, Chen, Wentao, Luo, Jian, Batty, Paul, Chen, Li-Ying, Nahler, Janina, Wu, Yianqui, Erpenbeck, Veit, Sandham, David, Xue, Luzheng and Ogg, Graham (2019) Fevipiprant, a selective prostaglandin-D2 receptor-2 antagonist, inhibits human group-2 innate lymphoid cell aggregation and function. Journal of Allergy and Clinical Immunology. ISSN 00916749

Harris, Emily and Bova, Kaitlin (2019) Patient engagement throughout drug development: understanding the role of patients and best practices for engagement. SOCRA Source, 101. pp. 28-31.

Harrison, Tyler, Bauer, Daniel, Berdichevsky, Alina, Chen, Xin, Duvadie, Rohit, Gilmore, Thomas, Hoogheem, Benjamin, Hatsis, Panagiotis, Liu, Qian, Mao, Justin, Rajaraman, Vasumathy, Rocheford, Erik, Zecri, Frederic, Zessis, Richard, Zheng, Rui, Streeper, Ryan, Patel, Sejal and Zhu, Qingming (2019) Successful strategies for mitigation of a preclinical signal for phototoxicity in a dgat1 inhibitor. ACS Medicinal Chemistry Letters, 10 (8). pp. 1128-1133. ISSN 19485875

Hauptmann, Astrid, Hoelzl, Georg and Loerting, Thomas (2019) Distribution of Protein Content and Number of Aggregates in Monoclonal Antibody Formulation After Large-Scale Freezing. AAPS PharmSciTech, 20 (2). ISSN 1530-9932

Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca and Hunziker, Juerg (2019) Evolved Aliphatic Halogenases Enable Regiocomplementary C-H Functionalization of an Added-Value Chemical. Angewandte Chemie (International ed. in English). ISSN 15213773

Hayman, Thomas J, Hsu, Alan C, Kolesnik, Tatiana B, Dagley, Laura F, Willemsen, Joschka, Tate, Michelle D, Baker, Paul J, Kershaw, Nadia J, Kedzierski, Lukasz, Webb, Andrew I, Wark, Peter A, Kedzierska, Katherine, Masters, Seth L, Belz, Gabrielle T, Binder, Marco, Hansbro, Philip M, Nicola, Nicos A and Nicholson, Sandra E (2019) RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses. Immunology and cell biology, 97 (9). pp. 840-852. ISSN 1440-1711

Heimbach, Tycho, Kesisoglou, Filippos, Suarez, Sharp, Kakhi, Maziar, Holmstock, Nico, Olivares-Morales, Andres, Pepin, Xavier, Sjögren, Erik, Tsakalozou, Eleftheria, Seo, Paul, Li, Min, Zhang, Xinyuan, Lin, Ho-Pi, Montague, Timothy, Mitra, Amitava, Morris, Denise and Patel, Nikunjkumar (2019) Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report. AAPS Journal, 21 (2). ISSN 15507416

Hernandez, Eloy , Zheng, Lianxing, Kim, Young, Fang, Bin, Valdez, Reginald, Dietrich, Bill, Rucker, Paul, Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn, Chen, Lihao, Joseph, Sean, Klickstein, Lloyd, Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David, Badman, Michael, Xu, Jie and Laffitte, Bryan (2019) Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With Antioxidative Gene Expression Profile in Rodents. Hepatology Communications, 3 (8). pp. 1085-1097. ISSN 2471-254X2471-254X

Hernandez, Eloy , Zheng, Lianxing, Kim, Young, Fang, Bin, Valdez, Reginald, Dietrich, Bill, Rucker, Paul, Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn, Chen, Lihao, Joseph, Sean, Klickstein, Lloyd, Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David, Badman, Michael, Xu, Jie and Laffitte, Bryan (2019) Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents. Hepatology Communications, 3 (8). pp. 1085-1097. ISSN 2471254X

Herrmann, Amanda C., Im, Jin S., Pareek, Sumedha, Ruiz-Vasquez, Wilfredo, Lu, Sijie, Sergeeva, Anna, Mehrens, Jennifer, He, Hong, Alatrash, Gheath, Sukhumalchandra, Pariya, St. John, Lisa, Clise-Dwyer, Karen, Zha, Dongxing and Molldrem, Jeffrey J. (2019) A Novel T-Cell Engaging Bi-specific Antibody Targeting the Leukemia Antigen PR1/HLA-A2. Frontiers in Immunology, 9. ISSN 1664-3224

High, Katherine A and Roncarolo, Maria G (2019) Gene Therapy. The New England journal of medicine, 381 (5). pp. 455-464. ISSN 1533-4406

Hijazi, Sara, Heistek, Tim S, Scheltens, Philip, Neumann, Ulf, Shimshek, Derya, Mansvelder, Huibert D, Smit, August D and van Kesteren, Ronald E (2019) Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease. Biological psychiatry.

Hill, Abby, Gleim, Scott, Kiefer, Florian, Sigoillot, Frederic, Loureiro, Joe, Jenkins, Jeremy and Morris, Melody (2019) Benchmarking network algorithms for contextualizing genes of interest. PLOS Comp Bio.

Himmel, Herbert, Delaunois, Annie, Deurinck, Mark, Dinklo, Theo, Errikson-Fälkler, Therese, Habermann, Christoph, Heers, Cara, Hempel, Katja, Lorenz, Helga, Schauerte, Heike, Teuns, Greet, Traebert, Martin, van Amsterdam, Christoph and van der Linde, Henk (2019) Variability of non-clinical behavioral CNS safety assessment: An intercompany comparison. Journal of Pharmacological and Toxicological Methods. ISSN 1873488X

Ho, Julie, Peters, Thomas, Dickson, Brendan, Swanson, David, Fernandez, Anita, Frova-Seguin, Aurelie, Valentin, Marie-Anne, Schramm-Franz, Ursula, Sultan, Marc, Nielsen, Torsten and Demicco, Elizabeth (2019) Detection of CSF1 rearrangements deleting the 3′ UTR in tenosynovial giant cell tumors. Genes Chromosomes and Cancer. ISSN 10982264

Hoegenauer, Klemens, Kallen, Joerg, Jimenez-Nunez, Eloisa, Strang, Ross, Ertl, Peter, Cooke, Nigel Graham, Hintermann, Samuel, Voegtle, Markus, Betschart, Claudia, McKay, Daniel, Wagner, Juergen, Ottl, Johannes, Beerli, Christian, Billich, Andreas, Dawson King, Janet, Kaupmann, Klemens, Streiff, Markus, Gobeau, Nathalie, Harlfinger, Stephanie, Stringer, Rowan and Guntermann, Christine (2019) Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors. Journal of medicinal chemistry, 62 (23). pp. 10816-10832. ISSN 1520-4804; 0022-2623

Huang, Zhihong, Molteni, Valentina, Liu, Yahu, Hao, Xueshi, Baaten, Janine, Hill, Robert, Meeusen, Shelly, Zou, Yefen, Yan, Shanshan, Jia, Yong, Tremblay, Matthew, Wu, Tom Y.-H. , Ding, Qiang, Liu, Bo, Nguyen-Tran, Van , Shen, Weijun, Bhat, Ganesh , Glynne, Richard, Laffitte, Bryan and Jing, Li (2019) Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes. ACS Omega, 4. pp. 3571-3581.

Huck, Catherine, Leppert, David, Wegert, Vanessa, Schmid, Cindy, Dunn, Bob, Weckbecker, Gisbert and Smith, Paul (2019) Low-dose subcutaneous anti-CD20 treatment depletes disease relevant B-cell subsets and attenuates neuroinflammation. Journal of neuroimmune pharmacology., 14 (1557-1). pp. 1-11. ISSN 1557-1904; 1557-1890

Huth, Felix, Gardin, Anne, Umehara, Ken-Ichi and He, Handan (2019) Prediction of the impact of CYP2C9 genotypes on the drug-drug interaction potential of siponimod with PBPK modeling: a comprehensive approach for drug label recommendations. Clinical Pharmacology & Therapeutics, 106 (5). pp. 1113-1124. ISSN 0009-92361532-6535

Hyrina, Anastasia, Holdorf, Meghan and Jones, Christopher (2019) ZCCHC14 is a novel host factor that is required for Hepatitis B virus RNA polyadenylation. Cell reports, 29 (10). pp. 2970-2978. ISSN 2211-1247

Hyrina, Anastasia, Jones, Christopher, Chen, Darlene, Clarkson, Scott, Cochran, Nadire, Feucht, Paul, Hoffman, Greg, Lindeman, Alicia, Russ, Carsten, Sigoillot, Frederic, Tsang, Tiffany, Uehara, Kyoko, Xie, Lili, Ganem, Donald and Holdorf, Meghan (2019) A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Cell Reports, 29 (10). 2970-2978.e6. ISSN 22111247

Hyrina, Anastasia, Jones, Christopher, Chen, Darlene, Clarkson, Scott, Cochran, Nadire, Feucht, Paul, Hoffman, Greg, Lindeman, Alicia, Russ, Carsten, Sigoillot, Frederic, Uehara, Kyoko, Xie, Lili, Ganem, Donald and Holdorf, Meghan (2019) A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Cell Reports, 29 (10). 2970-2978.e6. ISSN 22111247

Hyrina, Anastasia, Jones, Christopher, Chen, Darlene, Clarkson, Scott, Cochran, Nadire, Feucht, Paul, Hoffman, Greg, Lindeman, Alicia, Russ, Carsten, Sigoillot, Frederic, Uehara, Kyoko, Xie, Lili and Holdorf, Meghan (2019) A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Cell Reports, 29 (10). 2970-2978.e6. ISSN 22111247

Ian, Harrow, Rana, Balakrishnan, Ernesto, Jimenez-Ruiz, Simon, Jupp, Jane, Lomax, Jane, Reed, Martin, Romacker, Christian, Senger, Splendiani, Andrea, Jabe, Wilson and Peter, Wollard (2019) Ontology mapping for semantically enabled applications. Drug Discovery Today. ISSN 18785832

Imenez Silva, Pedro H, Benabbas, Chahira, Chan, Kessara, Ludwig, Marie-Gabrielle, Gasser, Juerg Andreas, Arnett, Timothy, Bonny, Olivier, Seuwen, Klaus and Wagner, Carsten A. (2019) The H+-Activated Ovarian Cancer G Protein-Coupled Receptor 1 (OGR1) is responsible for Renal Calcium Loss during Acidosis. Kidney international. ISSN 1523-1755; 0085-2538

Isobe, Yosuke, Okumura, Mikiko, White, Ross, McGregor, Lynn, McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Maimone, Thomas and Nomura, Daniel (2019) Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity. BioRXiv.

Isu, Giuseppe, Morbiducci, Umberto, De Nisco, Giuseppe, Kropp, Christina, Marsano, Anna, Deriu, Marco A., Zweigerdt, Robert, Audenino, Alberto and Massai, Diana (2019) Modeling methodology for defining a priori the hydrodynamics of a dynamic suspension bioreactor. Application to human induced pluripotent stem cell culture. Journal of Biomechanics, 94. pp. 99-106. ISSN 00219290

Iyer, Shwetha and Malyala, Padma (2019) Long-Acting Intraocular Delivery Strategies for Biological Therapy of Age-Related Macular Degeneration- A Review Article. Journal of controlled release.

JENSEN, Poul Erik Hyldgaard, Warnke, Clemens, Ingenhoven, Kathleen, Piccoli, Luca, Gasis, Marcia, Hermanrud, Christina, Fernandez-Rodriguez, Blanca, Ryner, Malin, Kramer, Daniel, Link, Jenny, Ramanujam, Ryan, Auer, Michael, Buck, Dorothea, Grummel, Verena, Bertotti, Elisa, Fissolo, Nicolas, Oliver-Martos, Begoña, Nytrova, Petra, Khalil, Michael, Guger, Michael, Rathmaier, Sandra, Sievers, Claudia, Lindberg, Raija, Hässler, Signe, Bachelet, Delphine, Aktas, Orhan, Donnellan, Naoimh, Lawton, Andy, Hemmer, Bernhard, Havrdova, Eva Kubala, Kieseier, Bernd, Hartung, Hans-Peter, Comabella, Manuel, Montalban, Xavier, Derfuss, Tobias, Sellebjerg, Finn, Dönnes, Pierre, Pallardy, Marc, Spindeldreher, Sebastian, Broët, Philippe, Deisenhammer, Florian, Fogdell-Hahn, Anna and Sorensen, Per Soelberg (2019) Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study. Journal of neuroimmunology, 326. pp. 19-27. ISSN 01655728

Jackson, Samual J, Authier, Simon, Brohmann, Henning, Goody, Susan MG, Jones, David, Prior, Helen, Rosch, Anke, Traebert, Martin, Tse, Karen, Valentin, Jean Pierre and Milne, Aileen (2019) Neurofunctional test batteries in safety pharmacology – Current and emerging considerations for the drug development process. Journal of pharmacological and toxicological methods, 100. ISSN 10568719

Jansen, Hanneke, De Pascale, Gianfranco, Lindvall, Mika, Moser, Heinz, Pfister, Keith, Wartchow, Charles, Fong, Susan and Warne, Bob (2019) Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns. Journal of chemical information and modeling, 59 (5). pp. 1709-1714. ISSN 1549-960X

Jansen, Hanneke, De Pascale, Gianfranco, Lindvall, Mika, Moser, Heinz, Pfister, Keith, Wartchow, Charles, Fong, Susan and Warne, Bob (2019) Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns. Journal of chemical information and modeling, 59 (5). pp. 1709-1714. ISSN 1549960X

Jaskelioff, Mariela (2019) Postdoc Mentor Profile. https://www.novartis.com/our-science/postdoc-program.

Jensen, Michael Rugaard, Cadapa Prahallad, Anirudh and Chapeau, Emilie (2019) Deciphering mechanisms of response and resistance in large-scale mouse cancer screens. Current Opinion in Genetics and Development, 54. pp. 48-54. ISSN 18790380

Jenul, Christian, Sieber, Simon, Daeppen, Christophe, Lardi, Martina, Pessi, Gabriela, Hoepfner, Dominic, Neuburger, Markus, Linden, Anthony, Gademann, Karl and Eberl, Leo (2019) Biosynthesis of fragin is controlled by a novel quorum sensing signal. Nature communications. ISSN 2041-1723

Jimenez, Jose, Sabbadin, Davide, Cuzzolin, Alberto, Martinez-Rosell, Gerard, Gora, Jacob, Manchester, John, Duca, Jose and DeFabritiis, Gianni (2019) PathwayMap: Molecular Pathway Association with Self-Normalizing Neural Networks. Journal of chemical information and modeling, 59 (3). pp. 1172-1181. ISSN 1549960X

John, Wise, Ian, Harrow, Rafael, Jimenez, Eric, Little, Kees, van Bochove, Gaspare, Mellino, Victoria, Hedley, Splendiani, Andrea, Alexandra, Grebe de Barron, Peter, Walgemond, Vibhor, Gupta, Jan, Taubert, Tom, Plasterer, Rainer, Winnenberg, Beeta, Balali-Mood, Drashiti, Vasant and Ian, Smith (2019) Implementation and Relevance of FAIR Data Principles in Biopharmaceutical Research and Development. Drug discovery today. ISSN 13596446

Joseph, Giselle, Shavlakadze, Tea, Glass, David, Wang, Sharon, Zhou, Weihua, Tse, Herman, Jacobs, Cody, Eash, John and Kimble, Garrett (2019) Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia. Molecular and Cellular Biology, 39 (19). ISSN 10985549

Jourdain, Marie and Hatakeyama, Shinji (2019) A novel tissue-selective β2-adrenoceptor agonist with minimized cardiovascular effects, 5-HOB, attenuates neuropathic pain in mice. BMC research notes, 12. ISSN 1756-0500

Jumani, Rajiv Satish, Spector, Jonathan, Diagana, Thierry, Manjunatha, Ujjini, Rasa, Izadnegahdar and Paul, Kelly (2019) Innovations in addressing pediatric diarrhea in low resource settings. ACS infectious diseases. ISSN 23738227

Juras, Vladimir, Schreiner, Markus, Laurent, Didier, Zbýň, Štefan, Mlynarik, Vladimir, Szomolanyi, Pavol, Hager, Benedikt, Scotti, Celeste, Goldhahn, Jörg, Heule, Rahel, Bieri, Oliver and Trattnig, Siegfried (2019) The comparison of the performance of 3 T and 7 T T mapping for untreated low-grade cartilage lesions. Magnetic resonance imaging, 55. pp. 86-92. ISSN 1873-5894

Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese-Marie, Salem, Bahaa, Chene, Patrick, Gessier, Francois, Holzer, Philipp and Furet, Pascal (2019) Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes. ChemMedChem, 14 (14). pp. 1305-1314. ISSN DOI: 10.1002/cmdc.201900201

Kane, Joshua, Fong, Susan, Shaul, Jacob, Frommlet, Alexandra, Frank, Andreas, Knapp, Mark, Bussiere, Dirksen, Kim, Peter, Ornelas, Elizabeth, Ceullar, Carlos, Abend, Johanna and Wartchow, Charles (2019) A VP2/3-derived peptide exhibits potent antiviral activity against BK and JC polyomaviruses by targeting a novel VP1 binding site. bioRxiv.

Karki, Rajeshri, Powers, James, Mainolfi, Nello, Anderson, Karen, Belanger, David, Liu, Donglei, Ji, Nan, Jendza, Keith, Gelin, Christine, Solovay, Catherine, Sweeney, Aengus, Delgado, Omar, Crowley, Maura, Liao, Sha-Mei, Argikar, Upendra, Flohr, Stefanie, La Bonte, Laura, Lorthiois, Edwige, Vulpetti, Anna, Cumin, Frederic, Brown, Ann, Adams, Christopher, Jaffee, Bruce and Mogi, Muneto (2019) Design, synthesis and pre-clinical characterization of selective Factor D inhibitors targeting the alternative complement pathway. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Karpov, Alexei, Nieto-Oberhuber, Cristina, Grotzfeld, Robert, Abrams, Tinya, Beng-Louka, Edwige, Chamoin, Sylvie, Chene, Patrick, Clark, Suzy, Dacquignies, Isabelle, Doumampouom Metoul, Lionel, Furegati, Markus, Granda, Brian, Joly, Emilie, Jones, Darryl, Lacaud-Baumlin, Marion, Guerro-Lagasse, Stephanie, Lorenzana, Edward, Martyniuk, Piotr, Marzinzik, Andreas, Mesrouze, Yannick, Nocito, Sandro, Oei, Yoko, Perruccio, Francesca, Richard, Etienne, Schindler, Patrick, Velay, Melanie, Venstrom, Kristine, Lafrance, Marc, Blanco, Enrique , Daniel, Dylan, Dillon, Michael, Drosos, Nikolaos, Fedoseev, Pavel, Mallet, William , Piizzi, Grazia, Wang, Peiyin , Zurini, Mauro and Rudewicz, Patrick (2019) Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Kingsley, Laura, Lelais, Gerald, Milliken, Kelly, Fuhs, Steve and Spraggon, Glen (2019) Development of a virtual reality platform for effective communication of structural data in drug discovery. Journal of Molecular Graphics and Modelling, 89. pp. 234-241. ISSN 18734243

Koch, Alexander, Schiering, Nikolaus, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, Mccormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, De Gagne, Julie, Krantz, Carsten, Eder, Joerg, Stoll, Brian, Kulmatycki, Kenneth, Basson, Craig, Frost, Robert, Melkko, Samu, Feldman, David, Hoffmann, Peter and Khder, Yasser (2019) MAA868, a novel Factor XI antibody with a unique binding mode, shows long-lasting anticoagulation effects in humans. Blood. ISSN 1528-0020

Koch, Alexander, Schiering, Nikolaus, Melkko, Samu, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, McCormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, Cote, Serge, De Gagne, Julie, Krantz, Carsten, Eder, Joerg, Stoll, Brian, Kulmatycki, Kenneth, Feldman, David, Hofmann, Peter, Basson, Craig, Frost, Robert and Khder, Yasser (2019) MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans. Blood, 133 (13). pp. 1507-1516. ISSN 15280020

Koo, Selene, Janeway, Katherine, Harris, Marian, Fryer, Christy, Aster, Jon, Al-Ilbraheemi, Al and Church, Alanna (2019) A distinctive genomic and immunohistochemical profile for NOTCH3 and PDGFRB in infantile myofibroma with diagnostic and therapeutic implications. International journal of surgical pathology., 78 (19). ISSN 1940-2465; 1066-8969

Korkmaz, Gozde, Manber, Zohar, Marques Lopes, Rui, Prekovic, Stefan, Schuurman, Karianne, Kim, Yongsoo, Teunissen, Hans, Flach, Koen, de Wit, Elzo, Galli, Giorgio, Zwart, Wilbert, Elkon, Ran and Agami, Reuven (2019) A CRISPR-Cas9 screen identifies essential CTCF anchor sites for the mitogenic function of ER-alpha in breast cancer. Nucleic Acids Research. ISSN 0305-10481362-4962

Korn, Paula, Kramer, Ina, Schlottig, Falko, Tödtmann, Ninette, Eckelt, Uwe, Bürki, Alexander, Ferguson, Stephen J., Kautz, Armin, Schnabelrauch, Matthias, Range, Ursula, Kneissel, Michaela and Stadlinger, Bernd (2019) Systemic sclerostin antibody treatment increases osseointegration and biomechanical competence of zoledronic-acid-coated dental implants in a rat osteoporosis model. European Cells and Materials, 37. pp. 333-346. ISSN 1473-2262

Koshiishi, Chie, Kanazawa, Takanori, Vangrevelinghe, Eric, Honda, Toshiyuki and Hatakeyama, Shinji (2019) Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist. Heliyon, 5 (11). e02849. ISSN 2405-8440

Koyanagi, Takaoki, Loren, Jon, Herath, Ananda, Chong, Ashley, Ratnikov, Max, Valiere, Andrew, Chang, Jim and Molteni, Valentina (2019) One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2–Sp3 Cross-Coupling. Organic Letters, 21 (3). pp. 816-820. ISSN 1523-70601523-7052

Koziczak-Holbro, Magdalena, Rigel, Dean, Dumotier, Berengere, Sykes, David A., Tsao, Jeffrey, Nguyen, Ngoc-Hong, Bösch, Julian, Jourdain, Marie, Flotte, Ludivine, Adachi, Yuichiro, Kiffe, Michael, Azria, Moise, Fairhurst, Robin, Charlton, Steven J., Trifilieff, Estelle, Glass, David, Richardson, Brian P., Ullrich, Thomas and Hatakeyama, Shinji (2019) Pharmacological characterization of a novel 5-hydroxybenzothiazolone (5-HOB) derived β2 adrenoceptor agonist with functional selectivity for anabolic effects on skeletal muscle resulting in a wider cardiovascular safety window in preclinical studies. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-35651521-0103

Krucker, Thomas (2019) Open Innovation @ NITD Unleash the potential and empower the next generation of global health researchers. to share with Gates Foundation.

Lakshman, Jay (2019) Opportunities in Doing the Greater Good: a Bigger Role for Pharma. Indian Drugs, 56 (03). pp. 5-6.

Laroche , Charlesa, Hartmann, Andreas and Cronin , Mark (2019) Finding synergies for the 3Rs – Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum. Regulatory Toxicology and Pharmacology, 108. ISSN 10960295

Larrow, Jay, Mikus, Malte, Sanchez, Carina and Fridrich, Cary (2019) Palladium-catalyzed C‒O coupling of amino alcohols for the synthesis of aryl ethers. Advanced Synthesis & Catalysis, 362 (2). pp. 430-436. ISSN 1615-41501615-4169

Lewis, Richard, Cruciani, Gabri, Stouch, Terry, Martin, Yvonne, Vinter, Andy and Gago, Federico (2019) How computational chemistry develops: a tribute to Peter Goodford. Journal of Computer-Aided Molecular Design, 33 (8). pp. 699-703. ISSN 15734951

Lewis, Richard, Ertl, Peter, Schneider, Nadine and Stiefl, Nikolaus (2019) Reducing the Concepts of Data Science and Machine Learning to Tools for the Bench Chemist. Chimia., 73 (12). pp. 1001-1005. ISSN 0009-4293

Li, Haoxin, Ning, Shaoyang, Apfel, Verena, Ghandi, Mahmoud, Kryukov, Gregory, Gopal, Shuba, Giannakis, Marios, Deik, Amy, Souza, Amanda, Pierce, Kerry, Keskula, Paula, Hernandez, Desiree, Ann, Julie, Shkoza, Dojna, Queiros De Almeida, Reinaldo, Tsherniak, Aviad, Weir, Barbara, Vazquez, Francisca, Hahn, William, Barretina, Jordi, Pagliarini, Raymond, Galli, Giorgio, Schreiber, Stuart, Clish, Clary, Sellers, William and Garraway, Levi (2019) The landscape of cancer cell line metabolism. Nature Medicine, 25 (5). pp. 850-860. ISSN 1546170X

Li, Ning, Rice, Dennis, Grosskreutz, Cyndy, Prasanna, Ganesh, Dryja, Thaddeus, Wang, Shirley and Gagne, Joshua (2019) Using healthcare databases to explore associations between drugs and progression of open angle glaucoma. Clinical pharmacology and therapeutics. ISSN 1532-6535

Lichitsky, Boris, Komogortsev, Andrey, Dudinov, Arkady, Krayushkin, Mikhail, Khodot, Evgenii, Samet, Alexander, Karpov, Alexei, Gorses, Delphine, Radimerski, Thomas, Semenova, Marina, Kiselyov, Alex and Semenov, Victor (2019) Benzimidazolyl-pyrazolo[3,4-b]pyridinones - selective inhibitors of MOLT-4 leukemia cell growth and sea urchin embryo spiculogenesis: Target quest. ACS combinatorial science. ISSN 2156-8944; 2156-8952

Ligibel, Mathieu, Moore, Charles, Bruccoleri, Robert and Snajdrova, Radka (2019) Identification and Application of Threonine Aldolase for Synthesis of valuable α-amino, β-hydroxy-Building Blocks. Biochimica et Biophysica Acta - Proteins and Proteomics .

Lonetto, Michael, Donohue, Timothy, Gross, Carol and Buttner, Mark (2019) Discovery of the extracytoplasmic function σ factors. Molecular Microbiology. ISSN 13652958

Lu, Henry and Hao, Huaixiang (2019) Structure of LFW527. Molecular cancer therapeutics. ISSN 1538-8514

Lu, Henry, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas, Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado Robles, Eusebio, Brachmann, Saskia, Moody, Susan, Engelman, Jeffrey, Hammerman, Peter, Caponigro, Giordano, Mohseni, Mori and Hao, Huaixiang (2019) SHP2 inhibition overcomes RTK-mediated pathway re-activation in KRAS mutant tumors treated with MEK inhibitors. Molecular cancer therapeutics. ISSN 1538-8514

Lu, Yipin, Anand, Shankara, Shirley, William, Gedeck, Peter, Kelley, Brian P, Skolnik, Suzanne, Rodde, Stephane, Nguyen, Mai, Lindvall, Mika and Jia, Weiping (2019) Prediction of pKa Using Machine Learning Methods with Rooted Topological Torsion Fingerprints: Application to Aliphatic Amines. Journal of chemical information and modeling, 59 (11). pp. 4706-4719. ISSN 1549-960X

Luo, Liqing, Chin, Sherry, Parkington, Jascha, Cadena, Samuel, Zhu, Jiang, Ibebunjo, Chikwendu, Summermatter, Serge, Londraville, Nicole, Patora-Komisarska, Krystyna, Widler, Leo, Zhai, Huili, Trendelenburg, Anne-Ulrike, Glass, David and Shi, Jun (2019) HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70. Cell Reports (29). pp. 749-763. ISSN 22111247

Ma, Xiaolei, Prathapam, Ramadevi, Wartchow, Charles, Chie Leon, Barbara, Chi-Min, Ho, DeVicente, Javier, Han, Wooseok, Li, Min, Lu, Yipin, Ramurthy, Savithri, Shia, Steven, Steffek, Micah and Ueharab, Tsuyoshi (2019) Structural and Biological Basis of Small Molecule Inhibition of Escherichia coli LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis. ACS Infectious Diseases. ISSN 23738227

Macdonald, Jonathan D, Chacón Simon, Selena, Han, Changho, Wang, Feng, Shaw, J Grace, Howes, Jennifer E, Sai, Jiqing, Yuh, Joannes P, Camper, Demarco, Alicie, Bethany M, Alvarado, Joseph, Nikhar, Sameer, Payne, William, Aho, Erin R, Bauer, Joshua A, Zhao, Bin, Phan, Jason, Thomas, Lance R, Rossanese, Olivia W, Tansey, William P, Waterson, Alex G, Stauffer, Shaun R and Fesik, Stephen W (2019) Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. Journal of medicinal chemistry. ISSN 1520-4804

Manjunatha, Ujjini, Rao, Srinivasa, Manu, Rycker and Ian, Gilbert (2019) "Setting our sights on infectious diseases" Meeting Summary. ACS Infectious Diseases. ISSN 10.1021/acsinfecdis.9b00371

Mannschott, Thomas, Krumme, Markus, Kreimer, Manuel, Zettl, Manuel, Aigner, Isabella, van der Wel, Peter and Khinast, Johannes G. (2019) Performance characterization of static mixers in precipitating environments. Organic Process Research & Development, 23 (7). pp. 1308-1320. ISSN 1083-61601520-586X

Martin, Eric, Polyakov, Valery, Zhu, Xiangwei, Tian, Li, liu, Win and Mukherjee, Prasenjit (2019) All-Assay-Max2 pQSAR: Activity predictions as accurate as 4-concentration IC50s for nearly 9,000 Novartis assays. Journal of Chemical Information and Modeling, 59 (10). pp. 4450-4459. ISSN 1549-95961549-960X

Meier, Peter, Battaglia, Nicole, Ertl, Peter and Pirard, Bernard (2019) 5,5- and 5,5-Membered Spirocyclic Indoline-pyrrolidinone Hit Finding Libraries. ACS Combinatorial Science, 21 (7). pp. 528-536. ISSN 2156-89522156-8944

Mercado, Nicolas, Schutzius, Gabi, Hauer, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, John, Knehr, Judith, Hoepfner, Dominic, Aebi, Alexandra, Ruffner, Heinz, Russ, Carsten, Bouwmeester, Antonius, Frederiksen, Mathias, Lohmann, Felix, Kirkland, Susan, Lin , Charles Y and Beck, Tanner (2019) IRF2 is a master regulator of human keratinocyte stem cell fate. Nature communications, 10 (Articl). ISSN 41467-019-12559-x

Metcalf, Chet, Svenson, Sonke , Hwang, Jungyeon, Tripathi, Snehlata, Gangal, Geeti, Kabir, Sujan, Lazarus, Douglas, Cole, Roderic, Sweryda-Krawiec, Beata, Shum, Pochi, Brown, Donna, Case, Roy, van der Poll, Derek, Harlfinger, Stephanie, Teng, Chi-Hse, Rohde, Ellen and Eliasof, Scott (2019) Discovery of a novel cabazitaxel nanoparticle-drug conjugate (CRLX522) with improved pharmacokinetic properties and anticancer effects using a β-cyclodextrin-PEG copolymer based delivery platform. Journal of Medicinal Chemistry, 62 (21). pp. 9541-9559. ISSN 0022-26231520-4804

Michaels, Philip, Reilly, John, Neef, James, Galyan, Keith, Poirier, Jennifer, Ginsburg-Moraff, Carol, Dunstan, David and Zhou, Xilin (2019) Enabling chiral separations in discovery chemistry with open-access chiral supercritical fluid chromatography. Chirality. ISSN 1520636X

Miller, Cara, Torbert, Bill, Wallis, Nancy and Yeyinmen, Karen (2019) Team Coaching through CDAI and the GLP. The Practitioner's Handbook of Team Coaching. pp. 420-431. ISSN 9781351130554

Morgan, Hannah, Riccardi, Sabrina and Gani, Zaahira (2019) Evaluation of in vitro assays to assess the modulation of dendritic cells functions by therapeutic antibodies and aggregates. Frontiers in immunology, 10. ISSN 1664-3224

Muenzker, Lena (2019) Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery. Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery.

Myers, Andrea, ISHIHARA, KAE, NATSUME, KAZUTO, KAKIZUME, TOMOYUKI, ESAKI, TAITO, HIRAI, FUMIHIKO, MAKIYAMA, AKITAKA, SETO, TAKASHI, BANDO, HIDEAKI, YOICHI, NAITO, YOH, KIYOTAKA and DOI, TOSHIHIKO (2019) Phase I dose-escalation study of capmatinib (INC280) in Japanese patients with advanced solid tumors. Cancer Science, 110 (4). pp. 1340-1351. ISSN 1347-90321349-7006

Neri, Marilisa, Wegmann, Rebekka, Schuierer, Sven, Bilican, Bilada, Hartkopf, Huyen, Mapa, Felipa, Waldt, Annick, Cuttat-Theurillat, Rachel, Salick, Max, Raymond, Joe, Kaykas, Ajamete, Roma, Guglielmo and Gubser Keller, Caroline (2019) CellSIUS provides sensitive and specific detection of rare cell populations from complex single cell RNA-seq data. Genome biology, 20 (142). ISSN 1474-760X; 1474-7596

Neumann, Ulf, Machauer, Rainer and Shimshek, Derya (2019) The BACE inhibitor NB-360 in preclinical models: From β-amyloid reduction to downstream disease-relevant effects. British journal of pharmacology, 176. pp. 1-12.

Nilsson, Inga, Lee, Sheng Y., Sawyer, William S., Baxter Rath, Christopher M., Lapointe, Guillaume and Six, David A. (2019) Metabolic labeling of phospholipids in intact bacteria enables a fluorescence assay to detect loss of outer membrane asymmetry. ACS infectious diseases.

Nimonkar, Amitabh, Weldon, Stephen, Godbout, Kevin, Panza, Darrell, Hanrahan, Susan, Cubbon, Rose, Xu, Fangmin, Trauger, John, Gao, Jiaping and Voznesensky, Andrei (2019) A lipoprotein lipase --GPI-anchored high density lipoprotein binding protein 1 fusion lowers triglycerides in mice: implications for managing familial chylomicronemia syndrome. JBC minireview series JBC., Epub a. ISSN 1083-351X

Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M. and Fryer, Christy J. (2019) Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nature Chemical Biology. ISSN 1552-4450

Nolin, Erin, Gans, Sara, Llamas, Luis, Brittain, Scott, Loureiro, Joe, Thomas, Jason, Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin, Ho, Samuel, Hoepfner, Dominic, Mcdonald, Rick, Dogra, Abhishek, Ding, Jian, Canham, Steve, Boynton, Geoffrey, George, Elizabeth, Kang, Zhao Bin, Antczak, Christophe, Porter, Jeffrey, Tallarico, John, Jenkins, Jeremy, Jain, Rishi, Bushell, Simon, Fryer, Christy, Reece-Hoyes, John, Tyskiewicz, Kayla and Weihofen, Wilhelm (2019) Discovery of a ZIP7 Inhibitor from a Notch Pathway Screen. Nature chemical biology, 15. pp. 179-188. ISSN 1552-4469

Ottl, Johannes, Leder, Lukas, Schaefer, Jonas and Dumelin, Christoph (2019) Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery. Molecules : a journal of synthetic chemistry and natural product chemistry, 24. ISSN 1420-3049

Ottl, Johannes, Leder, Lukas, Schaefer, Jonas and Dumelin, Christoph (2019) Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery. Molecules : a journal of synthetic chemistry and natural product chemistry, 24 (8). p. 1629. ISSN 1420-3049

Paglialunga, Sabina, Morimoto, Bruce, Clark, Matthew and Friedrichs, Gregory (2019) Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events. Journal of Pharmacological and Toxicological Methods, 99. p. 106596. ISSN 1873488X

Pan, Yue (2019) The dark side of fluorine. ACS Medicinal Chemistry Letters. pp. 1016-1019. ISSN 19485875

Park, Donglim Esther, Cheng, Jingwei, Berrios, Christian, Montero, Joan, Cortes-Cros, Marta, Ferretti, Stephane Raymond, Arora, Reety, Tillgren, Michelle, Gokhale, Prafulla and DeCaprio, James A. (2019) Dual Inhibition of MDM2 and MDM4 in Virus-Positive Merkel Cell Carcinoma Enhances the p53 Response. Proceedings of the National Academy of Sciences of the United States of America PNAS., 116 (3). pp. 1027-1032. ISSN 0027-8424

Parmentier, Michael, Gallou, Fabrice, Jakobi, Markus and Sparr, Christof (2019) A General Protocol for Robust Sonogashira Reactions in Micellar Medium. Helvetica chimica acta. ISSN 0018019X

Pauli, Victoria Isabell, Elbaz, Frantz, Kleinebudde, Peter and Krumme, Markus (2019) Orthogonal redundant monitoring of a new continuous fluid bed dryer for pharmaceutical processing by means of mass and energy balance calculations and spectroscopic techniques. Journal of Pharmaceutical Sciences.

Pauli, Victoria Isabell, Roggo, Yves, Ensslin, Simon, Krumme, Markus, Elbaz, Frantz, Pellegatti, Laurent, Nguyen Trung, Nhat Quang and Kleinebudde, Peter (2019) Process Analytical Technology for continuous manufacturing tableting processing : A case study. Journal of pharmaceutical and biomedical analysis, 162. pp. 101-111. ISSN 07317085

Pauli, Victoria Isabell, Roggo, Yves, Kleinebudde, Peter and Krumme, Markus (2019) Real-time monitoring of particle size distribution in a continuous granulation and drying process by near infrared spectroscopy. European journal of pharmaceutics and biopharmaceutics, 141. pp. 90-99. ISSN 09396411

Pedro, Liliana, Cross, Megan, Hofmann, Andreas, Mak, Tin and Quinn, Ronald J. (2019) Development of an HPLC-based guanosine monophosphate kinase assay and application to Plasmodium vivax guanylate kinase. Analytical Biochemistry, 575. pp. 63-69. ISSN 00032697

Perry, Evan, Mills, Jonathan J, Zhao, Bin, Wang, Feng, Sun, Qi, Christov, Plamen P, Tarr, James C, Rietz, Tyson A, Olejniczak, Edward T, Lee, Taekyu and Fesik, Stephen (2019) Fragment-based screening of programmed death ligand 1 (PD-L1). Bioorganic & medicinal chemistry letters, 29 (6). pp. 786-790. ISSN 1464-3405

Peters, Finn, Salihoglu, Hazal, Pratsch, Kathrin, Herzog, Ettienne, Pigoni, Martina, Lichtenthaler, Stefan, Neumann, Ulf, Brose, Nils and Herms, Jochen (2019) Tau deletion reduces beta-amyloid deposition by alleviating plaque-associated axonal damage. The EMBO Journal. ISSN 0261-41891460-2075

Petrick, Joy Kristin (2019) Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery. Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery .

Pettersen, Kristine, Andersen, Sonja, van der Veen, Anna, Nonstad, Unni, Hatakeyama, Shinji, Lambert, Christian, Trifilieff, Estelle, Moestue, Ilver, Cebulla, Jana, Grønberg, Bjørn Henning, Schilb, Alain, Jacobi, Carsten and Bjørkøy, Geir (2019) Autocrine activin A signaling in cancer cells controls secretion of IL-6 and autophagy in cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle. ISSN 2190-59912190-6009

Plummer, Scott (2019) A Green Chemistry Continuum for a Robust and Sustainable API Supply Chain. ACS Sustainable Chemistry & Engineering, 7 (20). pp. 16937-16951. ISSN 2168-0485

Plummer, Scott and Gallou, Fabrice (2019) Shielding Effect of Micelle for Highly Effective and Selective Monofluorination of Indoles in Water. ChemSusChem, 12. pp. 3037-3042. ISSN 1864-564X; 1864-5631

Pognan, Francois, Couttet, Philippe, Demin, Ivan, Jaitner, Birgit, Pang, Yinuo, Roubenoff, Ronenn, Sutter, Esther, Timsit, Yoav, Valentin, Marie-Anne, Vogel, Beate Elisabeth, Woerly, Gaetane, Wolf, Armin and Schramm-Franz, Ursula (2019) CSF-1 antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. Journal of Pharmacology and Experimental Therapeutics. ISSN 118.254128

Poller, Birk, Woessner, Ralph, Barve, Avantika, Tillmann, Hanns-Christian, Vemula, Janardhana Rao, Nica, Alexandra, Elbast, Walid, Schiller, Hilmar, End, Peter, Camenisch, Gian P. and Weiss, Markus (2019) Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes. Pulmonary Pharmacology and Therapeutics, 57. ISSN 15229629

Press, Neil, Joly, Emilie and Ertl, Peter (2019) Natural product drug delivery: A special challenge? Progress in Medicinal Chemistry, 58. pp. 157-187. ISSN 18757863

Proudfoot, Andrew, Hyrina, Anastasia, Holdorf, Meghan, Frank, Andreas and Bussiere, Dirksen (2019) First crystal structure of a nonstructural hepatitis E viral protein identifies a putative novel zinc-binding protein. Journal of Virology, 93 (13). ISSN 10985514

Pulz, Robert, Angst, Daniela, Dawson King, Janet, Gessier, Francois, Gutmann, Sascha, Hersperger, Rene, Hinniger, Alexandra, Janser, Philipp, Koch, Guido, Revesz, Laszlo, Vulpetti, Anna, Waelchli, Rudolf, Cenni, Bruno and Zimmerlin, Alfred Gilbert (2019) Design of potent and selective covalent inhibitors of Bruton’s Tyrosine Kinase targeting an inactive conformation. ACS Medicinal Chemistry Letters, 10 (10). pp. 1467-1472. ISSN 1948-58751948-5875

Rajman, Iris and Della Pasqua, Oscar (2019) Introducing Project Africa GRADIENT. Drug Discovery Today, 24 (12). pp. 2229-2230. ISSN 18785832

Rajman, Iris, Zhao, Sylvia, HIRANO, MASARU and HONMA, WATARU (2019) Expediting access to medicines in Asia: Recommendations for a new paradigm of global drug development. Drug discovery today. ISSN 1878-5832; 1359-6446

Ranjitkar, Srijan, Jones, Adriana, Mostafavi, Mina, Zwirko, Zachary, Iartchouk, Oleg, Barnes, Whitney, Walker, John, Willis, Thomas, Lee, Patrick and Dean, Charles (2019) Target (MexB) and efflux based mechanisms decreasing the effectiveness of the efflux pump inhibitor D13-9001 in P. aeruginosa PAO1: uncovering a new role for MexMN-OprM in efflux of β-lactams and a novel regulatory circuit controlling MexMN expression. Antimicrobial agents and chemotherapy, 63 (2). pp. 1-14. ISSN 1098-6596; 0066-4804

Raselli, T, Heran, T, Wyss, A, Atrott, K, Peter, A, Frey-Wagner, I, Spalinger, MR, Maggio, EM, Sailer, Andreas, Schmitt, J, Schreiner, P, Wiest, R, Moncsek, A, Mertens, J, Scharl, M, Griffiths, WJ, Bueter, M, Geier , A, Rogler, G, Wang, Y and Misselwitz, B (2019) Elevated oxysterol levels in human and mouse livers reflect non-alcoholic steatohepatitis. JLR papers in press, 60. pp. 1270-1283. ISSN 1539-7262

Raselli, T, Wyss, A, Gonzalez Alvarado, MN, Weder, B, Mamie, C, Spalinger, MR, van Haaften, T, Dijkstra, G, Sailer, Andreas, Imenez Silva, PH, Wagner, CA, Tosevski, V, Leibl, S, Scharl, M, Rogler, G, Hausmann, M and Misselwitz, B (2019) The oxysterol synthesizing enzyme CH25H contributes to the development intestinal fibrosis. Journal of Crohn's and colitis. ISSN 1876-4479

Reck, Folkert, Bermingham, Alun, Blais, Johanne, Cazarez, Anthony, Colvin, Richard, Dean, Charles, Furegati, Markus, gamboa, Luis, Growcott, Ellena, Li, Cindy, Lopez, Sara, Metzger, Louis, Nocito, Sandro, Ossola, Flavio, Rasper, Dita, Yue, Qin, Phizackerley, Kaci, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert L, Tang, Dazhi and Tashiro, Kyuto (2019) IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor. ACS infectious diseases. ISSN 23738227

Reich, K, Blauvelt , A, Armstrong, A, Langley, R, de Vera, Ana, Kolbinger, Frank, Spindeldreher, Sebastian and Bruin, Gerardus (2019) Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years. Journal of the European Academy of Dermatology and Venereology.

Reinisch, Jens, Diedenhofen, Michael, Wilcken, Rainer, Udvarhelyi, Aniko and Glöss, Andreas (2019) Benchmarking different QM-levels for usage with COSMO-RS. Journal of Chemical Information and Modeling. ISSN 1549-95961549-960X

Riede, Julia, Umehara, Ken-Ichi, Schweigler, Patrick, Huth, Felix, Schiller, Hilmar, Camenisch, Gian P. and Poller, Birk (2019) Examining P-gp efflux kinetics guided by the BDDCS – Rational selection of in vitro assay designs and mathematical models. European Journal of Pharmaceutical Sciences, 132. pp. 132-141. ISSN 18790720

Roggo, Yves, Pauli, Victoria Isabell, Jelsch, Morgane, Pellegatti, Laurent, Ensslin, Simon, Kleinebudde, Peter and Krumme, Markus (2019) Continuous manufacturing process monitoring of pharmaceutical solid dosage form: A case study. Journal of Pharmaceutical and Biomedical Analysis. ISSN 1873264X

Rooks, Daniel (2019) Sarcopenia: A muscle disease with decreased functional capacity and an increased risk of adverse health outcomes. Current Physical Medicine and Rehabilitation Reports.

Rooks, Daniel and Roubenoff, Ronenn (2019) Development of pharmacotherapies for the treatment of sarcopenia. Journal of Frailty and Aging.

Roth, Hans-Joerg, Fouche, Marianne, Blatter, Markus, Witek, Jagna, Wang, Shuzhe, Lingwood, Robin, Dounas, Andreas , Lemke, Oliver, Keller, Bettina and Riniker, Sereina (2019) Rationalization of the Membrane Permeability Differences in a Series of Analogue Cyclic Decapeptides. Journal of chemical information and modeling, 59 (1). pp. 294-308. ISSN 1549960X

Ruggiu, Fiorella, Yang, Shengtian, Robert, Simmons, Anthony, Casarez, Adriana, Jones, Cindy, Li, Jansen, Hanneke, Moser, Heinz, Charles, Dean, Folkert, Reck and Lindvall, Mika (2019) Size matters – and how you measure it: a gram-negative antibacterial example exceeding typical molecular weight limits. ACS Infectious Diseases. ISSN 2373-82272373-8227

Rux, Danielle, Decker, Rebekah, Koyama, Eiki and Pacifici, Maurizio (2019) Joints in the appendicular skeleton: Developmental mechanisms and evolutionary influences. Current topics in developmental biology.. ISSN 1557-8933; 0070-2153

SATO, MASAHIKO and MORIYA, ATSUKO (2019) Phase I study of BGT226, a pan-PI3K and mTOR inhibitor, in Japanese patients with advanced solid cancers. Cancer Chemotherapy and Pharmacology, 84 (2). pp. 337-343. ISSN 14320843

Sacher, Christian, Blume, Tanja, Beyer, Leonie, Peters, Finn, Eckenweber, Floria, Sgobio, Carmelo, Deussing, Maximilian, Albert, Nathalie, Unterrainer, Marcus, Lindner, Simon, Gildehaus, Franz-Joseph, von Ungern-Sternberg, Barbara, Brzak, Irena, Neumann, Ulf, Saito, Takashi, Saido, Takomi, Bartenstein, Peter, Rominger, Axel, Herms, Jochen and Brendel, Matthias (2019) Longitudinal in vivo PET assessment of cerebral β-Amyloid deposition and glial activation in knock-in mice non-overexpressing β-Amyloid precursor protein. Journal of nuclear medicine : JNM, 58 (2). ISSN 1535-5667; 0161-5505

Sager, Maximilian, Grimm, Michael, Jedamzik, Philipp, Merdivan, Simon, Kromrey, Marie-Luise, Hasan, Mahmoud, Koziolek, Mirko, Tzvetkov, Mladen V. and Weitschies, Werner (2019) Validation of the salivary tracer technique for the determination of the in vivo disintegration of hard gelatin capsules. Molecular Pharmaceutics. ISSN 1543-83841543-8392

Salazar, Valerie S, Capelo, Luciane P, Cantù, Claudio, Zimmerli, Dario, Gosalia, Nehal, Pregizer, Steven, Cox, Karen, Ohte, Satoshi, Feigenson, Marina, Gamer, Laura, Nyman, Jeffry S, Carey, David J, Economides, Aris, Basler, Konrad and Rosen, Vicki (2019) Reactivation of a developmental signaling center is required for therapeutic control of the murine periosteal niche. eLife, 8. ISSN 2050-084X

Sanderlin, Edward J., Marie, Mona , Velcicky, Juraj, Loetscher, Pius and Yang, Li V. (2019) Pharmacological Inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model. European journal of pharmacology, 852. pp. 218-230. ISSN 00142999

Santa Maria, John (2019) Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space. SLAS Discovery. p. 2472555219885373. ISSN 2472-5560

Sarver, Patrick, Acker, Michael, Bagdanoff, Jeffrey, Chen, Zhuoliang, Chen, Ying-Nan, Chan, Ho Man, Firestone, Brant, Fodor, Michelle, Garcia Fortanet, Jorge, Hao, Huaixiang, Hentemann, Martin, Kato, Mitsunori, Koenig, Robert, La Bonte, Laura, Liu, Gang, Liu, Shumei, Liu, Chen, McNeill, Eric, Mohseni, Mori, Sendzik, Martin, Stams, Travis, Spence, Stan, Tamez Jr., Victoriano, Tichkule, Ritesh, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah and Yu, Bing (2019) 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. Journal of Medicinal Chemistry, 62 (4). pp. 1793-1802. ISSN 15204804

Saunders, Ruth, Kaul, Himanshu, Berair, Rachid, Gonem, Sherif, Singapuri, Amisha, Sutcliffe, Amanda, Latifa, Chachi, Biddle, Michael, Kaur, Davinder, Bourne, Michelle, Pavord, Ian, Wardlaw, Andrew, Siddiqui, Salman, Brook, Bindi, Smallwood, Rod and Brightling, Christopher (2019) Prostaglandin D2 type 2 receptor antagonism reduces airway smooth muscle mass in asthma: mechanistic insights from in vitro and computational models. Science Translational Medicine, 11 (479). ISSN 1946-62341946-6242

Schelle, Juliane, Wegenast-Braun, Bettina, Fritschi, Sarah, Kaeser, Stephan A, Häsler, Lisa M, Wolfer, David, Mueggler, Thomas, Shimshek, Derya, Neumann, Ulf, Dodt, Hans-Ulrich, Staufenbiel, Matthias and Jucker, Mathias (2019) Aβ reduction at early disease stages prevents progression of cerebral amyloid angiopathy in a mouse model of hereditary cerebral hemorrhage with amyloidosis - Dutch type. Annals of Neurology. ISSN 0364-51341531-8249

Schoeberl, Birgit (2019) Quantitative Systems Pharmacology models as a key to translational medicine. Current Opinion in Systems Biology, 16. pp. 25-31. ISSN 24523100

Schubart Wellensiek, Anna (2019) The next-generation sphingosine 1 receptor modulator BAF312 (siponimod) improves cortical network functionality in autoimmune neurodegeneration. Neural Regeneration Research, 14 (11). pp. 1950-1960. ISSN doi: 10.4103/1673-5374.259622

Schubart Wellensiek, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, ehara, Takeru, Adams, Christopher, Mac Sweeney, Aengus, Liao, Sha-Mei, Crawley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valerie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard, Risitano, Antonio, Karki, Rajeshri, Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Aubin, Nicola, Smith, Thomas, Cumin, Frederic, Argikar, Upendra, Haraldsson, Boerje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Juergen Klaus, Flohr, Stefanie and Harrison, Richard (2019) Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proceedings of the National Academy of Sciences of the United States of America, 116 (16). pp. 7926-7931. ISSN 10916490

Schuepp, Patrick (2019) Green Chemistry Benchmarking and improvement proposals for the CHAD Green Chemistry Scorecard Process. MS Thesis from UZH.

Schwizer, Natascha (2019) Stereo-controlled lithiation-methylation and subsequent aminolysis of a chiral epoxide in continuous flow. Masters Thesis for the University of Applied Sciences NW-Switzerland.

Sebastiani, Paola, Monti, Stefano, Morris, Melody, Gurinovich, Anastasia, Toshiko, Tanaka, Andersen, Stacy, Sweigart, Benjamin, Ferrucci, Luigi, Jennings, Lori, Glass, David and Perls, Thomas (2019) A serum protein signature of APOE genotypes in centenarians. Aging cell, 18 (6). e13023. ISSN 1474-9726

Sedrani, Richard, Cottens, Sylvain, Schuler, Walter and Kallen, Jörg (2019) Derivation of Rapamycin: Adventures in Natural Product Chemistry. Chimia., 73 (7). pp. 581-590. ISSN 0009-4293

Shukui, Qin, Stephen, Lam Chan, Wattana, Sukeepaisarnjaroen, Guohong, Han, Su Pin , Choo, Virote , Sriuranpong, Hongming, Pan, Thomas , Yau, Yabing , Guo, Minshan , Chen, Zhenggang, Ren, Jianming, Xu, Chia-Jui , Yen, Zhong-Zhe , Lin, Gu, Gary, Sun, Yongjian , Tiedt, Ralph, Hao, Lu, Song, Vicky, Tanwandee, Tawesak and Manenti, Luigi (2019) A Phase II Study of the Efficacy and Safety of the MET Inhibitor Capmatinib (INC280) in Patients with Advanced Hepatocellular Carcinoma. Therapeutic Advances in Medical Oncology, 11 (2019 D). ISSN 1758-83591758-8359

Shultz, Michael (2019) Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs. Journal of Medicinal Chemistry, 62 (4). pp. 1701-1714. ISSN 15204804

Shutinoski, Bojan, Hakimi, Mansoureh, Harmsen, Irene, Lunn, Michaela, Rocha, Juliana, Lengacher, Nathalie, Zhou, Yi Yuan, Khan, Jasmine, Nguyen, Angela, Hage-Volling, Quinton, El-Kodsi, Daniel, Li, Juan, Alikashani, Azadeh, Beauchamp, Claudine, Majithia, Jay, Coombs, Kevin, Marcogliese, Paul C., Park, David S., Rioux, John D., Philpott, Dana, Woulfe, John M., Hayley, Shawn, Sad, Subash, Tomlinson, Julianna J., Brown, Earl G. and Schlossmacher, Michael G. (2019) Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner. Science Translational Medicine, 11 (511). ISSN 1946-62341946-6242

Shutinoski, Bojan, Harmsen, Irene, Hakimi, Mansoureh, Zhou, Yi Yuan, Rocha, Juliana, Woulfe, John M., Park, David S., Rioux, John D., Philpott, Dana, Sad, Subash, Tomlinson, Julianna J., Brown, Earl G. and Schlossmacher, Michael G. (2019) Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner. Science Translational Medicine, 11 (511). ISSN 19466242

Sijbesma, Eline, Hallenbeck, Kenneth, Leysen, Seppe, de Vink, Pim, Jahnke, Wolfgang, Brunsveld, Luc, Arkin, Michelle and Ottmann, Christian (2019) Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society, 141 (8). pp. 3524-3531. ISSN 15205126

Singh, Ajeet, Sosa, Maria, Fang, Jian, Shanmukhappa, Shiva, Hubaud, Alexis, Fawcett, Caroline, Molind, Gregory, Tsai, Ting, Capodieci, Paola, Wetzel, Kristie, Sanchez, Ellen, Wang, Guangliang, Coble, Matthew, Tang, Wenlong, Cadena, Samuel, Fishman, Mark and Glass, David (2019) α-Klotho regulates age-associated vascular mineralization and lifespan in zebrafish. Cell reports, 28 (11). pp. 2767-2776. ISSN 22111247

Singh, Nathan, Xu, Jun, Binder, Zev, Collins, McKensie, O'Rourke, Donald and Melenhorst, J. Joseph (2019) Mechanisms of resistance to CAR T cell therapies. Seminars in cancer biology. ISSN 1044579X

Slomp, Anne, Moesbergen, Laura M., Minnema, Monique C. and Peperzak, Victor (2019) Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting. Blood Advances, 3 (24). pp. 4202-4214. ISSN 24739537

Smith, Brian (2019) Where Will Statistical Sciences for Clinical Pharmacology Be in 2030? Clinical Pharmacology & Therapeutics, 107 (1). pp. 17-21. ISSN 0009-92361532-6535

Spiegel, Stephan, Hossain, Imtiaz, Ball, Christopher and Zhang, Xian (2019) Metadata-Guided Visual Representation Learning for Biomedical Images. BioRxiv.

Spradlin, Jessica N., Hu, Xirui, Ward, Carl C., Brittain, Scott, Jones, Michael, Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornelas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A., Bussiere, Dirksen, Thomas, Jason, Tallarico, John, McKenna, Jeffrey, Schirle, Markus, Maimone, Thomas J. and Nomura, Daniel K. (2019) Harnessing the anti-cancer natural product nimbolide for targeted protein degradation. Nature Chemical Biology, 15 (7). pp. 747-755. ISSN 15524469

Stauffer, Frederic, Weiss, Andreas, Scheufler, Clemens, Moebitz, Henrik, Ragot, Christian, Beyer, Kim, Calkins, Keith, Guthy, Daniel Alexander, Kiffe, Michael, Van Eerdenbrugh, Bernard, Tiedt, Ralph and Gaul, Christoph (2019) New potent DOT1L inhibitors for in vivo evaluation in mouse. ACS medicinal chemistry letters.

Studer, Christian, Hoepfner, Dominic, Roggo, Silvio, Helliwell, Stephen, Snyder, Nathan, Kim, Adam, Kester, Louis, Gale, Andrew and Cunningham, Kyle (2019) Auxin-inducible depletion of the essentialome suggests inhibition of TORC1 by auxins and inhibition of Vrg4 by SDZ 90-215, a natural antifungal cyclopeptide. G3: Genes, Genomes, Genetics, 9 (3). pp. 829-840. ISSN 21601836

Takase, Ryuta, Hino, Shinjiro, Nagaoka, Katsuya, Anan, Kotaro, Kohrogi, Kensaku, Araki, Hirotaka, Sakamoto, Akihisa, Nicholson, Thomas, Chen, Taiping and Nakao, Mitsuyoshi (2019) Lysine-specific demethylase-2 is distinctively involved in brown and beige adipogenic differentiation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (4). pp. 5300-5311. ISSN 15306860

Tan, Mario A., Zueger, Patrik and Roggo, Silvio (2019) Total synthesis of diaportheone A. Tetrahedron Letters, 60 (1). pp. 52-54. ISSN 18733581

Tang, Cong, Ksiazek, Iwona, Siccardi, Noemie, Gapp, Berangere, Weber, Delphine, Wirsching, Johann, Beck, Valerie, Reist, Matthias, Gaudet, Laurent, Beibel, Martin, Roma, Guglielmo, Gubser Keller, Caroline and Bassilana, Frederic (2019) UTS2B defines a novel enteroendocrine cell population and regulates GLP-1 secretion through SSTR5 in male mice. Endocrinology. ISSN 1945-7170

Tang, Wenlong, Fulk, George, Zeigler, Stacey, Zhang, Ting and Sazonov , Edward (2019) Estimating Berg Balance Scale and Mini Balance Evaluation System Test Scores by Using Wearable Shoe Sensors. Engineering in Medicine and Biology Society, Annual international confrerence of the IEEE.

Tarselli, Mike, Potier, Yohann and Fletcher, Allan (2019) Automating Automation – How Close are We to Artificial Intelligence Impact? Drug Discovery World - https://www.ddw-online.com/.

Tatrai, Peter, Schweigler, Patrick, Poller, Birk, Domange, Norbert, Hanna, Imad, Gaborik, Zsuzsanna and Huth, Felix (2019) A systematic in vitro investigation of the inhibitor preincubation effect on multiple classes of uptake transporters. Drug Metabolism and Disposition. ISSN 1521-009X

Thakare, Vivek, Mayr, Bettina, Artenjak, Andrej, Nianios, Dimitrios, Sest, Maike, Müller, Martin, Maltsev, Oleg V, Nowicki, Kajetan, Mischo, Andre, Ehrenstrasser, Christian, Fink, Matthias, Thanhaeuser, Silvia and Cerreti, Alessandra (2019) Investigation of drug product and container-closure interactions: A case study of diluent containing prefilled syringe. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 140. pp. 67-77. ISSN 1873-3441

Thangavelu, Govindarajan, Du, Jing, Paz, Katelyn, Loschi, Michael, Flynn, Ryan, Taylor, Patricia, Kirchmeier, Andrew, Zaiken, Micheal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli, Hill, Geoffrey, Maillard, Ivan, Munn, David, Serody, Jonathan, Murphy, William, Miklos, David, Cutler, Corey, Koreth, John, Antin, Joseph, Soiffer, Robert, Ritz, Jerome, Dahlberg-Bohl, Carol, Miller, Andrew and Blazar, Bruce (2019) Inhibition of Inositol kinase B controls acute and chronic graft-versus-host disease. Blood. ISSN 15280020

Theil, Diethilde, Smith, Paul, Huck, Catherine, Gilbart, Yoann, Kakarieka Weisskopf, Algirdas, Leppert, David, Rauld, Celine, Schmid, Cindy, Baumgartner, Reto, Stuber, Nathalie, Cordoba Castro, Francisco, Dubost, Valerie, Darribat, Katy, Jivkov, Magali Natacha, Frieauff, Wilfried, Kneuer, Rainer, Stoeckli, Markus, Reinker, Stefan, Mansfield, Keith, Carballido, Jose, Couttet, Philippe and Weckbecker, Gisbert (2019) Imaging Mass Cytometry and Single-cell Genomics Reveals Differential Depletion and Repletion of B cell Populations Following Ofatumumab Treatment in Cynomolgus Monkeys. Frontiers in immunology, 10 (1). pp. 1-11. ISSN 1664-3224

Tlili, Anis, Ghiazza, Clement and Thierry, Billard (2019) Chalcogen OCF3-isosteres Modulate Drug Properties without Introducing Inherent Liabilities. ChemMedChem : chemistry enabling drug discovery, 14 (17). pp. 1586-1589. ISSN 1860-71791860-7187

Trendelenburg, Anne-Ulrike, Scheuren, Ariane, Potter, Paul, Ralf , Mueller and Bellantuono, Ilaria (2019) Geroprotectors: A role in the treatment of frailty. Mechanisms of Ageing and Development, 180. pp. 11-20. ISSN 18726216

Troxler, Thomas J., Feuerbach, Dominik, Zhang, Xuechun, Yang, Charles, Lagu, Bharat, Perrone, Mark, Wang, Tie-Lin, Briner, Karin, bock, Mark and Auberson, Yves (2019) The discovery of LML134, a histamine H3 receptor inverse agonist for the clinical treatment of excessive sleep disorders. ChemMedChem. ISSN 18607187

Tulli, Ludovico, Pintassilgo Miranda, Daniela, Lee, Cameron, Sullivan, Yang, Grotzfeld, Robert, Hollingworth, Greg, Kneuer, Rainer and Karpov, Alexei (2019) Modular synthesis and post-modification of novel bifunctional dendrons. Organic and biomolecular chemistry. ISSN 1477-0539; 1477-0520

Turner, Oliver, Janardhan, Kyathanahalli, Kohnken, Rebecca , Channabasavaiah, Gurumurthy and Kovi, Ramesh (2019) Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future. Toxicologic Pathology, 47 (8). pp. 1082-1087. ISSN 15331601

Turner, Oliver, Saravanan, Chandrassegar, Sing, Tobias, Aeffner, Famke, Bangari, Dinesh, High, Wanda, Knight, Brian, Forest, Tom, Schumacher, Vanessa, Himmel, Lauren, Rudmann, Dan, Bhupinder, Bawa, Muthuswamy, Anantharaman, Edmondson, Elijah, Aina, Olulanu, Cossic, Brieuc, Brown, Danielle and Sebastian, Manu (2019) Society of Toxicologic Pathology Digital Pathology and Image Analysis Special Interest Group Article*: Opinion on the Application of Artificial Intelligence and Machine Learning to Digital Toxicologic Pathology. Toxicologic Pathology. ISSN 15331601

Turner, Patricia V, Pang, Daniel Sj and Lofgren, Jennifer Ls (2019) A Review of Pain Assessment Methods in Laboratory Rodents. Comparative medicine, 69 (6). pp. 451-467. ISSN 1532-0820

Uluckan, Ozge and Roediger, Ben (2019) Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1. Cell Reports, 29 (4). 844-859.e3. ISSN 22111247

Umehara, Ken-Ichi, Huth, Felix, Schiller, Hilmar, Jin, Yi, Aslanis, Vassilios, Heimbach, Tycho and He, Handan (2019) Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions. Drug Metabolism and Personalized Therapy, 34 (2). ISSN 23638915

Umehara, Ken-Ichi, Huth, Felix, Schiller, Hilmar, Jin, Yi, Aslanis, Vassilios, Heimbach, Tycho and He, Handan (2019) Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions. Drug Metabolism and Personalized Therapy, 34 (2). pp. 1-14. ISSN 23638915

Velcicky, Juraj, Mathison, Casey, Nikulin, Victor, Pflieger, Daniel, Epple, Robert, Azimioara, Mihai, Cow, Christopher, Michellys, Pierre, Rigollier, Pascal, Beisner, Daniel, Bodendorf, Ursula, Guerini, Danilo, Liu, Bo, Wen, Ben, Zaharevitz, Samantha and Brandl, Trixi (2019) Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors. ACS Medicinal Chemistry Letters, 10. ISSN 1948-58751948-5875

Vilgelm, Anna E., Saleh, Nabil, Riemenschneider, Kelsie, Slesur, Lauren, Chen, Sheau-Chian, Johnston, C. Andrew, Yang, Jinming, Johnson, Douglas B., Al-rohil, Rami Nayef, Halilovic, Ensar, Kauffmann, Rondi M., Hooks, Mary, Kelley, Mark, Ayers, Gregory D. and Richmond, Ann (2019) MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21. Science Translational Medicine, 11 (505). ISSN 19466242

Vorherr, Thomas, Lewis, Ian, Berghausen, Joerg, Huth, Felix, Schaefer, Michael, Wille, Roman Mariano, Gao, Jinhai and Wang, Bing (2019) Pyridyl-Ala modified cyclic hexapeptides: in-vitro and in-vivo profiling for oral bioavailability. International journal of peptide research and therapeutics., 19 (4). pp. 275-380. ISSN 1573-3149

Vorherr, Thomas, Lewis, Ian and Schaefer, Michael (2019) Late-stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents. Angewandte Chemie, 58. pp. 1-5.

Voshol, Johannes, Trojer, Dominic, Corso, Guilia, Heusermann, Wolf, Görgens, Andre, Steib, Emmanuelle, Graff, Alexandra, Genoud, Christel, Lee, Yi, Hean, Justin, Nordin, Joel, Wiklander, Oskar, El Andaloussi, Samir and Meisner-Kober, Nicole (2019) Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging. Journal of Extracellular Vesicles, 8 (1). ISSN 2001-3078

Walles, Markus and Hainzl, Dominik (2019) New guidelines for the pharmacokinetic and Drug drug interaction assessments of ADCS-input to templates for IQ consortium. the excel template swill be shared at IQ consortium (TC) , na (na). na. ISSN na

Wang, Andrew, Pham, Helen, Lipps, Jennifer, Brittain, Scott, Harrington, Edmund, Wang, Yuan, King, Frederick, Russ, Carsten, Pan, Xuewen, Hoepfner, Dominic, Tallarico, John, Feng, Yan, Jain, Rishi, Schirle, Markus and Thomas, Jason (2019) Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action. ACS Chemical Biology, 14 (1). pp. 20-26. ISSN 15548937

Wang, Yang, Zhong, Yang, Zhou, Yingyao, Tanaseichuk, Olga, Wilkinson, Jeremy, Li, Zhizhong and Zhao, Jing Crystal (2019) Identification of a Xist silencing domain 1 by Tiling CRISPR. Scientific Reports.

Ward, Carl C, Kleinman, Jordan, Brittain, Scott, Lee, Patrick, Chung, Clive Yik Sham, Kim, Kenneth, Petri, Yana, Thomas, Jason, Tallarico, John, McKenna, Jeffrey, Schirle, Markus and Nomura, Daniel K (2019) Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chemical Biology. ISSN 15548937

Weber, Judith, Bollepalli, Laura, Belenguer, Ana M, Antonio, Marco Di, De Mitri, Nicola, Joseph, James, Balasubramanian, Shankar, Hunter, Christopher A and Bohndiek, Sarah E (2019) An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging. Cancer research, 79 (20). pp. 5407-5417. ISSN 1538-7445

Weckbecker, Gisbert, Kneuer, Rainer, Migotto, Mary-Anne , Mardon, Karine , Orian, Jacqueline , Bhalla, Rajiv and Reutens, David C. (2019) Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice. Frontiers in Immunology, 10. ISSN 16643224

Weiss, William J, Pulse, ME, Nguyen, P and Growcott, Ellena (2019) In vivo efficacy of novel monobactam LYS228 in murine models of carbapenemase-producing Klebsiella pneumoniae infection. Journal of antimicrobial chemotherapy, 63 (4). e02214-e02218.

Wieczorek, Grazyna, Bigaud, Marc, Pfister, Sabina, Ceci, Melanie, McMichael, Katriona, Afatsawo, Catherine, Hamburger, Meike, Texier, Celine, Henry, Maurane, Cojean, Celine, Erard, Marinette, Mamber, Nadja and Rush, James S (2019) Blockade of CD40–CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren’s syndrome. Annals of the Rheumatic Diseases, 78 (7). pp. 974-978. ISSN 0003-4967

Withers, Nikki and Mellman, James (2019) European Pharmaceutical Review James Mellman. European pharmaceutical review : The quarterly review of pharmaceutical business & technology.. ISSN 1360-8608

Wu, Paul, Hartman, Taymar, Almond, Louise, Stevens, Jennitte, Thrift, John, Ojha, Juhi, Alves, Christina, Shaw, David, Laird, Mike, Emmins, Robyn, Zhu, Yuan, Liu, Ren, Du, Zhimei, Koehler, Rolf, Jostock, Thomas, Anderson, Karin, Campbell, Chris and Clarke, Howard (2019) Advancing Biologics Development Programs with Legacy Cell Lines: Advantages and Limitations of Genetic Testing for Addressing Clonality Concerns Prior to Availability of Late Stage Process and Product Consistency Data. PDA journal of pharmaceutical science and technology. ISSN 19482124

Wyss, Annika, Rasseli, Tina, Perkins, Nathan, Ruiz, Florian, Schmelczer, Gerard, Klinke, Glynis, Moncsek, Anja, Roth, Rene, Spalinger, Marianne, Hering, Larissa, Atrott, Kirstin, Lang, Silvia, Frey-Wagner, Isabelle, Mertens, Joachim, Scharl, Michael, Sailer, Andreas, Pabst, Oliver, Hersberger, Martin, Pot, Caroline, Rogler, Gerhard and Misselwitz, Benjamin (2019) The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis. Mucosal immunology. ISSN 1935-3456

Yamaura, Takeshi, Kasaoka, Tatsuhiko, KANEKO, NAOKO, Kimura, Masaaki and Hatakeyama, Shinji (2019) Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis. BMC research notes, 12. p. 200. ISSN 1756-0500

Yeyinmen, Karen and Stacey, Mary (2019) Team Coaching at Scale: Creating conditions for the emergence of adaptive leadership cultures. The Practitioner's Handbook of Team Coaching. pp. 405-419. ISSN 978-1-351-13055-4

Zerbi, Valerio, Markicevic, Marija, Gasparini, Fabrizio, Rudin, Markus and Wenderoth, Nicole (2019) Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice. NeuroImage, 191. pp. 392-402. ISSN 10959572

Zhou, Yingyao, Zhou, Bin, Pache, Lars, Chang, Max, Hadj Khodabakhshi, Alireza, Tanaseichuk, Olga, Benner, Chris and Chanda, Sumit (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nature Communications, 10 (1). p. 1523. ISSN 20411723

de Oliveira Mann, Carina, Orzalli, Megan, King, David , Kagan, Jonathan, Lee, Amy and Kranzusch, Philip (2019) Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation. Cell reports. ISSN 2211-1247

van Keulen, Danielle, Pouwer, Marianne G., Emilsson, Valur, Aldi, Silvia, Perisic Matic, Ljubica, Hedin, Ulf, Gudnason, Vilmundur, Jennings, Lori, Holstrom, Kim, Schnack Nielson, Boye, Pasterkamp, Gerard, Lindeman, Jan H.N., van Gool, Alain J., Sollewijn Gelpke, Maarten D., Princen, Hans M.G. and Tempel, Dennie (2019) Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humans. PLoS ONE, 14 (8). pp. 1-22. ISSN 19326203

vitobello, Antonio, Perner, Juliane, Beil, Johanna, Zhu, Jiang, Del Rio Espinola, Alberto, Morawiec, Laurent, Westphal, Magdalena, Dubost, Valerie, Altorfer, Marc, Naumann, Ulrike, Mueller, Arne, Kapur, Karen, Borowsky, Mark, Henderson, Colin, Wolf, Roland, Schwarz, Michael, Moggs, Jonathan and Terranova, Remi (2019) Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion. Life Science Alliance.

wu, jie, xue, chengwen, li, jiesheng and lee, jin ping (2019) Continuous Amination of Aryl/Heteroaryl Halides Using Aqueous Ammonia in a Teflon AF-2400 Tube-in-Tube Micro-Flow Reactor. Reaction Chemistry & Engineering, 4 (2). pp. 346-350. ISSN 2058-9883