Gallou, Fabrice (2019) Sustainable ppm Level Palladium-Catalyzed Aminations Under Mild, Aqueous Nanomicellar Conditions. chemical science, 2019.

Abstract

A 1:1 Pd:L complex, [t-BuXPhos(Pd-p-cinnamyl)]OTf, has been identified as a highly robust pre-catalyst for amination reactions leading to diarylamines, where loadings of metal are mainly at 1000 ppm Pd, run in water at temperatures between rt and 45 °C. The protocol is exceptionally simple, compares very favorably vs. traditional amination conditions, and has been shown to successfully lead to key medicinal intermediates.

Item Type:	Article
Date Deposited:	26 Nov 2019 00:45
Last Modified:	26 Nov 2019 00:45
URI:	https://oak.novartis.com/id/eprint/38829