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Introduction to Digital Image Analysis in Whole-Slide Imaging: A White Paper from the Digital Pathology Association

Aeffner, Famke and Zarella, Mark and Buchbinder, Nathan and Bui, Marilyn and Goodman, Matthew and Hartman, Douglas and Lujan, Giovanni and Molani, Mariam and Parwani, Anil and Tunstall, kate and Turner, Oliver and Vemuri, Venkata and Yuil-Valdes, Ana and Bowman, Douglas (2019) Introduction to Digital Image Analysis in Whole-Slide Imaging: A White Paper from the Digital Pathology Association. Journal of Pathology Informatics, 10 (9). pp. 1-17.

Abstract

The advent of whole-slide imaging in digital pathology has brought about the advancement of computer-aided examination of tissue via digital image analysis. Digitized slides can now be easily annotated and analyzed via a variety of algorithms. This paper reviews the fundamentals of tissue image analysis, and aims to provide pathologists with basic information regarding the features, applications, and general workflow of these new tools. The review gives an overview of the basic categories of software solutions available, potential analysis strategies, technical considerations and general algorithm readouts. Advantages and limitations of tissue image analysis are discussed and emerging concepts, such as artificial intelligence and machine learning, are introduced. Lastly, examples of how digital image analysis is currently being used in diagnostic laboratories, translational research and drug development are discussed.

Item Type: Article
Date Deposited: 05 Apr 2019 00:45
Last Modified: 05 Apr 2019 00:45
URI: https://oak.novartis.com/id/eprint/38084

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