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Benchmarking network algorithms for contextualizing genes of interest

Hill, Abby, Gleim, Scott, Kiefer, Florian, Sigoillot, Frederic, Loureiro, Joe, Jenkins, Jeremy and Morris, Melody (2019) Benchmarking network algorithms for contextualizing genes of interest. PLOS Comp Bio.


Computational approaches have shown promise in contextualizing genes of interest with known molecular interactions. In this work, we evaluate seventeen previously published algorithms based on characteristics of their output and their performance in three tasks: cross validation, prediction of drug targets, and behavior with random input. Our work highlights strengths and weaknesses of each algorithm and results in a recommendation of algorithms best suited for performing different tasks.

Item Type: Article
Date Deposited: 01 Sep 2022 00:46
Last Modified: 01 Sep 2022 00:46


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