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Multifunctional carrier based on halloysite/laponite hybrid hydrogel for kartogenin delivery

Arista, Luca and Ullrich, Thomas and Riela, Serena and Massaro, Marina and Buscemi, Gabriella and Biddeci, Giuseppa and Cavallaro, Giuseppe and D'Anna, Francesca and Di Blasi, Francesco and Ferrante, Angelo and Lazzara, Giuseppe and Rizzo, Carla and Spinelli, Gaetano (2019) Multifunctional carrier based on halloysite/laponite hybrid hydrogel for kartogenin delivery. ACS Medicinal Chemistry Letters, 2019 (10). pp. 419-424. ISSN 1948-58751948-5875

Abstract

A novel carrier system based on halloysite nanotubes (HNT), for the potential intraarticular delivery of kartogenin (KGN)
by means laponite (Lap) hydrogel (HNT/KGN/Lap), is developed. The drug was first loaded into HNT, and the hybrid composite obtained was used as filler for laponite hydrogel. Both the filler and the hydrogel were thoroughly investigated by several techniques and the hydrogel morphology was imaged by transmission electron microscopy. Furthermore, the gelating ability of laponite in the presence of the filler and the rheological properties of the hybrid hydrogel were also investigated. The kinetic release of kartogenin from HNT and HNT/Lap hybrid hydrogel was studied both in
physiological conditions and in ex vivo synovial fluid. In the last case, the kinetic results highlighted that HNT carrier can effectively release KGN in a sustained manner for at least 38 days. Finally, a preliminary biological assays showed that the HNT/KGN/Lap hybrid hydrogel did not exhibit any cytotoxic effect.

Item Type: Article
Date Deposited: 30 Apr 2019 00:45
Last Modified: 30 Apr 2019 00:45
URI: https://oak.novartis.com/id/eprint/36932

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