Schoeberl, Birgit (2019) Quantitative Systems Pharmacology models as a key to translational medicine. Current Opinion in Systems Biology, 16. pp. 25-31. ISSN 24523100

Abstract

Recent advances in experimentation and computation have allowed us to build multiscale models of unprecedented scale. Quantitative Systems Pharmacology (QSP) models are multiscale models that link protein-interaction or drug-interaction kinetics to cellular response in the context of animal or human (disease) physiology. One of the areas where QSP models hold the most promise is in translating preclinical science into the clinic. In the following, I describe recent examples of multiscale models such as bacterial whole-cell models, multiscale tumor growth inhibition models and human disease models. Challenges of multiscale models and emerging solutions will be discussed.

Item Type:	Article
Date Deposited:	17 Mar 2020 00:45
Last Modified:	17 Mar 2020 00:45
URI:	https://oak.novartis.com/id/eprint/42421