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Enabling chiral separations in discovery chemistry with open-access chiral supercritical fluid chromatography

Michaels, Philip and Reilly, John and Neef, James and Galyan, Keith and Poirier, Jennifer and Ginsburg-Moraff, Carol and Dunstan, David and Zhou, Xilin (2019) Enabling chiral separations in discovery chemistry with open-access chiral supercritical fluid chromatography. Chirality. ISSN 1520636X

Abstract

Work from this paper details a novel walk-up open-access (OA) approach to enable chiral analytical method development and preparative separation of enantiomers in early discovery chemistry using supercritical fluid chromatography (SFC). We have demonstrated the success of this OA approach using immobilized chiral stationary phases (CSPs). After screening a diverse set of racemic drug candidates, we have concluded that a simplified OA chiral SFC platform can successfully purify approximately 60% of the analysed racemates. This streamlined OA workflow enables medicinal chemists with limited expertise in chiral method development to successfully and rapidly purify enantiomers for their projects using Waters UPC2 and Prep100-SFC instrumentation.

Item Type: Article
Keywords: achiral, chiral, HPLC, screening, semi-preparative, SFC
Date Deposited: 30 Jul 2019 00:45
Last Modified: 30 Jul 2019 00:45
URI: https://oak.novartis.com/id/eprint/39282

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