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Total synthesis of diaportheone A

Tan, Mario A., Zueger, Patrik and Roggo, Silvio (2019) Total synthesis of diaportheone A. Tetrahedron Letters, 60 (1). pp. 52-54. ISSN 18733581


Diaportheone A (1), a chromone natural product was previously isolated from the endophytic fungi Diaporthe sp. P 133. Its structure was established by spectroscopic methods, however, its absolute configuration remained undefined. This study dealt on the total synthesis of diaportheone A (1) utilizing the cyclization and in situ thermal syn-elimination of a β-ketosulfoxide. The C-1R absolute configuration of the natural product was established by X-ray crystallography of the synthetic diaportheone A (1) (>99% ee) and comparison with the optical rotation.

Item Type: Article
Keywords: Chromone Diaportheone Pandanus X-ray crystallography
Date Deposited: 25 Apr 2019 00:45
Last Modified: 25 Apr 2019 00:45


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