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Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis

Yamaura, Takeshi and Kasaoka, Tatsuhiko and KANEKO, NAOKO and Kimura, Masaaki and Hatakeyama, Shinji (2019) Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis. BMC research notes, 12. p. 200. ISSN 1756-0500

Abstract

Objective: Therapeutic effects of focal adhesion kinase (FAK) inhibition using a small molecule inhibitor was evaluated in apolipoprotein E (apoE) knockout (KO) and low-density lipoprotein receptor (LDLr) KO mouse atherosclerosis models.
Results: The prevention trial consisted of 8-week concurrent treatment with a high fat (HF) / high cholesterol (HC) diet. The intervention trial consisted of 6- and 8-week treatment after 6- and 8-week pre-loading of a HF/HC diet in apoE KO and LDLr KO mice, respectively. The inhibitor was admixed with a HF/HC diet and mice were given free access to the admixture. The FAK inhibitor exhibited marked inhibition against the development of the atherosclerosis in both of prevention and intervention trials at a dose of 0.03% without showing any remarkable toxic properties in biochemical examinations. These results indicated that FAK inhibition might be a possible candidate for novel therapeutic targets against atherosclerosis.

Item Type: Article
Date Deposited: 18 Apr 2019 00:45
Last Modified: 18 Apr 2019 00:45
URI: https://oak.novartis.com/id/eprint/38234

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