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The comparison of the performance of 3 T and 7 T T mapping for untreated low-grade cartilage lesions.

Juras, Vladimir and Schreiner, Markus and Laurent, Didier and Zbýň, Štefan and Mlynarik, Vladimir and Szomolanyi, Pavol and Hager, Benedikt and Scotti, Celeste and Goldhahn, Jörg and Heule, Rahel and Bieri, Oliver and Trattnig, Siegfried (2019) The comparison of the performance of 3 T and 7 T T mapping for untreated low-grade cartilage lesions. Magnetic resonance imaging, 55. pp. 86-92. ISSN 1873-5894

Abstract

OBJECTIVE:
To investigate T mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners.

DESIGN:
Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points.

RESULTS:
A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of -5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of -6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T.

CONCLUSION:
The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.

Item Type: Article
Date Deposited: 26 Mar 2019 00:45
Last Modified: 26 Mar 2019 00:45
URI: https://oak.novartis.com/id/eprint/39300

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