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GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

Dranoff, Glenn and Dougan, Michael and Dougan, Stephanie (2019) GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity, 50 (4). pp. 796-811. ISSN 10974180

Abstract

The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Here, we review the functions of the β common cytokines in health and disease. We discuss preclinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, the limitations, and the important gaps in understanding of the basic biology of this cytokine family.

Dougan, Dranoff, and Dougan review the functions of the β common chain cytokines—GM-CSF, IL-3, and IL-5—in health and disease. They discuss current efforts targeting these pathways in the clinic and highlight important gaps in understanding of the basic biology of this cytokine family.

Item Type: Article
Keywords: allergic disease beta common cytokines eosinophils GM-CSF hematopoiesis IL-3 IL-5 tumor immunology
Date Deposited: 04 Jun 2019 00:45
Last Modified: 04 Jun 2019 00:45
URI: https://oak.novartis.com/id/eprint/38690

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