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Deciphering mechanisms of response and resistance in large-scale mouse cancer screens

Jensen, Michael Rugaard and Cadapa Prahallad, Anirudh and Chapeau, Emilie (2019) Deciphering mechanisms of response and resistance in large-scale mouse cancer screens. Current Opinion in Genetics and Development, 54. pp. 48-54. ISSN 18790380

Abstract

Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. Understanding the mechanistic reasons for tumor relapse supports the identification of novel combination therapies that could lead to more durable responses. Here, we will review large-scale in vivo screens in pre-clinical cancer models that employed genetic and pharmacological agents toward elucidating acquired drug resistance and informing on beneficial combinations to be tested in clinical trials.

Item Type: Article
Date Deposited: 09 Jul 2019 00:45
Last Modified: 09 Jul 2019 00:45
URI: https://oak.novartis.com/id/eprint/38371

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