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Performance characterization of static mixers in precipitating environments

Mannschott, Thomas and Krumme, Markus and Kreimer, Manuel and Zettl, Manuel and Aigner, Isabella and van der Wel, Peter and Khinast, Johannes G. (2019) Performance characterization of static mixers in precipitating environments. Organic Process Research & Development, 23 (7). pp. 1308-1320. ISSN 1083-61601520-586X

Abstract

Static mixers are extensively used in various industries (pharmaceutical, food processing, chemical, pulp and paper, polymer synthesis, water treatment and petrochemical). They offer several advantages with regard to continuous operation (e.g., intensified mixing, byproduct reduction and sharp residence time distribution, no moving parts) and are frequently used in harsh chemical environments, in which fouling could cause serious problems or to a shut-down of the entire production line. Fouling has diverse mechanisms: precipitation fouling, particulate fouling, corrosion fouling, chemical reaction fouling, solidification, biofouling and composite fouling. This work investigates the application of static mixers in pharmaceutical purification processes that involve solvent exchange washing. Various equipment configurations were investigated and fouling probability and stability was analyzed. It was established that co-axial mixing of feed and anti-solvent before the static mixer, with an application of ultrasound, resulted in the most stable process. Furthermore, the particle size in various feed and product suspensions was analyzed and correlations between the amount of suspended particles and the particle growth were determined.

Item Type: Article
Date Deposited: 16 Jan 2021 00:45
Last Modified: 16 Jan 2021 00:45
URI: https://oak.novartis.com/id/eprint/36891

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