A

Abraham, Yann, Gerrits, Bertran, Rebhan, Michael, Ludwig, Marie-Gabrielle and Gubser Keller, Caroline (2017) Exploring Glucocorticoid Receptor Agonists Mechanism of Action Through Mass Cytometry and Radial Visualizations. Cytometry. Part B : clinical cytometry., 92 (1). pp. 42-56. ISSN 1552-4957; 1552-4949

Altmann, Eva, Erbel, Paulus, Renatus, Martin, Schaefer, Michael, Schlierf, Anita, Druet, Adelaide, Kieffer, Laurence, Sorge, Mickael, Pfister, Keith, Hassiepen, Ulrich, Ostermeier, Daniela, Martoglio, Bruno, Jefferson , Anne B. and Ruedisser, Simon (2017) Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5. Chimia., 71 (4). p. 241. ISSN 10.2533/chimia2017.241

Altmann, Eva, Schlierf, Anita, Schaefer, Michael, Renatus, Martin, Ruedisser, Simon, Erbel, Paulus, Ostermeier, Daniela, Druet, Adelaide, Kieffer, Laurence, Sorge, Mickael, Hassiepen, Ulrich, Jones, Matthew, Pfister, Keith, Jefferson, Ann, Martoglio, Bruno and Quancard, Jean (2017) Azaindoles as zinc-binding small molecule inhibitors of the JAMM protease CSN5. Angewandte Chemie, 56 (5). pp. 1294-1297. ISSN 1433-7851

Ambrose, Jessi, Mapa, Felipa, Ross, Nathan, Chen, Julie, Ye, Chaoyang and Bilican, Bilada (2017) Automated Scale-up and Maintenance of Stem Cell-Induced Neurons for Long-Term Culture and High-Throughput Screening. SLAS Technology.

Amsler, Philipp, Heudi, Olivier, Lanshoeft, Christian, Bettighofer, Anja, Eisfeld, Jochen, Moenius, Thomas, Probst, Claudia Monika and Etter, Coralie (2017) Production and application of high quality stable isotope labeled monoclonal antibody for mass spectrometry analysis. Journal of labelled compounds and radiopharmaceuticals. ISSN 03624803

Argikar, Upendra, Dumouchel, Jennifer, Dunne, Christine and Andrea, Bushee (2017) Ocular Non-P450 oxidative, hydrolytic and conjugative drug metabolizing enzymes. Drug metabolism reviews. pp. 1-23. ISSN 1097-9883

Argikar, Upendra, Dumouchel, Jennifer, Kramlinger, Valerie, Cirello, Amanda, Gunduz, Mithat, Dunne, Christine and Sohal, Bindi (2017) Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? Journal of Pharmaceutical Sciences, 106 (9). pp. 2276-2281. ISSN 15206017

Arias, HR, Jin, Xiaotao, Feuerbach, Dominik and Drenan, RM (2017) Nicotinic acetylcholine receptor selectivity and inhibitory activity on mouse medial habenula by coronaridine congeners. international journal of biochemistry and cell biology, 92. pp. 202-209.

Auberson, Yves (2017) Editorial - In vivo molecular imaging tools facilitates Drug Discovery. Drug Discovery Today: Technologies, 25. pp. 1-2.

Ayalasomayajula, Surya, Pan , Wei , Han , Yi , Yang, Fan, Langenickel, Thomas Heiko, Pal, Parasar, Yao Zong , Yuan and Sunkara, Gangadhar (2017) Assessment of Drug–Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (2). pp. 309-318. ISSN 21070180

B

Badal Tejedor, Maria, Nordgren, Niklas, Rutland, Mark, Schuleit, Michael, Millqvist-Fureby, Anna, Alderborn, Goran and Pazesh, Samaneh (2017) Determination of Interfacial Amorphicity in Functional Powders. Langmuir the ACS journal of surfaces and colloids., 33 (33). pp. 920-926. ISSN 1520-5827; 0743-7463

Badal Tejedor, Maria, Nordgren, Niklas, Schuleit, Michael, Millqvist-Fureby, Anna and Rutland, Mark (2017) AFM colloidal probe measurements implicate capillary condensation in punch-particle surface interactions during tableting. Langmuir the ACS journal of surfaces and colloids., 33. pp. 13180-13188. ISSN 1520-5827; 0743-7463

Baenziger, Markus, Durantie, Estelle and Mathes, Christian (2017) Development of an Industrial Process Based on the Groebke– Blackburn–Bienaymé Multicomponent Reaction: Efficient Preparation of 3-Aminoimidazo[1,2-a]pyrazines. Synthesis.

Baguia, Hajar (2017) Fluoride-free Hiyama cross-coupling in presence of surfactants and water. Report to be submitted to Université Libre de Bruxelles.

Beckmann, Nicolau (2017) Editorial: In vivo imaging in pharmacological research. Frontiers in Pharmacology, 7 (JAN). pp. 7-511. ISSN 16639812

Bernabei, Roberto, Mariotti, Luca, Brodes, Philippe and Roubenoff, Ronenn (2017) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people. Aging Clinical and Experimental Research, 29 (1). ISSN 17208319

Bialucha, Carl, Collins, Scott, Li, Xiao, Saxena, Parmita, Zhang, Xiamei, Duerr, Clemens, Shim, Yeonju, Mosher, Rebecca, Ostrom, Lance, Hu, Tiancen, Bilic, Sanela, Liric Rajlic, Ivana, Capka, Vladimir, Sharp, Fiona, Antonakos, Brandon, Wagner, Joel, Elliott, Ginell, Veloso, Artur, Piel, Jessica, Xu, Jian, Flaherty, Meghan, Mansfield, Keith, London, Anne, Kurz, Markus, Nguyen, Duc, Meyer, Matthew, Faris, Jason, Janatpour, Mary, Chan, Vivien, Yoder, Nicholas, Catcott, Kelly, McShea, Molly, Sun, Xiuxia, Gao, Hui, Williams, Juliet, Hofmann, Francesco, Engelman, Jeffrey, Ettenberg, Seth, Sellers, William and Lees, Emma (2017) Discovery and optimization of HKT288, a cadherin-6-targeting ADC for the treatment of ovarian and renal cancers. Cancer Discovery, 7 (9). pp. 1030-1045. ISSN 21598290

Bizec, Jean-Claude, Glogovac, Milica, Gromek, Kamila, Prause, Maarten, Winkler, Gian Christian, Milton, Mark, Newton, Ronald and Lovsin Barle, Ester (2017) Determination of Permitted Daily Exposure for Topical Ocular Drugs. Determination of Permitted Daily Exposure for Topical Ocular Drugs (00). pp. 1-9. ISSN 1083-7450

Blanz, Joachim, Dayer, Jerome, Delemonte, Thierry, Gertsch, Werner, Ramstein, Philippe, Williams, Gareth, Aichholz, Reiner, Trunzer, Markus and Pearson, David (2017) Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery. Journal of Mass Spectrometry, 52 (4). pp. 210-217. ISSN 1096-9888

Blasko, Andrei, Rao, Raj, Kuehl, Philip J. , Holmes, Thomas D. , Reed, Matthew D., Xu, Fadi and Zhuang, Jianguo (2017) A Physicochemical Assessment of Acid-induced Post-inhalation Cough in Guinea Pigs Animal Model. American Journal of Advanced Drug Delivery, 5 (4). pp. 131-138. ISSN ISSN 2321-547X

Blasko, Andrei, Tam, Yat Kong and Haidar Ahmad, Imad A. (2017) Cleaning verification dilemma of manufacturing equipment: Can the analytical method validation fail due to the cleanliness of the stainless steel surfaces? Atlas of Science, Octobe.

Blatter, Markus, Krepl, Miroslav , Cléry, Antoine , Allain, Frédéric H.T. and Sponer, Jiri (2017) Structural study of the Fox-1 RRM protein hydration reveal a role for key water molecules in RRM-RNA recognition. Nucleic Acids Research. ISSN 0305-10481362-4962

Brecht, Karin, Riebel, Virginie, Couttet, Philippe, Paech, Franziska, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois, Krähenbühl, Stephan and Uteng, Marianne (2017) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Toxicology in vitro, 40. pp. 55-65. ISSN 08872333

Brocklehurst, Cara, Koch, Guido, Makarov, Ilya S., Karaghiosoff, Konstantin L. and Knochel, Paul (2017) Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane. Angewandte Chemie International Edition.

Brocklehurst, Cara, Rothe-Poellet, Stephanie, Koch, Guido and La Vecchia, Luigi (2017) In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines. Synlett. ISSN 14372096

Brown, Alan, Saravanan, Chandrassegar, Devine, Pj, Magnifico, Maria, Gao, Jiaping, Beaulieu, Valerie, Ma, Margaret, Yasoshima, Kayo, Barnes, David and Yamada, Ken (2017) Characterization of intra-articular dose administration in the stifle joint of rabbits for toxicity testing. International Journal of Toxicology, 36 (4). pp. 303-313. ISSN 1092874X

Bruin, Gerardus, Loesche, Christian, Nyirady, Judit and Sander, Oliver (2017) Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis. Journal of Clinical Pharmacology, 57 (7). pp. 876-885. ISSN 1552-4604

Burkhart, Christoph, Kucher, Klaus, Sloth, Birgitte and Huber, Roland (2017) 1st Newsletter for ESID level 3 project in APDS. 1st Newsletter for ESID level 3 project in APDS.

Burks, Heather, Abrams, Tinya, Baird, Jason, Fekete, Alexander, Hamann, Lawrence, Kim, Sunkyu, Kirby, Christina, Lambardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P. , Mishina, Yuji, Norris, John, Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel, Wang, Chunrong, Peukert, Stefan and Wang, Jianling (2017) Discovery of an acrylic acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERa+ Breast Cancer. Journal of Medicinal Chemistry.

C

Cahill, Katherine , Katz, Howard , Cui, Jing , Lai, Juying , Kazani, Shamsah, Crosby-Thompson, Allison , Garofalo, Denise , Castro, Mario, Jarjour, Nizar , DiMango, Emily , Erzurum, Serpil , Trevor, Jennifer, Shenoy, Kartik , Chinchilli, Vernon, Wechsler, Michael, Laidlaw, Tanya, Boyce, Joshua and Israel, Elliot (2017) KIT inhibition by imatinib in patients with severe refractory asthma. New England Journal of Medicine, 376 (20). pp. 1911-1920. ISSN 15334406

Caicedo, Juan, Cooper, Sam, Heigwer, Florian, Warchal, Scott, Qiu, Peng, Molnar, Csaba, Vasilevich, Aliaksei, Barry, Joseph, Singh, Harmanjit, Kraus, Oren, Wawer, Mathias, Paavolainen, Lassi, Herrmann, Markus, Rohban, Mohammad, Hung, Jane, Hennig, Holger, Concannon, John, Smith, Ian, Singh, Shantanu, Rees, Paul, Horvath, Peter, Linington, Roger and Carpenter, Anne (2017) Data-analysis strategies for image-based cell profiling. Nature Methods, 14 (9). pp. 849-863. ISSN 15487105

Chandra, Abhishek , Qin , Ling, Kneissel, Michaela, Kramer, Ina, Liu, Sherry, Young, Tiffany and Ma, Xiaoyuan (2017) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone and Mineral Research, 32 (2). pp. 360-372. ISSN 1523-4681

Chen, Chih-wei, Beyer, Christian, Liu, Jun, Maier, Christiane, Li, Chun, Trinh-Minh, Thuong, Xu, Xiaohan, Cole, Stuart, Hsieh, Mindy Hsieh, Ng, Nicholas, Althage, Alana, Meeusen, Shelly, Pan, Shifeng, Svensson, Eric, Seidel, Martin, Schett, Georg, Gergely, Peter, Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt Signaling. Annals of the Rheumatic Diseases (1-6). pp. 1-6.

Chen, Chih-wei, Beyer, Christian, Liu, Jun, Maier, Christiane, Li, Chun, Trinh-Minh, Thuong, Xu, Xiaohan, Cole, Stuart, Hsieh, Mindy Hsieh, Ng, Nicholas, Althage, Alana, Meeusen, Shelly, Pan, Shifeng, Svensson, Eric, Seidel, Martin, Schett, Georg, Gergely, Peter, Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling. Annals of the Rheumatic Diseases, 76 (4). pp. 773-778. ISSN 1468-2060

Chen, Huaibin, Marsiglia, William M, Cho, Min-Kyu, Huang, Zhifeng, Deng, Jingjing, Blais, Steven P, Gai, Weiming, Bhattacharya, Shibani, Neubert, Thomas A, Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Huaibin, Marsiglia, William M, Cho, Min-Kyu, Huang, Zhifeng, Deng, Jingjing, Blais, Steven P, Gai, Weiming, Bhattacharya, Shibani, Neubert, Thomas A, Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Jin, Meyers, Charles, Keefe, Debbi, Yu, Jing and Sunkara, Gangadhar (2017) Clinical Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase 1 Inhibitor. Journal of Drug Design and Research.

Chen, Xin, Giraldes, John, Sprague, Elizabeth, Shakya, Subarna, Chen, Zhuoliang, Wang, Kate, Joud-Caldwell, Carol, Mathieu, Simon, Chen, Christine, Straub, Christopher, Duca, Jose, Hurov, Kristen, Yuan, Yanqiu, Shao, Wenlin and Toure, Bakary-Barry (2017) “Addition” and “Subtraction”: Selectivity Design for Type-II Maternal Embryonic Leucine Zipper Kinase Inhibitors. Journal of Medicinal Chemistry, 60. pp. 2155-2161.

Chen, Zhao (2017) Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib. European Journal of Radiology, 88. pp. 15-20. ISSN 18727727

Cheung, Sheldon T., Miller, Michelle S., Pacoma, Reynand, Roland, Jason, Schumacher, Andrew, Liu, Jian and Hsieh-Wilson, Linda C. (2017) Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chemical Biology, 12 (12). pp. 3126-3133. ISSN 15548937

Chiang, Derek and Villanueva, Augusto (2017) Progress towards molecular patient stratification of hepatocellular carcinoma: Lost in translation? Journal of Hepatology, 67 (5). pp. 893-895. ISSN 16000641

Cho, Young, Liu, Gang, Caferro, Thomas, Shafer, Cynthia, Manning, James, Sendzik, Martin, Shultz, Michael, Chenail, Gregg, Dooley, Julie, Farsidjani, Alireza, Chen, Jinyun, Kulathila, Raviraj, Xie, Xiaoling, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Heimbach, Tycho, Slocum, Kelly, Pu, Minying, Pagliarini, Raymond and Growney, Joseph (2017) Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Medicinal Chemistry Letters, 8 (10). pp. 1116-1121. ISSN 19485875

Clarke, Adrian, Kotoni, Dorina, Dispas, Amandine, Guillarme, Davy, Hubert, Philippe, Desfontaine, Vincent and Lebrun, Pierre (2017) Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 134. pp. 170-180.

Clottu, A, Mathias, A, Sailer, Andreas, Schluep, M, Seebach, J, Du Pasquier, R and Pot, Caroline (2017) EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. Cell Reports, 18 (1). pp. 213-224.

Cowell, Annie, LaMonte, Greeg, Abraham, Matthew, Flannery, Erika, William, Roy, Sasaki, Erica, Corey, Victoria, Lukens, Amanda, Istvan, Eva, Lee, Marcus, Franco, Virginia, Reimer, Christin, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Bopp, Selina, Gupta, Purva, Fuchs, Olivia, Kim, Sang, Teng, Christine, Gnadig, Nina, Vanaerschot, Manu, Murithi, James, Linares, Maria, Cozar, Cristina, Gomez-Lorenzo, Maria, Prats, Sara, Arriaga, Ignacio, Wang, Lawrence, Ottilie, Sabine, Siegel, Dionicio, Tanaseichuk, Olga, Zhong, Yang, Zhou, Yingyao, Willis, Paul, Gamo, Francisco-Javier, Goldberg, Daniel, Fidock, David, Wirth, Dyann and Winzeler, Elizabeth (2017) Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics. Science.

Cox, Georgina, Sieron, Arthur, King, Andrew , De Pascale, Gianfranco, Pawlowski, Andrew, Koteva, Kalinka and Wright, Gerard (2017) A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. Cell chemical biology, 24. pp. 98-109. ISSN 2451-9456

Cramer, Christopher J, Johnson, Joshua and Kamel, Amin (2017) Prediction of Mass Spectral Response Factors from Predicted Chemometric Data for Druglike Molecules. Journal of the American Society for Mass Spectrometry, 28 (2). pp. 278-285. ISSN 1879-1123

Cruz, Leilani, Heidt, Analeah and Rowell, Emily (2017) Postdoc fellowship application for the Damon Runyon Cancer Research Fellowship entitled "Identifying novel pathways responsible for epigenetic modifications in aged regulatory T cells in the tumor microenvironment". Damon Runyon Cancer Research Fellowship.

Cruz, Leilani, Rowell, Emily and Heidt, Analeah (2017) Identification and targeting of novel pathways modifying the epigenome of aged regulatory T cells in the tumor microenvironment. Damon Runyon Cancer Research Fellowship.

Cunha, Andre, Zhang, Qin, Prentiss, Melissa, Wu, Xiaoqiu, Kainz, Vanessa, Xu, Yongyao, Vrouvlianis, Joanna, Li, Hui, Rangaswamy, Nalini, Leehy, Barrett, Mcgee, Terri, Bell, Christie, Bigelow, Chad, Kansara, Viralbhai, Huang, Qian and Wu, Henry (2017) The hierarchy of pro-inflammatory cytokines in ocular inflammation. Current eye research. pp. 1-13. ISSN 1460-2202

D

Dafflon, Caroline, Craig, Vanessa, Mereau, Helene, Gräsel, Julius, Schacher Engstler, Barbara, Hoffman, Gregory, Nigsch, Florian, Gaulis, Swann, Barys, Louise, Ito, Moriko, Aguadé Gorgorio, Julia, Bornhauser, Beat, Bourquin, Jean-Pierre, Proske, Amelie, Stork-Fux, Caroline, Murakami, Masato, Sellers, William, Hofmann, Francesco, Schwaller, Jürg and Tiedt, Ralph (2017) Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. Leukemia. ISSN 14765551

Dafflon, Caroline, Tiedt, Ralph and Schwaller, Jürg (2017) Targeting multiple nodes of MLL complexes to improve leukemia therapy. Oncotarget, 8 (53). pp. 90614-90615. ISSN 19492553

Dai, Chenkai, Lehar, Mohamed, Sun, Daniel, Swarthout, Lani, Carey, John, Maclachlan, Timothy, Brough, Doug, Staecker, Hinrich, Della Santina, Alexandra, Hullar, Timothy and Della Santina, Charles (2017) Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery. JARO - Journal of the Association for Research in Otolaryngology, 18 (4). pp. 601-617. ISSN 1438-7573

Dalvit, Claudio, Piotto, Martial and Vulpetti, Anna (2017) Fluorine NMR spectroscopy and computational calculations for assessing intramolecular hydrogen bond involving fluorine and for characterizing the dynamic of a fluorinated molecule. Journal of fluorine chemistry, 202. pp. 34-40. ISSN 00221139

Das, Suman, Morvan, Frederic, Jourde, Benjamin, Minetti, Giulia, Brebbia, Pascale, Toussaint, Gauthier, Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase regulates myofiber differentiation by altering histone acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 22111247

Das, Suman, Morvan, Frederic, Morozzi, Giulio, Jourde, Benjamin, Minetti, Giulia, Kahle, Peter, Rivet, Helene, Brebbia, Pascale, Toussaint, Gauthier, Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 2211-1247

Daugvilaite, Viktorija, Madsen, Christian Medom, Lückmann, Michael, Echeverria, Clara Castello, Sailer, Andreas, Frimurer, Thomas Michael, Rosenkilde, Mette Marie and Benned-Jensen, Tau (2017) Biased signaling and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus -induced gene 2. British journal of pharmacology. ISSN 1476-5381; 0007-1188

Davis, John, Kagan, Mark, Read, Jessica, Walles, Markus and Hatsis, Panagiotis (2017) Immunoprecipitation LC-MS Middle-up Approach for In Vivo Drug-To-Antibody Ratio Determination for Antibody Drug Conjugates. Bioanalysis.

Decker, Rebekah (2017) Articular cartilage and joint development from embryogenesis to adulthood. Seminars in cell & developmental biology, 62. pp. 50-56. ISSN 1096-3634

Decker, Rebekah, Um, Hyo-Bin, Dyment, Nathaniel A., Cottingham, Naiga, Usami, Yu, Enomoto-Iwamoto, Motomi, Kronenberg, Mark S., Maye, Peter, Rowe, David W., Koyama, Eiki and Pacifici, Maurizio (2017) Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Developmental biology, 426 (1). pp. 56-68. ISSN 00121606

Defontis, Myriam, Cote, Serge and Ledieu, David (2017) A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety. Experimental and Toxicologic Pathology. ISSN 1618-1433

Del Signore, Susanna and Roubenoff, Ronenn (2017) Physical frailty and sarcopenia (PF&S): a point of view from the industry. Aging Clinical and Experimental Research, Epub a. pp. 1-6. ISSN 17208319

Dex, Sarah, Alberton, Paolo, Willkomm, Lena, Soellradl, Thomas, Bago, Sandra, Milz, Stefan, Shakibaei, Mehdi, Ignatius, Anita, Bloch, Wilhelm, Clausen-Schaumann, Hauke, Shukunami, China, Schieker, Matthias and Docheva, Denitsa (2017) Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load. EBioMedicine, 20. pp. 240-254. ISSN 2352-3964

Dickson, Callum, Hornak, Viktor, Pearlstein, Robert and Duca, Jose (2017) Structure-kinetic relationships of passive membrane permeation from multiscale modeling. Journal of the American Chemical Society JACS., 139 (1). pp. 442-452.

Dickson, Callum, Pearlstein, Robert and Hornak, Viktor (2017) Contributions of the membrane dipole potential to the function of voltage-gated cation channels and modulation by small molecule potentiators. Biochimica et biophysica acta (BBA) - Biomembranes, 1859 (2). pp. 177-194. ISSN 00052736

Dumouchel, Jennifer, Argikar, Upendra, Spear, Jaimie, Brown, Ann, Dunne, Christine, Kramlinger, Valerie, Cirello, Amanda and Gunduz, Mithat (2017) An in vitro Investigation of Ocular Bioactivation Potential and the Role of CytochromeP450 2D Enzymes in Rat. Drug metabolism letters.. ISSN 1874-0758

Dégardin, Klara, Desponds, Anne and Roggo, Yves (2017) Protein-based medicines analysis by Raman spectroscopy for the detection of counterfeits. Forensic Science International, 278. pp. 313-325. ISSN 03790738

Dégardin, Klara and Roggo, Yves (2017) Innovative Strategy for Counterfeit Analysis. Medicine Access @ Point of Care, 1 (1). maapoc.0000013. ISSN 2399-2026

de Moura França, Leandro , Amigo, José Manuel , Cairós, Carlos , Bautista Mercader, Manuel and Fernanda Pimentel, Maria (2017) Evaluation and assessment of homogeneity in images. Part 1: Unique homogeneity percentage for binary images. Chemometrics and Intelligent Laboratory Systems, 171. pp. 26-39. ISSN 0169-7439

E

Ebata, Kevin T., Mesh, Kathryn, Liu, Shichong, Bilenky, Misha, Fekete, Alexander, Acker, Michael, Hirst, Martin, Garcia, Benjamin A and Ramalho-Santos, Miguel (2017) Vitamin C Induces Specific Demethylation of H3K9me2 in Mouse Embryonic Stem Cells via Kdm3a/b. Epigenetics & chromatin, 10. p. 36. ISSN 1756-8935

Ebhardt, H. Alexander, Degen, Simone, Tadini, Valentina, Schilb, Alain, Greig, Carolyn A., Fearon, Kenneth CH, Aebersold, Ruedi and Jacobi, Carsten (2017) Comprehensive proteome analysis of muscle composition and development in seniors. EMBO Molecular Medicine.

Eder, Joerg (2017) Opportunities and challenges in phenotypic drug discovery: An industry perspective. Nature Reviews Drug Discovery, 16 (8). pp. 531-543. ISSN 14741784

Edge, Stephen, Singh, Dilraj, Lewis, David and Rouse, Tim (2017) Defining the “Dose” for Dry Powder Inhalers: The challenge of correlating in-vitro dose delivery results with clinical efficacy. American pharmaceutical review, 20 (3). pp. 54-62.

Egger, Christine, Cannet, Catherine, Gerard Sachot, Christelle, Pierrat, Benoit, Suply, Thomas, Ksiazek, Iwona and Beckmann, Nicolau (2017) Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. European Journal of Pharmacology, 809. pp. 64-72. ISSN 18790712

Einolf, Heidi, Lin, Wen, Wang, Lai, Gu, Helen, Chun, Dung Y., Mangold, James B. and He, Handan (2017) Physiologically-based pharmacokinetic model predictions of panobinostat (LBH589) as a victim and perpetrator of drug-drug interactions. Drug Metabolism and Disposition.

Einolf, Heidi, Zhou, Jocelyn, Won, Christina, Wang, Lai and Rebello, Sam (2017) A physiologically-based pharmacokinetic modeling approach to predict drug-drug interactions of sonidegib (LDE225) with perpetrators of CYP3A in cancer patients. Drug metabolism and disposition, 45 (4). pp. 361-374. ISSN 1521-009X

Emery, Caroline, Monaco, Kelli-Ann, Wang, Ping, Balak, Marissa, Freeman, Alyson, Meltzer, Jodi, Delach, Scott, Rakiec, Daniel, Ruddy, David, Korn, Joshua, Haling, Jake, Acker, Michael and Caponigro, Giordano (2017) BRAF-inhibitor associated MEK mutations increase RAF-dependent and -independent enzymatic activity. Molecular Cancer Research, 15 (10). pp. 1431-1444. ISSN 1557-3125

Ertl, Peter (2017) An algorithm to identify functional groups in organic molecules. Journal of cheminformatics, 9 (1). p. 36. ISSN 1758-2946

Ertl, Peter, Lewis, Richard, Martin, Eric and Polyakov, Valery (2017) In silico generation of novel, drug-like chemical matter using the LSTM neural network. arXiv / talk at CCG User Group Meeting.

Estoppey, David, Hewett, Jeffrey, Guy, Chantale, Harrington, Edmund, Thomas, Jason, Schirle, Markus, Cuttat-Theurillat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory, Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John, Wang, Qiong, Chen, Xin, Mcallister, Gregory, Roma, Guglielmo, Bouwmeester, Antonius and Hoepfner, Dominic (2017) Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Scientific reports, 7 (42728). pp. 1-6. ISSN 2045-2322

Estoppey, David, Lee, Chia Min, Janoschke, Marco, Mathys, Philippe, Filipuzzi, Ireos, Schuhmann, Tim, Riedl, Ralph, Aust, Thomas, Galuba, Olaf, Mcallister, Gregory, Russ, Carsten, Spiess, Martin, Bouwmeester, Antonius, Bonamy, Ghislain and Hoepfner, Dominic (2017) The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase. Cell Reports, 19 (3). pp. 451-460. ISSN 22111247

F

Fairfield, Heather, Falank, Carolyne, Harris, Elizabeth, Demambro, Victoria, McDonald, Michelle, Pettitt, Jessica A., Mohanty, Sindhu T., Croucher, Peter, Kramer, Ina, Kneissel, Michaela, Rosen, Clifford J. and Reagan, Michaela R. (2017) The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. Journal of cellular physiology.

Fang, Jianwu, Ying, Haiyan, Mao, Ting, Fang, Yelena, Lu, Yuan, Wang, He, Zang, Irene, Wang, Zhaofu, Lin, Ying, Zhao, Mengxi, Luo, Xiao, Wang, Zongyao, Zhang, Yan, Zhang, Chao, Wang, William, Tan, Wei, Chen, Zhui, Lu, Chris, Atadja, Peter, Li, En, Zhao, Kehao, Liu, Jianfeng and Gu, Justin (2017) Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation promotion and suppresses cell proliferation in human monocytic leukemia cells. Oncotarget. ISSN 1949-2553

Felter, S, Foreman, J, Boobis, A, Corton, C, Doi, A, Flowers, L, Goodman, J, Haber, L, Jacobs, A, Klaunig, J, Lynch, A, Moggs, Jonathan and Pandiri, A (2017) Human Relevance of Rodent Liver Tumors: Key Insights from a Toxicology Forum Workshop on Nongenotoxic Modes of Action. Regulatory toxicology and pharmacology, 92. pp. 1-7. ISSN PMID: 29113941

Fernández-de Retana1, Sofia, Montañola, Alex, Marazuela, Paula, De La Cuesta, Maialen, Batlle, Aina, Fatar, Marc, Grudzenski, Saskia, Montaner, Joan and Hernández-Guillamon, Mar (2017) Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease. Neurobiology of Aging, 60. pp. 116-128. ISSN 15581497

Ferran, Sanz, Pognan, Francois, Steger-Hartmann, Thomas, Díaz, Carlos, Montserrat, Cases, Manuel, Pastor, Marc, Philippe, Wichard, Joerg, Briggs, Katherine, Watson, David, Schwab, Christof H. , Yang, Chihae, Amberg, Alexander , Beaumont, Maria, Brookes, Anthony, Brunak, Søren, Cronin, Mark T. D., Ecker, Gerhard F. , Escher, Sylvia, Greene, Nigel, Guzmán, Antonio, Hersey, Anne, Jacques, Pascale, Lammens, Lieve, Jordi, Mestres, Muster, Wolfgang, Northeved, Helle, Pinches, Marc, Sáiz, Javier, Sajot, Nicolas, Valencia, Alfonso, Van Der Lei, Johan , Vermeulen, Nico P. E., Vock, Esther, Wolber, Gerhard and Zamora, Ismael (2017) Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews Drug Discovery, 16 (12). pp. 811-812. ISSN 1474-17761474-1784

Ferretti, Stephane Raymond (2017) PDX-MI: Minimal information for patient-derived tumor xenograft models. Cancer Research, 77 (21). e62-e66. ISSN 15387445

Feuerbach, Dominik, Schindler, Patrick, Barske, Carmen, Joller, Stefanie, Beng-Louka, Edwige, Worringer, Katie, Kommineni, Sravya, Kaykas, Ajamete, Ho, Daniel, Welzenbach, Karl, Elain, Gaelle, Klein, Laurent, Mir, Anis Khusro, Farady, Christopher, Nakamura, MC, Hsieh, CL, Aichholz, Reiner, Popp, Simone, George, Nathalie and Neumann, Ulf (2017) ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. Neuroscience letter.

Filipuzzi, Ireos, Thomas, Jason, Pries, Verena, Estoppey, David, Salcius, Michael, Studer, Christian, Schirle, Markus and Hoepfner, Dominic (2017) Direct interaction of Chivosazole F with actin elicits cell responses similar to Latrunculin A but distinct from Chondramide. ACS chemical biology. ISSN 1554-8929

Flarakos, Jimmy, Du, Yancy, Gu, Helen, Wang, Lai, Einolf, Heidi, Chun, Dung Yu, Zhu, Bing, Alexander, Natalya, Natrillo, Adrienne, Hanna, Imad, Ting, Lillian, Zhou, Wei, Dole, Kiran, Sun, Haiying, Kovacs, Steven, Stein, Daniel, Tanaka, Ken and Mangold, James (2017) Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline. Xenobiotica, 47 (8). pp. 682-696. ISSN 1366-5928

Forkuo, Arnold Donkor , Ansah, Charles, Pearson, David, Gertsch, Werner, Cirello, Amanda, Amaral, Adam, Spear, Jaimie and Rynn, Caroline (2017) Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats. BMC Pharmacology and Toxicology, 18 (1). ISSN 20506511

Fredenhagen, Andreas, Eggimann, Fabian, Kittelmann, Matthias, Lochmann, Thomas and Kuehnoel, Juergen (2017) Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1H-indazole (benzpyrazole). Journal of analytical science and technology., 8 (10). p. 10. ISSN 2093-3371; 2093-3134

Frederiksen, Mathias, Drewry, David, Wells, Carrow, Andrews, David, Angell, Richard, Al-Ali, Hassan, Axtman, Alison, Capuzzi, Stephen, Elkins, Jonathan, Ettmayer, Peter, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Mueller-Knapp, Susanne, Muratov, Eugene, Denny, Aldrin, Robers, Matt, Saikatendu, Kumar, Trieber, Daniel, Zuercher, William and Willson, Timothy (2017) Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLoS ONE, 12 (8). ISSN 19326203

Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Kunz, Joachim, Marovca, Blerim, Horvath, Peter, Higi, Salome, Eugster, Sabrina, Delorenzi, Mauro, Cario, Gunnar, Stanulla, Martin, Kulozik, Andreas E., Muckenthaler, Martina, Eckert, Cornelia, Radimerski, Thomas, Bornhauser, Beat C. and Bourquin, Jean-Pierre (2017) Ex vivo drug response profiling detects recurrent sensitivity patterns in drug resistant ALL. Blood. ISSN 0006-4971

Furegati, Markus and Nocito, Sandro (2017) Practial isolation of the (1R,2R)-enantiomer from a racemic cis/trans mixture of 2-methylcyclohexyl-1-amine. Organic process research & development.

G

Galli, Giorgio and Dirk, Schuebeler (2017) Post-doctoral position (Giorgio Galli - co-mentor Dirk Schuebeler). NIBR PostDoc website.

Gallou, Fabrice and Fu, Jiping (2017) Development of a Cyclosporin derivative and of its synthesis as cyclophilin inhibitor with excellent anti-HCV potency. Bioorganic and Medecinal Chemistry.

Gallou, Fabrice and Handa, Sachin (2017) Micelle-Enabled Sustainable Heteroleptic Palladium Catalysis for Nitroalkane Arylations in Water Under Mild Conditions. ACS Catalysis.

Gallou, Fabrice and Lipshutz, Bruce (2017) Effects of Co-solvents on Reactions Run Under Micellar Catalysis Conditions. Organic letters, 19. pp. 194-197.

Gallou, Fabrice and Lipshutz, Bruce (2017) Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature. Green Chemistry, 19. pp. 2106-2109.

Gallou, Fabrice and Lipshutz, Bruce (2017) From Milligrams to Grams. SNAr Reactions in Aqueous Nanomicelles; No Dipolar Aprotic Solvents Needed. Org. Proc. Res. Dev., 2017 (21). pp. 218-221.

Gallou, Fabrice and Lipshutz, bruce (2017) Micellar catalysis enabled ppm Au-catalyzed reactions in water at room temperature. Chemical science, 8. pp. 6354-6358. ISSN 2041-6539; 2041-6520

Gan, Xin, Wang, Haifeng, Yu, Yanyan, Yi, Wei, Zhu, Shanshan, Gu, Baohua, Lu, Chris, Li, En and Liang, Yu (2017) Epigenetically repressing human Cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases. PLoS ONE, 12 (4). ISSN 1932-6203

Gao, Jinhai, Tsao, Jeffrey, Wang, Bing and Rajan, Srinivasan (2017) Optimal Flip Angle for Quantitative NMR Using External Standards. Analytical chemistry. ISSN 1520-6882; 0003-2700

Gardin, Anne, Dodman, Angela, Kalluri, Sampath, Neelakantham, Srikanth Raju, Legangneux, Eric and Shakeri-Nejad, Kasra (2017) Pharmacokinetics, safety, and tolerability of siponimod (BAF312) in subjects with severe renal impairment: A single-dose, open-label, parallel-group study. Pharmacokinetics, safety, and tolerability of siponimod (BAF312) in subjects with severe renal impairment: A single-dose, open-label, parallel-group study.

Garito, Tania, Roubenoff, Ronenn, Zakaria, Marjorie, Rooks, Daniel, Swan, Therese, Filosa, Lee Anne, Petricoul, Olivier, Laurent, Didier, Neelakantham, Srikanth Raju, Meyers, Charles, Hompesch, Marcus, morrow, linda, gomez, katherine and buchsbaum, monte (2017) Bimagrumab improves body composition and insulin sensitivity in insulin-resistant subjects. Diabetes, obesity and metabolism. ISSN 1463-1326

Gembarska, Agnieszka, Durand, Eric, Mandon, Emeline, Estadieu, Claire, Romanet, Vincent, Wiesmann, Marion, Lehar, Joseph, Tiedt, Ralph, De Weck, Antoine, Kauffmann, Audrey, Sutter, Esther, Grevot, Armelle, Moulin, Pierre, Murakami, Masato, Sellers, William, Hofmann, Francesco, Jensen, Michael Rugaard, Chapeau, Emilie and Rad, Roland (2017) Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/-mouse model. Proceedings of the National Academy of Sciences of the United States of America, 114 (12). pp. 3151-3156. ISSN 1091-6490

Gergely, Peter (2017) Challenges and opportunities of drug research and development in rare diseases. Journal of international pharmaceutical research.

Ghosh, Joy, Nguyen, Andrew, Bigelow, Chad, Poor, Stephen, Qiu, Yubin, Rangaswamy, Nalini, Ornberg, Richard, Jackson, Brittany, Mak, Howard, Ezell, Tucker, Ashminova, Vania, De La Cruz, Elisa, Carrion, Ana, Etemad-Gilbertson, Bijan, Garcia Caro, Roxana, Zhu, Kan, George, Vinney, Bai, Jirong, Sharma, Radhika, Shen, Siyuan, Wang, Yiqin, Subramanian, Kulandayan, Fassbender, Elizabeth, Maker, Michael, Hanks, Shawn, Vrouvlianis, Joanna, Leehy, Barrett, Long, Debby, Prentiss, Melissa, Kansara, Viralbhai, Jaffee, Bruce, Dryja, Ted and Roguska, Michael (2017) Long-acting protein drugs for the treatment of ocular diseases. Nature communications, 8. pp. 1-10. ISSN 2041-1723

Giggins, Oonagh, Clay, Ieuan and Walsh, Lorcan (2017) Physical Activity Monitoring in Patients with Neurological Disorders: A Review of the Validity and Reliability of Body Worn Monitors. Digital Biomarkers.

Ginster, Stefanie, Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Renner, Florian, Lam, Stephen, Freuler, Felix, Gerrits, Bertran, Voshol, Johannes, Calzascia, Thomas, Regnier, Catherine, Renatus, Martin, Nikolay, Rainer, Israel, Laura and Bornancin, Frederic (2017) Two antagonistic MALT1 auto-cleavage mechanisms reveal a role for TRAF6 to unleash MALT1 activation. PLoS ONE, 12 (1). e0169026. ISSN 1932-6203

Glorieux, Francis, Devogalaer, Jean-Pierre, Durigova, Michaela, Goemaere, Stefan, Hemsley, Sarah, Junker, Uwe, Ruckle, Jon, Seefried, Lothar and Winkle, Peter (2017) BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial. Journal of Bone and Mineral Research, 32 (7). pp. 1496-1504. ISSN 15234681

Glowienke, Susanne (2017) p-Aminophenol monograph. Regul Pharm Tox.

Godinez Navarro, William Jose, Hossain, Imtiaz, Lazic, Stanley, Davies, John and Zhang, Xian (2017) A Multi-scale Convolutional Neural Network for Phenotyping High Content Cellular Images. Bioinformatics. ISSN 1367-4811; 1367-4803

Goepfert, Arnaud, Lehmann, Sylvie, Wirth, Emmanuelle and Rondeau, Jean-Michel (2017) The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. Scientific reports, 7. p. 8906. ISSN 2045-2322

Gotwals, Philip, Cameron, Scott, Cipolletta, Daniela, Cremasco, Viviana, Crystal, Adam, Hewes, Becker, Mueller, Britta, Petruzzelli, Lilli, Quaratino, Sonia, Sabatos-Peyton, Catherine and Dranoff, Glenn (2017) Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nature Reviews Cancer, 17 (5). pp. 286-301. ISSN 1474-1768

Goyal, Lipika, Supriya, Saha K, Liu, Lea Y, Siravegna, Giulia, Leshchiner, Ignaty, Ahronian, Leanne G, Lennerz, Jochen K, Vu, Phuong, Deshpande, Vikram, Kambadakone, Avinash, Mussolin, Benedetta, Reyes, Stephanie, Henderson, Laura , Sun, Jiaoyuan Elisabeth, Van Seventer, Emily E, Gurski, Joseph M Jr, Baltschukat, Sabrina, Schacher Engstler, Barbara, Barys, Louise, Furet, Pascal, Ryan, David P, Stone, James R, Iafrate, John A, Getz, Gad, Graus Porta, Diana, Tiedt, Ralph, Bardelli, Alberto, Juric, Dejan, Corcoran, Ryan B, Bardeesy, Nabeel and Zhu, Andrew X (2017) Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in FGFR2 fusion-positive cholangiocarcinoma patients. Cancer discovery. ISSN 2159-8290; 2159-8274

Groth, K, Berezhanskyy, T, Aneja, MK, Geiger, J, Schweizer, M, Maucksch, L, Pasewald, T, Brill, T, Tigani, Bruno, Weber, Eckhard, Rudolph, C and Hasenpusch, G (2017) Tendon healing induced by chemically modified mRNAs. European cells and materials, 33. pp. 294-307. ISSN 1473-2262

Grove, Kerri, Kansara, Viralbhai, Prentiss, Melissa, Long, Debby, Mogi, Muneto, Kim, Sean and Rudewicz, Patrick (2017) Application of Imaging Mass Spectrometry to Assess Ocular Drug Transit. Journal of biomolecular screening. ISSN 1552-454X; 1087-0571

Grunewald, Jan, Jin, Yunho, Vance, Julie, Read, Jessica, Wang, William, Wan, Yongqin, Zhou, Huanfang, Ou, Weijia, Klock, Heath, Peters, Eric, Uno, Tetsuo, Brock, Ansgar and Geierstanger, Bernhard (2017) Optimization of an Enzymatic Antibody Drug Conjugation Ap-proach based on CoA Analogs. Bioconjugate chemistry. ISSN 1520-4812; 1043-1802

Gu, Helen, Dutreix, Catherine, Rebello, Sam, Ouatas, Taoufik, Wang, Lai, Chun, Dung Yu, Einolf, Heidi and He, Handan (2017) Simultaneous physiologically-based pharmacokinetic (PBPK) modeling of parent and active metabolites to investigate complex CYP3A4 drug-drug interaction potential: a case example of midostaurin. Drug metabolism and disposition.

Gubler, Hanspeter, Clare, Nicholas, Galafassi, Laurent, Girod, Michel, Herr, Guy and Geissler, Uwe (2017) Helios - History and Anatomy of a successful in-House Enterprise High-Throughput Screening and Profiling Data Analysis System. SLAS Discovery, 23 (5). pp. 474-488. ISSN 2472-5552

Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson King, Janet, Billich, Andreas and Guntermann, Christine (2017) Pharmacological inhibition of ROR gamma t suppresses the Th17 pathway and alleviates antigen-induced arthritis in-vivo. PLoS ONE, 12 (PLoS O). pp. 1-25. ISSN 1932-6203

Guntermann, Christine, Piaia, Alessandro, Hamel, Marie-Laure, Theil, Diethilde, Rubic-Schneider, Tina, Del Rio Espinola, Alberto, Dong, Linda, Billich, Andreas, Kaupmann, Klemens, Dawson King, Janet, Hoegenauer, Klemens, Orain, David, Hintermann, Samuel, Stringer, Rowan, Patel, Dhavalkumar, Doelemeyer, Arno, Deurinck, Mark and Schuemann, Jens (2017) Retinoic-acid-orphan-receptor C inhibition suppresses Th17 cells and induces thymic aberrations. The Journal of Clinical Investigation Insight (JCI Insight).

Guo, Hongqiu, Yeboah, Fred, Camargo, L. Miguel, Digan, Mary Ellen, Niu, Honglin, Pan, Yue, Reiling, Stephan, Soler-Llavina, Gil, Wang, Hao-Ran, Shanker, Gopi, Stams, Travis, Bill, Anke and Weihofen, Wilhelm (2017) A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine. Nature methods, 7 (1). p. 11608.

Gusev, Arkady and Wang, Tianke (2017) Ensuring quality and compliance in outsourcing of bioanalysis of clinical biomarkers. Bioanalysis, 9 (7). pp. 501-504. ISSN 1757-6199

Gutierrez, Marcelo, Spector, Jonathan, Felix, Sandra Daniela, Romero, Fernando, Pillai, Goonaseelan, Onyango, Kevin, Owusu-Agyei, Seth, Asante, Kwaku-Poku, Barnes, Karen, Allen, Elizabeth, Sinxadi, Phumla, Abdulla, Salim, Masimirembwa, Collen, Munyoro, Michelle, Yimer, Getnet, Gebre-Mariam, Tsige and Ogutu, Bernhards (2017) *Building capability for clinical pharmacology research in sub-Saharan Africa*. Clinical pharmacology and therapeutics. ISSN 1532-6535; 0009-9236

H

Haasen, Dorothea, Schopfer, Ulrich, Antczak, Christophe, Guy, Chantale, Fuchs, Florian and Selzer, Paul (2017) How phenotypic screening influenced drug discovery – lessons from 5 years practice. Assay and drug development technologies, 15 (6). pp. 239-246.

Hafner, Andreas, Mancino, Valentina, Meisenbach, Mark, Schenkel, Berthold and Sedelmeier, Joerg Mathias (2017) Dichloromethyl lithium: A valuable reagent in organic synthesis handled in continuous flow mode. Dichloromethyl lithium: A valuable reagent in organic synthesis handled in continuous flow mode.

Hamze, Moustafa, Meunier, Sylvain, Karle, Anette, Gdoura, Abdelaziz, Goudet, Amelie, Szely, Natacha, Pallardy, Marc, Carbonnel, Franck, Spindeldreher, Sebastian, Mariette, Xavier, Miceli-Richard, Corinne and Maillere, Bernard (2017) Characterization of CD4 T cell epitopes of infliximab and rituximab identified from healthy donors. Frontiers in immunology, 8 (MAY). pp. 1-11. ISSN 1664-3224

Han, Yi, Ayalasomayajula, Surya, Yang, Fan, Yuan, Yaozong, Langenickel, Thomas Heiko, Hinder, Markus, Kalluri, Sampath, Pal, Parasar and Sunkara, Gangadhar (2017) Pharmacokinetics, Safety and Tolerability of Sacubitril/Valsartan (LCZ696) After Single-Dose Administration in Healthy Chinese Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (1). pp. 109-116. ISSN 2107-0180

Hart, Lori, Rader, JulieAnn, Raman, Pichai, Batra, Vandana, Tsang, Matthew, Gagliardi, Maria, Martinez, Daniel, Wood, Andrew, Kim, Sunkyu, Parasuraman, Sudha, Delach, Scott, Cole, Kristina, Shiva, Krupa, Caponigro, Giordano, Peters, Malte, Boehm, Markus and Maris, John (2017) Preclinical therapeutic synergy of MEK1/2 and CDK4/6 inhibition in neuroblastoma. Clinical Cancer Research, 23 (7). pp. 1785-1796. ISSN 1557-3265

Hatsis, Panagiotis, Waters, Nigel and Argikar, Upendra (2017) Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards. Drug Metabolism and Disposition.

Hayes, Lilian, M., Press, Neil, Tocher, Derek, A. and Carmalt, Claire, J. (2017) Intermolecular interactions between encapsulated aromatic compounds and the host framework of a Crystalline Sponge. Crystal Growth & Design, 17 (2). pp. 858-863. ISSN 1528-74831528-7505

He, Handan, Tran, Phi, Gu, Helen, Tedesco, Vivienne, Zhang, Jin, Lin, Wen, Gatlik, Ewa, Klein, Kai and Heimbach, Tycho (2017) Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug. Drug metabolism and disposition: the biological fate of chemicals, 45 (5). pp. 540-555. ISSN 1521-009X

He, Xiaohui, DaRos, Sara, Zhu, Xuefeng, Nelson, John, Michellys, Pierre, Iskandar, Maya, Espinola, Sheryll, Bursulaya, Badry, Gao, Mu-Yun, Kreusch, Andreas, Baaten, Janine, Clemmer, Leah, Meeusen, Shelly, Huang, David, Hill, Robert, Nguyen-Tran, Van, Fathman, John, Liu, Bo, Tuntland, Tove, Ng, Kenneth, Shi, Jian, Bordone, Laura and Liu, Hong (2017) Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Helliwell, Stephen, Filipuzzi, Ireos, Steffen, Janos and Koehler, Carla (2017) Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Nature Chemical Biology. ISSN 1552-44501552-4469

Hoegenauer, Klemens, Soldermann, Nicolas, Zecri, Frederic, Strang, Ross, Graveleau, Nadege, Wolf, Romain, Cooke, Nigel Graham, Smith, Alexander Baxter, Hollingworth, Greg, Blanz, Joachim, Gutmann, Sascha, Rummel, Gabriele, Littlewood-Evans, Amanda and Burkhart, Christoph (2017) Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Medicinal Chemistry Letters, 8 (9). pp. 975-980. ISSN 19485875

Hoffmann, Peter (2017) An Evaluation of the Drug-induced Changes in Cardiac Inotropy (LVdP/dt40 and QA Interval) and Lusitropy (LVdP/dtmin and Tau) in Dogs: Results from a HESI-sponsored consortium. An Evaluation of the Drug-induced Changes in Cardiac Inotropy (LVdP/dt40 and QA Interval) and Lusitropy (LVdP/dtmin and Tau) in Dogs: Results from a HESI-sponsored consortium, Journa (85). pp. 1-21.

Holzer, Philipp (2017) Discovery of potent and selective p53-MDM2 protein-protein interaction inhibitors as anticancer drugs. Chimia : international journal for chemistry, 71 (10). pp. 716-721. ISSN 0009-4293

Horman, Shane, To, Jeremy, Lamb, John, Zoll, Jocelyn, Leonetti, Nicole, Tu, Buu, Moran, Rita, Newlin, Robbin, Walker, John and Orth, Anthony (2017) Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets. Oncotarget, 8 (59). pp. 99913-99930. ISSN 19492553

Hu, Tiancen, Sprague, Elizabeth, Fodor, Michelle, Stams, Travis, Clark, Kirk and Jacob, Sandra (2017) The impact of structural biology in medicine illustrated with four case studies. Journal of Molecular Medicine. pp. 1-11. ISSN 14321440

Huang, Ying, Zhang, Jeff, Yu, Zhengtian, Wang, Youzhen, Lingel, Andreas, Qi, Vicky, Gu, Justin, Zhao, Kehao, Wang, Long, Fu, Xingnian, Sun, Yongfeng, Jiang, Xiangqing, Zhang, Jiangwei, Zhang, Chunye, Li, Ling, Liu, Yueqin, Zhang, Maya, Zhang, Lijun, Zhao, Mengxi, Fang, Douglas, Shultz, Michael, Mi, Yuan, Gao, Zhenting, Oyang, Counde, Zhang , Hailong, Liu , Xianghui, Zhang, Qiong, Zhang, Chao, Gou, Haibing, Dillon, Michael, Atadja, Peter and Zeng, Jue (2017) Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. Journal of Medicinal Chemistry, 60 (6). pp. 2215-2226. ISSN 1520-4804

I

Ian, Harrow, Ernesto, Jimenez-Ruiz, Splendiani, Andrea, Martin, Romacker, Peter, Wollard, Scott, Markel, Yasmin, Alam-Faruque, Martin, Koch, James, Malone and Arild, Waaler (2017) Matching Disease and Phenotype Ontologies in the Ontology Alignment Evaluation Initiative. Journal of biomedical semantics, 8 (1). p. 55. ISSN 2041-1480

J

Jacob, Jaison, Ngo, Debby, Finkel, Nancy, Pitts, Rebecca, Gleim, Scott, Farrell, Laurie, Keyes, Michelle, Benson, Mark, Morgan, Thomas, Jennings, Lori and Gerszten, Robert (2017) Application of Large Scale Aptamer-Based Proteomic Profiling to "Planned" Myocardial Infarctions. Circulation. ISSN 1524-4539; 0009-7322

Jain, Jay Prakash, Leong, Franz Joel Wen, Chen, Lanna, Kalluri, Sampath, Koradia, Vishal, Stein, Daniel, Wolf, Marie-Christine, Sunkara, Gangadhar and Kota, Jagannath (2017) Bioavailability of lumefantrine is significantly enhanced with a novel formulation approach, an outcome from a randomized, Open-label pharmacokinetic study in healthy volunteers. Antimicrobial Agents and Chemotherapy, 61 (9). ISSN 1098-6596

James, Alexander David, Marvalin, Cyrille, Luneau, Alexandre, Meissner, Axel and Camenisch, Gian P. (2017) Comparison of 19F-NMR and 14C measurements for the assessment of ADME of BYL719 (Alpelisib) in humans. Drug metabolism and disposition, 45. pp. 900-907. ISSN 1521-009X

Jansen, Hanneke, Wartchow, Charles, Jahnke, Wolfgang, Fong, Susan, Tsang, Tiffany, Pfister, Keith, Zavorotinskaya, Tatiana, Bussiere, Dirksen, Cheng, Jan Marie, Crawford, Kenneth, Dai, Yumin, Dove, Jeffrey, Fang, Eric, Feng, Yun, Florent, Jean-Michel, Fuller, John, Gossert, Alvar, Hekmat-Nejad, Mohammad, Henry, Christelle, Klopp, Julia, Lenahan, William, Meyer, Arndt, Mishina, Yuji, Narberes, Jamie, Pardee, Gwynn, Ramurthy, Savithri, Rieffel, Sebastien, Stuart, Darrin, Subramanian, Sharadha, Tandeske, Laura, Widger, Stephania, Widmer, Armin, Winterhalter, Aurelie, Zaror, Isabel, Hardy, Stephen, Lingel, Andreas and Ma, Sylvia (2017) Inhibition of Prenylated KRAS in a Lipid Environment. PLoS ONE, 12 (4). ISSN 1932-6203

Jelsch, Morgane and Grandeury, Arnaud (2017) Crystal Morphology Prediction of active pharmaceutical ingredients. Internship - report for school.

Jenkins, Jeremy, Sigoillot, Frederic, Chen, Amy and Cong, Feng (2017) Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results. Cell Systems, 4 (2). 182-193.e4. ISSN 24054720

Ji, Lei, Jiang, Xiaomo, Kheifets, Olga, Chen, Amy, Mickanin, Craig, Bauer, Andreas, Cong, Feng, Jiang, Bo, Xu, wenqing and Yan, Xiaoxue (2017) The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation. Genes and Development, 31 (9). pp. 904-915. ISSN 1549-5477

Jia, Haoruo, Ma, Xiaoyuan, Tong, Wei, Wei, Yulong , Tower, Robert, Chandra, Abhishek, Wang, Luqiang, Sun, Zeyang, Yang, Zhaochun, Badar, Farid, Zhang, Kairui, Tseng, Wei-ju, Kramer, Ina, Kneissel, Michaela, Xia, Yang, Liu, X. Sherry, Wang, James H-C., Han, Lin, Enomoto-Iwamoto, Motomi and Qin, Ling (2017) Subchondral bone plate sclerosis during late osteoarthritis is caused by loading-induced reduction in Sclerostin. Arthritis and rheumatology.

Johannes, Jeffrey W. , Bates, Stephanie, Beigie, Carl, Belmonte, Matt , Breen, John , Cao, Shenggen , Centrella, Paolo A. , Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph, Ferguson, Andrew, Habeshian, Sevan , Hargreaves, David , Joubran, Camil , Kazmirski, Steven , Keefe, Anthony D. , Lamb, Michelle , Lan, Haiye , Li, Yunxia , Ma, Hao , Mlynarski, Scott , Packer, Martin J., Rawlins, Philip , Robbins, Daniel W. , Shen, Haidong , Sigel, Eric A., Soutter, Holly H. , Su, Nancy , Troast, Dawn M., Wang, Haiyun , Wickson, Kate F. , Wu, Chengyan , Zhang, Ying and Hird, Alex (2017) Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Johnson, Christopher N., Erlanson, Daniel A., Jahnke, Wolfgang, Rees, David C. and Mortenson, Paul N. (2017) Fragment-to-Lead Medicinal Chemistry Publications in 2016. Journal of Medicinal Chemistry. ISSN 15204804

Jones, Adriana, Woods, Angela, Takeoka, Ken, Shen, Xiaoyu, Wei, Jun-Rong, Caughlan, Ruth and Dean, Charles (2017) Determinants of antibacterial spectrum and resistance potential of the elongation factor G inhibitor argyrin B in key Gram negative pathogens. Antimicrobial agents and chemotherapy, 61 (4). ISSN 1098-6596

javle, milind, lowery, maeve, shroff, Rachna, weiss, karl heinz, springfield, Christoph, borad, mitesh, ramanathan, ramesh, goyal, lipika, sadeghi, saeed, maraculla, teresa, el-khoueiry, anthony, kelley, robin kate, borbath, ivan, choo, su pin, oh, Do-Youn, philip, a.philip, chen, li-tzong, reungwetwattana, thanyanan, van cutsem, eric, yeh, kun-huei, ciombor, kristen, zhu, andrew x, abou-alfa, ghassan k, bekaii-saab, tanios and finn, michael (2017) Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma. Journal of clinical oncology. ISSN 1527-7755; 0732-183X

K

Kaesler, Nadine, Verhulst, Anja, De Maré, Annelies, Deck, Annika, Behets, Geert J., Hyusein, Ayshe, Evenepoel, Pieter, Floege, Jürgen, Marx, Nikolaus, Babler, Anne, Kramer, Ina, Kneissel, Michaela, Kramann, Rafael, Weis, Daniel, D`Haese, Patrick C. and Brandenburg, Vincent M. (2017) Sclerostin deficiency modifies the development of CKD-MBD in mice. Bone. ISSN 1873-2763; 8756-3282

Kalkman, HO and Feuerbach, Dominik (2017) Microglia M2A-polarization as potential link between food allergy and autism spectrum disorders. Pharmaceuticals, 10 (95). ISSN 1424-8247

Kallen, Joerg, Izaac, Aude, Be, Celine, Arista, Luca, Orain, David, Kaupmann, Klemens, Guntermann, Christine, Hoegenauer, Klemens and Hintermann, Samuel (2017) Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. ChemMedChem, 12 (13). pp. 1014-1021. ISSN 18607187

Kammertoens, Thomas, Friese, Christian, Arina, Ainhoa, Idel , Christian, Briesemeister, Dana, Rothe, Michael, Sommermeyer, Daniel, Engels, Boris, Leisegang, Matthias, Fehling, Hans J, Fruttiger, Marcus, Herrmann, Andreas, Yu, Hua, Weichselbaum, Ralph, Uckert, Wolfgang, Schreiber, Hans and Blankenstein, Thomas (2017) Tumour ischaemia by interferon-γ resembles physiological blood vessel regression. Nature, 545 (7652). pp. 98-102. ISSN 14764687

Kammueller, Michael, Tsai, Tsen-Fang, Griffiths, Christopher EM, Kapoor, Nidhi, Kolattukudy, Pappachan E , Brees, Dominique, Chibout, Salah-Dine, Safi Jr., Jorge and Fox, Todd (2017) Inhibition of IL-17A by secukinumab shows no evidence of increased Mycobacterium tuberculosis infections. Clinical and translational immunology, 6 (8). e152. ISSN 2050-0068

Karle, Anette, Spindeldreher, Sebastian, Maillere, Bernard, Hamze, Moustafa, Meunier, Sylvain, de Bourayne, Marie and Gdoura, Abdelaziz (2017) Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 T cell epitopes. Frontiers in immunology, 8. ISSN 1664-3224

Kawamori, Dan, Shirakawa, Jun, Wee Liew , Chong, Hu, Jiang, Morioka, Tomoaki, Duttaroy, Alokesh, Burkey, Bryan and Kulkarni , Rohit (2017) GLP-1 signaling compensates for impaired insulin signaling regulating beta cell proliferation. GLP-1 signaling compensates for impaired insulin signaling regulating beta cell proliferation.

Keating, Alison, Soto, Jessica, Tuleu, Catherine, Forbes, Claire, Zhao, Min and Craig, Duncan Q.M. (2017) Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration. International journal of pharmaceutics. ISSN 03785173

Keller, Patrick and Yi, Boram (2017) NIBR Case Study for Contextual Inquiry. User Experience for Life Science (website).

Keskin, Aylin, Kekus, Maja, Adelsberger, Helmuth, Neumann, Ulf, Shimshek, Derya, Song, Beomjong, Peng, Tingying, Förstl, Hans, Staufenbiel, Matthias, Nelken, Isreal, Konnerth, Arthur and Busche, Marc Aurel (2017) BACE inhibition-dependent repair of Alzheimer´s pathophysiology. Proceedings of the National Academy of Sciences, 114 (32). pp. 8631-8636. ISSN 0027-84241091-6490

Kittelmann, Matthias, Schroer, Kirsten, Grumaz, Christian, Vainshtein, Yevhen , Kirstahler, Philipp , Girhard, Marco, Hilberath, Thomas , Worsch, Anne, Urlacher, Vlada, Czaja, Rico , Vogel, Andreas, Luetz, Stephan, Sohn, Kai and Sandberg, Marcel (2017) Draft genome sequences of three Actinobacteria strains presenting new candidate organisms with high potentials for specific P450 cytochromes. Genome announcements. ISSN 10.1128/genomeA.00532-17

Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Joerg, Zou, Chao, Voshol, Johannes, Genick, Christine, Lefeuvre, Peggy, Bitsch, Francis, Graus Porta, Diana and Furet, Pascal (2017) Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region. MedChemComm, 8 (8). pp. 1604-1613. ISSN 20402511

Koch, Guido (2017) Editorial Chimia special issue on Medicinal Chemistry. Chimia. (10). p. 843. ISSN 0009-4293

Kolbinger, Frank, Loesche, Christian, Valentin, Marie-Anne, Jiang, Xiaoyu, Cheng, Yi, Jarvis, Philip, Peters, Thomas, Calonder, Claudio, Bruin, Gerardus, Polus, Florine and Patel, Dhavalkumar (2017) β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis. Journal of Allergy and Clinical Immunology, 139 (3). 923-932.e8. ISSN 1097-6825

Koneti, Rao V, Webster, Sharon, Dalm , Virgil ASH, Sediva, Anna, van Hagen, Martin P, Holland, Steven, Rosenzweig, Sergio D, Christ, Andreas Dominik, Sloth, Birgitte, Cabanski, Maciej, Joshi, Aniket, De Buck, Stefan, Doucet, Julie, Guerini, Danilo, Kalis, Christoph, Pylvaenaeinen, Ilona, Soldermann, Nicolas, Kashyap, Anuj, Uzel , Gulbu, Leonardo, Michael J, Patel, Dhavalkumar, Lucas, Carrie L and Burkhart, Christoph (2017) Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine : NEJM. ISSN 0028-4793; 1533-4406

Kounde, Cyrille Stephane, Yeo, Hui Quan, Wang, Qingyin, Wan, Kah Fei, Dong, Hongping, Karuna, Ratnaningrum, Dix, Ina, Wagner, Beatrix, Zou, Bin, Simon, Oliver, Bonamy, Ghislain M. C., Yeung, Bryan King Sing and Yokokawa, Fumiaki (2017) Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit. Bioorganic and Medicinal Chemistry Letters, 27 (6). pp. 1385-1389. ISSN 1464-3405

Kropp, Christina, Massai, Diana and Zweigerdt, Robert (2017) Progress and challenges in large-scale expansion of human pluripotent stem cells. Process Biochemistry, 59. pp. 244-254. ISSN 13595113

L

Lanshoeft, Christian, Cianférani, Sarah and Heudi, Olivier (2017) Generic Hybrid Ligand Binding Assay Liquid Chromatography High-Resolution Mass Spectrometry-Based Workflow for Multiplexed Human Immunoglobulin G1 Quantification at the Intact Protein Level: Application to Preclinical Pharmacokinetic Studies. Analytical Chemistry.

Lapadula, Daniel, DeGeorge, JJ, Keller, DA, Andrews, P, Prescott, JS, Bogdanffy, MS, Mahoney, NM, Baker, R, Fields, FO, Paul, D, Platz, S, Reese, D and Stoch, A (2017) Evaluation of Therapeutics for Advanced-Stage Heart Failure and Other Severely-Debilitating or Life-Threatening Diseases. Clinical Pharmacology and Therapeutics, 102 (2). pp. 219-227. ISSN 15326535

Larochelle, Jonathan R., Ellegast, Jana M., Fodor, Michelle, Liu, Xiaoxi, Vemulalpalli, Vidyasiri, Mohseni, Mori, Stams, Travis, Lamarche, Matthew, Buhrlage, Sara J., Acker, Michael, Stegmaier, Kimberly and Blacklow, Stephen C. (2017) Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorganic and Medicinal Chemistry, 25 (24). pp. 6479-6485. ISSN 14643391

Leeds, Jennifer (2017) Lasker Foundation Newsletter. Lasker Foundation Newsletter.

Leeds, Jennifer, Nordmann, Patrice, Burnham, Carey-Ann, Patel, Jean and O'Grady, Justin (2017) Viewpoint: Diagnosing antimicrobial resistance. Nature Reviews Microbiology, 15 (11). pp. 697-703. ISSN 1740-15261740-1534

Leupin, Olivier (2017) Minimal mechanical loading protects tendon explants from the acquisition of tendinopathic features. Journal of orthopaedic research. ISSN 07360266

Li, Ling, Feng, Lijian, Shi, Minlong, Zeng, Jue, Chen, Jason, Zhong, Li, Huang, Li, Guo, Weihui, Huang, Ying, Qi, Vicky, Lu, Chris, Li, En, Zhao, Kehao and Gu, Justin (2017) Split luciferase-based biosensors for characterizing EED binders. Analytical Biochemistry, 522. pp. 37-45. ISSN 10960309

Li, Wenkui, Gong, Jiawei, Wang, Chuan, Lin, John and Flarakos, Jimmy (2017) ICP-MS determination of total serum aluminum in monkeys following subcutaneous administration of a drug candidate formulated with Alhydrogel. Bioanalysis, 9 (23). pp. 1873-1881. ISSN 1757-6180

Li, Xin, Xie, Chengzhi, Li, Xiyan , Yang, Jian, Yu, Tao, Zhang, Ruohan, Zhang, Tianqing, Saxena, Deepak , Snyder, Michael , Wu, Yingjie and Li, Xin (2017) Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nature communications, 8. p. 15621. ISSN 2041-1723

Liao, Sha-Mei, Zheng, Wei, Lewis, Casey, Delgado, Omar, Crowley, Maura, Buchanan, Natasha, Jaffee, Bruce, Dryja, Ted and Zhu, Jiang (2017) Specific correlation between the chromosome 10q26 haplotype conferring high risk for age-related macular degeneration and the expression of HTRA1 in human tissues. Molecular vision :, 23. pp. 318-333. ISSN 1090-0535

Lima, Fabio, Sharma, Upendra, Grunenberg, Lars, Saha, Debasmita, Johannsen, Sandra, Sedelmeier, Joerg Mathias, Van der Eycken, Erik and Ley, Steven (2017) A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters. Angewandte Chemie. International edition.

Lin, Wen, Flarakos, Jimmy, Du, Yancy, He, Handan and Mangold, James (2017) Pharmacokinetics, Distribution, Metabolism and Excretion of Omadacycline Following a Single Intravenous or Oral Dose of 14C-omadacycline in Rats. Antimicrobial Agents and Chemotherapy, 61 (1). NA-NA. ISSN 0066-4804

Lin, Wen, Ji, Tao, Ayalasomayajula, Surya, Hanna, Imad, Heimbach, Tycho, Jarugula, Venkateswar, He, Handan, Lin, Tsu-Han and Breen, Chris (2017) Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model. Journal of Pharmaceutical Science, 105 (5). pp. 1439-1451.

Lindner, Robert, Hartmann, Elisabeth, Tarnawski, Miroslaw, Winkler, Andreas, Lenherr-Frey, Daniel, Reinstein, Jochen, Meinhart, Anton and Schlichting, Ilme (2017) Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase. Journal of Molecular Biology, 429 (9). pp. 1336-1351. ISSN 00222836

Lingel, Andreas, Bussiere, Dirksen, Cantwell, John, Dillon, Michael, Fu, Xingnian, Fuller, John, Gu, Justin, Huang, Ying, Jiang, Xiangqing, Li, Ling, Liang, Fang, Lindvall, Mika, Mckenna, Maureen, Qi, Vicky, Rao, Weijun, Sendzik, Martin, Sheng, Xijun, Shu, Wei, Shultz, Michael, Taft, Benjamin, Wang, Long, Zeng, Jue, Zhang, Maya, Zhang, Hailong, Zhao, Kehao and Gabriel, Tobias (2017) Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Methyltransferase PRC2. Jounal of Medicinal Chemistry.

Little, David G., Peacock , Lauren , Mikulec , Kathy , Cheng , Tegan L , Schindeler , Aaron , Munns , Craig , Kneissel, Michaela and Kramer, Ina (2017) Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101. pp. 96-103. ISSN 8756-3282

Liu, Kevin, Flick, Andrew C, Ding, Hong X, Leverett, Carolyn A, Kyne, Robert E K, Fink, Sarah J and O'Donnell, Christopher J (2017) Synthetic Approaches to the New Drugs Approved during 2015. Journal of Medicinal Chemistry, 60 (15). pp. 6480-6515. ISSN 1520-4804

Liu, Yahu (2017) Palladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides. Organic Letters. ISSN 1523-70601523-7052

Liu, Yahu, Hu, Lu and Liao, Xuebin (2017) Construction of pyridines and indoles via azide-imine tandem reactions. Organic Letters, 3 (e17008). pp. 1-9.

Longo, Francesco, Mercatelli, Daniela, Salvatore, Novello, Ludovico, Arcuri, Alberto, Brugnoli, Fabrizio, Vincenzi, Isabella, Russo, Giulia, Berti, Omar, Mabrouk, Robert, Kennedy, Shimshek, Derya, Varani, Katia, Luigi, Bubacco, Elisa, Greggio and Michele, Morari (2017) Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta neuropathologica communications., 5. p. 22. ISSN 2051-5960

Lopez-Picon, F.R., Snellaman, A, Eskola, O, Helin, S, Trigg, W, Solin, O, Haaparanta-Solin, M and Rinne, J.O. (2017) Neuroinflammation appears early and then plateaus in a mouse model of Alzheimer´s disease shown by PET imaging. Journal of Nuclear Medicine (Oct 06). ISSN 0161-55052159-662X

Lorthiois, Edwige, Anderson, Karen, Vulpetti, Anna, Rogel, Olivier, Cumin, Frederic, Ostermann, Nils, Mac Sweeney, Aengus, Delgado, Omar, Liao, Sha-Mei, Randl, Stefan, Ruedisser, Simon, De Erkenez, Andrea, Yang, Louis, Hartwieg, Constanze, Argikar, Upendra, Newton, Ronald, Kansara, Viralbhai, Flohr, Stefanie, Hommel, Ulrich, Jaffee, Bruce and Maibaum, Juergen Klaus (2017) Discovery of highly potent and selective small-molecule reversible Factor D inhibitors demonstrating alternative complement pathway inhibition in vivo. Journal of medicinal chemistry.

Lovelle, Lucie (2017) Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides. European journal of organic chemistry. pp. 3222-3228. ISSN 1099-0690; 1434-193X

Lovelle, Lucie, Gallou, Fabrice, Jordine, Guido and Mirabilis consortium, over 30 companies (2017) A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies. Regulatory Toxicology and Pharmacology, 90. pp. 22-28. ISSN 10960295

Lozac'H, Frederic, Fahrni, Simon, De Maria, Daniele, Welte, Caroline, Synal, Hans-Arno, Pearson, David, Walles, Markus and Camenisch, Gian P. (2017) Evaluation of combustion AMS “MICADAS” for ADME studies. Bioanalysis (bio-20). ISSN ISSN 1757-6180

Lu, Chunliang, Dong, Minyu and Zhu, Hugh (2017) Regioselective Bromination of Thieno[2′,3′:4,5]pyrrolo[1,2‑d][1,2,4]triazin-8(7H)‑one and Sequential Suzuki Couplings. The Journal of Organic Chemistry. ISSN 0022-32631520-6904

Lu, Yipin, Knapp, Mark, Yan, Kelly, Warne, Robert, Crawford, Kenneth, Elling, Robert, Pan, Yue, Michael, Doyle, Sim, Janet, Albert, Lai, Paul, Barsanti, Bussiere, Dirksen, Pardee, Gwynn, Li, Zhang, Ma, Sylvia, Jansen, Hanneke and Zaror, Isabel (2017) Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. Journal of Molecular Biology, 429 (11). pp. 1684-1704. ISSN 10898638

Lucas, Andrew T., Herity, Leah B., Kornblum, Zack A., Madden, Andrew J., Gabizon, Alberto, Kabanov, Alexander V., Ajamie, Rose T., Bender, David M., Kulanthaivel, Palaniappan, Sanchez-Felix, Manuel V., Havel, Henry A. and Zamboni, William C. (2017) Pharmacokinetic and screening studies of the interaction between mononuclear phagocyte system and nanoparticle formulations and colloid forming drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 443-454. ISSN 03785173

Ludwig, Marie-Gabrielle, Seuwen, Klaus and Vidal, Solange (2017) Peptide Activation of Epithelial Adgrf5 (Gpr116) Regulates Pulmonary Alveolar Homeostasis. JCI Insight.

Lyons, Russ (2017) Community Exploration & Learning Lab Overview. NIBR Internet.

López-Massaguer, Oriol, Pinto-Gil, Kevin, Sanz, Ferran, Amberg, Alexander, Anger, Lennart, Stolte, Manuela, Ravagli, Carlo, Marc, Philippe and Pastor, Manuel (2017) Generating modelling data from repeat-dose toxicity reports. Toxicological Sciences. ISSN 1096-60801096-0929

M

Ma, Xiaolei, Xie, Lili, Wartchow, Charles, Warne, Robert, Rivkin, Alexey, Tully, David, Shia, Steven, Uehara, Kyoko, Muiru, Gladys, Zhong, Weidong, Zaror, Isabel, Bussiere, Dirksen, Leonard, Vincent and Baldwin, Dianna (2017) Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit. Scientific reports.

Macia, Maxence, Halbritter, Jan, Delous, Marion, Bredrup, Cecilie, Gutter, Arthur, Filhol, Emilie, Christensen Mellgren, Anne Elisabeth, Leh, Sabine, Braun, Daniela A, Gee, Heon Y, Legendre, Flora, Krug, Pauline, Bole-Feysot, Christine, Nitschke, Patrick, Joly, Dominique, Nicoud, Philippe, Paget, Andre, Haugland, Heidi, Brackmann, Damien, Ahmet, Nayir, Sandford, Richard, Cengiz, Nurcan, Knappskog, Per Morten, Boman, Helge, Linghu, Bolan, Yang, Fan, Oakeley, Edward James, Saint-Mezard, Pierre, Sailer, Andreas, Johansson, Stefan, Rodahl, Eyvind, Saunier, Sophie, Hildebrandt, Friedhelm and Benmerah, Alexandre (2017) Mutations in MAPKBP1 cause late onset cilia-independent nephronophthisis. American Journal of Human Genetics.

Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Chen, Shanni, Shoichet, Brian, Urban, Laszlo and DuMouchel, William (2017) Reverse translation of adverse event reports paves the way for derisking preclinical off-targets. eLife.

Manjunatha, Ujjini Havaldar, Diagana, Thierry Tidiane, Vinayak, Sumiti, Zambriski, Jennifer, Striepen, Boris, Chao, Alexander, Noble, Christian Guy, Bonamy, Ghislain, Kondreddi, Ravinder Reddy, Zou, Bin, Gedeck, Peter, Lakshminarayana, Suresh Bangalore, Lim, Siau Hoi, Yeung, Bryan King Sing, Bodenreider, Christophe, Gu, Feng, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, Franz Joel Wen, Sy, Tracy, Noh, Susan, Goodman, Laura, Brooks, Carrie, Herbert, Gillian, Sateriale, Adam and Tandel, Jayesh (2017) A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature. ISSN 0028-08361476-4687

Mannhardt, Ingra , Eder, Alexandra, Dumotier, Berengere, Traebert, Martin, Soehren, Klaus-Dieter, Christ, Torsten, Eschenhagen, Thomas and Hansen, Arne (2017) Blinded contractility analysis in hiPSC-cardiomyocytes in engineered heart tissue format: Comparison with human atrial trabeculae. Toxicological sciences, 158 (1). pp. 164-175.

Marlowe, Jenny, Akopian, Viola, Karmali, Priya, Kornbrust, Doug, Lockridge, Jennifer and Semple, Sean (2017) Recommendations of the Oligonucleotide Safety Working Group’s Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based Therapeutics. Nucleic Acid Therapeutics. ISSN 2159-33372159-3345

Martin, Benjamin, Haber, Julien, Venturoni, Francesco, Sedelmeier, Joerg Mathias, Schenkel, Berthold, Kleinbeck-Riniker, Florian, Kamptmann, Sonja, Pellegatti, Laurent, Bouisseau, Anais, Fernandez-Rodriguez, Patricia, Susanne, Flavien, Hoehn, Pascale, Lanz, Marian, Robertson, Jeremy and Willis, Michael (2017) Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode. Green chemistry, 19. pp. 1439-1448.

Martin, Eric and Polyakov, Valery (2017) Postdoc mentor profiles for Valery Polyakov and Eric Martin. NIBR.com postdoc page.

Martin, Eric, Polyakov, Valery and Tian, Li (2017) Additional supplementary materials for approved article OAK ID 31984. Journal of chemical information and modeling.

Martin, Eric, Polyakov, Valery and Tian, Li (2017) Profile-QSAR 2.0: Kinase Virtual Screening Accuracy comparable to 4-Concentration IC50 for Realistically Novel Compounds. Journal of Chemical Information and Modeling, 57 (8). pp. 2077-2088. ISSN DOI 10.1021/acs.jcim.7b00166

Marzinzik, Andreas, Koch, Guido, Spanka, Carsten, Lehmann, Hansjoerg, Hwang, Ye-Jin, Coley, Connor, Abolhasani, Milad and Jensen, Klavs (2017) Segmented Flow Platform for On-​Demand Medicinal Chemistry and Compound Synthesis in Oscillating Droplets. Chem. Commun.. ISSN 1359-73451364-548X

Massai, Diana, Bolesani, Emiliano, Diaz, Diana Robles, Kropp, Christina, Kempf, Henning, Halloin, Caroline, Martin, Ulrich, Braniste, Tudor, Isu, Giuseppe, Harms, Vanessa, Morbiducci, Umberto, Dräger, Gerald and Zweigerdt, Robert (2017) Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development. Scientific Reports, 7 (1). ISSN 2045-2322

Mattes, Henri, Orain, David, Tasdelen, Engin, Haessig, Samuel, Koller, Manuel, Picard, Anne, Dubois, Celine, Lingenhoehl, Kurt, Desrayaud, Sandrine, Floersheim, Philipp, Carcache, David, Urwyler, Stephan and Kallen, Joerg (2017) Design and synthesis of Selurampanel, a novel orally active and competitive AMPA receptor antagonist. ChemMedChem : chemistry enabling drug discovery, 12 (3). pp. 197-201. ISSN 18607179

McClatchey, P. Mason, Wu, Fan, Olfert, I. Mark, Ellis, Christopher G., Goldman, Daniel, Reusch, Jane E. B. and Frisbee, Jefferson C. (2017) Microvascular perfusion heterogeneity impairs oxygenation and contributes to peripheral vascular disease in metabolic syndrome. Journal of cardiovascular translational research. ISSN 1937-5395; 1937-5387

McDonald, Michelle M, Reagan, Michaela R, Youlten, Scott, Mohanty, Sindhu T, Seckinger, Anya, Terry, Rachael L, Pettitt, Jessica A, Simic, Marija K, Cheng, Tegan L, Morse, Alyson, Le, Lawrence, Abi-Hanna, David, Kramer, Ina, Falank, Carolyne, Fairfield, Heather , Ghobrial, Irene M., Baldock, Paul A, Little , David G, Kneissel, Michaela, Vanderkerken, Karin, Bassett, J H Duncan, Williams, Graham R, Oyajobi, Kayode, Hose, Dirk, Phan, Tri and Croucher, Peter I (2017) Inhibiting the osteocyte specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. ISSN 1528-0020; 0006-4971

McDonald, Michelle M, Reagan, Michaela R, Youlten, Scott, Mohanty, Sindhu T, Seckinger, Anya, Terry, Rachael L, Pettitt, Jessica A, Simic, Marija K, Cheng, Tegan L, Morse, Alyson, Le, Lawrence, David, David, Kramer, Ina, Frank, Carolyne, Ghobrial, Irene, Anthony, Anthony, Baldock, Paul A, Little , David G, Bassett, J H Duncan, Williams, Graham R, Kneissel, Michaela, Vanderkerken, Karin, Oyajobi, Kayode, Hose, Dirk, Phan, Tri and Croucher, Peter I (2017) Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood, 129 (26). pp. 3452-3464. ISSN 15280020

Mcdonald Iii, Earl, De Weck, Antoine, Kauffmann, Audrey, Schmelzle, Tobias and Golji, Javad (2017) Project DRIVE - A compendium of cancer dependencies and synthetic lethal relationships uncovered by large scale, deep RNAi screening. Cell, 170 (3). pp. 577-592.

Mckenna, Jeffrey, Talbot, Eric, Toste, F. Dean, Fernandes, Talita de A., Thornbury, Richard T., Saini, Vaneet, Santiago, Celine and Sigman, Matthew (2017) The Development and Mechanistic Investigation of a Palladium- Catalyzed 1,3-Arylfluorination of Chromenes. Chem Sci.

Merino, D, Whittle, J.R., Vaillant, F., Serrano, A., Gong, J.N., Maragno, A.L., Chanrion, M., Schneider, E., Pal, B., Giner, G., Li, X., Dewson, G., Gräsel, J., Lalaoui, N., Segal, D., Herold, M.J., Huang, D., Smyth, G.K., Geneste, O., Lessene, G., Visvader, J.E. and Lindeman, J.L. (2017) Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Science Translational Medicine, 9 (401). ISSN 19466242

Merz, Michael (2017) Emerging liver safety biomarkers: an evaluation in healthy volunteers and patients with drug-induced liver injury. Hepatology.

Metz, Martin, Staubach, Petra, Bauer, Andrea, Brehler, Randolf, Gericke, Janine, Kangas, Michael, Chess, Joanna, Jarvis, Philip, Georgiou, Panayiotis, Canvin, Janice, Hillenbrand, Rainer, Erpenbeck, Veit and Maurer, Marcus (2017) Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin. Theranostics, 7 (5). pp. 1266-1276.

Michlits, Georg, Hubmann, Maria, Wu, Szu-Hsien, Vainorius, Gintautas, Budusan, Elena, Zhuk, Sergei, Burkhard, Thomas, Novatchkova, Maria, Aichinger, Martin, Lu, Yiqing, Reece-Hoyes, John, Nitsch, Roberto, Schramek, Daniel, Hoepfner, Dominic and Elling, Ulrich (2017) CRISPR-UMI : single-cell lineage tracing of pooled CRISPR–Cas9 screens. Nature methods, 14 (12). pp. 1191-1197.

Milicevic Sephton, Selena, Vetterli, Peter, Pedani, Valentina, Cermak, Stjepko, Chiotellis, Aristeidis, Schibli, Roger, Auberson, Yves and Ametamey, Simon (2017) Synthesis and Biological Evaluation of Quinoxaline Derivatives for PET Imaging of the NMDA Receptor. Helvetica Chimica Acta, 100 (12). ISSN 15222675

Miller, Danforth, Tan, Trixie, Nakamura, John, Malcolmson, Richard, Tarara, Thomas and Weers, Jeff (2017) Physical characterization of Tobramycin Inhalation Powder: II. State Diagram of an Amorphous Engineered Particle. Molecular Pharmaceutics. ISSN 10.1021/acs.molpharmaceut.7b00036

Miltz, Wolfgang, Velcicky, Juraj, Dawson King, Janet, Littlewood-Evans, Amanda, Ludwig, Marie-Gabrielle, Seuwen, Klaus, Feifel, Roland, Oberhauser, Berndt, Meyer, Arndt, Gabriel, Daniela and Loetscher, Pius (2017) Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorganic & Medicinal Chemistry, 25 (16). pp. 4512-4525. ISSN 0968-0896

Miltz, Wolfgang, Velcicky, Juraj, Dawson King, Janet, Littlewood-Evans, Amanda, Ludwig, Marie-Gabrielle, Seuwen, Klaus, Feifel, Roland, Oberhauser, Berndt, Meyer, Arndt, Gabriel, Daniela and Loetscher, Pius (2017) Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorganic and Medicinal Chemistry, 25 (16). pp. 4512-4525. ISSN 14643391

Miraglia, Loren, Orth, Anthony, Bonamy, Ghislain, Britschgi, Adrian, Brinkhaus, Heike, Bentires-Alj, Mohamed, Reddy, Venkateshwar, Kim, Sungeun, Duss, Stephan, Cuoto, JP, Koren, S, De Silva, D, Mertz, KD, Kaud, D, Varga, Z, Voshol, H, Leroy, C, Roloff, T, Stadler, MB and Scheel, CH (2017) The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature, 541 (7638). pp. 541-545. ISSN 0028-0836, 1476-4687

Moebitz, Henrik, Jahnke, Wolfgang and Jacob, Sandra (2017) Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches. Current topics in medicinal chemistry, 17. pp. 59-70. ISSN 1873-4294

Moebitz, Henrik, Machauer, Rainer, Holzer, Philipp, Vaupel, Andrea, Stauffer, Frederic, Ragot, Christian, Caravatti, Giorgio, Scheufler, Clemens, Hommel, Ulrich, Tiedt, Ralph, Beyer, Kim, Chen, Chao, Zhu, Hugh and Gaul, Christoph (2017) Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Medicinal Chemistry Letters, 8 (3). pp. 338-343. ISSN 19485875

Moggs, Jonathan (2017) IMI MARCAR external communication materials - interview and factsheet. IMI web based dissemination.

Moggs, Jonathan (2017) A Synopsis of the “Influence of Epigenetics, Genetics, and Immunology” Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium. Toxicologic Pathology.

Morgan, Thomas and Rajman, Iris (2017) Implications of African allele frequency variation in CYP450 genes for drug safety, efficacy and the future of drug development. EBioMedicine.. ISSN 2352-3964

Morse, Morse Alyson, Schindeler, Aaron, McDonald, Michelle M, Kneissel, Michaela, Kramer, Ina and Little, David G (2017) Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of bone and mineral research.. ISSN 1523-4681; 0884-0431

Mortenson, Paul N, Erlanson, Daniel A, de Esch , Iwan JP, Jahnke, Wolfgang and Johnson, Christopher N (2017) Fragment-to-Lead Medicinal Chemistry Publications in 2015. Journal of Medicinal Chemistry, 60 (1). pp. 89-99. ISSN 15204804

Morvan, Frederic, Rondeau, Jean-Michel, Zou, Chao, Minetti, Giulia, Scharenberg, Meike, Jacobi, Carsten, Brebbia, Pascale, Ritter, Veronique O., Toussaint, Gauthier, Scheufler, Clemens, Lehmann, Sylvie, Koch, Elke, Koelbing, Claudia, Leber, Xavier Charles, Schilb, Alain, Witte, Florian, Geisse, Sabine, Glass, David and Trifilieff, Estelle (2017) Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 114 (47). pp. 12448-12453. ISSN 10916490

Moscaroli, Alessandra and Behe, Martin (2017) Radiolabeling and Characterization of 111In-FGF-2 for In Vivo Imaging. Mol Pharm. 2017 Mar 6;14(3):639-648. doi: 10.1021/acs.molpharmaceut.6b00913..

Murphy, Jason, Harrington, Edmund, Schirle, Markus, Wong, Margaret, Gower, Carrie and Maly, Dustin (2017) Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors. Proteome science, 15 (17). ISSN 1477-5956

N

Nakajima, Katsumasa, Chatelain, Ricardo, Clairmont, Kevin, Commerford, Susan, Coppola, Gary, Daniels, Thomas, Forster, Cornelia, Gilmore, Thomas, Gong, Yongjin, Jain, Monish, Kanter, Aaron, Kwak, Young-Shin, Li, Jingzhou, Meyers, Charles, Neubert, Alan, Szklennik, Paul, Tedesco, Vivienne, Thompson, Jed, Truong, David, Yang, Qing, Hubbard, Brian and Serrano-Wu, Michael (2017) Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans. Journal of Medicinal Chemistry, 60 (11). pp. 4657-4664. ISSN 15204804

Ngcungcu, Thandiswa, Oti, Martin, Sitek, Jan C, Haukanes, Bjørn I, Linghu, Bolan, Bruccoleri, Robert, Stokowy, Tomasz, Oakeley, Edward J, Yang, Fan, Zhu, Jiang, Sultan, Marc, Schalkwijk, Joost, van Vlijmen-Willems, Ivonne M J J, von der Lippe, Charlotte, Brunner, Han G, Ersland, Kari M, Grayson, Wayne, Buechmann-Moller, Stine, Sundnes, Olav, Nirmala, Nanguneri, Morgan, Thomas M, van Bokhoven, Hans, Steen, Vidar M, Hull, Peter R, Szustakowski, Joseph, Staedtler, Frank, Zhou, Huiqing, Fiskerstrand, Torunn and Ramsay, Michele (2017) Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families. American journal of human genetics, 100 (5). pp. 737-750. ISSN 1537-6605

Nguyen, Hung N., Noss, Erika H., Mizoguchi, Fumitaka, Huppertz, Christine, Wei, Kevin S., Watts, Gerald F.M. and Brenner, Michael B. (2017) Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators. Immunity, 46 (2). pp. 220-232. ISSN 10974180

Niggemann, Birgit, Atorf, Jenny, Fridrichs-Gromoll, Stephanie, Korte, Sven, Kremers, Jan, Mecklenburg, Lars, Wiederhold, Andreas, Hill, Marilyn, Pilling, Andrew and Mansfield, Keith (2017) Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset (Callithrix jacchus) monkeys. Primate Biology, 4, 93- (4-93-2). pp. 93-100.

Nilsson, Inga, Grove, Kerri, Dovala, Dustin, Uehara, Tsuyoshi, Lapointe, Guillaume and Six, David (2017) Molecular characterization and verification of azido-3,8dideoxy-D-manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide. Journal of Biological Chemistry, 292 (48). pp. 19840-19848. ISSN 1083351X

Nishikawa, Tadateru, Ishiyama, Noboru, Wang, Feng and Ikura, Mitsuhiko (2017) Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin. Biomolecular NMR assignments, 11 (1). pp. 21-24. ISSN 1874-270X

Numao, Shin, Miltz, Wolfgang and Roehn, Till (2017) Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors. Scientific Reports.

P

Palacios, Daniel, Meredith, Erik, Kawanami, Toshio, Chen, Xin, Darsigny, Veronique, Geno, Erin, Palermo, Mark, Guy, Chantale, Hewett, Jeffrey, Tierney, Laryssa, Thigale, Sachin, Weihofen, Wilhelm, Argikar, Upendra, Boynton, Geoffrey, George, Elizabeth, Wang, Louis, Adams, Christopher, Baird, Daniel and Busby, Scott (2017) Structure based design of Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen. ACS medicinal chemistry letters.

Parmentier, Celine, Uteng, Marianne, Couttet, Philippe, Wolf, Armin, Zaccharias, Thomas, Heyd, Bruno, Bachellier, Philippe and Richert, Lysiane (2017) Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes. Archives of Toxicology, 91 (8). pp. 2879-2893. ISSN 1432-0738

Parmentier, Michael, Guo, Murphy, Zhou, Jianguang, Gallou, Fabrice, Gabriel, Christopher and Isley, Nicholas (2017) Switching from organic solvents to water at an industrial scale. Current Opinion in Green and Sustainable Chemistry, 7. pp. 13-17. ISSN 24522236

Patel, Dhavalkumar, Antoni, Christian, Freedman, Steven, Levesque, Marc and Sundy, John (2017) Phase 2 to Phase 3 Clinical Trials: Reasons for Success and Failure in Immunologic Diseases. Journal of Allergy and Clinical Immunology.

Paterson, Andrew, McMullin, Claire, Mahon, Mary, Press, Neil and Frost, Christopher (2017) α-Halo carbonyls enable meta selective primary, secondary and tertiary C–H alkylations by ruthenium catalysis. Org. Biomol. Chem., 15 (28). pp. 5993-6000. ISSN 1477-05201477-0539

Pearlstein, Robert, Mckay, Daniel, Hornak, Viktor, Dickson, Callum, Golosov, Andrei, Harrison, Tyler, Camilo, Velez-Vega and Duca, Jose (2017) Building new bridges between in vitro and in vivo in early drug discovery: Where molecular modeling meets systems biology. Current Topics in Medicinal Chemistry, 17 (23). pp. 2642-2662. ISSN 1873-4294

Pearson, David, Weiss, H Markus, Jin, Yi, van Lier, Jan Jaap, Erpenbeck, Veit J, Glaenzel, Ulrike, End, Peter, Woessner, Ralph, Eggimann, Fabian and Camenisch, Gian (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Pearson, David, Weiss, Markus, Jin, Yi, van Lier, Jan Jaap, Erpenbeck, Veit, Glaenzel, Ulrike, End, Peter, Woessner, Ralph and Camenisch, Gian P. (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Pearson, David, Weiss, Markus, Jin, Yi, van Lier, Jan Jaap, Erpenbeck, Veit, Glaenzel, Ulrike, End, Peter, Woessner, Ralph, Camenisch, Gian P. and Eggimann, Fabian (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Peng, Yunshan, Dobler, Markus, Patnaik, Anup, Liu, Eugene, Nunez, Jill, Kerrigan, John, Dean, Charles, Mckenney, David, Osborne, Colin, Dzink-Fox, Joann, Bojkovic, Jade, Lilly, Maria-Dawn, Sprague, Elizabeth, Hoffmaster, Keith, Ranjitkar, Srijan, Wang, Bing, hamann, lawrence, tommasi, ruben, glick, meir, yang, xia, wang, honming, parker, david, wattanasin, som, lenoir, francois, Xie, Lili and Yu, Donghui (2017) Design, Synthesis and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. Journal of medicinal chemistry. ISSN 1520-4804

Pepini, Timothy, Pulichino, Anne-Marie , Carsillo, Thomas, Carlson, Alicia, Sari-Sarraf, Farid, Ramsauer, Katrin, Debasitis, Jason, Maruggi, Giulietta, Otten, Gillis, Geall, Andrew, Yu, Dong, Ulmer, Jeffrey and Iavarone, Carlo (2017) Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design Response by a Self-Amplifying RNA. Journal of Immunology, 198.

Peter , Gedeck, Skolnik, Suzanne and Rodde, Stephane (2017) Developing collaborative QSAR models without sharing structures. Journal of Chemical Information and Modeling, 57 (8). pp. 1847-1858. ISSN 1549-95961549-960X

Petrovic, Katarina, Pfeifer, Martin, Parker, Christian, Tallarico, John, Movva, Rao, Scheel, Guenther and Helliwell, Stephen (2017) Cell viability assays for Saccharomyces cerevisiae: Comparison of fluorescence (Alamar TM Blue) and optical density assays in High Throughput Screening format. Microbiological research., 199. pp. 10-18. ISSN 1618-0623; 0944-5013

Pflanz, David , Birkhold, Annette I. , Albiol, Laia , Thiele, Tobias , Duda, Georg , Checa, Sara , Willie, Bettina M., Kornak, Uwe , Kneissel, Michaela and Kramer, Ina (2017) Sost deficiency led to enhanced Dkk1 expression coincident with a greater cortical bone formation response to mechanical loading. Scientific reports. ISSN 2045-2322

Phizackerley, Kirsten, Jumaa, Mouhannad, Lopalco, Antonio, Wolfe, Bradley H. , Ablan, Christopher D. and Stella, Valentino J. (2017) Mechanism of Degradation of an -Keto-Epoxide, a Model for the Warhead for Various Proteasome Inhibitor Anticancer Agents. Journal of pharmaceutical sciences, 106. pp. 1051-1061.

Piirainen, Henni, Taura, Jaume, Kursula, Petri, Ciruela, Francisco and Jaakola, Veli-Pekka (2017) Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. Biochimica et biophysica acta. ISSN 0006-3002

Pikman, Yana, Furman, Emily S, Alexe, Gabriela, Place, Andrew E, Kim, Sunkyu, Sohal, Bindi, Modiste, Rebecca, Harris, Marian, Kung, Andrew L, Silverman, Lewis B and Stegmaier, Kimberly (2017) Synergistic drug combinations with a CDK4/6 inhibitor in T-cell acute lymphoblastic leukemia. Clinical Cancer Research, 23 (4). pp. 1012-1024. ISSN 1557-3265

Pillong, Max, Marx, Corinne, Piechon, Philippe, Wicker, Jerome GP, Cooper, Richard I and Wagner, Beatrix (2017) A publicly available crystallisation data set and its application in machine learning. CrystEngComm, 19 (27). pp. 3737-3745.

Plawinski, Jason, Reinker, Stefan, Kirkpatrick, Nathaniel and Oakeley, Edward James (2017) Summer internship at Novartis. Report to University of Strasbourg, France.

Pognan, Francois and Marc, Philippe (2017) Legacy data sharing to improve drug safety assessment: The eTOX project. Nature Reviews Drug Discovery, 16 (12). pp. 811-812. ISSN 14741784

Potting, Christoph, Sailer, Andreas and Helliwell, Stephen (2017) A genome-wide phenotypic CRISPR/Cas9 screen identifies novel regulators of PARK2 level and mitophagy priming. Proceedings of the National Academy of Sciences of the United States of America PNAS. (10.107). pp. 1-10. ISSN 1091-6490; 0027-8424

Proudfoot, Andrew, Bussiere, Dirksen and Lingel, Andreas (2017) High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. Journal of the American Chemical Society, 139 (49). pp. 17824-17833. ISSN 15205126

Pugsley, Michael K., Authier, Simon, Brabham, Tiffini, Soloviev, Maxim, Markgraf, Carrie G., Correll, Krystle, Traebert, Martin, Greiter-Wilke, Andrea, Valentin, Jean-Pierre, Vargas, Hugo, Botchway, Alfred, Leishman, Derek J. and Curtis, Michael J. (2017) The Safety Pharmacology Society salary survey. Journal of Pharmacological and Toxicological Methods, 88. pp. 85-91. ISSN 1873488X

Q

Qi, Vicky, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Maya, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chen, Zijun, Fang, Douglas, Fei, Qi, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Li, Guobin, Lingel, Andreas, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Chen, Ho Man, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter and Li, En (2017) An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nature Chemical Biology.

R

Radonjic-Hoesli, Susanne, Wang, Xiaoliang, de Graauw, Elisabeth, Merz-Stoeckle, Christina, Styp-Rekowska, Beata, Hlushchuk, Ruslan, Simon, Dagmar, Spaeth, Peter J, Yousefi, Shida and Simon, Hans-Uwe (2017) Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. The Journal of allergy and clinical immunology. ISSN 1097-6825

Ramos, Marcel, Schiffer, Lucas, Re, Angela, Azhar, Rimsha, Rodriguez Cabrera, Carmen , Chan, Tiffany, Chapman, Philip , Gomez-Cabrero, David, Haibe-Kains, Benjamin, Hansen, Kasper, Kodali, Hanish , Louis, Marie Stephie, Mer, Arvind , Riester, Markus, Morgan, Martin, Carey, Vincent and Waldron, Levi (2017) Software for the integration of multi-omics experiments in Bioconductor. Cancer research. ISSN 1538-7445; 0008-5472

Rao, Koneti V, Webster, Sharon, Dalm, Virgil ASH, Sediva, Anna, van Hagen, Martin P, Holland, Steven, Rosenzweig, Sergio D, Christ, Andreas Dominik, Sloth, Birgitte, Cabanski, Maciej, Joshi, Aniket, De Buck, Stefan, Doucet, Julie, Guerini, Danilo, Kalis, Christoph, Pylvaenaeinen, Ilona, Soldermann, Nicolas, Kashyap, Anuj, Gulbu, Uzel, Leonardo, Michael J, Patel, Dhavalkumar, Lucas, Carrie L and Burkhart, Christoph (2017) Effective ‘Activated PI3Kdelta Syndrome’-targeted therapy with PI3Kdelta inhibitor leniolisib. Blood, 130 (21). pp. 2307-2316. ISSN 1528-0020; 0006-4971

Rao, Koneti V, Webster, Sharon, Dalm, Virgil ASH, Sediva, Anna, van Hagen, Martin P, Holland, Steven, Rosenzweig, Sergio D, Christ, Andreas Dominik, Sloth, Birgitte, Cabanski, Maciej, Joshi, Aniket, De Buck, Stefan, Doucet, Julie, Guerini, Danilo, Kalis, Christoph, Pylvaenaeinen, Ilona, Soldermann, Nicolas, Kashyap, Anuj, Gulbu, Uzel, Leonardo, Michael J, Patel, Dhavalkumar, Lucas, Carrie L and Burkhart, Christoph (2017) Effective ‘Activated PI3Kdelta Syndrome’-targeted therapy with PI3Kdelta inhibitor leniolisib. Blood, 130 (21). pp. 2307-2316. ISSN 0006-4971

Rauch, Judith and Kallen, Joerg (2017) Hintergrundtext Medizinforschung am PSI. new magazine of the Paul Scherrer Institute PSI.

Ravagli, Carlo, Pognan, Francois and Marc, Philippe (2017) OntoBrowser: a tool for curating ontologies and code lists by subject matter experts. Bioinformatics, 33 (1). pp. 148-149. ISSN 1367-48031460-2059

Rebhan, Michael (2017) Towards a systems approach for chronic diseases, based on health state modeling. F1000Research., 6. p. 309. ISSN 2046-1402

Rehan, Shahid, Paavilainen, Ville O and Jaakola, Veli-Pekka (2017) Functional Reconstitution of Human Equilibrative Nucleoside Transporter-1 into Styrene Maleic Acid Co-polymer Lipid Particles. Biochimica et biophysica acta. ISSN 0006-3002

Reilly, John, Aliagas, Ignacio, Berger, Raphaelle, Goldberg, Kristin, Nishimura, Rachel, Richardson, Paul, Richter, Daniel, Sherer, Edward, Sparling, Brian and Marian, Bryan (2017) Sustainable Practices in Medicinal Chemistry Part 2: Green by Design. Journal of Medicinal Chemistry, 60 (14). pp. 5955-5968. ISSN 15204804

Ren, Shuang , Sechaud, Romain, Su, Frank, Tillmann, Hanns-Christian, Hara, Hisanori, Tan, Xuemei, Hou, Jie, Woessner, Ralph and Zhao, Rong (2017) Pharmacokinetics and safety of indacaterol and glycopyrronium (IND/GLY) following repeated once daily inhalation from a fixed-dose combination in healthy Chinese subjects. International Journal of Clinical Pharmacology and Therapeutics , 55 (2). pp. 147-155.

Riede, Julia, Camenisch, Gian P., Jörg, Huwyler and Poller, Birk (2017) Current methods to determine hepatic Kpuu: a comparison of their usefulness and limitations. Journal of pharmaceutical sciences. ISSN 00223549

Riede, Julia, Poller, Birk, Huwyler, Jörg and Camenisch, Gian P. (2017) Assessing the risk of drug-induced cholestasis using unbound intrahepatic concentrations. Drug metabolism and disposition. ISSN 1521-009X

Riss, Bernard (2017) TMS-ent-Bisabolangelone. Tetrahedron, 73 (23). pp. 3202-3212. ISSN 00404020

Robbins, Ken (2017) Sparse set of AWS tips for an enterprise cloud transformation. Ken Robbins' LinkedIn blog.

Roggo, Yves (2017) Forensic investigation in the pharmaceutical industry: Identification procedure of visible particles in (drug) solutions and different containers by combining vibrational and X-ray spectroscopic techniques. Journal of pharmaceutical and biomedical analysis. ISSN 1873-264X; 0731-7085

Roggo, Yves (2017) Global regression model for moisture content determination using near-infrared spectroscopy. European journal of pharmaceutics and biopharmaceutics. ISSN 1873-3441; 0939-6411

Rooks, Daniel, Praestgaard, Jens, Hariry, Sam, Laurent, Didier, Petricoul, Olivier, Perry, Robert G., Trifilieff, Estelle and Roubenoff, Ronenn (2017) Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. Journal of the American Geriatrics Society, 65 (9). pp. 1988-1995. ISSN 15325415

Rubic-Schneider, Tina, Kuwana, Masataka, Christen, Brigitte, Aßenmacher, Manuela, Hainzl, O., Zimmermann, F., Fischer, Robert, Koppenburg, Vera, Chibout, Salah-Dine, Wright, Timothy M., Seidl, Andreas and Kammueller, Michael (2017) T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia. Blood Advances, 1 (6). pp. 367-379. ISSN 2473-9537

Ruetz, Stephan, Chene, Patrick, Stachyra, Therese-Marie, Brock, Roland and Wallbrecher, Rike (2017) A critical assessment of the synthesis and biological activity of p53/Hdm2 stapled peptide inhibitors. British journal of pharmacology, 2017 .

Ruffner, Heinz, Ley, Svenja, Galuba, Olaf, Melin, Nicolas, Salathe, Adrian, Aebi, Alexandra, Pikiolek, Monika, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, D'Ario, Giovanni, Gubser Keller, Caroline, Bouwmeester, Antonius, Parker, Christian, Bouchez, Laure, Kirkland, Susan and Nigsch, Florian (2017) Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology. Journal of biomolecular screening. ISSN 1552-454X; 1087-0571

Rutkowska, Aleksandra, Sailer, Andreas and Dev, Kumlesh (2017) EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination. Journal of Neuroinflammation, 14 (1). ISSN 1742-2094

Rutrick, Daniel , Stein, Dan , Fava, Maurizio, Hasler, Gregor, Cha, Jang-Ho, Donchev, Toni , Ocwieja, Magdalena and Gomez-Mancilla, Baltazar (2017) Mavoglurant in Obsessive-Compulsive Disorder Resistant to Selective Serotonin Reuptake Inhibitor: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 study. Advances in therapy..

S

Salick, Max, Wells, Michael F, Eggan, Kevin and Kaykas, Ajamete (2017) Modelling Zika virus infection of the developing human brain in vitro using stem cell-derived cerebral organoids. Journal of visualized experiments : JoVE (127). ISSN 1940-087X

Sandham, David, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Charlton, Steven, Chatterjee, Devnandan, Cox, Brian, Dubois, Gerald, Duggan, Nicholas, Hall, Edward, Hatto, Julia, Maas, David, Manini, Jodie, Profit, Rachael, Riddy, Darren, Ritchie, Cathy, Sohal, Bindi, Shaw, Duncan, Stringer, Rowan, Sykes, David, Turner, Katharine, Watson, Simon, West, Ryan, Willard, Elizabeth, Williams, Gareth and Willis, Jennifer (2017) Discovery of Fevipiprant (NVP-QAW039), a potent and selective CRTh2 receptor antagonist for treatment of allergic diseases. ACS Medicinal Chemistry Letters.

Sangana, Ramachandra, Gu, Helen, Chun, Dung Yu and Einolf, Heidi (2017) Evaluation of clinical drug interaction potential of clofazimine using static and dynamic modeling approaches. Drug metabolism and disposition.

Sasseville, Vito, Milton, Mark, Maclachlan, Timothy and Newton, Ronald (2017) Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics. Regulatory Toxicology and Pharmacology, 86. pp. 221-230. ISSN 1096-0295

Schenkel, Berthold, Venturoni, Francesco, Aubry, Michel, Sevinc, Serbuelent, Sedelmeier, Joerg Mathias, Martin, Benjamin, Susanne, Flavien, Lima, Fabio and Piccioni, Lorenzo (2017) Match-making reactors to chemistry: a continuous manufacturing-enabled sequence to a key benzoxazole pharmaceutical intermediate. Organic process research & development, 21. pp. 1779-1793.

Schlesinger, Ann and Hunt, Ian (2017) Video of 2016 Novartis Open Framework Symposium. this link was shared with externals but not published.

Schuierer, Sven, Carbone, Walter, Petitjean, Virginie, Fernandez, Anita, Sultan, Marc and Roma, Guglielmo (2017) A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples. BMC Genomics, 18 (1). ISSN 14712164

Seefried, Lothar, Baumann, Jasmin, Hemsley, Sarah, Hofmann, Christine, Kunstmann, Erdmute, Kiese, Beate, Huang, Yue, Chivers, Simon, Valentin, Marie-Anne, Borah, Babul, Roubenoff, Ronenn, Junker, Uwe and Jakob, Franz (2017) Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia. Journal of Clinical Investigation, 127 (6). pp. 2148-2158. ISSN 1558-8238

Segatto, Marco, Fittipaldi, Raffaella, Pin, Fabrizio, Sartori, Roberta, Ko, Kyung Dae, Zare, Hossein, Fenizia, Claudio, Zanchettin, Gianpietro, Pierobon, Elisa Sefora, Hatakeyama, Shinji, Sperti, Cosimo, Merigliano, Stefano, Sandri, Marco, Filippakopoulos, Panagis, Costelli, Paola, Sartorelli, Vittorio and Caretti, Giuseppina (2017) Epigenetic Targeting of Bromodomain Protein BRD4 Counteracts Cancer Cachexia and Prolongs Survival. Nature Communications.

Seroutou, Abdelkader, Tian, Xianbin, Fernandez, Rose, Morozov, Alex, Sheng, Qing, Ramkumar, Thiruvamoor and Zubel, Angela (2017) A Phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer. BMC Cancer, 17(1) (646). ISSN 1471-2407

Shimshek, Derya R., Bus, Thorsten, Schupp, Bettina, Jensen, Vidar, Marx, Verena, Layer, Liliana E., Köhr, Georg and Sprengel, Rolf (2017) Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation. Frontiers in Molecular Neuroscience, 10. ISSN 1662-5099

Silver-Brown, Serena, Hoffman, Ann, Horvath, Peter, Lovitt, Carrie, Easton, Evan, LaBarbera, Daniel, Mendez, Melissa, Rothernberg, Mark, Seldin, Jan and Fennell, Myles (2017) SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium. Assay and drug development technologies, 15 (1). pp. 1-7.

Sivasankaran, Rajeev, Teider, Natalia, Mcnally, Anna, Bradner, Jay and Worringer, Katie (2017) Synthetic Transcription Elongation Factors license transcription across repressive heterochromatin. Science. pp. 1617-1622.

Skilitsi, Anastasia Ioanna, Turko, Timothé, Cianfarani, Damien, Barre, Sophie, Uhring, Wilfried, Hassiepen, Ulrich and Léonard, Jérémie (2017) Towards Sensitive, High-Throughput, Biomolecular Assays Based on Fluorescence Lifetime. Methods and applications in fluorescence /. ISSN 2050-6120

Skolnik, Suzanne, Geraci, Gina and Dodd, Stephanie (2017) AUTOMATED SUPERATURATION STABILITY ASSAY TO DIFFERENTIATE POORLY SOLUBLE COMPOUNDS IN DRUG DISCOVERY. Journal of pharmaceutical sciences. ISSN 1520-6017

Skolnik, Suzanne, Geraci, Gina and Dodd, Stephanie (2017) Automated Supersaturation Stability Assay to Differentiate Poorly Soluble Compounds in Drug Discovery. Journal of Pharmaceutical Sciences. ISSN 1520-6017

Skora, Lukasz and Jahnke, Wolfgang (2017) 19F-NMR-based dual-site reporter assay for the discovery and distinction of catalytic and allosteric kinase inhibitors. ACS medicinal chemistry letters, 8. pp. 632-635.

Skora, Lukasz, Jahnke, Wolfgang, Sijbesma, Eline, Leysen, Seppe, Brunsveld, Luc, Wolf, Alexander, Nussbaumer, Peter and Ottmann, Christian (2017) Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56 (30). pp. 3972-3982. ISSN 15204995

Smith, Aaron, Ni, ZJ, Poon, Daniel, Huang, Zilin, Chen, Zheng, Zhang, Qiong, Tandeske, Laura, Merritt, Hanne, Shoemaker, Kevin, Chang, John, Kaufman, Sue, Huh, Kay, Murray, Jeremy, Appleton, Brent A., Jacob, Sandra, Scheufler, Clemens, Kanazawa, Takanori, Jansen, Hanneke, Stuart, Darrin and Shafer, Cynthia (2017) Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405

Smith, Nichola (2017) Epithelial Na+ channel inhibitors for the treatment of cystic fibrosis. Pharmaceutical Patent Analyst, 6 (4). pp. 179-188. ISSN 2046-8962

Smith, Philip, O’Sullivan, Catherine and Gergely, Peter (2017) Sphingosine 1-phosphate signalling in allogeneic hematopoietic stem cell transplantation (HSCT). International Journal of Molecular Sciences , 18 (10). pp. 1-12. ISSN 18102027

Snellman, Anniina, Rokka, Johanna, Lopez-Picon, Francisco R, Helin, Semi, La Ferla, Barbara, Torittu, Annamari, Löyttyniemi, Eliisa, Pihlaja, Rea, Masserini, Massimo, Solin, Olof, Rinne, Juha O and Haaparanta-Solin, Merja (2017) Treatment effect of functionalized nanoliposomes to beta-amyloid deposition in APP23 transgenic mouse model of Alzheimer’s disease – A follow-up study using [11C]PIB micro-PET imaging. Neurobiology of aging, 57. pp. 84-94. ISSN 01974580

Snowdon, Victoria K., Lachlan, Neil J., Hadoke, Patrick W.F., Hoy, Anna M., Semple, Scott, Patel, Dilip, Mungall, Will, Kendall, Timothy J., Thomson, Adrian, Lennen, Ross J., Jansen, Mauritis A., Moran, Carmel M., Pellicoro, Antonella, Ramachandran, Prakash, Shaw, Isaac, Aucott, Rebecca L. , Severin, Thomas, Saini, Rajnish, Pak, Judy, Yates, Denise, Dongre, Neelesh, Duffield, Jeremy S., Webb, David J., Iredale, John P., Hayes, Peter C. and Fallowfield, Jonathan A. (2017) Serelaxin for the Treatment of Renal Dysfunction in Cirrhosis: Preclinical Evaluation and Results of a Randomized Phase 2 Trial. PLoS medicine. ISSN 1549-1676; 1549-1277

Solt, Andras, Bostock, Mark J., Shrestha, Binesh, Kumar, Prashant, Warne, Tony, Tate, Christopher G and Nietlispach, Daniel (2017) Insight into partial agonism by observing ligand-modulated conformational equilibria of a Gs-mimetic nanobody-bound B1-adrenergic receptor. Nature communications, 8. p. 1795. ISSN 2041-1723

Sorde, Laetitia, Spindeldreher, Sebastian and Karle, Anette (2017) Massive immune response against IVIg interferes with response against other antigens in mice: A new mode of action? PLoS ONE, 12 (10). ISSN 19326203

Sorde, Laetitia, Spindeldreher, Sebastian and Karle, Anette (2017) Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg? European journal of immunology. ISSN 2050-4527

Srinivas, Honnappa and Wilcken, Rainer (2017) Manuscript: SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency. Note: Details of NIBR contribution to manuscript: The results of Mutational analysis of SGPL1: In silico modelling ( were approved in OAK before-ref link https://oak-intra.novartis.com/25460/). Mutational analysis of SGPL1: In silico modelling results were shared with Prof. Friedhelm Hildebrandt, Harvard medical school, Division of Nephrology Boston Children's Hospital. These results, that were shared with Prof. Friedhelm Hildebrandt is now a part of full manuscript for publication with Prof. Friedhelm Hildebrandt as corresponding author . Honnappa Srinivas and Rainer Wilcken are the co-authors from NIBR. Please find attached the full manuscript. The Journal of clinical investigation : JCI, 127. pp. 912-928. ISSN 1558-8238

Stanley, Aryan, Ashrafi, Hossein, Seddon, Alan / M and Modjtahedi, Helmout (2017) INVESTIGATION INTO THE THERAPEUTIC BENEFITS OF VARIOUS FORMS OF HER INHIBITORS WHEN COMBININED WITH IGF-1R, C-MET AND SRC TARGETING AGENTS IN BREAST CANCER. Scientific reports. ISSN 2045-2322

Steger-Hartmann, Thomas and Pognan, Francois (2017) The eTOX Consortium: To Improve the Safety Assessment of New Drug Candidates. Pharmazeutische Medizin, 1. pp. 3-13. ISSN ISSN 2191-6039

Stein, Andrew (2017) Practical unidentifiability of receptor density in target mediated drug disposition models can lead to over-interpretation of drug concentration data. Practical unidentifiability of receptor density in target mediated drug disposition models can lead to over-interpretation of drug concentration data.

Stein, Andrew and Ramakrishna, Ramprasad (2017) AFIR: A dimensionless potency metric for characterizing the activity of monoclonal antibodies. CPT: pharmacometrics & systems pharmacology.. ISSN 21638306

Stiehl, Daniel Philipp, Tritto, Elaine, Chibout, Salah-Dine, Cordier, Andre and Moulin, Pierre (2017) The Utility of Gene Expression Profiling from Tissue Samples to Support Drug Safety Assessments. ILAR Journal. pp. 1-11. ISSN 1084-20201930-6180

Street, Steven T. G. , Chin, Donovan, Hollingworth, Greg, Berry, Monica, Morales, Juan C. and Galan, M. Carmen (2017) Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K+ buffer. Chemistry - a European journal, 23 (29). pp. 6953-6958. ISSN 09476539

Stringer, Rowan, Cordier, Valerie, Afatsawo, Catherine, Arabin, Philip, Desrayaud, Sandrine, Hoffmann, Laurent, Lehmann, Daniel, Lowe, Phil, Risser, Francis, Thiel, Julia, Widmer, Toni, Wipfli, Peter and Bigaud, Marc (2017) Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice. Xenobiotica. ISSN 1366-5928; 0049-8254

Stutz, Katharina , Hiss, Jan A., Schneider, Petra , Blatter, Markus, Pfeiffer, Bernhard , Posselt, Gernot and Schneider, Gisbert (2017) Peptide-membrane interaction between targeting and lysis. ACS Chemical Biology. ISSN 1554-89291554-8937

Subramanian, Aravind, Narayan, Rajiv, Corsello, Steven M., Peck, David D., Natoli, Ted E., Lu, Xiaodong, Gould, Joshua, Davis, John F., Tubelli, Andrew A., Asiedu, Jacob K., Lahr, David L., Hirschman, Jodi E., Liu, Zihan, Donahue, Melanie, Julian, Bina, Khan, Mariya, Wadden, David, Smith, Ian, Lam, Daniel, Liberzon, Arthur, Toder, Courtney, Bagul, Mukta, Orzechowski, Marek, Enache, Oana M., Piccioni, Frederica, Berger, Alice H., Shamji, Alykhan, Brooks, Angela N., Vrcic, Anita, Flynn, Corey, Rosains, Jacqueline, Takeda, David, Davison, Desiree, Lamb, Justin, Ardlie, Kristin, Hogstrom, Larson, Gray, Nathanael S., Clemons, Paul A., Silver, Serena, Wu, Xiaoyun, Zhao, Wen-Ning, Read-Button, Willis, Wu, Xiaohua, Haggarty, Stephen J., Ronco, Lucienne V., Boehm, Jesse S., Schreiber, Stuart L., Doench, John G., Bittker, Joshua A., Root, David E., Wong, Bang and Golub, Todd R. (2017) A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles. Biorxiv.

Sullivan, Ryan (2017) CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. Journal of Clinical Investigation, 127 (11). pp. 4042-4058. ISSN 0021-9738

Summermatter, Serge, Bouzan, Anais, Pierrel, Eliane, Melly, Stefan, Gutzwiller, Sabine, Fryer, Christy, Nolin, Erin, Dornelas, Christina, Leighton-Davies, Juliet, Palmer , Amy, Qin, Yan, Glass, David and Fournier, Brigitte (2017) Blockade of metallothioneins 1 and 2 increases skeletal muscle mass and strength. Molecular and cellular biology, 37 (5). e000305-e000316. ISSN 1098-5549; 0270-7306

Suply, Thomas, Hannedouche, Sebastien, Carte, Nathalie, Li, Jianping, Grosshans, Bianka, Schaefer, Michael, Raad, Layla, Beck, Valerie, Vidal, Solange, Beluch, Noemie, Barbieri, Samuel, Wirsching, Johann, Lageyre, Nadine, Lannoy, Vincent, Detheux, Michel, Bitsch, Francis, Falchetto, Rocco Angelo, Bouwmeester, Antonius, Porter, Jeffrey, Baumgarten, Birgit, Mansfield, Keith, Carballido, Jose, Seuwen, Klaus and Bassilana, Frederic (2017) A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Science Signaling, 10 (496). ISSN 19379145

Surdziel, Ewa, Clay, Ieuan, Nigsch, Florian, Thiemeyer, Anke, Allard, Cyril, Hoffman, Gregory, Reece-Hoyes, John, Phadke, Tanushree, Gambert, Romain, Gubser Keller, Caroline, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Frederiksen, Mathias, Schuebeler, Dirk, Seuwen, Klaus, Bouwmeester, Antonius and Fodor, Barna (2017) Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization. PLoS ONE, 12 (8). pp. 1-20. ISSN 1932-6203

Surdziel, Ewa, Clay, Ieuan, Nigsch, Florian, Thiemeyer, Anke, Allard, Cyril, Hoffman, Gregory, Reece-Hoyes, John, Phadke, Tanushree, Gambert, Romain, Gubser Keller, Caroline, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Frederiksen, Mathias, Schuebeler, Dirk, Seuwen, Klaus, Bouwmeester, Antonius and Fodor, Barna (2017) Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization. PLoS ONE, 12 (8). ISSN 19326203

Swaller, Tim (2017) GNF recipient of the 2017 IEA Earth Month Award. GNF Website Recent Updates section.

T

Takahashi, Shunji , Kobayashi, Takayuki, Tomomatsu, Junichi, Ito, Yoshinori, Oda, Hisanobu, Kajitani, Tatsuhiro, Kakizume, Tomoyuki, Tajima, Takeshi, Takeuchi, Hiromi, Maacke, Heiko and Esaki, Taito (2017) Phase I study of LJM716 in Japanese patients. LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer, 79. pp. 131-138.

Tam, Yat Kong and Blasko, Andrei (2017) Mitigating the Effect of Surfactants in Sample Preparation of a Phospholipid Formulation for Impurities Analysis by Reversed-Phase Liquid Chromatography. LCGC North America, 35 (5). pp. 321-328. ISSN 1939-1889

Tan, Kian, Grob, Jonathan, Hajdin, Christine, Siuti, Piro, Lilly, Jeremiah, Andorfer, Mary, Chael, Julia and Lewis, Jared (2017) Understanding Flavin-Dependent Halogenase Reactivity via Sub-strate Activity Profiling. ACS Catalysis, 7 (3). pp. 1897-1904. ISSN 2155-54352155-5435

Tarselli, Mike (2017) Insights: Artificial Intelligence in Research. Science, 357 (6346). pp. 28-30.

Tarselli, Mike (2017) Nature Chemistry Reactions Follow-up Interview: Mike Tarselli. Nature chemistry.

Tarselli, Mike (2017) Tin can. Nature chemistry, 9. p. 500. ISSN doi:10.1038/nchem.2769

Teodoro, Douglas, Mottin, Luc, Gobeill, Julien, Gaudinat, Arnaud, Vachon, Therese and Ruch, Patrick (2017) Improving average ranking precision in user searches for biomedical research datasets. Database the journal of biological databases and curation., 2017. ISSN 1758-0463

Terranova, Remi, Vitobello, Antonio, Del Rio Espinola, Alberto, Wolf, Roland, Schwarz, Michael, Thomson, John, Meehan, Richard and Moggs, Jonathan (2017) Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis. Current Opinion in Toxicology, 3. pp. 62-70. ISSN 2468-2020

Tian, Hua, Six, David, Krucker, Thomas, Leeds, Jennifer and Winograd, Nicholas (2017) Subcellular chemical imaging of antibiotics in single bacteria using C60-secondary ion mass spectrometry. Analytical Chemistry, 89 (9). pp. 5050-5057. ISSN 0003-27001520-6882

Tiedt, Ralph, Delach, Scott, Kovats, Steven, Horn, Thomas, Acker, Michael, Schacher Engstler, Barbara, Su, Fei and Caponigro, Giordano (2017) Pre-clinical Selectivity Profile of the CDK4/6 Inhibitor Ribociclib Compared With That of Palbociclib and Abemaciclib. AACR Annual meeting 2017 .

Tosato, Matteo, Marzetti, Emanuele, Cesari, Matteo, Savera, Giulia, Miller, Ram R, Bernabei, Roberto, Landi, Francesco and Calvani, Riccardo (2017) Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging clinical and experimental research. ISSN 1720-8319

Tully, David, Rucker, Paul, Chianelli, Donatella, Williams, Jennifer, Biggart, Agnes, Alper, Phillip, Schmeits, James, Zoll, Jocelyn, Kim, Young, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean, Laffitte, Bryan, Wu, Xiangdong, Mcnamara, Peter, Seidel, Martin, Mutnick, Daniel, Bursulaya, Badry, Bao, Dingjiu and Groessl, Todd (2017) Discovery of tropifexor (LJN452), a highly potent non-bile acid FXR Agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH). Journal of Medicinal Chemistry, 60 (24). pp. 9960-9973. ISSN 0022-26231520-4804

U

Umehara, Ken-Ichi, Huth, Felix, Gu, Helen, Schiller, Hilmar, Heimbach, Tycho and He, Handan (2017) Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - A comparison with the chemical inhibition method. Drug Metabolism and Personalized Therapy, 32 (4). pp. 191-200. ISSN 23638915

Unterreiner, Adeline, Stoehr, Natacha, Huppertz, Christine, Calzascia, Thomas, Farady, Christopher and Bornancin, Frederic (2017) Selective MALT1 paracaspase inhibition does not block TNF-a production downstream of TLR4 in myeloid cells. Immunology letters.

V

Van Berkel, Gary, Kertesz, Vilmos, Orcutt, Matt, Bentley, Adam, Glick, Jim and Flarakos, Jimmy (2017) Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry. Analytical Chemistry, 89 (22). pp. 12578-12586. ISSN 0003-27001520-6882

Van Dam, Joris, Onyango, Kevin Omondi , Midamba, Brian, Groosman, Nele, Hooper, Norman, Spector, Jonathan, Pillai, Goonaseelan and Ogutu, Bernards (2017) An open-source mobile digital platform for clinical trial data collection in low-resource settings. BMJ Innovations. ISSN doi:10.1136/bmjinnov-2016-000164

Van Eis, Maurice, Evenou, Jean-Pierre, Schuler, Walter, Von Matt, Peter, Vangrevelinghe, Eric, Wagner, Juergen and Zenke, Gerhard (2017) Indolyl-naphthyl-maleimides as potent and selective Inhibitors of Protein Kinase C-alpha/beta. Bioorganic and medicinal chemistry letters, 27 (4). pp. 781-786. ISSN 1464-3405

Vapurcuyan, Arpine, Crouthamel, Matthew, Davis, John, Tran, Phi, Natrillo, Adrienne and Zhu, Bing (2017) Transport properties of valsartan, sacubitril, and its active metabolite (LBQ657) as determinants of disposition. Xenobiotica, omline (Publis). pp. 1366-5928. ISSN 0049-8254

Velcicky, Juraj, Miltz, Wolfgang, Oberhauser, Berndt, Orain, David, Vaupel, Andrea, Weigand, Klaus, Dawson King, Janet, Littlewood-Evans, Amanda, Nash, Mark, Feifel, Roland and Loetscher, Pius (2017) Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Verras, Andreas, Waller, Christopher, Gedeck, Peter, Green, Darren, Kogej, Thierry, Raichurkar, Anandkumar, Panda, Manoranjan, Shelat, Anang, Guy, Kip, Papadatos, George and Burrows, Jeremy (2017) Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition. Journal of chemical information and modeling, 57 (3). pp. 445-453. ISSN 1549-960X

Vigne, Solenne , Fanny, Chalmin, Duc, Donovan , Clottu, Aurélie , Apetoh, Lionel, Marc, Lobaccaro, Pot, Caroline , Zhang, Juan and Christen, Isabelle (2017) Interleukin-27 drives oxysterol production that regulate the adaptive Immune response. Frontiers in immunology, 8. ISSN 1664-3224

Vitobello, Antonio, Pouche, Lucie, Romer, Michael, Glogovac, Milica, MacLeod, Kenneth, Ellinger-Ziegelbauer, Heidrun, Westphal, Magdalena, Dubost, Valerie, Stiehl, Daniel Philipp, Dumotier, Berengere, Fekete, Alexander, Moulin, Pierre, Zell, Andreas, Schwarz, Michael, Moreno, Rita, Huang, Jeffrey, Elcombe, Cliff, Henderson, Colin, Wolf, Roland, Moggs, Jonathan and Terranova, Remi (2017) Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver. Toxicological sciences, 158 (2). pp. 367-378. ISSN 1096-0929; 1096-6080

Vorherr, Thomas and D'Alessandro, Pier Luca (2017) Evaluating Cellular Uptake of Drugs with Fluorescent Sensor Proteins. ACS Sensors, 8 (2). pp. 1191-1197.

Vorherr, Thomas, Lewis, Ian, Berghausen, Joerg, Desrayaud, Sandrine and Schaefer, Michael (2017) Modulation of oral bioavailability and metabolism for closely related cyclic hexapeptides. International journal of peptide research and therapeutics..

Vulpetti, Anna, Ruedisser, Simon, Ostermann, Nils, Erbel, Paulus, Zoller, Thomas, Salem, Bahaa, Gerhartz, Bernd, Hommel, Ulrich, Lorthiois, Edwige and Maibaum, Juergen Klaus (2017) Structure-based library design and fragment-based screening for the identification of novel Factor D inhibitors. Journal of medicinal chemistry.

vandenberghe, Rik, Riviere, Marie-Emmanuelle, Caputo, Angelika, Maguire, Paul, farlow, martin, marotta, giovanni, sanchez-valle, raquel, scheltens, philip, Graf, Ana, Ryan, Joseph and Sovago, Judit (2017) Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3 (1). pp. 10-22. ISSN 2352-8737

W

Waldkirch, Stephnie, d' Errico, Paolo, Sauer, Jonas-Frederic, Savanthrapadian, Shakuntala, Loreth, Desiree, Katzmarski, Natalie, Bartos, Marlene, Prinz, marco and Meyer-Luehmann, Melanie (2017) Seed-induced Abeta deposition impairs adult neurogenesis, triggers neurodegeneration and is modulated by microglia under environmental enrichment. The EMBO Journal, 37 (2). pp. 167-182. ISSN 0261-41891460-2075

Wang, Haizhen, Nicolay, Brandon N., Chick, Joel, Gao, Xueliang, Geng, Yan, Ren, Hong, Ligon, Keith L., Roberts, Thomas M., Gao, Hui, Williams, Juliet, Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J. and Sicinski, Piotr (2017) The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature, 546 (7658). pp. 426-430. ISSN 1476-4687

Wang, Hui-Qin, Halilovic, Ensar, Li, Xiaoyan, Liang, Jinsheng, Cao, Yichen, Rakiec, Daniel, Ruddy, David, Jeay, Sebastien, Li, Nanxin, Williams, Juliet, Sellers, William, Huang, Alan and Li, Fang (2017) Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models. eLife, 6. ISSN 2050-084X

Wang, Tao, Glendinning, John, Grushka, Miriam, Hummel, Thomas and Mansfield, Keith (2017) Drug-induced taste disorders in clinical practice and preclinical safety evaluation. Toxicological Sciences, 156 (2). pp. 315-324. ISSN 1096-0929

Wang, Xinting, Koehne-Voss, Stephan, Anumolu, Sree and Yu, Jing (2017) Population Pharmacokinetics of Tobramycin Inhalation Solution in Pediatric Patients With Cystic Fibrosis. Journal of Pharmaceutical Sciences, 106 (11). pp. 3402-3409. ISSN 1520-6017

Wanke, Florian, Moos, Sonja, Croxford, Andrew L, Heinen, André P, Gräf, Stephanie, Kalt, Bettina, Tischner, Denise, Zhang, Juan, Christen, Isabelle, Bruttger, Julia, Yogev, Nir, Tang, Yilang, Zayoud, Morad, Israel, Nicole, Karram, Khalad, Reißig, Sonja, Lacher, Sonja M, Reichhold, Christian, Mufazalov, Ilgiz A, Ben-Nun, Avraham, Kuhlmann, Tanja, Wettschureck, Nina, Sailer, Andreas W, Rajewsky, Klaus, Casola, Stefano, Waisman, Ari and Kurschus, Florian C (2017) EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell reports, 18 (5). pp. 1270-1284. ISSN 2211-1247

Wei, Jun-Rong, Richie, Daryl, Mostafavi, Mina, Metzger Iv, Louis, Rath, Christopher, Sawyer, William, Takeoka, Ken and Dean, Charles (2017) LpxK is essential for growth of Acinetobacter baumannii ATCC 19606: relationship to toxic accumulation of lipid A pathway intermediates. mSphere, 2 (4).

Welink, Jan, Yang, Eric, Hughes, Nicola, Rago, Brian, Woolf, Eric, sydor, jens, coppola, laura, ackermann, brad, Li, Wenkui, alley, stephen, arnold, mark, berger, isabella, briscoe, chad, buonarati, michael, bustard, mark, cancilla, mark, cho, seongeun, duggan, jeff, fraier, daniela, garofolo, fabio, green, rachel, haidar, sam, hittle, lucinda, ishiiwatabe, akiko, islam, rafig, jenkins, rand, jones, barry, kadavil, john, kassim, sean, kavetska, olga, le blaye, olivier, lee, anita, liu, hanlan, mehl, john, mendes, gustavo, santos, lima, musuku, adien, ramanathan, ragu, saito, yoshiro, savoie, natasha, summerfield, scott, surapaneni, sekhaer, szapacs, matthew, tampal, nilufer, verhaegher, tom, vinter, stephen and whale, emma (2017) 2017 White Paper on recent issues in bioanalysis: Aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: Small molecules, peptides and small molecule biomarkers). Bioanalysis, 9 (22). pp. 1807-1825. ISSN 17576199

Witek, Jagna, Mühlbauer, Max, Keller, Bettina G., Blatter, Markus, Meissner, Axel, Wagner, Beatrix and Riniker, Sereina (2017) Interconversion Rates Between Conformational States as Rationale for the Membrane Permeability of Cyclosporines. Chemphyschem. ISSN 14394235

Wong, Harvey, Bohnert, Tonika, Damian-Iordache, Valeriu, Gibson, Christopher, Hsu, Cheng-Pang, Krishnatry, Anu Shilpa, Liederer, Bianca M, Lin, Jing, Lu, Qiang, Mettetal, Jerome T, Mudra, Daniel R, Nijsen, Marjoleen JMA, Schroeder, Patricia, Schuck, Edgar, Suryawanshi, Satyendra, Trapa, Patrick, Tsai, Alice, Wang, Haiqing and Wu, Fan (2017) Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: An IQ Consortium PK-PD Discussion Group perspective. Drug Discovery Today. ISSN 18785832

Wozniak-Knopp, Gordana, Stadlmayr, Gerhard, Perthold, Jan Walther, Stadlbauer, Katharina, Woisetschläger, Maximilian, Sun, Haijun and Rüker, Florian (2017) Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments. Protein engineering, design & selection : PEDS, 30 (9). pp. 657-671. ISSN 1741-0134

Wright, Kirk (2017) Biophysics: for HTS hit validation, chemical lead optimization and beyond. Expert opinion on drug discovery, 12 (9). pp. 1-11. ISSN 1746-045X

Wright, Kirk (2017) Comparison of sensitivityBiacore™ S200, Biacore 8K and Biacore T200. GE Heathcare Tech Note.

Wu, Fan, Heimbach, Tycho, Hatsis, Panagiotis, Tang, Hai-Ming, Dugyala, Raviprakash, Yue, Qin, Wang, Tao and He, Handan (2017) Integrated TK–TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs. Journal of Pharmacokinetics and Pharmacodynamics. pp. 1-14. ISSN 15738744

Wylie, Andrew, Schoepfer, Joseph, Jahnke, Wolfgang, Jacob, Sandra, Loo, Alice, Furet, Pascal, Marzinzik, Andreas, Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David, Hughes, Timothy, Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas and Sellers, William (2017) The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature.

X

Xie, Xiaoling, Mckay, Daniel, Kulathila, Raviraj, Wright, Kirk, Sage, David, Fortin, Pascal, Lin, Fallon, Chen, Jinyun, Levell, Julian and Pagliarini, Raymond (2017) Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25 (3). pp. 506-513. ISSN 1878-4186

Xiong, Tina, Meister, Glenna E., Workman, Rachael E., Kato, Nathaniel C., Spellberg, Michael J., Turker, Fulya, Timp, Winston, Ostermeier, Marc and Novina, Carl D. (2017) Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. Scientific Reports, 7 (1). ISSN 2045-2322

Xu, Chi, Govindarajan, Lakshmi Narasimha, Zhang, Yu, Stewart, James, Bichler, Zoë, Jesuthasan, Suresh, Claridge-Chang, Adam, Mathuru, Ajay Sriram, Tang, Wenlong, Zhu, Peixin and Cheng, Li (2017) Lie-X: Depth Image Based Articulated Object Pose Estimation, Tracking, and Action Recognition on Lie Groups. International journal of computer vision, 123 (3). pp. 454-478.

Y

Yamada, Ken, Brousseau, Margaret, Honma, Wataru, Iimura, Akiko, Imase, Hidetomo, Iwaki, Yuki, Kawanami, Toshio, LaSala, Daniel, Liang, Guiqing, Mitani, Hironobu, Nonomura, Kazuhiko, Ohmori, Osamu, Pan, Meihui, Rigel, Dean, Umemura, Ichiro, Yasoshima, Kayo, Zhu, Guoming and Mogi, Muneto (2017) Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma. Journal of Medicinal Chemistry, 60 (20). pp. 8466-8481. ISSN 0022-26231520-4804

Yamada, Ken, Levell, Julian, Yoon, Taeyoung, Kohls, Darcy, Yowe, David, Rigel, Dean, Imase, Hidetomo, Yuan, Jun, Yasoshima, Kayo, DiPetrillo, Keith, Monovich, Lauren, Xu, Lingfei, Kato, Mitsunori, Jain, Monish, Zhu, Na, Idamakanti, Neeraja, Taslimi, Paul, Kawanami, Toshio, Argikar, Upendra, Kunjathoor, Vidya, Xie, Xiaoling, Yagi, Yukiko, Matsumoto, Yuki, Robinson, Zachary and Park, Hyi-Man (2017) Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. Journal of Medicinal Chemistry, 60 (16). pp. 7099-7107. ISSN 15204804

Yan, Si, Shaw, Duncan, Sandham, David, Healy, Mark, Reilly, John and Wang, Bing (2017) Interactions between β2-adrenoceptor Ligands and Membrane: Atomic-level Insights from Magic Angle Spinning NMR. Journal of Medicinal Chemistry, 60 (16). pp. 6867-6879. ISSN 0022-26231520-4804

Yang, Yang and Hardman, Clayton (2017) The Synthesis of Chiral Beta-Amino Acids and Beta-Lactams via Oxidative Cleavage of Chiral Dihydropyridones Derived from Vinylogous Mannich Reaction (VMR). Org. Biomol. Chem., 15 (40). pp. 8576-8593. ISSN 1477-05201477-0539

Yang, Zinger (2017) The Retromer Complex Member VPS35 regulates Iron Homeostasis through mediating Hepcidin-induced Ferroportin Degradation. Harvard University's Electronic Thesis and Dissertation .

Yilmaz, Yildiz, Williams, Gareth, Schiller, Hilmar, Faller, Thomas, Walles, Markus, Camenisch, Gian P., Umehara, Ken-Ichi, Krähenbühl, Stephan and Manevski, Nenad (2017) Metabolism of AFQ056 (Mavoglurant) by Rat Pulmonary CYP1A1. Xenobiotica, Online. ISSN 0049-8254

Yilmaz, Yildiz, Williams, Gareth, Schiller, Hilmar, Faller, Thomas, Walles, Markus, Camenisch, Gian P., Umehara, Ken-Ichi, Krähenbühl, Stephan and Manevski, Nenad (2017) Metabolism of AFQ056 (Mavoglurant) by Rat Pulmonary CYP1A1. Xenobiotica. ISSN 1366-5928

Z

Zhang, Qiao, O'Rourke, Jason, Corbel, Stephane, Moran, Rita, Romero, Angelica, Miraglia, Loren, Zhang, Jia, Durrant, Eric, Schmedt, Christian, Sampath, Srinath and Sampath, Srihari (2017) The microprotein Minion controls cell fusion and muscle formation. Nature Communications, 8. ISSN 20411723

Zhang, Xian, Goette, Marjo, Ibig-Rehm, Yvonne, Kamke, Marion, Schuffenhauer, Ansgar, Beisner, Daniel, Siebert, Daniela, Guerini, Danilo, Bonamy, Ghislain, Gabriel, Daniela and Bodendorf, Ursula (2017) Multiparametric analysis of a high-content ultra-high-throughput screen identifies inhibitors of the intramembrane protease SPPL2a. SLAS discovery. ISSN 2472-5560

Zhou, Enhua, Paolucci, Michael, Dryja, Ted, Manley, Ted, Rice, Dennis, Prasanna, Ganesh and Chen, Amy (2017) A compact whole-eye perfusion system to evaluate pharmacologic responses of outflow facility. Investigative Ophthalmology and Visual Science, 58 (7). pp. 2991-3003. ISSN 15525783