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Number of items: 378.

A

Abraham, Yann and Gerrits, Bertran and Rebhan, Michael and Ludwig, Marie-Gabrielle and Gubser Keller, Caroline (2017) Exploring Glucocorticoid Receptor Agonists Mechanism of Action Through Mass Cytometry and Radial Visualizations. Cytometry. Part B : clinical cytometry., 92 (1). pp. 42-56. ISSN 1552-4957; 1552-4949

Altmann, Eva and Erbel, Paulus and Renatus, Martin and Schaefer, Michael and Schlierf, Anita and Druet, Adelaide and Kieffer, Laurence and Sorge, Mickael and Pfister, Keith and Hassiepen, Ulrich and Ostermeier, Daniela and Martoglio, Bruno and Jefferson , Anne B. and Ruedisser, Simon (2017) Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5. Chimia., 71 (4). p. 241. ISSN 10.2533/chimia2017.241

Altmann, Eva and Schlierf, Anita and Schaefer, Michael and Renatus, Martin and Ruedisser, Simon and Erbel, Paulus and Ostermeier, Daniela and Druet, Adelaide and Kieffer, Laurence and Sorge, Mickael and Hassiepen, Ulrich and Jones, Matthew and Pfister, Keith and Jefferson, Ann and Martoglio, Bruno and Quancard, Jean (2017) Azaindoles as zinc-binding small molecule inhibitors of the JAMM protease CSN5. Angewandte Chemie, 56 (5). pp. 1294-1297. ISSN 1433-7851

Ambrose, Jessi and Mapa, Felipa and Ross, Nathan and Chen, Julie and Ye, Chaoyang and Bilican, Bilada (2017) Automated Scale-up and Maintenance of Stem Cell-Induced Neurons for Long-Term Culture and High-Throughput Screening. SLAS Technology.

Amsler, Philipp and Heudi, Olivier and Lanshoeft, Christian and Bettighofer, Anja and Eisfeld, Jochen and Moenius, Thomas and Probst, Claudia Monika and Etter, Coralie (2017) Production and application of high quality stable isotope labeled monoclonal antibody for mass spectrometry analysis. Journal of labelled compounds and radiopharmaceuticals. ISSN 03624803

Argikar, Upendra and Dumouchel, Jennifer and Dunne, Christine and Andrea, Bushee (2017) Ocular Non-P450 oxidative, hydrolytic and conjugative drug metabolizing enzymes. Drug metabolism reviews. pp. 1-23. ISSN 1097-9883

Argikar, Upendra and Dumouchel, Jennifer and Kramlinger, Valerie and Cirello, Amanda and Gunduz, Mithat and Dunne, Christine and Sohal, Bindi (2017) Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? Journal of Pharmaceutical Sciences, 106 (9). pp. 2276-2281. ISSN 15206017

Arias, HR and Jin, Xiaotao and Feuerbach, Dominik and Drenan, RM (2017) Nicotinic acetylcholine receptor selectivity and inhibitory activity on mouse medial habenula by coronaridine congeners. international journal of biochemistry and cell biology, 92. pp. 202-209.

Auberson, Yves (2017) Editorial - In vivo molecular imaging tools facilitates Drug Discovery. Drug Discovery Today: Technologies, 25. pp. 1-2.

Ayalasomayajula, Surya and Pan , Wei and Han , Yi and Yang, Fan and Langenickel, Thomas Heiko and Pal, Parasar and Yao Zong , Yuan and Sunkara, Gangadhar (2017) Assessment of Drug–Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (2). pp. 309-318. ISSN 21070180

B

Badal Tejedor, Maria and Nordgren, Niklas and Rutland, Mark and Schuleit, Michael and Millqvist-Fureby, Anna and Alderborn, Goran and Pazesh, Samaneh (2017) Determination of Interfacial Amorphicity in Functional Powders. Langmuir the ACS journal of surfaces and colloids., 33 (33). pp. 920-926. ISSN 1520-5827; 0743-7463

Badal Tejedor, Maria and Nordgren, Niklas and Schuleit, Michael and Millqvist-Fureby, Anna and Rutland, Mark (2017) AFM colloidal probe measurements implicate capillary condensation in punch-particle surface interactions during tableting. Langmuir the ACS journal of surfaces and colloids., 33. pp. 13180-13188. ISSN 1520-5827; 0743-7463

Baenziger, Markus and Durantie, Estelle and Mathes, Christian (2017) Development of an Industrial Process Based on the Groebke– Blackburn–Bienaymé Multicomponent Reaction: Efficient Preparation of 3-Aminoimidazo[1,2-a]pyrazines. Synthesis.

Baguia, Hajar (2017) Fluoride-free Hiyama cross-coupling in presence of surfactants and water. Report to be submitted to Université Libre de Bruxelles.

Beckmann, Nicolau (2017) Editorial: In vivo imaging in pharmacological research. Frontiers in Pharmacology, 7 (JAN). pp. 7-511. ISSN 16639812

Bernabei, Roberto and Mariotti, Luca and Brodes, Philippe and Roubenoff, Ronenn (2017) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people. Aging Clinical and Experimental Research, 29 (1). ISSN 17208319

Bialucha, Carl and Collins, Scott and Li, Xiao and Saxena, Parmita and Zhang, Xiamei and Duerr, Clemens and Shim, Yeonju and Mosher, Rebecca and Ostrom, Lance and Hu, Tiancen and Bilic, Sanela and Liric Rajlic, Ivana and Capka, Vladimir and Sharp, Fiona and Antonakos, Brandon and Wagner, Joel and Elliott, Ginell and Veloso, Artur and Piel, Jessica and Xu, Jian and Flaherty, Meghan and Mansfield, Keith and London, Anne and Kurz, Markus and Nguyen, Duc and Meyer, Matthew and Faris, Jason and Janatpour, Mary and Chan, Vivien and Yoder, Nicholas and Catcott, Kelly and McShea, Molly and Sun, Xiuxia and Gao, Hui and Williams, Juliet and Hofmann, Francesco and Engelman, Jeffrey and Ettenberg, Seth and Sellers, William and Lees, Emma (2017) Discovery and optimization of HKT288, a cadherin-6-targeting ADC for the treatment of ovarian and renal cancers. Cancer Discovery, 7 (9). pp. 1030-1045. ISSN 21598290

Bizec, Jean-Claude and Glogovac, Milica and Gromek, Kamila and Prause, Maarten and Winkler, Gian Christian and Milton, Mark and Newton, Ronald and Lovsin Barle, Ester (2017) Determination of Permitted Daily Exposure for Topical Ocular Drugs. Determination of Permitted Daily Exposure for Topical Ocular Drugs (00). pp. 1-9. ISSN 1083-7450

Blanz, Joachim and Dayer, Jerome and Delemonte, Thierry and Gertsch, Werner and Ramstein, Philippe and Williams, Gareth and Aichholz, Reiner and Trunzer, Markus and Pearson, David (2017) Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery. Journal of Mass Spectrometry, 52 (4). pp. 210-217. ISSN 1096-9888

Blasko, Andrei and Rao, Raj and Kuehl, Philip J. and Holmes, Thomas D. and Reed, Matthew D. and Xu, Fadi and Zhuang, Jianguo (2017) A Physicochemical Assessment of Acid-induced Post-inhalation Cough in Guinea Pigs Animal Model. American Journal of Advanced Drug Delivery, 5 (4). pp. 131-138. ISSN ISSN 2321-547X

Blasko, Andrei and Tam, Yat Kong and Haidar Ahmad, Imad A. (2017) Cleaning verification dilemma of manufacturing equipment: Can the analytical method validation fail due to the cleanliness of the stainless steel surfaces? Atlas of Science, Octobe.

Blatter, Markus and Krepl, Miroslav and Cléry, Antoine and Allain, Frédéric H.T. and Sponer, Jiri (2017) Structural study of the Fox-1 RRM protein hydration reveal a role for key water molecules in RRM-RNA recognition. Nucleic Acids Research. ISSN 0305-10481362-4962

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne (2017) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Toxicology in vitro, 40. pp. 55-65. ISSN 08872333

Brocklehurst, Cara and Koch, Guido and Makarov, Ilya S. and Karaghiosoff, Konstantin L. and Knochel, Paul (2017) Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane. Angewandte Chemie International Edition.

Brocklehurst, Cara and Rothe-Poellet, Stephanie and Koch, Guido and La Vecchia, Luigi (2017) In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines. Synlett. ISSN 14372096

Brown, Alan and Saravanan, Chandrassegar and Devine, Pj and Magnifico, Maria and Gao, Jiaping and Beaulieu, Valerie and Ma, Margaret and Yasoshima, Kayo and Barnes, David and Yamada, Ken (2017) Characterization of intra-articular dose administration in the stifle joint of rabbits for toxicity testing. International Journal of Toxicology, 36 (4). pp. 303-313. ISSN 1092874X

Bruin, Gerardus and Loesche, Christian and Nyirady, Judit and Sander, Oliver (2017) Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis. Journal of Clinical Pharmacology, 57 (7). pp. 876-885. ISSN 1552-4604

Burkhart, Christoph and Kucher, Klaus and Sloth, Birgitte and Huber, Roland (2017) 1st Newsletter for ESID level 3 project in APDS. 1st Newsletter for ESID level 3 project in APDS.

Burks, Heather and Abrams, Tinya and Baird, Jason and Fekete, Alexander and Hamann, Lawrence and Kim, Sunkyu and Kirby, Christina and Lambardo, Franco and Loo, Alice and Lubicka, Danuta and Macchi, Kaitlin and McDonnell, Donald P. and Mishina, Yuji and Norris, John and Nunez, Jill and Saran, Chitra and Sun, Yingchuan and Thomsen, Noel and Wang, Chunrong and Peukert, Stefan and Wang, Jianling (2017) Discovery of an acrylic acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERa+ Breast Cancer. Journal of Medicinal Chemistry.

C

Cahill, Katherine and Katz, Howard and Cui, Jing and Lai, Juying and Kazani, Shamsah and Crosby-Thompson, Allison and Garofalo, Denise and Castro, Mario and Jarjour, Nizar and DiMango, Emily and Erzurum, Serpil and Trevor, Jennifer and Shenoy, Kartik and Chinchilli, Vernon and Wechsler, Michael and Laidlaw, Tanya and Boyce, Joshua and Israel, Elliot (2017) KIT inhibition by imatinib in patients with severe refractory asthma. New England Journal of Medicine, 376 (20). pp. 1911-1920. ISSN 15334406

Caicedo, Juan and Cooper, Sam and Heigwer, Florian and Warchal, Scott and Qiu, Peng and Molnar, Csaba and Vasilevich, Aliaksei and Barry, Joseph and Singh, Harmanjit and Kraus, Oren and Wawer, Mathias and Paavolainen, Lassi and Herrmann, Markus and Rohban, Mohammad and Hung, Jane and Hennig, Holger and Concannon, John and Smith, Ian and Singh, Shantanu and Rees, Paul and Horvath, Peter and Linington, Roger and Carpenter, Anne (2017) Data-analysis strategies for image-based cell profiling. Nature Methods, 14 (9). pp. 849-863. ISSN 15487105

Chandra, Abhishek and Qin , Ling and Kneissel, Michaela and Kramer, Ina and Liu, Sherry and Young, Tiffany and Ma, Xiaoyuan (2017) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone and Mineral Research, 32 (2). pp. 360-372. ISSN 1523-4681

Chen, Chih-wei and Beyer, Christian and Liu, Jun and Maier, Christiane and Li, Chun and Trinh-Minh, Thuong and Xu, Xiaohan and Cole, Stuart and Hsieh, Mindy Hsieh and Ng, Nicholas and Althage, Alana and Meeusen, Shelly and Pan, Shifeng and Svensson, Eric and Seidel, Martin and Schett, Georg and Gergely, Peter and Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt Signaling. Annals of the Rheumatic Diseases (1-6). pp. 1-6.

Chen, Chih-wei and Beyer, Christian and Liu, Jun and Maier, Christiane and Li, Chun and Trinh-Minh, Thuong and Xu, Xiaohan and Cole, Stuart and Hsieh, Mindy Hsieh and Ng, Nicholas and Althage, Alana and Meeusen, Shelly and Pan, Shifeng and Svensson, Eric and Seidel, Martin and Schett, Georg and Gergely, Peter and Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling. Annals of the Rheumatic Diseases, 76 (4). pp. 773-778. ISSN 1468-2060

Chen, Huaibin and Marsiglia, William M and Cho, Min-Kyu and Huang, Zhifeng and Deng, Jingjing and Blais, Steven P and Gai, Weiming and Bhattacharya, Shibani and Neubert, Thomas A and Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Huaibin and Marsiglia, William M and Cho, Min-Kyu and Huang, Zhifeng and Deng, Jingjing and Blais, Steven P and Gai, Weiming and Bhattacharya, Shibani and Neubert, Thomas A and Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Jin and Meyers, Charles and Keefe, Debbi and Yu, Jing and Sunkara, Gangadhar (2017) Clinical Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase 1 Inhibitor. Journal of Drug Design and Research.

Chen, Xin and Giraldes, John and Sprague, Elizabeth and Shakya, Subarna and Chen, Zhuoliang and Wang, Kate and Joud-Caldwell, Carol and Mathieu, Simon and Chen, Christine and Straub, Christopher and Duca, Jose and Hurov, Kristen and Yuan, Yanqiu and Shao, Wenlin and Toure, Bakary-Barry (2017) “Addition” and “Subtraction”: Selectivity Design for Type-II Maternal Embryonic Leucine Zipper Kinase Inhibitors. Journal of Medicinal Chemistry, 60. pp. 2155-2161.

Chen, Zhao (2017) Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib. European Journal of Radiology, 88. pp. 15-20. ISSN 18727727

Cheung, Sheldon T. and Miller, Michelle S. and Pacoma, Reynand and Roland, Jason and Schumacher, Andrew and Liu, Jian and Hsieh-Wilson, Linda C. (2017) Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chemical Biology, 12 (12). pp. 3126-3133. ISSN 15548937

Chiang, Derek and Villanueva, Augusto (2017) Progress towards molecular patient stratification of hepatocellular carcinoma: Lost in translation? Journal of Hepatology, 67 (5). pp. 893-895. ISSN 16000641

Cho, Young and Liu, Gang and Caferro, Thomas and Shafer, Cynthia and Manning, James and Sendzik, Martin and Shultz, Michael and Chenail, Gregg and Dooley, Julie and Farsidjani, Alireza and Chen, Jinyun and Kulathila, Raviraj and Xie, Xiaoling and Dodd, Stephanie and Gould, Ty and Liang, Guiqing and Heimbach, Tycho and Slocum, Kelly and Pu, Minying and Pagliarini, Raymond and Growney, Joseph (2017) Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Medicinal Chemistry Letters, 8 (10). pp. 1116-1121. ISSN 19485875

Clarke, Adrian and Kotoni, Dorina and Dispas, Amandine and Guillarme, Davy and Hubert, Philippe and Desfontaine, Vincent and Lebrun, Pierre (2017) Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 134. pp. 170-180.

Clottu, A and Mathias, A and Sailer, Andreas and Schluep, M and Seebach, J and Du Pasquier, R and Pot, Caroline (2017) EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. Cell Reports, 18 (1). pp. 213-224.

Cowell, Annie and LaMonte, Greeg and Abraham, Matthew and Flannery, Erika and William, Roy and Sasaki, Erica and Corey, Victoria and Lukens, Amanda and Istvan, Eva and Lee, Marcus and Franco, Virginia and Reimer, Christin and Magistrado, Pamela and Coburn-Flynn, Olivia and Sakata-Kato, Tomoyo and Bopp, Selina and Gupta, Purva and Fuchs, Olivia and Kim, Sang and Teng, Christine and Gnadig, Nina and Vanaerschot, Manu and Murithi, James and Linares, Maria and Cozar, Cristina and Gomez-Lorenzo, Maria and Prats, Sara and Arriaga, Ignacio and Wang, Lawrence and Ottilie, Sabine and Siegel, Dionicio and Tanaseichuk, Olga and Zhong, Yang and Zhou, Yingyao and Willis, Paul and Gamo, Francisco-Javier and Goldberg, Daniel and Fidock, David and Wirth, Dyann and Winzeler, Elizabeth (2017) Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics. Science.

Cox, Georgina and Sieron, Arthur and King, Andrew and De Pascale, Gianfranco and Pawlowski, Andrew and Koteva, Kalinka and Wright, Gerard (2017) A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. Cell chemical biology, 24. pp. 98-109. ISSN 2451-9456

Cramer, Christopher J and Johnson, Joshua and Kamel, Amin (2017) Prediction of Mass Spectral Response Factors from Predicted Chemometric Data for Druglike Molecules. Journal of the American Society for Mass Spectrometry, 28 (2). pp. 278-285. ISSN 1879-1123

Cruz, Leilani and Heidt, Analeah and Rowell, Emily (2017) Postdoc fellowship application for the Damon Runyon Cancer Research Fellowship entitled "Identifying novel pathways responsible for epigenetic modifications in aged regulatory T cells in the tumor microenvironment". Damon Runyon Cancer Research Fellowship.

Cruz, Leilani and Rowell, Emily and Heidt, Analeah (2017) Identification and targeting of novel pathways modifying the epigenome of aged regulatory T cells in the tumor microenvironment. Damon Runyon Cancer Research Fellowship.

Cunha, Andre and Zhang, Qin and Prentiss, Melissa and Wu, Xiaoqiu and Kainz, Vanessa and Xu, Yongyao and Vrouvlianis, Joanna and Li, Hui and Rangaswamy, Nalini and Leehy, Barrett and Mcgee, Terri and Bell, Christie and Bigelow, Chad and Kansara, Viralbhai and Huang, Qian and Wu, Henry (2017) The hierarchy of pro-inflammatory cytokines in ocular inflammation. Current eye research. pp. 1-13. ISSN 1460-2202

D

Dafflon, Caroline and Craig, Vanessa and Mereau, Helene and Gräsel, Julius and Schacher Engstler, Barbara and Hoffman, Gregory and Nigsch, Florian and Gaulis, Swann and Barys, Louise and Ito, Moriko and Aguadé Gorgorio, Julia and Bornhauser, Beat and Bourquin, Jean-Pierre and Proske, Amelie and Stork-Fux, Caroline and Murakami, Masato and Sellers, William and Hofmann, Francesco and Schwaller, Jürg and Tiedt, Ralph (2017) Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. Leukemia. ISSN 14765551

Dafflon, Caroline and Tiedt, Ralph and Schwaller, Jürg (2017) Targeting multiple nodes of MLL complexes to improve leukemia therapy. Oncotarget, 8 (53). pp. 90614-90615. ISSN 19492553

Dai, Chenkai and Lehar, Mohamed and Sun, Daniel and Swarthout, Lani and Carey, John and Maclachlan, Timothy and Brough, Doug and Staecker, Hinrich and Della Santina, Alexandra and Hullar, Timothy and Della Santina, Charles (2017) Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery. JARO - Journal of the Association for Research in Otolaryngology, 18 (4). pp. 601-617. ISSN 1438-7573

Dalvit, Claudio and Piotto, Martial and Vulpetti, Anna (2017) Fluorine NMR spectroscopy and computational calculations for assessing intramolecular hydrogen bond involving fluorine and for characterizing the dynamic of a fluorinated molecule. Journal of fluorine chemistry, 202. pp. 34-40. ISSN 00221139

Das, Suman and Morvan, Frederic and Jourde, Benjamin and Minetti, Giulia and Brebbia, Pascale and Toussaint, Gauthier and Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase regulates myofiber differentiation by altering histone acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 22111247

Das, Suman and Morvan, Frederic and Morozzi, Giulio and Jourde, Benjamin and Minetti, Giulia and Kahle, Peter and Rivet, Helene and Brebbia, Pascale and Toussaint, Gauthier and Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 2211-1247

Daugvilaite, Viktorija and Madsen, Christian Medom and Lückmann, Michael and Echeverria, Clara Castello and Sailer, Andreas and Frimurer, Thomas Michael and Rosenkilde, Mette Marie and Benned-Jensen, Tau (2017) Biased signaling and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus -induced gene 2. British journal of pharmacology. ISSN 1476-5381; 0007-1188

Davis, John and Kagan, Mark and Read, Jessica and Walles, Markus and Hatsis, Panagiotis (2017) Immunoprecipitation LC-MS Middle-up Approach for In Vivo Drug-To-Antibody Ratio Determination for Antibody Drug Conjugates. Bioanalysis.

Decker, Rebekah (2017) Articular cartilage and joint development from embryogenesis to adulthood. Seminars in cell & developmental biology, 62. pp. 50-56. ISSN 1096-3634

Decker, Rebekah and Um, Hyo-Bin and Dyment, Nathaniel A. and Cottingham, Naiga and Usami, Yu and Enomoto-Iwamoto, Motomi and Kronenberg, Mark S. and Maye, Peter and Rowe, David W. and Koyama, Eiki and Pacifici, Maurizio (2017) Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Developmental biology, 426 (1). pp. 56-68. ISSN 00121606

Defontis, Myriam and Cote, Serge and Ledieu, David (2017) A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety. Experimental and Toxicologic Pathology. ISSN 1618-1433

Del Signore, Susanna and Roubenoff, Ronenn (2017) Physical frailty and sarcopenia (PF&S): a point of view from the industry. Aging Clinical and Experimental Research, Epub a. pp. 1-6. ISSN 17208319

Dex, Sarah and Alberton, Paolo and Willkomm, Lena and Soellradl, Thomas and Bago, Sandra and Milz, Stefan and Shakibaei, Mehdi and Ignatius, Anita and Bloch, Wilhelm and Clausen-Schaumann, Hauke and Shukunami, China and Schieker, Matthias and Docheva, Denitsa (2017) Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load. EBioMedicine, 20. pp. 240-254. ISSN 2352-3964

Dickson, Callum and Hornak, Viktor and Pearlstein, Robert and Duca, Jose (2017) Structure-kinetic relationships of passive membrane permeation from multiscale modeling. Journal of the American Chemical Society JACS., 139 (1). pp. 442-452.

Dickson, Callum and Pearlstein, Robert and Hornak, Viktor (2017) Contributions of the membrane dipole potential to the function of voltage-gated cation channels and modulation by small molecule potentiators. Biochimica et biophysica acta (BBA) - Biomembranes, 1859 (2). pp. 177-194. ISSN 00052736

Dumouchel, Jennifer and Argikar, Upendra and Spear, Jaimie and Brown, Ann and Dunne, Christine and Kramlinger, Valerie and Cirello, Amanda and Gunduz, Mithat (2017) An in vitro Investigation of Ocular Bioactivation Potential and the Role of CytochromeP450 2D Enzymes in Rat. Drug metabolism letters.. ISSN 1874-0758

Dégardin, Klara and Desponds, Anne and Roggo, Yves (2017) Protein-based medicines analysis by Raman spectroscopy for the detection of counterfeits. Forensic Science International, 278. pp. 313-325. ISSN 03790738

Dégardin, Klara and Roggo, Yves (2017) Innovative Strategy for Counterfeit Analysis. Medicine Access @ Point of Care, 1 (1). maapoc.0000013. ISSN 2399-2026

de Moura França, Leandro and Amigo, José Manuel and Cairós, Carlos and Bautista Mercader, Manuel and Fernanda Pimentel, Maria (2017) Evaluation and assessment of homogeneity in images. Part 1: Unique homogeneity percentage for binary images. Chemometrics and Intelligent Laboratory Systems, 171. pp. 26-39. ISSN 0169-7439

E

Ebata, Kevin T. and Mesh, Kathryn and Liu, Shichong and Bilenky, Misha and Fekete, Alexander and Acker, Michael and Hirst, Martin and Garcia, Benjamin A and Ramalho-Santos, Miguel (2017) Vitamin C Induces Specific Demethylation of H3K9me2 in Mouse Embryonic Stem Cells via Kdm3a/b. Epigenetics & chromatin, 10. p. 36. ISSN 1756-8935

Ebhardt, H. Alexander and Degen, Simone and Tadini, Valentina and Schilb, Alain and Greig, Carolyn A. and Fearon, Kenneth CH and Aebersold, Ruedi and Jacobi, Carsten (2017) Comprehensive proteome analysis of muscle composition and development in seniors. EMBO Molecular Medicine.

Eder, Joerg (2017) Opportunities and challenges in phenotypic drug discovery: An industry perspective. Nature Reviews Drug Discovery, 16 (8). pp. 531-543. ISSN 14741784

Edge, Stephen and Singh, Dilraj and Lewis, David and Rouse, Tim (2017) Defining the “Dose” for Dry Powder Inhalers: The challenge of correlating in-vitro dose delivery results with clinical efficacy. American pharmaceutical review, 20 (3). pp. 54-62.

Egger, Christine and Cannet, Catherine and Gerard Sachot, Christelle and Pierrat, Benoit and Suply, Thomas and Ksiazek, Iwona and Beckmann, Nicolau (2017) Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. European Journal of Pharmacology, 809. pp. 64-72. ISSN 18790712

Einolf, Heidi and Lin, Wen and Wang, Lai and Gu, Helen and Chun, Dung Y. and Mangold, James B. and He, Handan (2017) Physiologically-based pharmacokinetic model predictions of panobinostat (LBH589) as a victim and perpetrator of drug-drug interactions. Drug Metabolism and Disposition.

Einolf, Heidi and Zhou, Jocelyn and Won, Christina and Wang, Lai and Rebello, Sam (2017) A physiologically-based pharmacokinetic modeling approach to predict drug-drug interactions of sonidegib (LDE225) with perpetrators of CYP3A in cancer patients. Drug metabolism and disposition, 45 (4). pp. 361-374. ISSN 1521-009X

Emery, Caroline and Monaco, Kelli-Ann and Wang, Ping and Balak, Marissa and Freeman, Alyson and Meltzer, Jodi and Delach, Scott and Rakiec, Daniel and Ruddy, David and Korn, Joshua and Haling, Jake and Acker, Michael and Caponigro, Giordano (2017) BRAF-inhibitor associated MEK mutations increase RAF-dependent and -independent enzymatic activity. Molecular Cancer Research, 15 (10). pp. 1431-1444. ISSN 1557-3125

Ertl, Peter and Lewis, Richard and Martin, Eric and Polyakov, Valery (2017) In silico generation of novel, drug-like chemical matter using the LSTM neural network. arXiv / talk at CCG User Group Meeting.

Estoppey, David and Hewett, Jeffrey and Guy, Chantale and Harrington, Edmund and Thomas, Jason and Schirle, Markus and Cuttat-Theurillat, Rachel and Waldt, Annick and Gerrits, Bertran and Yang, Zinger and Schuierer, Sven and Carbone, Walter and Knehr, Judith and Lindeman, Alicia and Russ, Carsten and Frias, Elizabeth and Hoffman, Gregory and Varadarajan, Malini and Ramadan, Nadire and Reece-Hoyes, John and Wang, Qiong and Chen, Xin and Mcallister, Gregory and Roma, Guglielmo and Bouwmeester, Antonius and Hoepfner, Dominic (2017) Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Scientific reports, 7 (42728). pp. 1-6. ISSN 2045-2322

Estoppey, David and Lee, Chia Min and Janoschke, Marco and Mathys, Philippe and Filipuzzi, Ireos and Schuhmann, Tim and Riedl, Ralph and Aust, Thomas and Galuba, Olaf and Mcallister, Gregory and Russ, Carsten and Spiess, Martin and Bouwmeester, Antonius and Bonamy, Ghislain and Hoepfner, Dominic (2017) The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase. Cell Reports, 19 (3). pp. 451-460. ISSN 22111247

F

Fairfield, Heather and Falank, Carolyne and Harris, Elizabeth and Demambro, Victoria and McDonald, Michelle and Pettitt, Jessica A. and Mohanty, Sindhu T. and Croucher, Peter and Kramer, Ina and Kneissel, Michaela and Rosen, Clifford J. and Reagan, Michaela R. (2017) The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. Journal of cellular physiology.

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Giggins, Oonagh and Clay, Ieuan and Walsh, Lorcan (2017) Physical Activity Monitoring in Patients with Neurological Disorders: A Review of the Validity and Reliability of Body Worn Monitors. Digital Biomarkers.

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Glorieux, Francis and Devogalaer, Jean-Pierre and Durigova, Michaela and Goemaere, Stefan and Hemsley, Sarah and Junker, Uwe and Ruckle, Jon and Seefried, Lothar and Winkle, Peter (2017) BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial. Journal of Bone and Mineral Research, 32 (7). pp. 1496-1504. ISSN 15234681

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Guendisch, Ulf and Weiss, Jessica and Ecoeur, Florence and Riker, Julia and Kaupmann, Klemens and Kallen, Joerg and Hintermann, Samuel and Orain, David and Dawson King, Janet and Billich, Andreas and Guntermann, Christine (2017) Pharmacological inhibition of ROR gamma t suppresses the Th17 pathway and alleviates antigen-induced arthritis in-vivo. PLoS ONE, 12 (PLoS O). pp. 1-25. ISSN 1932-6203

Guntermann, Christine and Piaia, Alessandro and Hamel, Marie-Laure and Theil, Diethilde and Rubic-Schneider, Tina and Del Rio Espinola, Alberto and Dong, Linda and Billich, Andreas and Kaupmann, Klemens and Dawson King, Janet and Hoegenauer, Klemens and Orain, David and Hintermann, Samuel and Stringer, Rowan and Patel, Dhavalkumar and Doelemeyer, Arno and Deurinck, Mark and Schuemann, Jens (2017) Retinoic-acid-orphan-receptor C inhibition suppresses Th17 cells and induces thymic aberrations. The Journal of Clinical Investigation Insight (JCI Insight).

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Han, Yi and Ayalasomayajula, Surya and Yang, Fan and Yuan, Yaozong and Langenickel, Thomas Heiko and Hinder, Markus and Kalluri, Sampath and Pal, Parasar and Sunkara, Gangadhar (2017) Pharmacokinetics, Safety and Tolerability of Sacubitril/Valsartan (LCZ696) After Single-Dose Administration in Healthy Chinese Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (1). pp. 109-116. ISSN 2107-0180

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Hatsis, Panagiotis and Waters, Nigel and Argikar, Upendra (2017) Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards. Drug Metabolism and Disposition.

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Helliwell, Stephen and Filipuzzi, Ireos and Steffen, Janos and Koehler, Carla (2017) Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Nature Chemical Biology. ISSN 1552-44501552-4469

Hoegenauer, Klemens and Soldermann, Nicolas and Zecri, Frederic and Strang, Ross and Graveleau, Nadege and Wolf, Romain and Cooke, Nigel Graham and Smith, Alexander Baxter and Hollingworth, Greg and Blanz, Joachim and Gutmann, Sascha and Rummel, Gabriele and Littlewood-Evans, Amanda and Burkhart, Christoph (2017) Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Medicinal Chemistry Letters, 8 (9). pp. 975-980. ISSN 19485875

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Holzer, Philipp (2017) Discovery of potent and selective p53-MDM2 protein-protein interaction inhibitors as anticancer drugs. Chimia : international journal for chemistry, 71 (10). pp. 716-721. ISSN 0009-4293

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Jelsch, Morgane and Grandeury, Arnaud (2017) Crystal Morphology Prediction of active pharmaceutical ingredients. Internship - report for school.

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Lovelle, Lucie and Gallou, Fabrice and Jordine, Guido and Mirabilis consortium, over 30 companies (2017) A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies. Regulatory Toxicology and Pharmacology, 90. pp. 22-28. ISSN 10960295

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Lyons, Russ (2017) Community Exploration & Learning Lab Overview. NIBR Internet.

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Marzinzik, Andreas and Koch, Guido and Spanka, Carsten and Lehmann, Hansjoerg and Hwang, Ye-Jin and Coley, Connor and Abolhasani, Milad and Jensen, Klavs (2017) Segmented Flow Platform for On-​Demand Medicinal Chemistry and Compound Synthesis in Oscillating Droplets. Chem. Commun.. ISSN 1359-73451364-548X

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Milicevic Sephton, Selena and Vetterli, Peter and Pedani, Valentina and Cermak, Stjepko and Chiotellis, Aristeidis and Schibli, Roger and Auberson, Yves and Ametamey, Simon (2017) Synthesis and Biological Evaluation of Quinoxaline Derivatives for PET Imaging of the NMDA Receptor. Helvetica Chimica Acta, 100 (12). ISSN 15222675

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Moggs, Jonathan (2017) IMI MARCAR external communication materials - interview and factsheet. IMI web based dissemination.

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Plawinski, Jason and Reinker, Stefan and Kirkpatrick, Nathaniel and Oakeley, Edward James (2017) Summer internship at Novartis. Report to University of Strasbourg, France.

Pognan, Francois and Marc, Philippe (2017) Legacy data sharing to improve drug safety assessment: The eTOX project. Nature Reviews Drug Discovery, 16 (12). pp. 811-812. ISSN 14741784

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Rauch, Judith and Kallen, Joerg (2017) Hintergrundtext Medizinforschung am PSI. new magazine of the Paul Scherrer Institute PSI.

Ravagli, Carlo and Pognan, Francois and Marc, Philippe (2017) OntoBrowser: a tool for curating ontologies and code lists by subject matter experts. Bioinformatics, 33 (1). pp. 148-149. ISSN 1367-48031460-2059

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Reilly, John and Aliagas, Ignacio and Berger, Raphaelle and Goldberg, Kristin and Nishimura, Rachel and Richardson, Paul and Richter, Daniel and Sherer, Edward and Sparling, Brian and Marian, Bryan (2017) Sustainable Practices in Medicinal Chemistry Part 2: Green by Design. Journal of Medicinal Chemistry, 60 (14). pp. 5955-5968. ISSN 15204804

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Riss, Bernard (2017) TMS-ent-Bisabolangelone. Tetrahedron, 73 (23). pp. 3202-3212. ISSN 00404020

Robbins, Ken (2017) Sparse set of AWS tips for an enterprise cloud transformation. Ken Robbins' LinkedIn blog.

Roggo, Yves (2017) Forensic investigation in the pharmaceutical industry: Identification procedure of visible particles in (drug) solutions and different containers by combining vibrational and X-ray spectroscopic techniques. Journal of pharmaceutical and biomedical analysis. ISSN 1873-264X; 0731-7085

Roggo, Yves (2017) Global regression model for moisture content determination using near-infrared spectroscopy. European journal of pharmaceutics and biopharmaceutics. ISSN 1873-3441; 0939-6411

Rooks, Daniel and Praestgaard, Jens and Hariry, Sam and Laurent, Didier and Petricoul, Olivier and Perry, Robert G. and Trifilieff, Estelle and Roubenoff, Ronenn (2017) Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. Journal of the American Geriatrics Society, 65 (9). pp. 1988-1995. ISSN 15325415

Rubic-Schneider, Tina and Kuwana, Masataka and Christen, Brigitte and Aßenmacher, Manuela and Hainzl, O. and Zimmermann, F. and Fischer, Robert and Koppenburg, Vera and Chibout, Salah-Dine and Wright, Timothy M. and Seidl, Andreas and Kammueller, Michael (2017) T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia. Blood Advances, 1 (6). pp. 367-379. ISSN 2473-9537

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Sandham, David and Barker, Lucy and Brown, Lyndon and Brown, Zarin and Budd, David and Charlton, Steven and Chatterjee, Devnandan and Cox, Brian and Dubois, Gerald and Duggan, Nicholas and Hall, Edward and Hatto, Julia and Maas, David and Manini, Jodie and Profit, Rachael and Riddy, Darren and Ritchie, Cathy and Sohal, Bindi and Shaw, Duncan and Stringer, Rowan and Sykes, David and Turner, Katharine and Watson, Simon and West, Ryan and Willard, Elizabeth and Williams, Gareth and Willis, Jennifer (2017) Discovery of Fevipiprant (NVP-QAW039), a potent and selective CRTh2 receptor antagonist for treatment of allergic diseases. ACS Medicinal Chemistry Letters.

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Schlesinger, Ann and Hunt, Ian (2017) Video of 2016 Novartis Open Framework Symposium. this link was shared with externals but not published.

Schuierer, Sven and Carbone, Walter and Petitjean, Virginie and Fernandez, Anita and Sultan, Marc and Roma, Guglielmo (2017) A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples. BMC Genomics, 18 (1). ISSN 14712164

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Silver-Brown, Serena and Hoffman, Ann and Horvath, Peter and Lovitt, Carrie and Easton, Evan and LaBarbera, Daniel and Mendez, Melissa and Rothernberg, Mark and Seldin, Jan and Fennell, Myles (2017) SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium. Assay and drug development technologies, 15 (1). pp. 1-7.

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Skilitsi, Anastasia Ioanna and Turko, Timothé and Cianfarani, Damien and Barre, Sophie and Uhring, Wilfried and Hassiepen, Ulrich and Léonard, Jérémie (2017) Towards Sensitive, High-Throughput, Biomolecular Assays Based on Fluorescence Lifetime. Methods and applications in fluorescence /. ISSN 2050-6120

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Skolnik, Suzanne and Geraci, Gina and Dodd, Stephanie (2017) Automated Supersaturation Stability Assay to Differentiate Poorly Soluble Compounds in Drug Discovery. Journal of Pharmaceutical Sciences. ISSN 1520-6017

Skora, Lukasz and Jahnke, Wolfgang (2017) 19F-NMR-based dual-site reporter assay for the discovery and distinction of catalytic and allosteric kinase inhibitors. ACS medicinal chemistry letters, 8. pp. 632-635.

Skora, Lukasz and Jahnke, Wolfgang and Sijbesma, Eline and Leysen, Seppe and Brunsveld, Luc and Wolf, Alexander and Nussbaumer, Peter and Ottmann, Christian (2017) Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56 (30). pp. 3972-3982. ISSN 15204995

Smith, Aaron and Ni, ZJ and Poon, Daniel and Huang, Zilin and Chen, Zheng and Zhang, Qiong and Tandeske, Laura and Merritt, Hanne and Shoemaker, Kevin and Chang, John and Kaufman, Sue and Huh, Kay and Murray, Jeremy and Appleton, Brent A. and Jacob, Sandra and Scheufler, Clemens and Kanazawa, Takanori and Jansen, Hanneke and Stuart, Darrin and Shafer, Cynthia (2017) Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405

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Snowdon, Victoria K. and Lachlan, Neil J. and Hadoke, Patrick W.F. and Hoy, Anna M. and Semple, Scott and Patel, Dilip and Mungall, Will and Kendall, Timothy J. and Thomson, Adrian and Lennen, Ross J. and Jansen, Mauritis A. and Moran, Carmel M. and Pellicoro, Antonella and Ramachandran, Prakash and Shaw, Isaac and Aucott, Rebecca L. and Severin, Thomas and Saini, Rajnish and Pak, Judy and Yates, Denise and Dongre, Neelesh and Duffield, Jeremy S. and Webb, David J. and Iredale, John P. and Hayes, Peter C. and Fallowfield, Jonathan A. (2017) Serelaxin for the Treatment of Renal Dysfunction in Cirrhosis: Preclinical Evaluation and Results of a Randomized Phase 2 Trial. PLoS medicine. ISSN 1549-1676; 1549-1277

Solt, Andras and Bostock, Mark J. and Shrestha, Binesh and Kumar, Prashant and Warne, Tony and Tate, Christopher G and Nietlispach, Daniel (2017) Insight into partial agonism by observing ligand-modulated conformational equilibria of a Gs-mimetic nanobody-bound B1-adrenergic receptor. Nature communications, 8. p. 1795. ISSN 2041-1723

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Sorde, Laetitia and Spindeldreher, Sebastian and Karle, Anette (2017) Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg? European journal of immunology. ISSN 2050-4527

Srinivas, Honnappa and Wilcken, Rainer (2017) Manuscript: SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency. Note: Details of NIBR contribution to manuscript: The results of Mutational analysis of SGPL1: In silico modelling ( were approved in OAK before-ref link https://oak-intra.novartis.com/25460/). Mutational analysis of SGPL1: In silico modelling results were shared with Prof. Friedhelm Hildebrandt, Harvard medical school, Division of Nephrology Boston Children's Hospital. These results, that were shared with Prof. Friedhelm Hildebrandt is now a part of full manuscript for publication with Prof. Friedhelm Hildebrandt as corresponding author . Honnappa Srinivas and Rainer Wilcken are the co-authors from NIBR. Please find attached the full manuscript. The Journal of clinical investigation : JCI, 127. pp. 912-928. ISSN 1558-8238

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Sullivan, Ryan (2017) CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. Journal of Clinical Investigation, 127 (11). pp. 4042-4058. ISSN 0021-9738

Summermatter, Serge and Bouzan, Anais and Pierrel, Eliane and Melly, Stefan and Gutzwiller, Sabine and Fryer, Christy and Nolin, Erin and Dornelas, Christina and Leighton-Davies, Juliet and Palmer , Amy and Qin, Yan and Glass, David and Fournier, Brigitte (2017) Blockade of metallothioneins 1 and 2 increases skeletal muscle mass and strength. Molecular and cellular biology, 37 (5). e000305-e000316. ISSN 1098-5549; 0270-7306

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Swaller, Tim (2017) GNF recipient of the 2017 IEA Earth Month Award. GNF Website Recent Updates section.

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Wang, Xinting and Koehne-Voss, Stephan and Anumolu, Sree and Yu, Jing (2017) Population Pharmacokinetics of Tobramycin Inhalation Solution in Pediatric Patients With Cystic Fibrosis. Journal of Pharmaceutical Sciences, 106 (11). pp. 3402-3409. ISSN 1520-6017

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Wong, Harvey and Bohnert, Tonika and Damian-Iordache, Valeriu and Gibson, Christopher and Hsu, Cheng-Pang and Krishnatry, Anu Shilpa and Liederer, Bianca M and Lin, Jing and Lu, Qiang and Mettetal, Jerome T and Mudra, Daniel R and Nijsen, Marjoleen JMA and Schroeder, Patricia and Schuck, Edgar and Suryawanshi, Satyendra and Trapa, Patrick and Tsai, Alice and Wang, Haiqing and Wu, Fan (2017) Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: An IQ Consortium PK-PD Discussion Group perspective. Drug Discovery Today. ISSN 18785832

Wozniak-Knopp, Gordana and Stadlmayr, Gerhard and Perthold, Jan Walther and Stadlbauer, Katharina and Woisetschläger, Maximilian and Sun, Haijun and Rüker, Florian (2017) Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments. Protein engineering, design & selection : PEDS, 30 (9). pp. 657-671. ISSN 1741-0134

Wright, Kirk (2017) Biophysics: for HTS hit validation, chemical lead optimization and beyond. Expert opinion on drug discovery, 12 (9). pp. 1-11. ISSN 1746-045X

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Xiong, Tina and Meister, Glenna E. and Workman, Rachael E. and Kato, Nathaniel C. and Spellberg, Michael J. and Turker, Fulya and Timp, Winston and Ostermeier, Marc and Novina, Carl D. (2017) Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. Scientific Reports, 7 (1). ISSN 2045-2322

Xu, Chi and Govindarajan, Lakshmi Narasimha and Zhang, Yu and Stewart, James and Bichler, Zoë and Jesuthasan, Suresh and Claridge-Chang, Adam and Mathuru, Ajay Sriram and Tang, Wenlong and Zhu, Peixin and Cheng, Li (2017) Lie-X: Depth Image Based Articulated Object Pose Estimation, Tracking, and Action Recognition on Lie Groups. International journal of computer vision, 123 (3). pp. 454-478.

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This list was generated on Mon Dec 9 05:41:59 2019 UTC.

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