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Number of items: 385.


Abraham, Yann and Gerrits, Bertran and Rebhan, Michael and Ludwig, Marie-Gabrielle and Gubser Keller, Caroline (2017) Exploring Glucocorticoid Receptor Agonists Mechanism of Action Through Mass Cytometry and Radial Visualizations. Cytometry. Part B : clinical cytometry., 92 (1). pp. 42-56. ISSN 1552-4957; 1552-4949

Altmann, Eva and Erbel, Paulus and Renatus, Martin and Schaefer, Michael and Schlierf, Anita and Druet, Adelaide and Kieffer, Laurence and Sorge, Mickael and Pfister, Keith and Hassiepen, Ulrich and Ostermeier, Daniela and Martoglio, Bruno and Jefferson , Anne B. and Ruedisser, Simon (2017) Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5. Chimia., 71 (4). p. 241. ISSN 10.2533/chimia2017.241

Altmann, Eva and Schlierf, Anita and Schaefer, Michael and Renatus, Martin and Ruedisser, Simon and Erbel, Paulus and Ostermeier, Daniela and Druet, Adelaide and Kieffer, Laurence and Sorge, Mickael and Hassiepen, Ulrich and Jones, Matthew and Pfister, Keith and Jefferson, Ann and Martoglio, Bruno and Quancard, Jean (2017) Azaindoles as zinc-binding small molecule inhibitors of the JAMM protease CSN5. Angewandte Chemie, 56 (5). pp. 1294-1297. ISSN 1433-7851

Ambrose, Jessi and Mapa, Felipa and Ross, Nathan and Chen, Julie and Ye, Chaoyang and Bilican, Bilada (2017) Automated Scale-up and Maintenance of Stem Cell-Induced Neurons for Long-Term Culture and High-Throughput Screening. SLAS Technology.

Amsler, Philipp and Heudi, Olivier and Lanshoeft, Christian and Bettighofer, Anja and Eisfeld, Jochen and Moenius, Thomas and Probst, Claudia Monika and Etter, Coralie (2017) Production and application of high quality stable isotope labeled monoclonal antibody for mass spectrometry analysis. Journal of labelled compounds and radiopharmaceuticals. ISSN 03624803

Argikar, Upendra and Dumouchel, Jennifer and Dunne, Christine and Andrea, Bushee (2017) Ocular Non-P450 oxidative, hydrolytic and conjugative drug metabolizing enzymes. Drug metabolism reviews. pp. 1-23. ISSN 1097-9883

Argikar, Upendra and Dumouchel, Jennifer and Kramlinger, Valerie and Cirello, Amanda and Gunduz, Mithat and Dunne, Christine and Sohal, Bindi (2017) Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? Journal of Pharmaceutical Sciences, 106 (9). pp. 2276-2281. ISSN 15206017

Arias, HR and Jin, Xiaotao and Feuerbach, Dominik and Drenan, RM (2017) Nicotinic acetylcholine receptor selectivity and inhibitory activity on mouse medial habenula by coronaridine congeners. international journal of biochemistry and cell biology, 92. pp. 202-209.

Auberson, Yves (2017) Editorial - In vivo molecular imaging tools facilitates Drug Discovery. Drug Discovery Today: Technologies, 25. pp. 1-2.

Ayalasomayajula, Surya and Pan , Wei and Han , Yi and Yang, Fan and Langenickel, Thomas Heiko and Pal, Parasar and Yao Zong , Yuan and Sunkara, Gangadhar (2017) Assessment of Drug–Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (2). pp. 309-318. ISSN 21070180


Badal Tejedor, Maria and Nordgren, Niklas and Rutland, Mark and Schuleit, Michael and Millqvist-Fureby, Anna and Alderborn, Goran and Pazesh, Samaneh (2017) Determination of Interfacial Amorphicity in Functional Powders. Langmuir the ACS journal of surfaces and colloids., 33 (33). pp. 920-926. ISSN 1520-5827; 0743-7463

Badal Tejedor, Maria and Nordgren, Niklas and Schuleit, Michael and Millqvist-Fureby, Anna and Rutland, Mark (2017) AFM colloidal probe measurements implicate capillary condensation in punch-particle surface interactions during tableting. Langmuir the ACS journal of surfaces and colloids., 33. pp. 13180-13188. ISSN 1520-5827; 0743-7463

Baenziger, Markus and Durantie, Estelle and Mathes, Christian (2017) Development of an Industrial Process Based on the Groebke– Blackburn–Bienaymé Multicomponent Reaction: Efficient Preparation of 3-Aminoimidazo[1,2-a]pyrazines. Synthesis.

Baguia, Hajar (2017) Fluoride-free Hiyama cross-coupling in presence of surfactants and water. Report to be submitted to Université Libre de Bruxelles.

Beckmann, Nicolau (2017) Editorial: In vivo imaging in pharmacological research. Frontiers in Pharmacology, 7 (JAN). pp. 7-511. ISSN 16639812

Bernabei, Roberto and Mariotti, Luca and Brodes, Philippe and Roubenoff, Ronenn (2017) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people. Aging Clinical and Experimental Research, 29 (1). ISSN 17208319

Bialucha, Carl and Collins, Scott and Li, Xiao and Saxena, Parmita and Zhang, Xiamei and Duerr, Clemens and Shim, Yeonju and Mosher, Rebecca and Ostrom, Lance and Hu, Tiancen and Bilic, Sanela and Liric Rajlic, Ivana and Capka, Vladimir and Sharp, Fiona and Antonakos, Brandon and Wagner, Joel and Elliott, Ginell and Veloso, Artur and Piel, Jessica and Xu, Jian and Flaherty, Meghan and Mansfield, Keith and London, Anne and Kurz, Markus and Nguyen, Duc and Meyer, Matthew and Faris, Jason and Janatpour, Mary and Chan, Vivien and Yoder, Nicholas and Catcott, Kelly and McShea, Molly and Sun, Xiuxia and Gao, Hui and Williams, Juliet and Hofmann, Francesco and Engelman, Jeffrey and Ettenberg, Seth and Sellers, William and Lees, Emma (2017) Discovery and optimization of HKT288, a cadherin-6-targeting ADC for the treatment of ovarian and renal cancers. Cancer Discovery, 7 (9). pp. 1030-1045. ISSN 21598290

Bizec, Jean-Claude and Glogovac, Milica and Gromek, Kamila and Prause, Maarten and Winkler, Gian Christian and Milton, Mark and Newton, Ronald and Lovsin Barle, Ester (2017) Determination of Permitted Daily Exposure for Topical Ocular Drugs. Determination of Permitted Daily Exposure for Topical Ocular Drugs (00). pp. 1-9. ISSN 1083-7450

Blanz, Joachim and Dayer, Jerome and Delemonte, Thierry and Gertsch, Werner and Ramstein, Philippe and Williams, Gareth and Aichholz, Reiner and Trunzer, Markus and Pearson, David (2017) Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery. Journal of Mass Spectrometry, 52 (4). pp. 210-217. ISSN 1096-9888

Blasko, Andrei and Rao, Raj and Kuehl, Philip J. and Holmes, Thomas D. and Reed, Matthew D. and Xu, Fadi and Zhuang, Jianguo (2017) A Physicochemical Assessment of Acid-induced Post-inhalation Cough in Guinea Pigs Animal Model. American Journal of Advanced Drug Delivery, 5 (4). pp. 131-138. ISSN ISSN 2321-547X

Blasko, Andrei and Tam, Yat Kong and Haidar Ahmad, Imad A. (2017) Cleaning verification dilemma of manufacturing equipment: Can the analytical method validation fail due to the cleanliness of the stainless steel surfaces? Atlas of Science, Octobe.

Blatter, Markus and Krepl, Miroslav and Cléry, Antoine and Allain, Frédéric H.T. and Sponer, Jiri (2017) Structural study of the Fox-1 RRM protein hydration reveal a role for key water molecules in RRM-RNA recognition. Nucleic Acids Research. ISSN 0305-10481362-4962

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne (2017) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Toxicology in vitro, 40. pp. 55-65. ISSN 08872333

Brocklehurst, Cara and Koch, Guido and Makarov, Ilya S. and Karaghiosoff, Konstantin L. and Knochel, Paul (2017) Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane. Angewandte Chemie International Edition.

Brocklehurst, Cara and Rothe-Poellet, Stephanie and Koch, Guido and La Vecchia, Luigi (2017) In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines. Synlett. ISSN 14372096

Brown, Alan and Saravanan, Chandrassegar and Devine, Pj and Magnifico, Maria and Gao, Jiaping and Beaulieu, Valerie and Ma, Margaret and Yasoshima, Kayo and Barnes, David and Yamada, Ken (2017) Characterization of intra-articular dose administration in the stifle joint of rabbits for toxicity testing. International Journal of Toxicology, 36 (4). pp. 303-313. ISSN 1092874X

Bruin, Gerardus and Loesche, Christian and Nyirady, Judit and Sander, Oliver (2017) Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis. Journal of Clinical Pharmacology, 57 (7). pp. 876-885. ISSN 1552-4604

Burkhart, Christoph and Kucher, Klaus and Sloth, Birgitte and Huber, Roland (2017) 1st Newsletter for ESID level 3 project in APDS. 1st Newsletter for ESID level 3 project in APDS.

Burks, Heather and Abrams, Tinya and Baird, Jason and Fekete, Alexander and Hamann, Lawrence and Kim, Sunkyu and Kirby, Christina and Lambardo, Franco and Loo, Alice and Lubicka, Danuta and Macchi, Kaitlin and McDonnell, Donald P. and Mishina, Yuji and Norris, John and Nunez, Jill and Saran, Chitra and Sun, Yingchuan and Thomsen, Noel and Wang, Chunrong and Peukert, Stefan and Wang, Jianling (2017) Discovery of an acrylic acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERa+ Breast Cancer. Journal of Medicinal Chemistry.


Cahill, Katherine and Katz, Howard and Cui, Jing and Lai, Juying and Kazani, Shamsah and Crosby-Thompson, Allison and Garofalo, Denise and Castro, Mario and Jarjour, Nizar and DiMango, Emily and Erzurum, Serpil and Trevor, Jennifer and Shenoy, Kartik and Chinchilli, Vernon and Wechsler, Michael and Laidlaw, Tanya and Boyce, Joshua and Israel, Elliot (2017) KIT inhibition by imatinib in patients with severe refractory asthma. New England Journal of Medicine, 376 (20). pp. 1911-1920. ISSN 15334406

Caicedo, Juan and Cooper, Sam and Heigwer, Florian and Warchal, Scott and Qiu, Peng and Molnar, Csaba and Vasilevich, Aliaksei and Barry, Joseph and Singh, Harmanjit and Kraus, Oren and Wawer, Mathias and Paavolainen, Lassi and Herrmann, Markus and Rohban, Mohammad and Hung, Jane and Hennig, Holger and Concannon, John and Smith, Ian and Singh, Shantanu and Rees, Paul and Horvath, Peter and Linington, Roger and Carpenter, Anne (2017) Data-analysis strategies for image-based cell profiling. Nature Methods, 14 (9). pp. 849-863. ISSN 15487105

Chandra, Abhishek and Qin , Ling and Kneissel, Michaela and Kramer, Ina and Liu, Sherry and Young, Tiffany and Ma, Xiaoyuan (2017) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone and Mineral Research, 32 (2). pp. 360-372. ISSN 1523-4681

Chen, Chih-wei and Beyer, Christian and Liu, Jun and Maier, Christiane and Li, Chun and Trinh-Minh, Thuong and Xu, Xiaohan and Cole, Stuart and Hsieh, Mindy Hsieh and Ng, Nicholas and Althage, Alana and Meeusen, Shelly and Pan, Shifeng and Svensson, Eric and Seidel, Martin and Schett, Georg and Gergely, Peter and Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt Signaling. Annals of the Rheumatic Diseases (1-6). pp. 1-6.

Chen, Chih-wei and Beyer, Christian and Liu, Jun and Maier, Christiane and Li, Chun and Trinh-Minh, Thuong and Xu, Xiaohan and Cole, Stuart and Hsieh, Mindy Hsieh and Ng, Nicholas and Althage, Alana and Meeusen, Shelly and Pan, Shifeng and Svensson, Eric and Seidel, Martin and Schett, Georg and Gergely, Peter and Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling. Annals of the Rheumatic Diseases, 76 (4). pp. 773-778. ISSN 1468-2060

Chen, Huaibin and Marsiglia, William M and Cho, Min-Kyu and Huang, Zhifeng and Deng, Jingjing and Blais, Steven P and Gai, Weiming and Bhattacharya, Shibani and Neubert, Thomas A and Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Huaibin and Marsiglia, William M and Cho, Min-Kyu and Huang, Zhifeng and Deng, Jingjing and Blais, Steven P and Gai, Weiming and Bhattacharya, Shibani and Neubert, Thomas A and Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Jin and Meyers, Charles and Keefe, Debbi and Yu, Jing and Sunkara, Gangadhar (2017) Clinical Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase 1 Inhibitor. Journal of Drug Design and Research.

Chen, Xin and Giraldes, John and Sprague, Elizabeth and Shakya, Subarna and Chen, Zhuoliang and Wang, Kate and Joud-Caldwell, Carol and Mathieu, Simon and Chen, Christine and Straub, Christopher and Duca, Jose and Hurov, Kristen and Yuan, Yanqiu and Shao, Wenlin and Toure, Bakary-Barry (2017) “Addition” and “Subtraction”: Selectivity Design for Type-II Maternal Embryonic Leucine Zipper Kinase Inhibitors. Journal of Medicinal Chemistry, 60. pp. 2155-2161.

Chen, Zhao (2017) Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib. European Journal of Radiology, 88. pp. 15-20. ISSN 18727727

Cheung, Sheldon T. and Miller, Michelle S. and Pacoma, Reynand and Roland, Jason and Schumacher, Andrew and Liu, Jian and Hsieh-Wilson, Linda C. (2017) Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chemical Biology, 12 (12). pp. 3126-3133. ISSN 15548937

Chiang, Derek and Villanueva, Augusto (2017) Progress towards molecular patient stratification of hepatocellular carcinoma: Lost in translation? Journal of Hepatology, 67 (5). pp. 893-895. ISSN 16000641

Cho, Young and Liu, Gang and Caferro, Thomas and Shafer, Cynthia and Manning, James and Sendzik, Martin and Shultz, Michael and Chenail, Gregg and Dooley, Julie and Farsidjani, Alireza and Chen, Jinyun and Kulathila, Raviraj and Xie, Xiaoling and Dodd, Stephanie and Gould, Ty and Liang, Guiqing and Heimbach, Tycho and Slocum, Kelly and Pu, Minying and Pagliarini, Raymond and Growney, Joseph (2017) Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Medicinal Chemistry Letters, 8 (10). pp. 1116-1121. ISSN 19485875

Clarke, Adrian and Kotoni, Dorina and Dispas, Amandine and Guillarme, Davy and Hubert, Philippe and Desfontaine, Vincent and Lebrun, Pierre (2017) Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 134. pp. 170-180.

Clottu, A and Mathias, A and Sailer, Andreas and Schluep, M and Seebach, J and Du Pasquier, R and Pot, Caroline (2017) EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. Cell Reports, 18 (1). pp. 213-224.

Cowell, Annie and LaMonte, Greeg and Abraham, Matthew and Flannery, Erika and William, Roy and Sasaki, Erica and Corey, Victoria and Lukens, Amanda and Istvan, Eva and Lee, Marcus and Franco, Virginia and Reimer, Christin and Magistrado, Pamela and Coburn-Flynn, Olivia and Sakata-Kato, Tomoyo and Bopp, Selina and Gupta, Purva and Fuchs, Olivia and Kim, Sang and Teng, Christine and Gnadig, Nina and Vanaerschot, Manu and Murithi, James and Linares, Maria and Cozar, Cristina and Gomez-Lorenzo, Maria and Prats, Sara and Arriaga, Ignacio and Wang, Lawrence and Ottilie, Sabine and Siegel, Dionicio and Tanaseichuk, Olga and Zhong, Yang and Zhou, Yingyao and Willis, Paul and Gamo, Francisco-Javier and Goldberg, Daniel and Fidock, David and Wirth, Dyann and Winzeler, Elizabeth (2017) Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics. Science.

Cox, Georgina and Sieron, Arthur and King, Andrew and De Pascale, Gianfranco and Pawlowski, Andrew and Koteva, Kalinka and Wright, Gerard (2017) A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. Cell chemical biology, 24. pp. 98-109. ISSN 2451-9456

Cramer, Christopher J and Johnson, Joshua and Kamel, Amin (2017) Prediction of Mass Spectral Response Factors from Predicted Chemometric Data for Druglike Molecules. Journal of the American Society for Mass Spectrometry, 28 (2). pp. 278-285. ISSN 1879-1123

Cruz, Leilani and Heidt, Analeah and Rowell, Emily (2017) Postdoc fellowship application for the Damon Runyon Cancer Research Fellowship entitled "Identifying novel pathways responsible for epigenetic modifications in aged regulatory T cells in the tumor microenvironment". Damon Runyon Cancer Research Fellowship.

Cruz, Leilani and Rowell, Emily and Heidt, Analeah (2017) Identification and targeting of novel pathways modifying the epigenome of aged regulatory T cells in the tumor microenvironment. Damon Runyon Cancer Research Fellowship.

Cunha, Andre and Zhang, Qin and Prentiss, Melissa and Wu, Xiaoqiu and Kainz, Vanessa and Xu, Yongyao and Vrouvlianis, Joanna and Li, Hui and Rangaswamy, Nalini and Leehy, Barrett and Mcgee, Terri and Bell, Christie and Bigelow, Chad and Kansara, Viralbhai and Huang, Qian and Wu, Henry (2017) The hierarchy of pro-inflammatory cytokines in ocular inflammation. Current eye research. pp. 1-13. ISSN 1460-2202


Dafflon, Caroline and Craig, Vanessa and Mereau, Helene and Gräsel, Julius and Schacher Engstler, Barbara and Hoffman, Gregory and Nigsch, Florian and Gaulis, Swann and Barys, Louise and Ito, Moriko and Aguadé Gorgorio, Julia and Bornhauser, Beat and Bourquin, Jean-Pierre and Proske, Amelie and Stork-Fux, Caroline and Murakami, Masato and Sellers, William and Hofmann, Francesco and Schwaller, Jürg and Tiedt, Ralph (2017) Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. Leukemia. ISSN 14765551

Dafflon, Caroline and Tiedt, Ralph and Schwaller, Jürg (2017) Targeting multiple nodes of MLL complexes to improve leukemia therapy. Oncotarget, 8 (53). pp. 90614-90615. ISSN 19492553

Dai, Chenkai and Lehar, Mohamed and Sun, Daniel and Swarthout, Lani and Carey, John and Maclachlan, Timothy and Brough, Doug and Staecker, Hinrich and Della Santina, Alexandra and Hullar, Timothy and Della Santina, Charles (2017) Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery. JARO - Journal of the Association for Research in Otolaryngology, 18 (4). pp. 601-617. ISSN 1438-7573

Dalvit, Claudio and Piotto, Martial and Vulpetti, Anna (2017) Fluorine NMR spectroscopy and computational calculations for assessing intramolecular hydrogen bond involving fluorine and for characterizing the dynamic of a fluorinated molecule. Journal of fluorine chemistry, 202. pp. 34-40. ISSN 00221139

Das, Suman and Morvan, Frederic and Jourde, Benjamin and Minetti, Giulia and Brebbia, Pascale and Toussaint, Gauthier and Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase regulates myofiber differentiation by altering histone acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 22111247

Das, Suman and Morvan, Frederic and Morozzi, Giulio and Jourde, Benjamin and Minetti, Giulia and Kahle, Peter and Rivet, Helene and Brebbia, Pascale and Toussaint, Gauthier and Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 2211-1247

Daugvilaite, Viktorija and Madsen, Christian Medom and Lückmann, Michael and Echeverria, Clara Castello and Sailer, Andreas and Frimurer, Thomas Michael and Rosenkilde, Mette Marie and Benned-Jensen, Tau (2017) Biased signaling and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus -induced gene 2. British journal of pharmacology. ISSN 1476-5381; 0007-1188

Davis, John and Kagan, Mark and Read, Jessica and Walles, Markus and Hatsis, Panagiotis (2017) Immunoprecipitation LC-MS Middle-up Approach for In Vivo Drug-To-Antibody Ratio Determination for Antibody Drug Conjugates. Bioanalysis.

Decker, Rebekah (2017) Articular cartilage and joint development from embryogenesis to adulthood. Seminars in cell & developmental biology, 62. pp. 50-56. ISSN 1096-3634

Decker, Rebekah and Um, Hyo-Bin and Dyment, Nathaniel A. and Cottingham, Naiga and Usami, Yu and Enomoto-Iwamoto, Motomi and Kronenberg, Mark S. and Maye, Peter and Rowe, David W. and Koyama, Eiki and Pacifici, Maurizio (2017) Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Developmental biology, 426 (1). pp. 56-68. ISSN 00121606

Defontis, Myriam and Cote, Serge and Ledieu, David (2017) A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety. Experimental and Toxicologic Pathology. ISSN 1618-1433

Del Signore, Susanna and Roubenoff, Ronenn (2017) Physical frailty and sarcopenia (PF&S): a point of view from the industry. Aging Clinical and Experimental Research, Epub a. pp. 1-6. ISSN 17208319

Dex, Sarah and Alberton, Paolo and Willkomm, Lena and Soellradl, Thomas and Bago, Sandra and Milz, Stefan and Shakibaei, Mehdi and Ignatius, Anita and Bloch, Wilhelm and Clausen-Schaumann, Hauke and Shukunami, China and Schieker, Matthias and Docheva, Denitsa (2017) Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load. EBioMedicine, 20. pp. 240-254. ISSN 2352-3964

Dickson, Callum and Hornak, Viktor and Pearlstein, Robert and Duca, Jose (2017) Structure-kinetic relationships of passive membrane permeation from multiscale modeling. Journal of the American Chemical Society JACS., 139 (1). pp. 442-452.

Dickson, Callum and Pearlstein, Robert and Hornak, Viktor (2017) Contributions of the membrane dipole potential to the function of voltage-gated cation channels and modulation by small molecule potentiators. Biochimica et biophysica acta (BBA) - Biomembranes, 1859 (2). pp. 177-194. ISSN 00052736

Dumouchel, Jennifer and Argikar, Upendra and Spear, Jaimie and Brown, Ann and Dunne, Christine and Kramlinger, Valerie and Cirello, Amanda and Gunduz, Mithat (2017) An in vitro Investigation of Ocular Bioactivation Potential and the Role of CytochromeP450 2D Enzymes in Rat. Drug metabolism letters.. ISSN 1874-0758

Dégardin, Klara and Desponds, Anne and Roggo, Yves (2017) Protein-based medicines analysis by Raman spectroscopy for the detection of counterfeits. Forensic Science International, 278. pp. 313-325. ISSN 03790738

Dégardin, Klara and Roggo, Yves (2017) Innovative Strategy for Counterfeit Analysis. Medicine Access @ Point of Care, 1 (1). maapoc.0000013. ISSN 2399-2026

de Moura França, Leandro and Amigo, José Manuel and Cairós, Carlos and Bautista Mercader, Manuel and Fernanda Pimentel, Maria (2017) Evaluation and assessment of homogeneity in images. Part 1: Unique homogeneity percentage for binary images. Chemometrics and Intelligent Laboratory Systems, 171. pp. 26-39. ISSN 0169-7439


Ebata, Kevin T. and Mesh, Kathryn and Liu, Shichong and Bilenky, Misha and Fekete, Alexander and Acker, Michael and Hirst, Martin and Garcia, Benjamin A and Ramalho-Santos, Miguel (2017) Vitamin C Induces Specific Demethylation of H3K9me2 in Mouse Embryonic Stem Cells via Kdm3a/b. Epigenetics & chromatin, 10. p. 36. ISSN 1756-8935

Ebhardt, H. Alexander and Degen, Simone and Tadini, Valentina and Schilb, Alain and Greig, Carolyn A. and Fearon, Kenneth CH and Aebersold, Ruedi and Jacobi, Carsten (2017) Comprehensive proteome analysis of muscle composition and development in seniors. EMBO Molecular Medicine.

Eder, Joerg (2017) Opportunities and challenges in phenotypic drug discovery: An industry perspective. Nature Reviews Drug Discovery, 16 (8). pp. 531-543. ISSN 14741784

Edge, Stephen and Singh, Dilraj and Lewis, David and Rouse, Tim (2017) Defining the “Dose” for Dry Powder Inhalers: The challenge of correlating in-vitro dose delivery results with clinical efficacy. American pharmaceutical review, 20 (3). pp. 54-62.

Egger, Christine and Cannet, Catherine and Gerard Sachot, Christelle and Pierrat, Benoit and Suply, Thomas and Ksiazek, Iwona and Beckmann, Nicolau (2017) Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. European Journal of Pharmacology, 809. pp. 64-72. ISSN 18790712

Einolf, Heidi and Lin, Wen and Wang, Lai and Gu, Helen and Chun, Dung Y. and Mangold, James B. and He, Handan (2017) Physiologically-based pharmacokinetic model predictions of panobinostat (LBH589) as a victim and perpetrator of drug-drug interactions. Drug Metabolism and Disposition.

Einolf, Heidi and Zhou, Jocelyn and Won, Christina and Wang, Lai and Rebello, Sam (2017) A physiologically-based pharmacokinetic modeling approach to predict drug-drug interactions of sonidegib (LDE225) with perpetrators of CYP3A in cancer patients. Drug metabolism and disposition, 45 (4). pp. 361-374. ISSN 1521-009X

Emery, Caroline and Monaco, Kelli-Ann and Wang, Ping and Balak, Marissa and Freeman, Alyson and Meltzer, Jodi and Delach, Scott and Rakiec, Daniel and Ruddy, David and Korn, Joshua and Haling, Jake and Acker, Michael and Caponigro, Giordano (2017) BRAF-inhibitor associated MEK mutations increase RAF-dependent and -independent enzymatic activity. Molecular Cancer Research, 15 (10). pp. 1431-1444. ISSN 1557-3125

Ertl, Peter (2017) An algorithm to identify functional groups in organic molecules. Journal of cheminformatics, 9 (1). p. 36. ISSN 1758-2946

Ertl, Peter and Lewis, Richard and Martin, Eric and Polyakov, Valery (2017) In silico generation of novel, drug-like chemical matter using the LSTM neural network. arXiv / talk at CCG User Group Meeting.

Estoppey, David and Hewett, Jeffrey and Guy, Chantale and Harrington, Edmund and Thomas, Jason and Schirle, Markus and Cuttat-Theurillat, Rachel and Waldt, Annick and Gerrits, Bertran and Yang, Zinger and Schuierer, Sven and Carbone, Walter and Knehr, Judith and Lindeman, Alicia and Russ, Carsten and Frias, Elizabeth and Hoffman, Gregory and Varadarajan, Malini and Ramadan, Nadire and Reece-Hoyes, John and Wang, Qiong and Chen, Xin and Mcallister, Gregory and Roma, Guglielmo and Bouwmeester, Antonius and Hoepfner, Dominic (2017) Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Scientific reports, 7 (42728). pp. 1-6. ISSN 2045-2322

Estoppey, David and Lee, Chia Min and Janoschke, Marco and Mathys, Philippe and Filipuzzi, Ireos and Schuhmann, Tim and Riedl, Ralph and Aust, Thomas and Galuba, Olaf and Mcallister, Gregory and Russ, Carsten and Spiess, Martin and Bouwmeester, Antonius and Bonamy, Ghislain and Hoepfner, Dominic (2017) The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase. Cell Reports, 19 (3). pp. 451-460. ISSN 22111247


Fairfield, Heather and Falank, Carolyne and Harris, Elizabeth and Demambro, Victoria and McDonald, Michelle and Pettitt, Jessica A. and Mohanty, Sindhu T. and Croucher, Peter and Kramer, Ina and Kneissel, Michaela and Rosen, Clifford J. and Reagan, Michaela R. (2017) The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. Journal of cellular physiology.

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Hatsis, Panagiotis and Waters, Nigel and Argikar, Upendra (2017) Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards. Drug Metabolism and Disposition.

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Jelsch, Morgane and Grandeury, Arnaud (2017) Crystal Morphology Prediction of active pharmaceutical ingredients. Internship - report for school.

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Miller, Danforth and Tan, Trixie and Nakamura, John and Malcolmson, Richard and Tarara, Thomas and Weers, Jeff (2017) Physical characterization of Tobramycin Inhalation Powder: II. State Diagram of an Amorphous Engineered Particle. Molecular Pharmaceutics. ISSN 10.1021/acs.molpharmaceut.7b00036

Miltz, Wolfgang and Velcicky, Juraj and Dawson King, Janet and Littlewood-Evans, Amanda and Ludwig, Marie-Gabrielle and Seuwen, Klaus and Feifel, Roland and Oberhauser, Berndt and Meyer, Arndt and Gabriel, Daniela and Loetscher, Pius (2017) Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorganic & Medicinal Chemistry, 25 (16). pp. 4512-4525. ISSN 0968-0896

Miltz, Wolfgang and Velcicky, Juraj and Dawson King, Janet and Littlewood-Evans, Amanda and Ludwig, Marie-Gabrielle and Seuwen, Klaus and Feifel, Roland and Oberhauser, Berndt and Meyer, Arndt and Gabriel, Daniela and Loetscher, Pius (2017) Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorganic and Medicinal Chemistry, 25 (16). pp. 4512-4525. ISSN 14643391

Miraglia, Loren and Orth, Anthony and Bonamy, Ghislain and Britschgi, Adrian and Brinkhaus, Heike and Bentires-Alj, Mohamed and Reddy, Venkateshwar and Kim, Sungeun and Duss, Stephan and Cuoto, JP and Koren, S and De Silva, D and Mertz, KD and Kaud, D and Varga, Z and Voshol, H and Leroy, C and Roloff, T and Stadler, MB and Scheel, CH (2017) The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature, 541 (7638). pp. 541-545. ISSN 0028-0836, 1476-4687

Moebitz, Henrik and Jahnke, Wolfgang and Jacob, Sandra (2017) Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches. Current topics in medicinal chemistry, 17. pp. 59-70. ISSN 1873-4294

Moebitz, Henrik and Machauer, Rainer and Holzer, Philipp and Vaupel, Andrea and Stauffer, Frederic and Ragot, Christian and Caravatti, Giorgio and Scheufler, Clemens and Hommel, Ulrich and Tiedt, Ralph and Beyer, Kim and Chen, Chao and Zhu, Hugh and Gaul, Christoph (2017) Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Medicinal Chemistry Letters, 8 (3). pp. 338-343. ISSN 19485875

Moggs, Jonathan (2017) IMI MARCAR external communication materials - interview and factsheet. IMI web based dissemination.

Moggs, Jonathan (2017) A Synopsis of the “Influence of Epigenetics, Genetics, and Immunology” Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium. Toxicologic Pathology.

Morgan, Thomas and Rajman, Iris (2017) Implications of African allele frequency variation in CYP450 genes for drug safety, efficacy and the future of drug development. EBioMedicine.. ISSN 2352-3964

Morse, Morse Alyson and Schindeler, Aaron and McDonald, Michelle M and Kneissel, Michaela and Kramer, Ina and Little, David G (2017) Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of bone and mineral research.. ISSN 1523-4681; 0884-0431

Mortenson, Paul N and Erlanson, Daniel A and de Esch , Iwan JP and Jahnke, Wolfgang and Johnson, Christopher N (2017) Fragment-to-Lead Medicinal Chemistry Publications in 2015. Journal of Medicinal Chemistry, 60 (1). pp. 89-99. ISSN 15204804

Morvan, Frederic and Rondeau, Jean-Michel and Zou, Chao and Minetti, Giulia and Scharenberg, Meike and Jacobi, Carsten and Brebbia, Pascale and Ritter, Veronique O. and Toussaint, Gauthier and Scheufler, Clemens and Lehmann, Sylvie and Koch, Elke and Koelbing, Claudia and Leber, Xavier Charles and Schilb, Alain and Witte, Florian and Geisse, Sabine and Glass, David and Trifilieff, Estelle (2017) Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 114 (47). pp. 12448-12453. ISSN 10916490

Moscaroli, Alessandra and Behe, Martin (2017) Radiolabeling and Characterization of 111In-FGF-2 for In Vivo Imaging. Mol Pharm. 2017 Mar 6;14(3):639-648. doi: 10.1021/acs.molpharmaceut.6b00913..

Murphy, Jason and Harrington, Edmund and Schirle, Markus and Wong, Margaret and Gower, Carrie and Maly, Dustin (2017) Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors. Proteome science, 15 (17). ISSN 1477-5956


Nakajima, Katsumasa and Chatelain, Ricardo and Clairmont, Kevin and Commerford, Susan and Coppola, Gary and Daniels, Thomas and Forster, Cornelia and Gilmore, Thomas and Gong, Yongjin and Jain, Monish and Kanter, Aaron and Kwak, Young-Shin and Li, Jingzhou and Meyers, Charles and Neubert, Alan and Szklennik, Paul and Tedesco, Vivienne and Thompson, Jed and Truong, David and Yang, Qing and Hubbard, Brian and Serrano-Wu, Michael (2017) Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans. Journal of Medicinal Chemistry, 60 (11). pp. 4657-4664. ISSN 15204804

Ngcungcu, Thandiswa and Oti, Martin and Sitek, Jan C and Haukanes, Bjørn I and Linghu, Bolan and Bruccoleri, Robert and Stokowy, Tomasz and Oakeley, Edward J and Yang, Fan and Zhu, Jiang and Sultan, Marc and Schalkwijk, Joost and van Vlijmen-Willems, Ivonne M J J and von der Lippe, Charlotte and Brunner, Han G and Ersland, Kari M and Grayson, Wayne and Buechmann-Moller, Stine and Sundnes, Olav and Nirmala, Nanguneri and Morgan, Thomas M and van Bokhoven, Hans and Steen, Vidar M and Hull, Peter R and Szustakowski, Joseph and Staedtler, Frank and Zhou, Huiqing and Fiskerstrand, Torunn and Ramsay, Michele (2017) Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families. American journal of human genetics, 100 (5). pp. 737-750. ISSN 1537-6605

Nguyen, Hung N. and Noss, Erika H. and Mizoguchi, Fumitaka and Huppertz, Christine and Wei, Kevin S. and Watts, Gerald F.M. and Brenner, Michael B. (2017) Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators. Immunity, 46 (2). pp. 220-232. ISSN 10974180

Niggemann, Birgit and Atorf, Jenny and Fridrichs-Gromoll, Stephanie and Korte, Sven and Kremers, Jan and Mecklenburg, Lars and Wiederhold, Andreas and Hill, Marilyn and Pilling, Andrew and Mansfield, Keith (2017) Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset (Callithrix jacchus) monkeys. Primate Biology, 4, 93- (4-93-2). pp. 93-100.

Nilsson, Inga and Grove, Kerri and Dovala, Dustin and Uehara, Tsuyoshi and Lapointe, Guillaume and Six, David (2017) Molecular characterization and verification of azido-3,8dideoxy-D-manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide. Journal of Biological Chemistry, 292 (48). pp. 19840-19848. ISSN 1083351X

Nishikawa, Tadateru and Ishiyama, Noboru and Wang, Feng and Ikura, Mitsuhiko (2017) Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin. Biomolecular NMR assignments, 11 (1). pp. 21-24. ISSN 1874-270X

Numao, Shin and Miltz, Wolfgang and Roehn, Till (2017) Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors. Scientific Reports.


Palacios, Daniel and Meredith, Erik and Kawanami, Toshio and Chen, Xin and Darsigny, Veronique and Geno, Erin and Palermo, Mark and Guy, Chantale and Hewett, Jeffrey and Tierney, Laryssa and Thigale, Sachin and Weihofen, Wilhelm and Argikar, Upendra and Boynton, Geoffrey and George, Elizabeth and Wang, Louis and Adams, Christopher and Baird, Daniel and Busby, Scott (2017) Structure based design of Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen. ACS medicinal chemistry letters.

Parmentier, Celine and Uteng, Marianne and Couttet, Philippe and Wolf, Armin and Zaccharias, Thomas and Heyd, Bruno and Bachellier, Philippe and Richert, Lysiane (2017) Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes. Archives of Toxicology, 91 (8). pp. 2879-2893. ISSN 1432-0738

Parmentier, Michael and Guo, Murphy and Zhou, Jianguang and Gallou, Fabrice and Gabriel, Christopher and Isley, Nicholas (2017) Switching from organic solvents to water at an industrial scale. Current Opinion in Green and Sustainable Chemistry, 7. pp. 13-17. ISSN 24522236

Patel, Dhavalkumar and Antoni, Christian and Freedman, Steven and Levesque, Marc and Sundy, John (2017) Phase 2 to Phase 3 Clinical Trials: Reasons for Success and Failure in Immunologic Diseases. Journal of Allergy and Clinical Immunology.

Paterson, Andrew and McMullin, Claire and Mahon, Mary and Press, Neil and Frost, Christopher (2017) α-Halo carbonyls enable meta selective primary, secondary and tertiary C–H alkylations by ruthenium catalysis. Org. Biomol. Chem., 15 (28). pp. 5993-6000. ISSN 1477-05201477-0539

Pearlstein, Robert and Mckay, Daniel and Hornak, Viktor and Dickson, Callum and Golosov, Andrei and Harrison, Tyler and Camilo, Velez-Vega and Duca, Jose (2017) Building new bridges between in vitro and in vivo in early drug discovery: Where molecular modeling meets systems biology. Current Topics in Medicinal Chemistry, 17 (23). pp. 2642-2662. ISSN 1873-4294

Pearson, David and Weiss, H Markus and Jin, Yi and van Lier, Jan Jaap and Erpenbeck, Veit J and Glaenzel, Ulrike and End, Peter and Woessner, Ralph and Eggimann, Fabian and Camenisch, Gian (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Pearson, David and Weiss, Markus and Jin, Yi and van Lier, Jan Jaap and Erpenbeck, Veit and Glaenzel, Ulrike and End, Peter and Woessner, Ralph and Camenisch, Gian P. (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Pearson, David and Weiss, Markus and Jin, Yi and van Lier, Jan Jaap and Erpenbeck, Veit and Glaenzel, Ulrike and End, Peter and Woessner, Ralph and Camenisch, Gian P. and Eggimann, Fabian (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Peng, Yunshan and Dobler, Markus and Patnaik, Anup and Liu, Eugene and Nunez, Jill and Kerrigan, John and Dean, Charles and Mckenney, David and Osborne, Colin and Dzink-Fox, Joann and Bojkovic, Jade and Lilly, Maria-Dawn and Sprague, Elizabeth and Hoffmaster, Keith and Ranjitkar, Srijan and Wang, Bing and hamann, lawrence and tommasi, ruben and glick, meir and yang, xia and wang, honming and parker, david and wattanasin, som and lenoir, francois and Xie, Lili and Yu, Donghui (2017) Design, Synthesis and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. Journal of medicinal chemistry. ISSN 1520-4804

Pepini, Timothy and Pulichino, Anne-Marie and Carsillo, Thomas and Carlson, Alicia and Sari-Sarraf, Farid and Ramsauer, Katrin and Debasitis, Jason and Maruggi, Giulietta and Otten, Gillis and Geall, Andrew and Yu, Dong and Ulmer, Jeffrey and Iavarone, Carlo (2017) Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design Response by a Self-Amplifying RNA. Journal of Immunology, 198.

Peter , Gedeck and Skolnik, Suzanne and Rodde, Stephane (2017) Developing collaborative QSAR models without sharing structures. Journal of Chemical Information and Modeling, 57 (8). pp. 1847-1858. ISSN 1549-95961549-960X

Petrovic, Katarina and Pfeifer, Martin and Parker, Christian and Tallarico, John and Movva, Rao and Scheel, Guenther and Helliwell, Stephen (2017) Cell viability assays for Saccharomyces cerevisiae: Comparison of fluorescence (Alamar TM Blue) and optical density assays in High Throughput Screening format. Microbiological research., 199. pp. 10-18. ISSN 1618-0623; 0944-5013

Pflanz, David and Birkhold, Annette I. and Albiol, Laia and Thiele, Tobias and Duda, Georg and Checa, Sara and Willie, Bettina M. and Kornak, Uwe and Kneissel, Michaela and Kramer, Ina (2017) Sost deficiency led to enhanced Dkk1 expression coincident with a greater cortical bone formation response to mechanical loading. Scientific reports. ISSN 2045-2322

Phizackerley, Kirsten and Jumaa, Mouhannad and Lopalco, Antonio and Wolfe, Bradley H. and Ablan, Christopher D. and Stella, Valentino J. (2017) Mechanism of Degradation of an -Keto-Epoxide, a Model for the Warhead for Various Proteasome Inhibitor Anticancer Agents. Journal of pharmaceutical sciences, 106. pp. 1051-1061.

Piirainen, Henni and Taura, Jaume and Kursula, Petri and Ciruela, Francisco and Jaakola, Veli-Pekka (2017) Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. Biochimica et biophysica acta. ISSN 0006-3002

Pikman, Yana and Furman, Emily S and Alexe, Gabriela and Place, Andrew E and Kim, Sunkyu and Sohal, Bindi and Modiste, Rebecca and Harris, Marian and Kung, Andrew L and Silverman, Lewis B and Stegmaier, Kimberly (2017) Synergistic drug combinations with a CDK4/6 inhibitor in T-cell acute lymphoblastic leukemia. Clinical Cancer Research, 23 (4). pp. 1012-1024. ISSN 1557-3265

Pillong, Max and Marx, Corinne and Piechon, Philippe and Wicker, Jerome GP and Cooper, Richard I and Wagner, Beatrix (2017) A publicly available crystallisation data set and its application in machine learning. CrystEngComm, 19 (27). pp. 3737-3745.

Plawinski, Jason and Reinker, Stefan and Kirkpatrick, Nathaniel and Oakeley, Edward James (2017) Summer internship at Novartis. Report to University of Strasbourg, France.

Pognan, Francois and Marc, Philippe (2017) Legacy data sharing to improve drug safety assessment: The eTOX project. Nature Reviews Drug Discovery, 16 (12). pp. 811-812. ISSN 14741784

Potting, Christoph and Sailer, Andreas and Helliwell, Stephen (2017) A genome-wide phenotypic CRISPR/Cas9 screen identifies novel regulators of PARK2 level and mitophagy priming. Proceedings of the National Academy of Sciences of the United States of America PNAS. (10.107). pp. 1-10. ISSN 1091-6490; 0027-8424

Proudfoot, Andrew and Bussiere, Dirksen and Lingel, Andreas (2017) High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. Journal of the American Chemical Society, 139 (49). pp. 17824-17833. ISSN 15205126

Pugsley, Michael K. and Authier, Simon and Brabham, Tiffini and Soloviev, Maxim and Markgraf, Carrie G. and Correll, Krystle and Traebert, Martin and Greiter-Wilke, Andrea and Valentin, Jean-Pierre and Vargas, Hugo and Botchway, Alfred and Leishman, Derek J. and Curtis, Michael J. (2017) The Safety Pharmacology Society salary survey. Journal of Pharmacological and Toxicological Methods, 88. pp. 85-91. ISSN 1873488X


Qi, Vicky and Zhao, Kehao and Gu, Justin and Huang, Ying and Wang, Youzhen and Zhang, Hailong and Zhang, Maya and Zhang, Jeff and Yu, Zhengtian and Li, Ling and Teng, Lin and Chuai, Shannon and Zhang, Chao and Zhao, Mengxi and Chen, Zijun and Fang, Douglas and Fei, Qi and Feng, Leying and Feng, Lijian and Gao, Yuan and Ge, Hui and Ge, Xinjian and Li, Guobin and Lingel, Andreas and Lin, Ying and Liu, Yueqin and Luo, Fangjun and Shi, Minlong and Wang, Long and Wang, Zhaofu and Yu, Yanyan and Zeng, Jue and Zeng, Chenhui and Chen, Ho Man and Zhang, Lijun and Zhang, Qiong and Zhou, Shaolian and Oyang, Counde and Atadja, Peter and Li, En (2017) An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nature Chemical Biology.


Radonjic-Hoesli, Susanne and Wang, Xiaoliang and de Graauw, Elisabeth and Merz-Stoeckle, Christina and Styp-Rekowska, Beata and Hlushchuk, Ruslan and Simon, Dagmar and Spaeth, Peter J and Yousefi, Shida and Simon, Hans-Uwe (2017) Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. The Journal of allergy and clinical immunology. ISSN 1097-6825

Ramos, Marcel and Schiffer, Lucas and Re, Angela and Azhar, Rimsha and Rodriguez Cabrera, Carmen and Chan, Tiffany and Chapman, Philip and Gomez-Cabrero, David and Haibe-Kains, Benjamin and Hansen, Kasper and Kodali, Hanish and Louis, Marie Stephie and Mer, Arvind and Riester, Markus and Morgan, Martin and Carey, Vincent and Waldron, Levi (2017) Software for the integration of multi-omics experiments in Bioconductor. Cancer research. ISSN 1538-7445; 0008-5472

Rao, Koneti V and Webster, Sharon and Dalm, Virgil ASH and Sediva, Anna and van Hagen, Martin P and Holland, Steven and Rosenzweig, Sergio D and Christ, Andreas Dominik and Sloth, Birgitte and Cabanski, Maciej and Joshi, Aniket and De Buck, Stefan and Doucet, Julie and Guerini, Danilo and Kalis, Christoph and Pylvaenaeinen, Ilona and Soldermann, Nicolas and Kashyap, Anuj and Gulbu, Uzel and Leonardo, Michael J and Patel, Dhavalkumar and Lucas, Carrie L and Burkhart, Christoph (2017) Effective ‘Activated PI3Kdelta Syndrome’-targeted therapy with PI3Kdelta inhibitor leniolisib. Blood, 130 (21). pp. 2307-2316. ISSN 1528-0020; 0006-4971

Rao, Koneti V and Webster, Sharon and Dalm, Virgil ASH and Sediva, Anna and van Hagen, Martin P and Holland, Steven and Rosenzweig, Sergio D and Christ, Andreas Dominik and Sloth, Birgitte and Cabanski, Maciej and Joshi, Aniket and De Buck, Stefan and Doucet, Julie and Guerini, Danilo and Kalis, Christoph and Pylvaenaeinen, Ilona and Soldermann, Nicolas and Kashyap, Anuj and Gulbu, Uzel and Leonardo, Michael J and Patel, Dhavalkumar and Lucas, Carrie L and Burkhart, Christoph (2017) Effective ‘Activated PI3Kdelta Syndrome’-targeted therapy with PI3Kdelta inhibitor leniolisib. Blood, 130 (21). pp. 2307-2316. ISSN 0006-4971

Rauch, Judith and Kallen, Joerg (2017) Hintergrundtext Medizinforschung am PSI. new magazine of the Paul Scherrer Institute PSI.

Ravagli, Carlo and Pognan, Francois and Marc, Philippe (2017) OntoBrowser: a tool for curating ontologies and code lists by subject matter experts. Bioinformatics, 33 (1). pp. 148-149. ISSN 1367-48031460-2059

Rebhan, Michael (2017) Towards a systems approach for chronic diseases, based on health state modeling. F1000Research., 6. p. 309. ISSN 2046-1402

Rehan, Shahid and Paavilainen, Ville O and Jaakola, Veli-Pekka (2017) Functional Reconstitution of Human Equilibrative Nucleoside Transporter-1 into Styrene Maleic Acid Co-polymer Lipid Particles. Biochimica et biophysica acta. ISSN 0006-3002

Reilly, John and Aliagas, Ignacio and Berger, Raphaelle and Goldberg, Kristin and Nishimura, Rachel and Richardson, Paul and Richter, Daniel and Sherer, Edward and Sparling, Brian and Marian, Bryan (2017) Sustainable Practices in Medicinal Chemistry Part 2: Green by Design. Journal of Medicinal Chemistry, 60 (14). pp. 5955-5968. ISSN 15204804

Ren, Shuang and Sechaud, Romain and Su, Frank and Tillmann, Hanns-Christian and Hara, Hisanori and Tan, Xuemei and Hou, Jie and Woessner, Ralph and Zhao, Rong (2017) Pharmacokinetics and safety of indacaterol and glycopyrronium (IND/GLY) following repeated once daily inhalation from a fixed-dose combination in healthy Chinese subjects. International Journal of Clinical Pharmacology and Therapeutics , 55 (2). pp. 147-155.

Riede, Julia and Camenisch, Gian P. and Jörg, Huwyler and Poller, Birk (2017) Current methods to determine hepatic Kpuu: a comparison of their usefulness and limitations. Journal of pharmaceutical sciences. ISSN 00223549

Riede, Julia and Poller, Birk and Huwyler, Jörg and Camenisch, Gian P. (2017) Assessing the risk of drug-induced cholestasis using unbound intrahepatic concentrations. Drug metabolism and disposition. ISSN 1521-009X

Riss, Bernard (2017) TMS-ent-Bisabolangelone. Tetrahedron, 73 (23). pp. 3202-3212. ISSN 00404020

Robbins, Ken (2017) Sparse set of AWS tips for an enterprise cloud transformation. Ken Robbins' LinkedIn blog.

Roggo, Yves (2017) Forensic investigation in the pharmaceutical industry: Identification procedure of visible particles in (drug) solutions and different containers by combining vibrational and X-ray spectroscopic techniques. Journal of pharmaceutical and biomedical analysis. ISSN 1873-264X; 0731-7085

Roggo, Yves (2017) Global regression model for moisture content determination using near-infrared spectroscopy. European journal of pharmaceutics and biopharmaceutics. ISSN 1873-3441; 0939-6411

Rooks, Daniel and Praestgaard, Jens and Hariry, Sam and Laurent, Didier and Petricoul, Olivier and Perry, Robert G. and Trifilieff, Estelle and Roubenoff, Ronenn (2017) Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. Journal of the American Geriatrics Society, 65 (9). pp. 1988-1995. ISSN 15325415

Rubic-Schneider, Tina and Kuwana, Masataka and Christen, Brigitte and Aßenmacher, Manuela and Hainzl, O. and Zimmermann, F. and Fischer, Robert and Koppenburg, Vera and Chibout, Salah-Dine and Wright, Timothy M. and Seidl, Andreas and Kammueller, Michael (2017) T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia. Blood Advances, 1 (6). pp. 367-379. ISSN 2473-9537

Ruetz, Stephan and Chene, Patrick and Stachyra, Therese-Marie and Brock, Roland and Wallbrecher, Rike (2017) A critical assessment of the synthesis and biological activity of p53/Hdm2 stapled peptide inhibitors. British journal of pharmacology, 2017 .

Ruffner, Heinz and Ley, Svenja and Galuba, Olaf and Melin, Nicolas and Salathe, Adrian and Aebi, Alexandra and Pikiolek, Monika and Knehr, Judith and Carbone, Walter and Beibel, Martin and Roma, Guglielmo and D'Ario, Giovanni and Gubser Keller, Caroline and Bouwmeester, Antonius and Parker, Christian and Bouchez, Laure and Kirkland, Susan and Nigsch, Florian (2017) Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology. Journal of biomolecular screening. ISSN 1552-454X; 1087-0571

Rutkowska, Aleksandra and Sailer, Andreas and Dev, Kumlesh (2017) EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination. Journal of Neuroinflammation, 14 (1). ISSN 1742-2094

Rutrick, Daniel and Stein, Dan and Fava, Maurizio and Hasler, Gregor and Cha, Jang-Ho and Donchev, Toni and Ocwieja, Magdalena and Gomez-Mancilla, Baltazar (2017) Mavoglurant in Obsessive-Compulsive Disorder Resistant to Selective Serotonin Reuptake Inhibitor: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 study. Advances in therapy..


Salick, Max and Wells, Michael F and Eggan, Kevin and Kaykas, Ajamete (2017) Modelling Zika virus infection of the developing human brain in vitro using stem cell-derived cerebral organoids. Journal of visualized experiments : JoVE (127). ISSN 1940-087X

Sandham, David and Barker, Lucy and Brown, Lyndon and Brown, Zarin and Budd, David and Charlton, Steven and Chatterjee, Devnandan and Cox, Brian and Dubois, Gerald and Duggan, Nicholas and Hall, Edward and Hatto, Julia and Maas, David and Manini, Jodie and Profit, Rachael and Riddy, Darren and Ritchie, Cathy and Sohal, Bindi and Shaw, Duncan and Stringer, Rowan and Sykes, David and Turner, Katharine and Watson, Simon and West, Ryan and Willard, Elizabeth and Williams, Gareth and Willis, Jennifer (2017) Discovery of Fevipiprant (NVP-QAW039), a potent and selective CRTh2 receptor antagonist for treatment of allergic diseases. ACS Medicinal Chemistry Letters.

Sangana, Ramachandra and Gu, Helen and Chun, Dung Yu and Einolf, Heidi (2017) Evaluation of clinical drug interaction potential of clofazimine using static and dynamic modeling approaches. Drug metabolism and disposition.

Sasseville, Vito and Milton, Mark and Maclachlan, Timothy and Newton, Ronald (2017) Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics. Regulatory Toxicology and Pharmacology, 86. pp. 221-230. ISSN 1096-0295

Schenkel, Berthold and Venturoni, Francesco and Aubry, Michel and Sevinc, Serbuelent and Sedelmeier, Joerg Mathias and Martin, Benjamin and Susanne, Flavien and Lima, Fabio and Piccioni, Lorenzo (2017) Match-making reactors to chemistry: a continuous manufacturing-enabled sequence to a key benzoxazole pharmaceutical intermediate. Organic process research & development, 21. pp. 1779-1793.

Schlesinger, Ann and Hunt, Ian (2017) Video of 2016 Novartis Open Framework Symposium. this link was shared with externals but not published.

Schuierer, Sven and Carbone, Walter and Petitjean, Virginie and Fernandez, Anita and Sultan, Marc and Roma, Guglielmo (2017) A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples. BMC Genomics, 18 (1). ISSN 14712164

Seefried, Lothar and Baumann, Jasmin and Hemsley, Sarah and Hofmann, Christine and Kunstmann, Erdmute and Kiese, Beate and Huang, Yue and Chivers, Simon and Valentin, Marie-Anne and Borah, Babul and Roubenoff, Ronenn and Junker, Uwe and Jakob, Franz (2017) Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia. Journal of Clinical Investigation, 127 (6). pp. 2148-2158. ISSN 1558-8238

Segatto, Marco and Fittipaldi, Raffaella and Pin, Fabrizio and Sartori, Roberta and Ko, Kyung Dae and Zare, Hossein and Fenizia, Claudio and Zanchettin, Gianpietro and Pierobon, Elisa Sefora and Hatakeyama, Shinji and Sperti, Cosimo and Merigliano, Stefano and Sandri, Marco and Filippakopoulos, Panagis and Costelli, Paola and Sartorelli, Vittorio and Caretti, Giuseppina (2017) Epigenetic Targeting of Bromodomain Protein BRD4 Counteracts Cancer Cachexia and Prolongs Survival. Nature Communications.

Seroutou, Abdelkader and Tian, Xianbin and Fernandez, Rose and Morozov, Alex and Sheng, Qing and Ramkumar, Thiruvamoor and Zubel, Angela (2017) A Phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer. BMC Cancer, 17(1) (646). ISSN 1471-2407

Shimshek, Derya R. and Bus, Thorsten and Schupp, Bettina and Jensen, Vidar and Marx, Verena and Layer, Liliana E. and Köhr, Georg and Sprengel, Rolf (2017) Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation. Frontiers in Molecular Neuroscience, 10. ISSN 1662-5099

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Swaller, Tim (2017) GNF recipient of the 2017 IEA Earth Month Award. GNF Website Recent Updates section.


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Yan, Si and Shaw, Duncan and Sandham, David and Healy, Mark and Reilly, John and Wang, Bing (2017) Interactions between β2-adrenoceptor Ligands and Membrane: Atomic-level Insights from Magic Angle Spinning NMR. Journal of Medicinal Chemistry, 60 (16). pp. 6867-6879. ISSN 0022-26231520-4804

Yang, Yang and Hardman, Clayton (2017) The Synthesis of Chiral Beta-Amino Acids and Beta-Lactams via Oxidative Cleavage of Chiral Dihydropyridones Derived from Vinylogous Mannich Reaction (VMR). Org. Biomol. Chem., 15 (40). pp. 8576-8593. ISSN 1477-05201477-0539

Yang, Zinger (2017) The Retromer Complex Member VPS35 regulates Iron Homeostasis through mediating Hepcidin-induced Ferroportin Degradation. Harvard University's Electronic Thesis and Dissertation .

Yilmaz, Yildiz and Williams, Gareth and Schiller, Hilmar and Faller, Thomas and Walles, Markus and Camenisch, Gian P. and Umehara, Ken-Ichi and Krähenbühl, Stephan and Manevski, Nenad (2017) Metabolism of AFQ056 (Mavoglurant) by Rat Pulmonary CYP1A1. Xenobiotica, Online. ISSN 0049-8254

Yilmaz, Yildiz and Williams, Gareth and Schiller, Hilmar and Faller, Thomas and Walles, Markus and Camenisch, Gian P. and Umehara, Ken-Ichi and Krähenbühl, Stephan and Manevski, Nenad (2017) Metabolism of AFQ056 (Mavoglurant) by Rat Pulmonary CYP1A1. Xenobiotica. ISSN 1366-5928


Zhang, Qiao and O'Rourke, Jason and Corbel, Stephane and Moran, Rita and Romero, Angelica and Miraglia, Loren and Zhang, Jia and Durrant, Eric and Schmedt, Christian and Sampath, Srinath and Sampath, Srihari (2017) The microprotein Minion controls cell fusion and muscle formation. Nature Communications, 8. ISSN 20411723

Zhang, Xian and Goette, Marjo and Ibig-Rehm, Yvonne and Kamke, Marion and Schuffenhauer, Ansgar and Beisner, Daniel and Siebert, Daniela and Guerini, Danilo and Bonamy, Ghislain and Gabriel, Daniela and Bodendorf, Ursula (2017) Multiparametric analysis of a high-content ultra-high-throughput screen identifies inhibitors of the intramembrane protease SPPL2a. SLAS discovery. ISSN 2472-5560

Zhou, Enhua and Paolucci, Michael and Dryja, Ted and Manley, Ted and Rice, Dennis and Prasanna, Ganesh and Chen, Amy (2017) A compact whole-eye perfusion system to evaluate pharmacologic responses of outflow facility. Investigative Ophthalmology and Visual Science, 58 (7). pp. 2991-3003. ISSN 15525783

This list was generated on Thu Jun 30 11:04:34 2022 UTC.


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