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Number of items: 378.


Abraham, Yann and Gerrits, Bertran and Rebhan, Michael and Ludwig, Marie-Gabrielle and Gubser Keller, Caroline (2017) Exploring Glucocorticoid Receptor Agonists Mechanism of Action Through Mass Cytometry and Radial Visualizations. Cytometry. Part B : clinical cytometry., 92 (1). pp. 42-56. ISSN 1552-4957; 1552-4949

Altmann, Eva and Erbel, Paulus and Renatus, Martin and Schaefer, Michael and Schlierf, Anita and Druet, Adelaide and Kieffer, Laurence and Sorge, Mickael and Pfister, Keith and Hassiepen, Ulrich and Ostermeier, Daniela and Martoglio, Bruno and Jefferson , Anne B. and Ruedisser, Simon (2017) Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5. Chimia., 71 (4). p. 241. ISSN 10.2533/chimia2017.241

Altmann, Eva and Schlierf, Anita and Schaefer, Michael and Renatus, Martin and Ruedisser, Simon and Erbel, Paulus and Ostermeier, Daniela and Druet, Adelaide and Kieffer, Laurence and Sorge, Mickael and Hassiepen, Ulrich and Jones, Matthew and Pfister, Keith and Jefferson, Ann and Martoglio, Bruno and Quancard, Jean (2017) Azaindoles as zinc-binding small molecule inhibitors of the JAMM protease CSN5. Angewandte Chemie, 56 (5). pp. 1294-1297. ISSN 1433-7851

Ambrose, Jessi and Mapa, Felipa and Ross, Nathan and Chen, Julie and Ye, Chaoyang and Bilican, Bilada (2017) Automated Scale-up and Maintenance of Stem Cell-Induced Neurons for Long-Term Culture and High-Throughput Screening. SLAS Technology.

Amsler, Philipp and Heudi, Olivier and Lanshoeft, Christian and Bettighofer, Anja and Eisfeld, Jochen and Moenius, Thomas and Probst, Claudia Monika and Etter, Coralie (2017) Production and application of high quality stable isotope labeled monoclonal antibody for mass spectrometry analysis. Journal of labelled compounds and radiopharmaceuticals. ISSN 03624803

Argikar, Upendra and Dumouchel, Jennifer and Dunne, Christine and Andrea, Bushee (2017) Ocular Non-P450 oxidative, hydrolytic and conjugative drug metabolizing enzymes. Drug metabolism reviews. pp. 1-23. ISSN 1097-9883

Argikar, Upendra and Dumouchel, Jennifer and Kramlinger, Valerie and Cirello, Amanda and Gunduz, Mithat and Dunne, Christine and Sohal, Bindi (2017) Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? Journal of Pharmaceutical Sciences, 106 (9). pp. 2276-2281. ISSN 15206017

Arias, HR and Jin, Xiaotao and Feuerbach, Dominik and Drenan, RM (2017) Nicotinic acetylcholine receptor selectivity and inhibitory activity on mouse medial habenula by coronaridine congeners. international journal of biochemistry and cell biology, 92. pp. 202-209.

Auberson, Yves (2017) Editorial - In vivo molecular imaging tools facilitates Drug Discovery. Drug Discovery Today: Technologies, 25. pp. 1-2.

Ayalasomayajula, Surya and Pan , Wei and Han , Yi and Yang, Fan and Langenickel, Thomas Heiko and Pal, Parasar and Yao Zong , Yuan and Sunkara, Gangadhar (2017) Assessment of Drug–Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (2). pp. 309-318. ISSN 21070180


Badal Tejedor, Maria and Nordgren, Niklas and Rutland, Mark and Schuleit, Michael and Millqvist-Fureby, Anna and Alderborn, Goran and Pazesh, Samaneh (2017) Determination of Interfacial Amorphicity in Functional Powders. Langmuir the ACS journal of surfaces and colloids., 33 (33). pp. 920-926. ISSN 1520-5827; 0743-7463

Badal Tejedor, Maria and Nordgren, Niklas and Schuleit, Michael and Millqvist-Fureby, Anna and Rutland, Mark (2017) AFM colloidal probe measurements implicate capillary condensation in punch-particle surface interactions during tableting. Langmuir the ACS journal of surfaces and colloids., 33. pp. 13180-13188. ISSN 1520-5827; 0743-7463

Baenziger, Markus and Durantie, Estelle and Mathes, Christian (2017) Development of an Industrial Process Based on the Groebke– Blackburn–Bienaymé Multicomponent Reaction: Efficient Preparation of 3-Aminoimidazo[1,2-a]pyrazines. Synthesis.

Baguia, Hajar (2017) Fluoride-free Hiyama cross-coupling in presence of surfactants and water. Report to be submitted to Université Libre de Bruxelles.

Beckmann, Nicolau (2017) Editorial: In vivo imaging in pharmacological research. Frontiers in Pharmacology, 7 (JAN). pp. 7-511. ISSN 16639812

Bernabei, Roberto and Mariotti, Luca and Brodes, Philippe and Roubenoff, Ronenn (2017) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people. Aging Clinical and Experimental Research, 29 (1). ISSN 17208319

Bialucha, Carl and Collins, Scott and Li, Xiao and Saxena, Parmita and Zhang, Xiamei and Duerr, Clemens and Shim, Yeonju and Mosher, Rebecca and Ostrom, Lance and Hu, Tiancen and Bilic, Sanela and Liric Rajlic, Ivana and Capka, Vladimir and Sharp, Fiona and Antonakos, Brandon and Wagner, Joel and Elliott, Ginell and Veloso, Artur and Piel, Jessica and Xu, Jian and Flaherty, Meghan and Mansfield, Keith and London, Anne and Kurz, Markus and Nguyen, Duc and Meyer, Matthew and Faris, Jason and Janatpour, Mary and Chan, Vivien and Yoder, Nicholas and Catcott, Kelly and McShea, Molly and Sun, Xiuxia and Gao, Hui and Williams, Juliet and Hofmann, Francesco and Engelman, Jeffrey and Ettenberg, Seth and Sellers, William and Lees, Emma (2017) Discovery and optimization of HKT288, a cadherin-6-targeting ADC for the treatment of ovarian and renal cancers. Cancer Discovery, 7 (9). pp. 1030-1045. ISSN 21598290

Bizec, Jean-Claude and Glogovac, Milica and Gromek, Kamila and Prause, Maarten and Winkler, Gian Christian and Milton, Mark and Newton, Ronald and Lovsin Barle, Ester (2017) Determination of Permitted Daily Exposure for Topical Ocular Drugs. Determination of Permitted Daily Exposure for Topical Ocular Drugs (00). pp. 1-9. ISSN 1083-7450

Blanz, Joachim and Dayer, Jerome and Delemonte, Thierry and Gertsch, Werner and Ramstein, Philippe and Williams, Gareth and Aichholz, Reiner and Trunzer, Markus and Pearson, David (2017) Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery. Journal of Mass Spectrometry, 52 (4). pp. 210-217. ISSN 1096-9888

Blasko, Andrei and Rao, Raj and Kuehl, Philip J. and Holmes, Thomas D. and Reed, Matthew D. and Xu, Fadi and Zhuang, Jianguo (2017) A Physicochemical Assessment of Acid-induced Post-inhalation Cough in Guinea Pigs Animal Model. American Journal of Advanced Drug Delivery, 5 (4). pp. 131-138. ISSN ISSN 2321-547X

Blasko, Andrei and Tam, Yat Kong and Haidar Ahmad, Imad A. (2017) Cleaning verification dilemma of manufacturing equipment: Can the analytical method validation fail due to the cleanliness of the stainless steel surfaces? Atlas of Science, Octobe.

Blatter, Markus and Krepl, Miroslav and Cléry, Antoine and Allain, Frédéric H.T. and Sponer, Jiri (2017) Structural study of the Fox-1 RRM protein hydration reveal a role for key water molecules in RRM-RNA recognition. Nucleic Acids Research. ISSN 0305-10481362-4962

Brecht, Karin and Riebel, Virginie and Couttet, Philippe and Paech, Franziska and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Krähenbühl, Stephan and Uteng, Marianne (2017) Mechanistic insights into selective killing of OXPHOS-dependent pancreatic cancer cells by arctigenin. Toxicology in vitro, 40. pp. 55-65. ISSN 08872333

Brocklehurst, Cara and Koch, Guido and Makarov, Ilya S. and Karaghiosoff, Konstantin L. and Knochel, Paul (2017) Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane. Angewandte Chemie International Edition.

Brocklehurst, Cara and Rothe-Poellet, Stephanie and Koch, Guido and La Vecchia, Luigi (2017) In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines. Synlett. ISSN 14372096

Brown, Alan and Saravanan, Chandrassegar and Devine, Pj and Magnifico, Maria and Gao, Jiaping and Beaulieu, Valerie and Ma, Margaret and Yasoshima, Kayo and Barnes, David and Yamada, Ken (2017) Characterization of intra-articular dose administration in the stifle joint of rabbits for toxicity testing. International Journal of Toxicology, 36 (4). pp. 303-313. ISSN 1092874X

Bruin, Gerardus and Loesche, Christian and Nyirady, Judit and Sander, Oliver (2017) Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis. Journal of Clinical Pharmacology, 57 (7). pp. 876-885. ISSN 1552-4604

Burkhart, Christoph and Kucher, Klaus and Sloth, Birgitte and Huber, Roland (2017) 1st Newsletter for ESID level 3 project in APDS. 1st Newsletter for ESID level 3 project in APDS.

Burks, Heather and Abrams, Tinya and Baird, Jason and Fekete, Alexander and Hamann, Lawrence and Kim, Sunkyu and Kirby, Christina and Lambardo, Franco and Loo, Alice and Lubicka, Danuta and Macchi, Kaitlin and McDonnell, Donald P. and Mishina, Yuji and Norris, John and Nunez, Jill and Saran, Chitra and Sun, Yingchuan and Thomsen, Noel and Wang, Chunrong and Peukert, Stefan and Wang, Jianling (2017) Discovery of an acrylic acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERa+ Breast Cancer. Journal of Medicinal Chemistry.


Cahill, Katherine and Katz, Howard and Cui, Jing and Lai, Juying and Kazani, Shamsah and Crosby-Thompson, Allison and Garofalo, Denise and Castro, Mario and Jarjour, Nizar and DiMango, Emily and Erzurum, Serpil and Trevor, Jennifer and Shenoy, Kartik and Chinchilli, Vernon and Wechsler, Michael and Laidlaw, Tanya and Boyce, Joshua and Israel, Elliot (2017) KIT inhibition by imatinib in patients with severe refractory asthma. New England Journal of Medicine, 376 (20). pp. 1911-1920. ISSN 15334406

Caicedo, Juan and Cooper, Sam and Heigwer, Florian and Warchal, Scott and Qiu, Peng and Molnar, Csaba and Vasilevich, Aliaksei and Barry, Joseph and Singh, Harmanjit and Kraus, Oren and Wawer, Mathias and Paavolainen, Lassi and Herrmann, Markus and Rohban, Mohammad and Hung, Jane and Hennig, Holger and Concannon, John and Smith, Ian and Singh, Shantanu and Rees, Paul and Horvath, Peter and Linington, Roger and Carpenter, Anne (2017) Data-analysis strategies for image-based cell profiling. Nature Methods, 14 (9). pp. 849-863. ISSN 15487105

Chandra, Abhishek and Qin , Ling and Kneissel, Michaela and Kramer, Ina and Liu, Sherry and Young, Tiffany and Ma, Xiaoyuan (2017) Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. Journal of Bone and Mineral Research, 32 (2). pp. 360-372. ISSN 1523-4681

Chen, Chih-wei and Beyer, Christian and Liu, Jun and Maier, Christiane and Li, Chun and Trinh-Minh, Thuong and Xu, Xiaohan and Cole, Stuart and Hsieh, Mindy Hsieh and Ng, Nicholas and Althage, Alana and Meeusen, Shelly and Pan, Shifeng and Svensson, Eric and Seidel, Martin and Schett, Georg and Gergely, Peter and Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt Signaling. Annals of the Rheumatic Diseases (1-6). pp. 1-6.

Chen, Chih-wei and Beyer, Christian and Liu, Jun and Maier, Christiane and Li, Chun and Trinh-Minh, Thuong and Xu, Xiaohan and Cole, Stuart and Hsieh, Mindy Hsieh and Ng, Nicholas and Althage, Alana and Meeusen, Shelly and Pan, Shifeng and Svensson, Eric and Seidel, Martin and Schett, Georg and Gergely, Peter and Harris, Jennifer and Distler , Jorg (2017) Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling. Annals of the Rheumatic Diseases, 76 (4). pp. 773-778. ISSN 1468-2060

Chen, Huaibin and Marsiglia, William M and Cho, Min-Kyu and Huang, Zhifeng and Deng, Jingjing and Blais, Steven P and Gai, Weiming and Bhattacharya, Shibani and Neubert, Thomas A and Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Huaibin and Marsiglia, William M and Cho, Min-Kyu and Huang, Zhifeng and Deng, Jingjing and Blais, Steven P and Gai, Weiming and Bhattacharya, Shibani and Neubert, Thomas A and Traaseth, Nathaniel J and Mohammadi, Moosa (2017) Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. eLife, 6. ISSN 2050-084X

Chen, Jin and Meyers, Charles and Keefe, Debbi and Yu, Jing and Sunkara, Gangadhar (2017) Clinical Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase 1 Inhibitor. Journal of Drug Design and Research.

Chen, Xin and Giraldes, John and Sprague, Elizabeth and Shakya, Subarna and Chen, Zhuoliang and Wang, Kate and Joud-Caldwell, Carol and Mathieu, Simon and Chen, Christine and Straub, Christopher and Duca, Jose and Hurov, Kristen and Yuan, Yanqiu and Shao, Wenlin and Toure, Bakary-Barry (2017) “Addition” and “Subtraction”: Selectivity Design for Type-II Maternal Embryonic Leucine Zipper Kinase Inhibitors. Journal of Medicinal Chemistry, 60. pp. 2155-2161.

Chen, Zhao (2017) Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib. European Journal of Radiology, 88. pp. 15-20. ISSN 18727727

Cheung, Sheldon T. and Miller, Michelle S. and Pacoma, Reynand and Roland, Jason and Schumacher, Andrew and Liu, Jian and Hsieh-Wilson, Linda C. (2017) Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chemical Biology, 12 (12). pp. 3126-3133. ISSN 15548937

Chiang, Derek and Villanueva, Augusto (2017) Progress towards molecular patient stratification of hepatocellular carcinoma: Lost in translation? Journal of Hepatology, 67 (5). pp. 893-895. ISSN 16000641

Cho, Young and Liu, Gang and Caferro, Thomas and Shafer, Cynthia and Manning, James and Sendzik, Martin and Shultz, Michael and Chenail, Gregg and Dooley, Julie and Farsidjani, Alireza and Chen, Jinyun and Kulathila, Raviraj and Xie, Xiaoling and Dodd, Stephanie and Gould, Ty and Liang, Guiqing and Heimbach, Tycho and Slocum, Kelly and Pu, Minying and Pagliarini, Raymond and Growney, Joseph (2017) Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Medicinal Chemistry Letters, 8 (10). pp. 1116-1121. ISSN 19485875

Clarke, Adrian and Kotoni, Dorina and Dispas, Amandine and Guillarme, Davy and Hubert, Philippe and Desfontaine, Vincent and Lebrun, Pierre (2017) Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 134. pp. 170-180.

Clottu, A and Mathias, A and Sailer, Andreas and Schluep, M and Seebach, J and Du Pasquier, R and Pot, Caroline (2017) EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. Cell Reports, 18 (1). pp. 213-224.

Cowell, Annie and LaMonte, Greeg and Abraham, Matthew and Flannery, Erika and William, Roy and Sasaki, Erica and Corey, Victoria and Lukens, Amanda and Istvan, Eva and Lee, Marcus and Franco, Virginia and Reimer, Christin and Magistrado, Pamela and Coburn-Flynn, Olivia and Sakata-Kato, Tomoyo and Bopp, Selina and Gupta, Purva and Fuchs, Olivia and Kim, Sang and Teng, Christine and Gnadig, Nina and Vanaerschot, Manu and Murithi, James and Linares, Maria and Cozar, Cristina and Gomez-Lorenzo, Maria and Prats, Sara and Arriaga, Ignacio and Wang, Lawrence and Ottilie, Sabine and Siegel, Dionicio and Tanaseichuk, Olga and Zhong, Yang and Zhou, Yingyao and Willis, Paul and Gamo, Francisco-Javier and Goldberg, Daniel and Fidock, David and Wirth, Dyann and Winzeler, Elizabeth (2017) Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics. Science.

Cox, Georgina and Sieron, Arthur and King, Andrew and De Pascale, Gianfranco and Pawlowski, Andrew and Koteva, Kalinka and Wright, Gerard (2017) A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. Cell chemical biology, 24. pp. 98-109. ISSN 2451-9456

Cramer, Christopher J and Johnson, Joshua and Kamel, Amin (2017) Prediction of Mass Spectral Response Factors from Predicted Chemometric Data for Druglike Molecules. Journal of the American Society for Mass Spectrometry, 28 (2). pp. 278-285. ISSN 1879-1123

Cruz, Leilani and Heidt, Analeah and Rowell, Emily (2017) Postdoc fellowship application for the Damon Runyon Cancer Research Fellowship entitled "Identifying novel pathways responsible for epigenetic modifications in aged regulatory T cells in the tumor microenvironment". Damon Runyon Cancer Research Fellowship.

Cruz, Leilani and Rowell, Emily and Heidt, Analeah (2017) Identification and targeting of novel pathways modifying the epigenome of aged regulatory T cells in the tumor microenvironment. Damon Runyon Cancer Research Fellowship.

Cunha, Andre and Zhang, Qin and Prentiss, Melissa and Wu, Xiaoqiu and Kainz, Vanessa and Xu, Yongyao and Vrouvlianis, Joanna and Li, Hui and Rangaswamy, Nalini and Leehy, Barrett and Mcgee, Terri and Bell, Christie and Bigelow, Chad and Kansara, Viralbhai and Huang, Qian and Wu, Henry (2017) The hierarchy of pro-inflammatory cytokines in ocular inflammation. Current eye research. pp. 1-13. ISSN 1460-2202


Dafflon, Caroline and Craig, Vanessa and Mereau, Helene and Gräsel, Julius and Schacher Engstler, Barbara and Hoffman, Gregory and Nigsch, Florian and Gaulis, Swann and Barys, Louise and Ito, Moriko and Aguadé Gorgorio, Julia and Bornhauser, Beat and Bourquin, Jean-Pierre and Proske, Amelie and Stork-Fux, Caroline and Murakami, Masato and Sellers, William and Hofmann, Francesco and Schwaller, Jürg and Tiedt, Ralph (2017) Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. Leukemia. ISSN 14765551

Dafflon, Caroline and Tiedt, Ralph and Schwaller, Jürg (2017) Targeting multiple nodes of MLL complexes to improve leukemia therapy. Oncotarget, 8 (53). pp. 90614-90615. ISSN 19492553

Dai, Chenkai and Lehar, Mohamed and Sun, Daniel and Swarthout, Lani and Carey, John and Maclachlan, Timothy and Brough, Doug and Staecker, Hinrich and Della Santina, Alexandra and Hullar, Timothy and Della Santina, Charles (2017) Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery. JARO - Journal of the Association for Research in Otolaryngology, 18 (4). pp. 601-617. ISSN 1438-7573

Dalvit, Claudio and Piotto, Martial and Vulpetti, Anna (2017) Fluorine NMR spectroscopy and computational calculations for assessing intramolecular hydrogen bond involving fluorine and for characterizing the dynamic of a fluorinated molecule. Journal of fluorine chemistry, 202. pp. 34-40. ISSN 00221139

Das, Suman and Morvan, Frederic and Jourde, Benjamin and Minetti, Giulia and Brebbia, Pascale and Toussaint, Gauthier and Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase regulates myofiber differentiation by altering histone acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 22111247

Das, Suman and Morvan, Frederic and Morozzi, Giulio and Jourde, Benjamin and Minetti, Giulia and Kahle, Peter and Rivet, Helene and Brebbia, Pascale and Toussaint, Gauthier and Glass, David and Fornaro, Mara (2017) ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation. Cell reports, 21 (11). pp. 3003-3011. ISSN 2211-1247

Daugvilaite, Viktorija and Madsen, Christian Medom and Lückmann, Michael and Echeverria, Clara Castello and Sailer, Andreas and Frimurer, Thomas Michael and Rosenkilde, Mette Marie and Benned-Jensen, Tau (2017) Biased signaling and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus -induced gene 2. British journal of pharmacology. ISSN 1476-5381; 0007-1188

Davis, John and Kagan, Mark and Read, Jessica and Walles, Markus and Hatsis, Panagiotis (2017) Immunoprecipitation LC-MS Middle-up Approach for In Vivo Drug-To-Antibody Ratio Determination for Antibody Drug Conjugates. Bioanalysis.

Decker, Rebekah (2017) Articular cartilage and joint development from embryogenesis to adulthood. Seminars in cell & developmental biology, 62. pp. 50-56. ISSN 1096-3634

Decker, Rebekah and Um, Hyo-Bin and Dyment, Nathaniel A. and Cottingham, Naiga and Usami, Yu and Enomoto-Iwamoto, Motomi and Kronenberg, Mark S. and Maye, Peter and Rowe, David W. and Koyama, Eiki and Pacifici, Maurizio (2017) Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Developmental biology, 426 (1). pp. 56-68. ISSN 00121606

Defontis, Myriam and Cote, Serge and Ledieu, David (2017) A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety. Experimental and Toxicologic Pathology. ISSN 1618-1433

Del Signore, Susanna and Roubenoff, Ronenn (2017) Physical frailty and sarcopenia (PF&S): a point of view from the industry. Aging Clinical and Experimental Research, Epub a. pp. 1-6. ISSN 17208319

Dex, Sarah and Alberton, Paolo and Willkomm, Lena and Soellradl, Thomas and Bago, Sandra and Milz, Stefan and Shakibaei, Mehdi and Ignatius, Anita and Bloch, Wilhelm and Clausen-Schaumann, Hauke and Shukunami, China and Schieker, Matthias and Docheva, Denitsa (2017) Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load. EBioMedicine, 20. pp. 240-254. ISSN 2352-3964

Dickson, Callum and Hornak, Viktor and Pearlstein, Robert and Duca, Jose (2017) Structure-kinetic relationships of passive membrane permeation from multiscale modeling. Journal of the American Chemical Society JACS., 139 (1). pp. 442-452.

Dickson, Callum and Pearlstein, Robert and Hornak, Viktor (2017) Contributions of the membrane dipole potential to the function of voltage-gated cation channels and modulation by small molecule potentiators. Biochimica et biophysica acta (BBA) - Biomembranes, 1859 (2). pp. 177-194. ISSN 00052736

Dumouchel, Jennifer and Argikar, Upendra and Spear, Jaimie and Brown, Ann and Dunne, Christine and Kramlinger, Valerie and Cirello, Amanda and Gunduz, Mithat (2017) An in vitro Investigation of Ocular Bioactivation Potential and the Role of CytochromeP450 2D Enzymes in Rat. Drug metabolism letters.. ISSN 1874-0758

Dégardin, Klara and Desponds, Anne and Roggo, Yves (2017) Protein-based medicines analysis by Raman spectroscopy for the detection of counterfeits. Forensic Science International, 278. pp. 313-325. ISSN 03790738

Dégardin, Klara and Roggo, Yves (2017) Innovative Strategy for Counterfeit Analysis. Medicine Access @ Point of Care, 1 (1). maapoc.0000013. ISSN 2399-2026

de Moura França, Leandro and Amigo, José Manuel and Cairós, Carlos and Bautista Mercader, Manuel and Fernanda Pimentel, Maria (2017) Evaluation and assessment of homogeneity in images. Part 1: Unique homogeneity percentage for binary images. Chemometrics and Intelligent Laboratory Systems, 171. pp. 26-39. ISSN 0169-7439


Ebata, Kevin T. and Mesh, Kathryn and Liu, Shichong and Bilenky, Misha and Fekete, Alexander and Acker, Michael and Hirst, Martin and Garcia, Benjamin A and Ramalho-Santos, Miguel (2017) Vitamin C Induces Specific Demethylation of H3K9me2 in Mouse Embryonic Stem Cells via Kdm3a/b. Epigenetics & chromatin, 10. p. 36. ISSN 1756-8935

Ebhardt, H. Alexander and Degen, Simone and Tadini, Valentina and Schilb, Alain and Greig, Carolyn A. and Fearon, Kenneth CH and Aebersold, Ruedi and Jacobi, Carsten (2017) Comprehensive proteome analysis of muscle composition and development in seniors. EMBO Molecular Medicine.

Eder, Joerg (2017) Opportunities and challenges in phenotypic drug discovery: An industry perspective. Nature Reviews Drug Discovery, 16 (8). pp. 531-543. ISSN 14741784

Edge, Stephen and Singh, Dilraj and Lewis, David and Rouse, Tim (2017) Defining the “Dose” for Dry Powder Inhalers: The challenge of correlating in-vitro dose delivery results with clinical efficacy. American pharmaceutical review, 20 (3). pp. 54-62.

Egger, Christine and Cannet, Catherine and Gerard Sachot, Christelle and Pierrat, Benoit and Suply, Thomas and Ksiazek, Iwona and Beckmann, Nicolau (2017) Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. European Journal of Pharmacology, 809. pp. 64-72. ISSN 18790712

Einolf, Heidi and Lin, Wen and Wang, Lai and Gu, Helen and Chun, Dung Y. and Mangold, James B. and He, Handan (2017) Physiologically-based pharmacokinetic model predictions of panobinostat (LBH589) as a victim and perpetrator of drug-drug interactions. Drug Metabolism and Disposition.

Einolf, Heidi and Zhou, Jocelyn and Won, Christina and Wang, Lai and Rebello, Sam (2017) A physiologically-based pharmacokinetic modeling approach to predict drug-drug interactions of sonidegib (LDE225) with perpetrators of CYP3A in cancer patients. Drug metabolism and disposition, 45 (4). pp. 361-374. ISSN 1521-009X

Emery, Caroline and Monaco, Kelli-Ann and Wang, Ping and Balak, Marissa and Freeman, Alyson and Meltzer, Jodi and Delach, Scott and Rakiec, Daniel and Ruddy, David and Korn, Joshua and Haling, Jake and Acker, Michael and Caponigro, Giordano (2017) BRAF-inhibitor associated MEK mutations increase RAF-dependent and -independent enzymatic activity. Molecular Cancer Research, 15 (10). pp. 1431-1444. ISSN 1557-3125

Ertl, Peter and Lewis, Richard and Martin, Eric and Polyakov, Valery (2017) In silico generation of novel, drug-like chemical matter using the LSTM neural network. arXiv / talk at CCG User Group Meeting.

Estoppey, David and Hewett, Jeffrey and Guy, Chantale and Harrington, Edmund and Thomas, Jason and Schirle, Markus and Cuttat-Theurillat, Rachel and Waldt, Annick and Gerrits, Bertran and Yang, Zinger and Schuierer, Sven and Carbone, Walter and Knehr, Judith and Lindeman, Alicia and Russ, Carsten and Frias, Elizabeth and Hoffman, Gregory and Varadarajan, Malini and Ramadan, Nadire and Reece-Hoyes, John and Wang, Qiong and Chen, Xin and Mcallister, Gregory and Roma, Guglielmo and Bouwmeester, Antonius and Hoepfner, Dominic (2017) Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Scientific reports, 7 (42728). pp. 1-6. ISSN 2045-2322

Estoppey, David and Lee, Chia Min and Janoschke, Marco and Mathys, Philippe and Filipuzzi, Ireos and Schuhmann, Tim and Riedl, Ralph and Aust, Thomas and Galuba, Olaf and Mcallister, Gregory and Russ, Carsten and Spiess, Martin and Bouwmeester, Antonius and Bonamy, Ghislain and Hoepfner, Dominic (2017) The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase. Cell Reports, 19 (3). pp. 451-460. ISSN 22111247


Fairfield, Heather and Falank, Carolyne and Harris, Elizabeth and Demambro, Victoria and McDonald, Michelle and Pettitt, Jessica A. and Mohanty, Sindhu T. and Croucher, Peter and Kramer, Ina and Kneissel, Michaela and Rosen, Clifford J. and Reagan, Michaela R. (2017) The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. Journal of cellular physiology.

Fang, Jianwu and Ying, Haiyan and Mao, Ting and Fang, Yelena and Lu, Yuan and Wang, He and Zang, Irene and Wang, Zhaofu and Lin, Ying and Zhao, Mengxi and Luo, Xiao and Wang, Zongyao and Zhang, Yan and Zhang, Chao and Wang, William and Tan, Wei and Chen, Zhui and Lu, Chris and Atadja, Peter and Li, En and Zhao, Kehao and Liu, Jianfeng and Gu, Justin (2017) Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation promotion and suppresses cell proliferation in human monocytic leukemia cells. Oncotarget. ISSN 1949-2553

Felter, S and Foreman, J and Boobis, A and Corton, C and Doi, A and Flowers, L and Goodman, J and Haber, L and Jacobs, A and Klaunig, J and Lynch, A and Moggs, Jonathan and Pandiri, A (2017) Human Relevance of Rodent Liver Tumors: Key Insights from a Toxicology Forum Workshop on Nongenotoxic Modes of Action. Regulatory toxicology and pharmacology, 92. pp. 1-7. ISSN PMID: 29113941

Fernández-de Retana1, Sofia and Montañola, Alex and Marazuela, Paula and De La Cuesta, Maialen and Batlle, Aina and Fatar, Marc and Grudzenski, Saskia and Montaner, Joan and Hernández-Guillamon, Mar (2017) Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease. Neurobiology of Aging, 60. pp. 116-128. ISSN 15581497

Ferran, Sanz and Pognan, Francois and Steger-Hartmann, Thomas and Díaz, Carlos and Montserrat, Cases and Manuel, Pastor and Marc, Philippe and Wichard, Joerg and Briggs, Katherine and Watson, David and Schwab, Christof H. and Yang, Chihae and Amberg, Alexander and Beaumont, Maria and Brookes, Anthony and Brunak, Søren and Cronin, Mark T. D. and Ecker, Gerhard F. and Escher, Sylvia and Greene, Nigel and Guzmán, Antonio and Hersey, Anne and Jacques, Pascale and Lammens, Lieve and Jordi, Mestres and Muster, Wolfgang and Northeved, Helle and Pinches, Marc and Sáiz, Javier and Sajot, Nicolas and Valencia, Alfonso and Van Der Lei, Johan and Vermeulen, Nico P. E. and Vock, Esther and Wolber, Gerhard and Zamora, Ismael (2017) Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews Drug Discovery, 16 (12). pp. 811-812. ISSN 1474-17761474-1784

Ferretti, Stephane Raymond (2017) PDX-MI: Minimal information for patient-derived tumor xenograft models. Cancer Research, 77 (21). e62-e66. ISSN 15387445

Feuerbach, Dominik and Schindler, Patrick and Barske, Carmen and Joller, Stefanie and Beng-Louka, Edwige and Worringer, Katie and Kommineni, Sravya and Kaykas, Ajamete and Ho, Daniel and Welzenbach, Karl and Elain, Gaelle and Klein, Laurent and Mir, Anis Khusro and Farady, Christopher and Nakamura, MC and Hsieh, CL and Aichholz, Reiner and Popp, Simone and George, Nathalie and Neumann, Ulf (2017) ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. Neuroscience letter.

Filipuzzi, Ireos and Thomas, Jason and Pries, Verena and Estoppey, David and Salcius, Michael and Studer, Christian and Schirle, Markus and Hoepfner, Dominic (2017) Direct interaction of Chivosazole F with actin elicits cell responses similar to Latrunculin A but distinct from Chondramide. ACS chemical biology. ISSN 1554-8929

Flarakos, Jimmy and Du, Yancy and Gu, Helen and Wang, Lai and Einolf, Heidi and Chun, Dung Yu and Zhu, Bing and Alexander, Natalya and Natrillo, Adrienne and Hanna, Imad and Ting, Lillian and Zhou, Wei and Dole, Kiran and Sun, Haiying and Kovacs, Steven and Stein, Daniel and Tanaka, Ken and Mangold, James (2017) Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline. Xenobiotica, 47 (8). pp. 682-696. ISSN 1366-5928

Forkuo, Arnold Donkor and Ansah, Charles and Pearson, David and Gertsch, Werner and Cirello, Amanda and Amaral, Adam and Spear, Jaimie and Rynn, Caroline (2017) Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats. BMC Pharmacology and Toxicology, 18 (1). ISSN 20506511

Fredenhagen, Andreas and Eggimann, Fabian and Kittelmann, Matthias and Lochmann, Thomas and Kuehnoel, Juergen (2017) Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1H-indazole (benzpyrazole). Journal of analytical science and technology., 8 (10). p. 10. ISSN 2093-3371; 2093-3134

Frederiksen, Mathias and Drewry, David and Wells, Carrow and Andrews, David and Angell, Richard and Al-Ali, Hassan and Axtman, Alison and Capuzzi, Stephen and Elkins, Jonathan and Ettmayer, Peter and Gileadi, Opher and Gray, Nathanael and Hooper, Alice and Knapp, Stefan and Laufer, Stefan and Luecking, Ulrich and Michaelides, Michael and Mueller-Knapp, Susanne and Muratov, Eugene and Denny, Aldrin and Robers, Matt and Saikatendu, Kumar and Trieber, Daniel and Zuercher, William and Willson, Timothy (2017) Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLoS ONE, 12 (8). ISSN 19326203

Frismantas, Viktoras and Dobay, Maria Pamela and Rinaldi, Anna and Kunz, Joachim and Marovca, Blerim and Horvath, Peter and Higi, Salome and Eugster, Sabrina and Delorenzi, Mauro and Cario, Gunnar and Stanulla, Martin and Kulozik, Andreas E. and Muckenthaler, Martina and Eckert, Cornelia and Radimerski, Thomas and Bornhauser, Beat C. and Bourquin, Jean-Pierre (2017) Ex vivo drug response profiling detects recurrent sensitivity patterns in drug resistant ALL. Blood. ISSN 0006-4971

Furegati, Markus and Nocito, Sandro (2017) Practial isolation of the (1R,2R)-enantiomer from a racemic cis/trans mixture of 2-methylcyclohexyl-1-amine. Organic process research & development.


Galli, Giorgio and Dirk, Schuebeler (2017) Post-doctoral position (Giorgio Galli - co-mentor Dirk Schuebeler). NIBR PostDoc website.

Gallou, Fabrice and Fu, Jiping (2017) Development of a Cyclosporin derivative and of its synthesis as cyclophilin inhibitor with excellent anti-HCV potency. Bioorganic and Medecinal Chemistry.

Gallou, Fabrice and Handa, Sachin (2017) Micelle-Enabled Sustainable Heteroleptic Palladium Catalysis for Nitroalkane Arylations in Water Under Mild Conditions. ACS Catalysis.

Gallou, Fabrice and Lipshutz, Bruce (2017) Effects of Co-solvents on Reactions Run Under Micellar Catalysis Conditions. Organic letters, 19. pp. 194-197.

Gallou, Fabrice and Lipshutz, Bruce (2017) Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature. Green Chemistry, 19. pp. 2106-2109.

Gallou, Fabrice and Lipshutz, Bruce (2017) From Milligrams to Grams. SNAr Reactions in Aqueous Nanomicelles; No Dipolar Aprotic Solvents Needed. Org. Proc. Res. Dev., 2017 (21). pp. 218-221.

Gallou, Fabrice and Lipshutz, bruce (2017) Micellar catalysis enabled ppm Au-catalyzed reactions in water at room temperature. Chemical science, 8. pp. 6354-6358. ISSN 2041-6539; 2041-6520

Gan, Xin and Wang, Haifeng and Yu, Yanyan and Yi, Wei and Zhu, Shanshan and Gu, Baohua and Lu, Chris and Li, En and Liang, Yu (2017) Epigenetically repressing human Cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases. PLoS ONE, 12 (4). ISSN 1932-6203

Gao, Jinhai and Tsao, Jeffrey and Wang, Bing and Rajan, Srinivasan (2017) Optimal Flip Angle for Quantitative NMR Using External Standards. Analytical chemistry. ISSN 1520-6882; 0003-2700

Gardin, Anne and Dodman, Angela and Kalluri, Sampath and Neelakantham, Srikanth Raju and Legangneux, Eric and Shakeri-Nejad, Kasra (2017) Pharmacokinetics, safety, and tolerability of siponimod (BAF312) in subjects with severe renal impairment: A single-dose, open-label, parallel-group study. Pharmacokinetics, safety, and tolerability of siponimod (BAF312) in subjects with severe renal impairment: A single-dose, open-label, parallel-group study.

Garito, Tania and Roubenoff, Ronenn and Zakaria, Marjorie and Rooks, Daniel and Swan, Therese and Filosa, Lee Anne and Petricoul, Olivier and Laurent, Didier and Neelakantham, Srikanth Raju and Meyers, Charles and Hompesch, Marcus and morrow, linda and gomez, katherine and buchsbaum, monte (2017) Bimagrumab improves body composition and insulin sensitivity in insulin-resistant subjects. Diabetes, obesity and metabolism. ISSN 1463-1326

Gembarska, Agnieszka and Durand, Eric and Mandon, Emeline and Estadieu, Claire and Romanet, Vincent and Wiesmann, Marion and Lehar, Joseph and Tiedt, Ralph and De Weck, Antoine and Kauffmann, Audrey and Sutter, Esther and Grevot, Armelle and Moulin, Pierre and Murakami, Masato and Sellers, William and Hofmann, Francesco and Jensen, Michael Rugaard and Chapeau, Emilie and Rad, Roland (2017) Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/-mouse model. Proceedings of the National Academy of Sciences of the United States of America, 114 (12). pp. 3151-3156. ISSN 1091-6490

Gergely, Peter (2017) Challenges and opportunities of drug research and development in rare diseases. Journal of international pharmaceutical research.

Ghosh, Joy and Nguyen, Andrew and Bigelow, Chad and Poor, Stephen and Qiu, Yubin and Rangaswamy, Nalini and Ornberg, Richard and Jackson, Brittany and Mak, Howard and Ezell, Tucker and Ashminova, Vania and De La Cruz, Elisa and Carrion, Ana and Etemad-Gilbertson, Bijan and Garcia Caro, Roxana and Zhu, Kan and George, Vinney and Bai, Jirong and Sharma, Radhika and Shen, Siyuan and Wang, Yiqin and Subramanian, Kulandayan and Fassbender, Elizabeth and Maker, Michael and Hanks, Shawn and Vrouvlianis, Joanna and Leehy, Barrett and Long, Debby and Prentiss, Melissa and Kansara, Viralbhai and Jaffee, Bruce and Dryja, Ted and Roguska, Michael (2017) Long-acting protein drugs for the treatment of ocular diseases. Nature communications, 8. pp. 1-10. ISSN 2041-1723

Giggins, Oonagh and Clay, Ieuan and Walsh, Lorcan (2017) Physical Activity Monitoring in Patients with Neurological Disorders: A Review of the Validity and Reliability of Body Worn Monitors. Digital Biomarkers.

Ginster, Stefanie and Bardet, Maureen and Unterreiner, Adeline and Malinverni, Claire and Renner, Florian and Lam, Stephen and Freuler, Felix and Gerrits, Bertran and Voshol, Johannes and Calzascia, Thomas and Regnier, Catherine and Renatus, Martin and Nikolay, Rainer and Israel, Laura and Bornancin, Frederic (2017) Two antagonistic MALT1 auto-cleavage mechanisms reveal a role for TRAF6 to unleash MALT1 activation. PLoS ONE, 12 (1). e0169026. ISSN 1932-6203

Glorieux, Francis and Devogalaer, Jean-Pierre and Durigova, Michaela and Goemaere, Stefan and Hemsley, Sarah and Junker, Uwe and Ruckle, Jon and Seefried, Lothar and Winkle, Peter (2017) BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial. Journal of Bone and Mineral Research, 32 (7). pp. 1496-1504. ISSN 15234681

Glowienke, Susanne (2017) p-Aminophenol monograph. Regul Pharm Tox.

Godinez Navarro, William Jose and Hossain, Imtiaz and Lazic, Stanley and Davies, John and Zhang, Xian (2017) A Multi-scale Convolutional Neural Network for Phenotyping High Content Cellular Images. Bioinformatics. ISSN 1367-4811; 1367-4803

Goepfert, Arnaud and Lehmann, Sylvie and Wirth, Emmanuelle and Rondeau, Jean-Michel (2017) The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. Scientific reports, 7. p. 8906. ISSN 2045-2322

Gotwals, Philip and Cameron, Scott and Cipolletta, Daniela and Cremasco, Viviana and Crystal, Adam and Hewes, Becker and Mueller, Britta and Petruzzelli, Lilli and Quaratino, Sonia and Sabatos-Peyton, Catherine and Dranoff, Glenn (2017) Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nature Reviews Cancer, 17 (5). pp. 286-301. ISSN 1474-1768

Goyal, Lipika and Supriya, Saha K and Liu, Lea Y and Siravegna, Giulia and Leshchiner, Ignaty and Ahronian, Leanne G and Lennerz, Jochen K and Vu, Phuong and Deshpande, Vikram and Kambadakone, Avinash and Mussolin, Benedetta and Reyes, Stephanie and Henderson, Laura and Sun, Jiaoyuan Elisabeth and Van Seventer, Emily E and Gurski, Joseph M Jr and Baltschukat, Sabrina and Schacher Engstler, Barbara and Barys, Louise and Furet, Pascal and Ryan, David P and Stone, James R and Iafrate, John A and Getz, Gad and Graus Porta, Diana and Tiedt, Ralph and Bardelli, Alberto and Juric, Dejan and Corcoran, Ryan B and Bardeesy, Nabeel and Zhu, Andrew X (2017) Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in FGFR2 fusion-positive cholangiocarcinoma patients. Cancer discovery. ISSN 2159-8290; 2159-8274

Groth, K and Berezhanskyy, T and Aneja, MK and Geiger, J and Schweizer, M and Maucksch, L and Pasewald, T and Brill, T and Tigani, Bruno and Weber, Eckhard and Rudolph, C and Hasenpusch, G (2017) Tendon healing induced by chemically modified mRNAs. European cells and materials, 33. pp. 294-307. ISSN 1473-2262

Grunewald, Jan and Jin, Yunho and Vance, Julie and Read, Jessica and Wang, William and Wan, Yongqin and Zhou, Huanfang and Ou, Weijia and Klock, Heath and Peters, Eric and Uno, Tetsuo and Brock, Ansgar and Geierstanger, Bernhard (2017) Optimization of an Enzymatic Antibody Drug Conjugation Ap-proach based on CoA Analogs. Bioconjugate chemistry. ISSN 1520-4812; 1043-1802

Gu, Helen and Dutreix, Catherine and Rebello, Sam and Ouatas, Taoufik and Wang, Lai and Chun, Dung Yu and Einolf, Heidi and He, Handan (2017) Simultaneous physiologically-based pharmacokinetic (PBPK) modeling of parent and active metabolites to investigate complex CYP3A4 drug-drug interaction potential: a case example of midostaurin. Drug metabolism and disposition.

Gubler, Hanspeter and Clare, Nicholas and Galafassi, Laurent and Girod, Michel and Herr, Guy and Geissler, Uwe (2017) Helios - History and Anatomy of a successful in-House Enterprise High-Throughput Screening and Profiling Data Analysis System. SLAS Discovery, 23 (5). pp. 474-488. ISSN 2472-5552

Guendisch, Ulf and Weiss, Jessica and Ecoeur, Florence and Riker, Julia and Kaupmann, Klemens and Kallen, Joerg and Hintermann, Samuel and Orain, David and Dawson King, Janet and Billich, Andreas and Guntermann, Christine (2017) Pharmacological inhibition of ROR gamma t suppresses the Th17 pathway and alleviates antigen-induced arthritis in-vivo. PLoS ONE, 12 (PLoS O). pp. 1-25. ISSN 1932-6203

Guntermann, Christine and Piaia, Alessandro and Hamel, Marie-Laure and Theil, Diethilde and Rubic-Schneider, Tina and Del Rio Espinola, Alberto and Dong, Linda and Billich, Andreas and Kaupmann, Klemens and Dawson King, Janet and Hoegenauer, Klemens and Orain, David and Hintermann, Samuel and Stringer, Rowan and Patel, Dhavalkumar and Doelemeyer, Arno and Deurinck, Mark and Schuemann, Jens (2017) Retinoic-acid-orphan-receptor C inhibition suppresses Th17 cells and induces thymic aberrations. The Journal of Clinical Investigation Insight (JCI Insight).

Guo, Hongqiu and Yeboah, Fred and Camargo, L. Miguel and Digan, Mary Ellen and Niu, Honglin and Pan, Yue and Reiling, Stephan and Soler-Llavina, Gil and Wang, Hao-Ran and Shanker, Gopi and Stams, Travis and Bill, Anke and Weihofen, Wilhelm (2017) A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine. Nature methods, 7 (1). p. 11608.

Gusev, Arkady and Wang, Tianke (2017) Ensuring quality and compliance in outsourcing of bioanalysis of clinical biomarkers. Bioanalysis, 9 (7). pp. 501-504. ISSN 1757-6199

Gutierrez, Marcelo and Spector, Jonathan and Felix, Sandra Daniela and Romero, Fernando and Pillai, Goonaseelan and Onyango, Kevin and Owusu-Agyei, Seth and Asante, Kwaku-Poku and Barnes, Karen and Allen, Elizabeth and Sinxadi, Phumla and Abdulla, Salim and Masimirembwa, Collen and Munyoro, Michelle and Yimer, Getnet and Gebre-Mariam, Tsige and Ogutu, Bernhards (2017) *Building capability for clinical pharmacology research in sub-Saharan Africa*. Clinical pharmacology and therapeutics. ISSN 1532-6535; 0009-9236


Haasen, Dorothea and Schopfer, Ulrich and Antczak, Christophe and Guy, Chantale and Fuchs, Florian and Selzer, Paul (2017) How phenotypic screening influenced drug discovery – lessons from 5 years practice. Assay and drug development technologies, 15 (6). pp. 239-246.

Hafner, Andreas and Mancino, Valentina and Meisenbach, Mark and Schenkel, Berthold and Sedelmeier, Joerg Mathias (2017) Dichloromethyl lithium: A valuable reagent in organic synthesis handled in continuous flow mode. Dichloromethyl lithium: A valuable reagent in organic synthesis handled in continuous flow mode.

Hamze, Moustafa and Meunier, Sylvain and Karle, Anette and Gdoura, Abdelaziz and Goudet, Amelie and Szely, Natacha and Pallardy, Marc and Carbonnel, Franck and Spindeldreher, Sebastian and Mariette, Xavier and Miceli-Richard, Corinne and Maillere, Bernard (2017) Characterization of CD4 T cell epitopes of infliximab and rituximab identified from healthy donors. Frontiers in immunology, 8 (MAY). pp. 1-11. ISSN 1664-3224

Han, Yi and Ayalasomayajula, Surya and Yang, Fan and Yuan, Yaozong and Langenickel, Thomas Heiko and Hinder, Markus and Kalluri, Sampath and Pal, Parasar and Sunkara, Gangadhar (2017) Pharmacokinetics, Safety and Tolerability of Sacubitril/Valsartan (LCZ696) After Single-Dose Administration in Healthy Chinese Subjects. European Journal of Drug Metabolism and Pharmacokinetics, 42 (1). pp. 109-116. ISSN 2107-0180

Hart, Lori and Rader, JulieAnn and Raman, Pichai and Batra, Vandana and Tsang, Matthew and Gagliardi, Maria and Martinez, Daniel and Wood, Andrew and Kim, Sunkyu and Parasuraman, Sudha and Delach, Scott and Cole, Kristina and Shiva, Krupa and Caponigro, Giordano and Peters, Malte and Boehm, Markus and Maris, John (2017) Preclinical therapeutic synergy of MEK1/2 and CDK4/6 inhibition in neuroblastoma. Clinical Cancer Research, 23 (7). pp. 1785-1796. ISSN 1557-3265

Hatsis, Panagiotis and Waters, Nigel and Argikar, Upendra (2017) Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards. Drug Metabolism and Disposition.

Hayes, Lilian, M. and Press, Neil and Tocher, Derek, A. and Carmalt, Claire, J. (2017) Intermolecular interactions between encapsulated aromatic compounds and the host framework of a Crystalline Sponge. Crystal Growth & Design, 17 (2). pp. 858-863. ISSN 1528-74831528-7505

He, Handan and Tran, Phi and Gu, Helen and Tedesco, Vivienne and Zhang, Jin and Lin, Wen and Gatlik, Ewa and Klein, Kai and Heimbach, Tycho (2017) Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug. Drug metabolism and disposition: the biological fate of chemicals, 45 (5). pp. 540-555. ISSN 1521-009X

He, Xiaohui and DaRos, Sara and Zhu, Xuefeng and Nelson, John and Michellys, Pierre and Iskandar, Maya and Espinola, Sheryll and Bursulaya, Badry and Gao, Mu-Yun and Kreusch, Andreas and Baaten, Janine and Clemmer, Leah and Meeusen, Shelly and Huang, David and Hill, Robert and Nguyen-Tran, Van and Fathman, John and Liu, Bo and Tuntland, Tove and Ng, Kenneth and Shi, Jian and Bordone, Laura and Liu, Hong (2017) Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Helliwell, Stephen and Filipuzzi, Ireos and Steffen, Janos and Koehler, Carla (2017) Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Nature Chemical Biology. ISSN 1552-44501552-4469

Hoegenauer, Klemens and Soldermann, Nicolas and Zecri, Frederic and Strang, Ross and Graveleau, Nadege and Wolf, Romain and Cooke, Nigel Graham and Smith, Alexander Baxter and Hollingworth, Greg and Blanz, Joachim and Gutmann, Sascha and Rummel, Gabriele and Littlewood-Evans, Amanda and Burkhart, Christoph (2017) Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Medicinal Chemistry Letters, 8 (9). pp. 975-980. ISSN 19485875

Hoffmann, Peter (2017) An Evaluation of the Drug-induced Changes in Cardiac Inotropy (LVdP/dt40 and QA Interval) and Lusitropy (LVdP/dtmin and Tau) in Dogs: Results from a HESI-sponsored consortium. An Evaluation of the Drug-induced Changes in Cardiac Inotropy (LVdP/dt40 and QA Interval) and Lusitropy (LVdP/dtmin and Tau) in Dogs: Results from a HESI-sponsored consortium, Journa (85). pp. 1-21.

Holzer, Philipp (2017) Discovery of potent and selective p53-MDM2 protein-protein interaction inhibitors as anticancer drugs. Chimia : international journal for chemistry, 71 (10). pp. 716-721. ISSN 0009-4293

Horman, Shane and To, Jeremy and Lamb, John and Zoll, Jocelyn and Leonetti, Nicole and Tu, Buu and Moran, Rita and Newlin, Robbin and Walker, John and Orth, Anthony (2017) Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets. Oncotarget, 8 (59). pp. 99913-99930. ISSN 19492553

Hu, Tiancen and Sprague, Elizabeth and Fodor, Michelle and Stams, Travis and Clark, Kirk and Jacob, Sandra (2017) The impact of structural biology in medicine illustrated with four case studies. Journal of Molecular Medicine. pp. 1-11. ISSN 14321440

Huang, Ying and Zhang, Jeff and Yu, Zhengtian and Wang, Youzhen and Lingel, Andreas and Qi, Vicky and Gu, Justin and Zhao, Kehao and Wang, Long and Fu, Xingnian and Sun, Yongfeng and Jiang, Xiangqing and Zhang, Jiangwei and Zhang, Chunye and Li, Ling and Liu, Yueqin and Zhang, Maya and Zhang, Lijun and Zhao, Mengxi and Fang, Douglas and Shultz, Michael and Mi, Yuan and Gao, Zhenting and Oyang, Counde and Zhang , Hailong and Liu , Xianghui and Zhang, Qiong and Zhang, Chao and Gou, Haibing and Dillon, Michael and Atadja, Peter and Zeng, Jue (2017) Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. Journal of Medicinal Chemistry, 60 (6). pp. 2215-2226. ISSN 1520-4804


Ian, Harrow and Ernesto, Jimenez-Ruiz and Splendiani, Andrea and Martin, Romacker and Peter, Wollard and Scott, Markel and Yasmin, Alam-Faruque and Martin, Koch and James, Malone and Arild, Waaler (2017) Matching Disease and Phenotype Ontologies in the Ontology Alignment Evaluation Initiative. Journal of biomedical semantics, 8 (1). p. 55. ISSN 2041-1480


Jacob, Jaison and Ngo, Debby and Finkel, Nancy and Pitts, Rebecca and Gleim, Scott and Farrell, Laurie and Keyes, Michelle and Benson, Mark and Morgan, Thomas and Jennings, Lori and Gerszten, Robert (2017) Application of Large Scale Aptamer-Based Proteomic Profiling to "Planned" Myocardial Infarctions. Circulation. ISSN 1524-4539; 0009-7322

Jain, Jay Prakash and Leong, Franz Joel Wen and Chen, Lanna and Kalluri, Sampath and Koradia, Vishal and Stein, Daniel and Wolf, Marie-Christine and Sunkara, Gangadhar and Kota, Jagannath (2017) Bioavailability of lumefantrine is significantly enhanced with a novel formulation approach, an outcome from a randomized, Open-label pharmacokinetic study in healthy volunteers. Antimicrobial Agents and Chemotherapy, 61 (9). ISSN 1098-6596

James, Alexander David and Marvalin, Cyrille and Luneau, Alexandre and Meissner, Axel and Camenisch, Gian P. (2017) Comparison of 19F-NMR and 14C measurements for the assessment of ADME of BYL719 (Alpelisib) in humans. Drug metabolism and disposition, 45. pp. 900-907. ISSN 1521-009X

Jansen, Hanneke and Wartchow, Charles and Jahnke, Wolfgang and Fong, Susan and Tsang, Tiffany and Pfister, Keith and Zavorotinskaya, Tatiana and Bussiere, Dirksen and Cheng, Jan Marie and Crawford, Kenneth and Dai, Yumin and Dove, Jeffrey and Fang, Eric and Feng, Yun and Florent, Jean-Michel and Fuller, John and Gossert, Alvar and Hekmat-Nejad, Mohammad and Henry, Christelle and Klopp, Julia and Lenahan, William and Meyer, Arndt and Mishina, Yuji and Narberes, Jamie and Pardee, Gwynn and Ramurthy, Savithri and Rieffel, Sebastien and Stuart, Darrin and Subramanian, Sharadha and Tandeske, Laura and Widger, Stephania and Widmer, Armin and Winterhalter, Aurelie and Zaror, Isabel and Hardy, Stephen and Lingel, Andreas and Ma, Sylvia (2017) Inhibition of Prenylated KRAS in a Lipid Environment. PLoS ONE, 12 (4). ISSN 1932-6203

Jelsch, Morgane and Grandeury, Arnaud (2017) Crystal Morphology Prediction of active pharmaceutical ingredients. Internship - report for school.

Jenkins, Jeremy and Sigoillot, Frederic and Chen, Amy and Cong, Feng (2017) Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results. Cell Systems, 4 (2). 182-193.e4. ISSN 24054720

Ji, Lei and Jiang, Xiaomo and Kheifets, Olga and Chen, Amy and Mickanin, Craig and Bauer, Andreas and Cong, Feng and Jiang, Bo and Xu, wenqing and Yan, Xiaoxue (2017) The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation. Genes and Development, 31 (9). pp. 904-915. ISSN 1549-5477

Jia, Haoruo and Ma, Xiaoyuan and Tong, Wei and Wei, Yulong and Tower, Robert and Chandra, Abhishek and Wang, Luqiang and Sun, Zeyang and Yang, Zhaochun and Badar, Farid and Zhang, Kairui and Tseng, Wei-ju and Kramer, Ina and Kneissel, Michaela and Xia, Yang and Liu, X. Sherry and Wang, James H-C. and Han, Lin and Enomoto-Iwamoto, Motomi and Qin, Ling (2017) Subchondral bone plate sclerosis during late osteoarthritis is caused by loading-induced reduction in Sclerostin. Arthritis and rheumatology.

Johannes, Jeffrey W. and Bates, Stephanie and Beigie, Carl and Belmonte, Matt and Breen, John and Cao, Shenggen and Centrella, Paolo A. and Clark, Matthew A. and Cuozzo, John W. and Dumelin, Christoph and Ferguson, Andrew and Habeshian, Sevan and Hargreaves, David and Joubran, Camil and Kazmirski, Steven and Keefe, Anthony D. and Lamb, Michelle and Lan, Haiye and Li, Yunxia and Ma, Hao and Mlynarski, Scott and Packer, Martin J. and Rawlins, Philip and Robbins, Daniel W. and Shen, Haidong and Sigel, Eric A. and Soutter, Holly H. and Su, Nancy and Troast, Dawn M. and Wang, Haiyun and Wickson, Kate F. and Wu, Chengyan and Zhang, Ying and Hird, Alex (2017) Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

Johnson, Christopher N. and Erlanson, Daniel A. and Jahnke, Wolfgang and Rees, David C. and Mortenson, Paul N. (2017) Fragment-to-Lead Medicinal Chemistry Publications in 2016. Journal of Medicinal Chemistry. ISSN 15204804

Jones, Adriana and Woods, Angela and Takeoka, Ken and Shen, Xiaoyu and Wei, Jun-Rong and Caughlan, Ruth and Dean, Charles (2017) Determinants of antibacterial spectrum and resistance potential of the elongation factor G inhibitor argyrin B in key Gram negative pathogens. Antimicrobial agents and chemotherapy, 61 (4). ISSN 1098-6596

javle, milind and lowery, maeve and shroff, Rachna and weiss, karl heinz and springfield, Christoph and borad, mitesh and ramanathan, ramesh and goyal, lipika and sadeghi, saeed and maraculla, teresa and el-khoueiry, anthony and kelley, robin kate and borbath, ivan and choo, su pin and oh, Do-Youn and philip, a.philip and chen, li-tzong and reungwetwattana, thanyanan and van cutsem, eric and yeh, kun-huei and ciombor, kristen and zhu, andrew x and abou-alfa, ghassan k and bekaii-saab, tanios and finn, michael (2017) Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma. Journal of clinical oncology. ISSN 1527-7755; 0732-183X


Kaesler, Nadine and Verhulst, Anja and De Maré, Annelies and Deck, Annika and Behets, Geert J. and Hyusein, Ayshe and Evenepoel, Pieter and Floege, Jürgen and Marx, Nikolaus and Babler, Anne and Kramer, Ina and Kneissel, Michaela and Kramann, Rafael and Weis, Daniel and D`Haese, Patrick C. and Brandenburg, Vincent M. (2017) Sclerostin deficiency modifies the development of CKD-MBD in mice. Bone. ISSN 1873-2763; 8756-3282

Kalkman, HO and Feuerbach, Dominik (2017) Microglia M2A-polarization as potential link between food allergy and autism spectrum disorders. Pharmaceuticals, 10 (95). ISSN 1424-8247

Kallen, Joerg and Izaac, Aude and Be, Celine and Arista, Luca and Orain, David and Kaupmann, Klemens and Guntermann, Christine and Hoegenauer, Klemens and Hintermann, Samuel (2017) Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. ChemMedChem, 12 (13). pp. 1014-1021. ISSN 18607187

Kammertoens, Thomas and Friese, Christian and Arina, Ainhoa and Idel , Christian and Briesemeister, Dana and Rothe, Michael and Sommermeyer, Daniel and Engels, Boris and Leisegang, Matthias and Fehling, Hans J and Fruttiger, Marcus and Herrmann, Andreas and Yu, Hua and Weichselbaum, Ralph and Uckert, Wolfgang and Schreiber, Hans and Blankenstein, Thomas (2017) Tumour ischaemia by interferon-γ resembles physiological blood vessel regression. Nature, 545 (7652). pp. 98-102. ISSN 14764687

Kammueller, Michael and Tsai, Tsen-Fang and Griffiths, Christopher EM and Kapoor, Nidhi and Kolattukudy, Pappachan E and Brees, Dominique and Chibout, Salah-Dine and Safi Jr., Jorge and Fox, Todd (2017) Inhibition of IL-17A by secukinumab shows no evidence of increased Mycobacterium tuberculosis infections. Clinical and translational immunology, 6 (8). e152. ISSN 2050-0068

Kawamori, Dan and Shirakawa, Jun and Wee Liew , Chong and Hu, Jiang and Morioka, Tomoaki and Duttaroy, Alokesh and Burkey, Bryan and Kulkarni , Rohit (2017) GLP-1 signaling compensates for impaired insulin signaling regulating beta cell proliferation. GLP-1 signaling compensates for impaired insulin signaling regulating beta cell proliferation.

Keating, Alison and Soto, Jessica and Tuleu, Catherine and Forbes, Claire and Zhao, Min and Craig, Duncan Q.M. (2017) Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration. International journal of pharmaceutics. ISSN 03785173

Keller, Patrick and Yi, Boram (2017) NIBR Case Study for Contextual Inquiry. User Experience for Life Science (website).

Keskin, Aylin and Kekus, Maja and Adelsberger, Helmuth and Neumann, Ulf and Shimshek, Derya and Song, Beomjong and Peng, Tingying and Förstl, Hans and Staufenbiel, Matthias and Nelken, Isreal and Konnerth, Arthur and Busche, Marc Aurel (2017) BACE inhibition-dependent repair of Alzheimer´s pathophysiology. Proceedings of the National Academy of Sciences, 114 (32). pp. 8631-8636. ISSN 0027-84241091-6490

Kittelmann, Matthias and Schroer, Kirsten and Grumaz, Christian and Vainshtein, Yevhen and Kirstahler, Philipp and Girhard, Marco and Hilberath, Thomas and Worsch, Anne and Urlacher, Vlada and Czaja, Rico and Vogel, Andreas and Luetz, Stephan and Sohn, Kai and Sandberg, Marcel (2017) Draft genome sequences of three Actinobacteria strains presenting new candidate organisms with high potentials for specific P450 cytochromes. Genome announcements. ISSN 10.1128/genomeA.00532-17

Knoepfel, Thomas and Leblanc, Catherine and Buschmann, Nicole and Gaul, Christoph and Blank, Jutta and Galuba, Inga and Trappe, Joerg and Zou, Chao and Voshol, Johannes and Genick, Christine and Lefeuvre, Peggy and Bitsch, Francis and Graus Porta, Diana and Furet, Pascal (2017) Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region. MedChemComm, 8 (8). pp. 1604-1613. ISSN 20402511

Koch, Guido (2017) Editorial Chimia special issue on Medicinal Chemistry. Chimia. (10). p. 843. ISSN 0009-4293

Kolbinger, Frank and Loesche, Christian and Valentin, Marie-Anne and Jiang, Xiaoyu and Cheng, Yi and Jarvis, Philip and Peters, Thomas and Calonder, Claudio and Bruin, Gerardus and Polus, Florine and Patel, Dhavalkumar (2017) β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis. Journal of Allergy and Clinical Immunology, 139 (3). 923-932.e8. ISSN 1097-6825

Koneti, Rao V and Webster, Sharon and Dalm , Virgil ASH and Sediva, Anna and van Hagen, Martin P and Holland, Steven and Rosenzweig, Sergio D and Christ, Andreas Dominik and Sloth, Birgitte and Cabanski, Maciej and Joshi, Aniket and De Buck, Stefan and Doucet, Julie and Guerini, Danilo and Kalis, Christoph and Pylvaenaeinen, Ilona and Soldermann, Nicolas and Kashyap, Anuj and Uzel , Gulbu and Leonardo, Michael J and Patel, Dhavalkumar and Lucas, Carrie L and Burkhart, Christoph (2017) Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine : NEJM. ISSN 0028-4793; 1533-4406

Kounde, Cyrille Stephane and Yeo, Hui Quan and Wang, Qingyin and Wan, Kah Fei and Dong, Hongping and Karuna, Ratnaningrum and Dix, Ina and Wagner, Beatrix and Zou, Bin and Simon, Oliver and Bonamy, Ghislain M. C. and Yeung, Bryan King Sing and Yokokawa, Fumiaki (2017) Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit. Bioorganic and Medicinal Chemistry Letters, 27 (6). pp. 1385-1389. ISSN 1464-3405


Lanshoeft, Christian and Cianférani, Sarah and Heudi, Olivier (2017) Generic Hybrid Ligand Binding Assay Liquid Chromatography High-Resolution Mass Spectrometry-Based Workflow for Multiplexed Human Immunoglobulin G1 Quantification at the Intact Protein Level: Application to Preclinical Pharmacokinetic Studies. Analytical Chemistry.

Lapadula, Daniel and DeGeorge, JJ and Keller, DA and Andrews, P and Prescott, JS and Bogdanffy, MS and Mahoney, NM and Baker, R and Fields, FO and Paul, D and Platz, S and Reese, D and Stoch, A (2017) Evaluation of Therapeutics for Advanced-Stage Heart Failure and Other Severely-Debilitating or Life-Threatening Diseases. Clinical Pharmacology and Therapeutics, 102 (2). pp. 219-227. ISSN 15326535

Larochelle, Jonathan R. and Ellegast, Jana M. and Fodor, Michelle and Liu, Xiaoxi and Vemulalpalli, Vidyasiri and Mohseni, Mori and Stams, Travis and Lamarche, Matthew and Buhrlage, Sara J. and Acker, Michael and Stegmaier, Kimberly and Blacklow, Stephen C. (2017) Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorganic and Medicinal Chemistry, 25 (24). pp. 6479-6485. ISSN 14643391

Leeds, Jennifer (2017) Lasker Foundation Newsletter. Lasker Foundation Newsletter.

Leeds, Jennifer and Nordmann, Patrice and Burnham, Carey-Ann and Patel, Jean and O'Grady, Justin (2017) Viewpoint: Diagnosing antimicrobial resistance. Nature Reviews Microbiology, 15 (11). pp. 697-703. ISSN 1740-15261740-1534

Leupin, Olivier (2017) Minimal mechanical loading protects tendon explants from the acquisition of tendinopathic features. Journal of orthopaedic research. ISSN 07360266

Li, Ling and Feng, Lijian and Shi, Minlong and Zeng, Jue and Chen, Jason and Zhong, Li and Huang, Li and Guo, Weihui and Huang, Ying and Qi, Vicky and Lu, Chris and Li, En and Zhao, Kehao and Gu, Justin (2017) Split luciferase-based biosensors for characterizing EED binders. Analytical Biochemistry, 522. pp. 37-45. ISSN 10960309

Li, Wenkui and Gong, Jiawei and Wang, Chuan and Lin, John and Flarakos, Jimmy (2017) ICP-MS determination of total serum aluminum in monkeys following subcutaneous administration of a drug candidate formulated with Alhydrogel. Bioanalysis, 9 (23). pp. 1873-1881. ISSN 1757-6180

Li, Xin and Xie, Chengzhi and Li, Xiyan and Yang, Jian and Yu, Tao and Zhang, Ruohan and Zhang, Tianqing and Saxena, Deepak and Snyder, Michael and Wu, Yingjie and Li, Xin (2017) Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nature communications, 8. p. 15621. ISSN 2041-1723

Liao, Sha-Mei and Zheng, Wei and Lewis, Casey and Delgado, Omar and Crowley, Maura and Buchanan, Natasha and Jaffee, Bruce and Dryja, Ted and Zhu, Jiang (2017) Specific correlation between the chromosome 10q26 haplotype conferring high risk for age-related macular degeneration and the expression of HTRA1 in human tissues. Molecular vision :, 23. pp. 318-333. ISSN 1090-0535

Lima, Fabio and Sharma, Upendra and Grunenberg, Lars and Saha, Debasmita and Johannsen, Sandra and Sedelmeier, Joerg Mathias and Van der Eycken, Erik and Ley, Steven (2017) A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters. Angewandte Chemie. International edition.

Lin, Wen and Flarakos, Jimmy and Du, Yancy and He, Handan and Mangold, James (2017) Pharmacokinetics, Distribution, Metabolism and Excretion of Omadacycline Following a Single Intravenous or Oral Dose of 14C-omadacycline in Rats. Antimicrobial Agents and Chemotherapy, 61 (1). NA-NA. ISSN 0066-4804

Lin, Wen and Ji, Tao and Ayalasomayajula, Surya and Hanna, Imad and Heimbach, Tycho and Jarugula, Venkateswar and He, Handan and Lin, Tsu-Han and Breen, Chris (2017) Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model. Journal of Pharmaceutical Science, 105 (5). pp. 1439-1451.

Lindner, Robert and Hartmann, Elisabeth and Tarnawski, Miroslaw and Winkler, Andreas and Lenherr-Frey, Daniel and Reinstein, Jochen and Meinhart, Anton and Schlichting, Ilme (2017) Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase. Journal of Molecular Biology, 429 (9). pp. 1336-1351. ISSN 00222836

Lingel, Andreas and Bussiere, Dirksen and Cantwell, John and Dillon, Michael and Fu, Xingnian and Fuller, John and Gu, Justin and Huang, Ying and Jiang, Xiangqing and Li, Ling and Liang, Fang and Lindvall, Mika and Mckenna, Maureen and Qi, Vicky and Rao, Weijun and Sendzik, Martin and Sheng, Xijun and Shu, Wei and Shultz, Michael and Taft, Benjamin and Wang, Long and Zeng, Jue and Zhang, Maya and Zhang, Hailong and Zhao, Kehao and Gabriel, Tobias (2017) Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Methyltransferase PRC2. Jounal of Medicinal Chemistry.

Little, David G. and Peacock , Lauren and Mikulec , Kathy and Cheng , Tegan L and Schindeler , Aaron and Munns , Craig and Kneissel, Michaela and Kramer, Ina (2017) Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101. pp. 96-103. ISSN 8756-3282

Liu, Kevin and Flick, Andrew C and Ding, Hong X and Leverett, Carolyn A and Kyne, Robert E K and Fink, Sarah J and O'Donnell, Christopher J (2017) Synthetic Approaches to the New Drugs Approved during 2015. Journal of Medicinal Chemistry, 60 (15). pp. 6480-6515. ISSN 1520-4804

Liu, Yahu (2017) Palladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides. Organic Letters. ISSN 1523-70601523-7052

Longo, Francesco and Mercatelli, Daniela and Salvatore, Novello and Ludovico, Arcuri and Alberto, Brugnoli and Fabrizio, Vincenzi and Isabella, Russo and Giulia, Berti and Omar, Mabrouk and Robert, Kennedy and Shimshek, Derya and Varani, Katia and Luigi, Bubacco and Elisa, Greggio and Michele, Morari (2017) Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta neuropathologica communications., 5. p. 22. ISSN 2051-5960

Lopez-Picon, F.R. and Snellaman, A and Eskola, O and Helin, S and Trigg, W and Solin, O and Haaparanta-Solin, M and Rinne, J.O. (2017) Neuroinflammation appears early and then plateaus in a mouse model of Alzheimer´s disease shown by PET imaging. Journal of Nuclear Medicine (Oct 06). ISSN 0161-55052159-662X

Lorthiois, Edwige and Anderson, Karen and Vulpetti, Anna and Rogel, Olivier and Cumin, Frederic and Ostermann, Nils and Mac Sweeney, Aengus and Delgado, Omar and Liao, Sha-Mei and Randl, Stefan and Ruedisser, Simon and De Erkenez, Andrea and Yang, Louis and Hartwieg, Constanze and Argikar, Upendra and Newton, Ronald and Kansara, Viralbhai and Flohr, Stefanie and Hommel, Ulrich and Jaffee, Bruce and Maibaum, Juergen Klaus (2017) Discovery of highly potent and selective small-molecule reversible Factor D inhibitors demonstrating alternative complement pathway inhibition in vivo. Journal of medicinal chemistry.

Lovelle, Lucie (2017) Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides. European journal of organic chemistry. pp. 3222-3228. ISSN 1099-0690; 1434-193X

Lovelle, Lucie and Gallou, Fabrice and Jordine, Guido and Mirabilis consortium, over 30 companies (2017) A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies. Regulatory Toxicology and Pharmacology, 90. pp. 22-28. ISSN 10960295

Lozac'H, Frederic and Fahrni, Simon and De Maria, Daniele and Welte, Caroline and Synal, Hans-Arno and Pearson, David and Walles, Markus and Camenisch, Gian P. (2017) Evaluation of combustion AMS “MICADAS” for ADME studies. Bioanalysis (bio-20). ISSN ISSN 1757-6180

Lu, Chunliang and Dong, Minyu and Zhu, Hugh (2017) Regioselective Bromination of Thieno[2′,3′:4,5]pyrrolo[1,2‑d][1,2,4]triazin-8(7H)‑one and Sequential Suzuki Couplings. The Journal of Organic Chemistry. ISSN 0022-32631520-6904

Lu, Yipin and Knapp, Mark and Yan, Kelly and Warne, Robert and Crawford, Kenneth and Elling, Robert and Pan, Yue and Michael, Doyle and Sim, Janet and Albert, Lai and Paul, Barsanti and Bussiere, Dirksen and Pardee, Gwynn and Li, Zhang and Ma, Sylvia and Jansen, Hanneke and Zaror, Isabel (2017) Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. Journal of Molecular Biology, 429 (11). pp. 1684-1704. ISSN 10898638

Lucas, Andrew T. and Herity, Leah B. and Kornblum, Zack A. and Madden, Andrew J. and Gabizon, Alberto and Kabanov, Alexander V. and Ajamie, Rose T. and Bender, David M. and Kulanthaivel, Palaniappan and Sanchez-Felix, Manuel V. and Havel, Henry A. and Zamboni, William C. (2017) Pharmacokinetic and screening studies of the interaction between mononuclear phagocyte system and nanoparticle formulations and colloid forming drugs. International Journal of Pharmaceutics, 526 (1-2). pp. 443-454. ISSN 03785173

Ludwig, Marie-Gabrielle and Seuwen, Klaus and Vidal, Solange (2017) Peptide Activation of Epithelial Adgrf5 (Gpr116) Regulates Pulmonary Alveolar Homeostasis. JCI Insight.

Lyons, Russ (2017) Community Exploration & Learning Lab Overview. NIBR Internet.

López-Massaguer, Oriol and Pinto-Gil, Kevin and Sanz, Ferran and Amberg, Alexander and Anger, Lennart and Stolte, Manuela and Ravagli, Carlo and Marc, Philippe and Pastor, Manuel (2017) Generating modelling data from repeat-dose toxicity reports. Toxicological Sciences. ISSN 1096-60801096-0929


Ma, Xiaolei and Xie, Lili and Wartchow, Charles and Warne, Robert and Rivkin, Alexey and Tully, David and Shia, Steven and Uehara, Kyoko and Muiru, Gladys and Zhong, Weidong and Zaror, Isabel and Bussiere, Dirksen and Leonard, Vincent and Baldwin, Dianna (2017) Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit. Scientific reports.

Macia, Maxence and Halbritter, Jan and Delous, Marion and Bredrup, Cecilie and Gutter, Arthur and Filhol, Emilie and Christensen Mellgren, Anne Elisabeth and Leh, Sabine and Braun, Daniela A and Gee, Heon Y and Legendre, Flora and Krug, Pauline and Bole-Feysot, Christine and Nitschke, Patrick and Joly, Dominique and Nicoud, Philippe and Paget, Andre and Haugland, Heidi and Brackmann, Damien and Ahmet, Nayir and Sandford, Richard and Cengiz, Nurcan and Knappskog, Per Morten and Boman, Helge and Linghu, Bolan and Yang, Fan and Oakeley, Edward James and Saint-Mezard, Pierre and Sailer, Andreas and Johansson, Stefan and Rodahl, Eyvind and Saunier, Sophie and Hildebrandt, Friedhelm and Benmerah, Alexandre (2017) Mutations in MAPKBP1 cause late onset cilia-independent nephronophthisis. American Journal of Human Genetics.

Maciejewski, Mateusz and Lounkine, Eugen and Whitebread, Steven and Chen, Shanni and Shoichet, Brian and Urban, Laszlo and DuMouchel, William (2017) Reverse translation of adverse event reports paves the way for derisking preclinical off-targets. eLife.

Manjunatha, Ujjini Havaldar and Diagana, Thierry Tidiane and Vinayak, Sumiti and Zambriski, Jennifer and Striepen, Boris and Chao, Alexander and Noble, Christian Guy and Bonamy, Ghislain and Kondreddi, Ravinder Reddy and Zou, Bin and Gedeck, Peter and Lakshminarayana, Suresh Bangalore and Lim, Siau Hoi and Yeung, Bryan King Sing and Bodenreider, Christophe and Gu, Feng and Zhang, Lijun and Blasco, Francesca and Wagner, Juergen and Leong, Franz Joel Wen and Sy, Tracy and Noh, Susan and Goodman, Laura and Brooks, Carrie and Herbert, Gillian and Sateriale, Adam and Tandel, Jayesh (2017) A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature. ISSN 0028-08361476-4687

Mannhardt, Ingra and Eder, Alexandra and Dumotier, Berengere and Traebert, Martin and Soehren, Klaus-Dieter and Christ, Torsten and Eschenhagen, Thomas and Hansen, Arne (2017) Blinded contractility analysis in hiPSC-cardiomyocytes in engineered heart tissue format: Comparison with human atrial trabeculae. Toxicological sciences, 158 (1). pp. 164-175.

Marlowe, Jenny and Akopian, Viola and Karmali, Priya and Kornbrust, Doug and Lockridge, Jennifer and Semple, Sean (2017) Recommendations of the Oligonucleotide Safety Working Group’s Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based Therapeutics. Nucleic Acid Therapeutics. ISSN 2159-33372159-3345

Martin, Benjamin and Haber, Julien and Venturoni, Francesco and Sedelmeier, Joerg Mathias and Schenkel, Berthold and Kleinbeck-Riniker, Florian and Kamptmann, Sonja and Pellegatti, Laurent and Bouisseau, Anais and Fernandez-Rodriguez, Patricia and Susanne, Flavien and Hoehn, Pascale and Lanz, Marian and Robertson, Jeremy and Willis, Michael (2017) Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode. Green chemistry, 19. pp. 1439-1448.

Martin, Eric and Polyakov, Valery (2017) Postdoc mentor profiles for Valery Polyakov and Eric Martin. postdoc page.

Martin, Eric and Polyakov, Valery and Tian, Li (2017) Additional supplementary materials for approved article OAK ID 31984. Journal of chemical information and modeling.

Martin, Eric and Polyakov, Valery and Tian, Li (2017) Profile-QSAR 2.0: Kinase Virtual Screening Accuracy comparable to 4-Concentration IC50 for Realistically Novel Compounds. Journal of Chemical Information and Modeling, 57 (8). pp. 2077-2088. ISSN DOI 10.1021/acs.jcim.7b00166

Marzinzik, Andreas and Koch, Guido and Spanka, Carsten and Lehmann, Hansjoerg and Hwang, Ye-Jin and Coley, Connor and Abolhasani, Milad and Jensen, Klavs (2017) Segmented Flow Platform for On-​Demand Medicinal Chemistry and Compound Synthesis in Oscillating Droplets. Chem. Commun.. ISSN 1359-73451364-548X

Mattes, Henri and Orain, David and Tasdelen, Engin and Haessig, Samuel and Koller, Manuel and Picard, Anne and Dubois, Celine and Lingenhoehl, Kurt and Desrayaud, Sandrine and Floersheim, Philipp and Carcache, David and Urwyler, Stephan and Kallen, Joerg (2017) Design and synthesis of Selurampanel, a novel orally active and competitive AMPA receptor antagonist. ChemMedChem : chemistry enabling drug discovery, 12 (3). pp. 197-201. ISSN 18607179

McClatchey, P. Mason and Wu, Fan and Olfert, I. Mark and Ellis, Christopher G. and Goldman, Daniel and Reusch, Jane E. B. and Frisbee, Jefferson C. (2017) Microvascular perfusion heterogeneity impairs oxygenation and contributes to peripheral vascular disease in metabolic syndrome. Journal of cardiovascular translational research. ISSN 1937-5395; 1937-5387

McDonald, Michelle M and Reagan, Michaela R and Youlten, Scott and Mohanty, Sindhu T and Seckinger, Anya and Terry, Rachael L and Pettitt, Jessica A and Simic, Marija K and Cheng, Tegan L and Morse, Alyson and Le, Lawrence and Abi-Hanna, David and Kramer, Ina and Falank, Carolyne and Fairfield, Heather and Ghobrial, Irene M. and Baldock, Paul A and Little , David G and Kneissel, Michaela and Vanderkerken, Karin and Bassett, J H Duncan and Williams, Graham R and Oyajobi, Kayode and Hose, Dirk and Phan, Tri and Croucher, Peter I (2017) Inhibiting the osteocyte specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. ISSN 1528-0020; 0006-4971

McDonald, Michelle M and Reagan, Michaela R and Youlten, Scott and Mohanty, Sindhu T and Seckinger, Anya and Terry, Rachael L and Pettitt, Jessica A and Simic, Marija K and Cheng, Tegan L and Morse, Alyson and Le, Lawrence and David, David and Kramer, Ina and Frank, Carolyne and Ghobrial, Irene and Anthony, Anthony and Baldock, Paul A and Little , David G and Bassett, J H Duncan and Williams, Graham R and Kneissel, Michaela and Vanderkerken, Karin and Oyajobi, Kayode and Hose, Dirk and Phan, Tri and Croucher, Peter I (2017) Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood, 129 (26). pp. 3452-3464. ISSN 15280020

Mcdonald Iii, Earl and De Weck, Antoine and Kauffmann, Audrey and Schmelzle, Tobias and Golji, Javad (2017) Project DRIVE - A compendium of cancer dependencies and synthetic lethal relationships uncovered by large scale, deep RNAi screening. Cell, 170 (3). pp. 577-592.

Mckenna, Jeffrey and Talbot, Eric and Toste, F. Dean and Fernandes, Talita de A. and Thornbury, Richard T. and Saini, Vaneet and Santiago, Celine and Sigman, Matthew (2017) The Development and Mechanistic Investigation of a Palladium- Catalyzed 1,3-Arylfluorination of Chromenes. Chem Sci.

Merino, D and Whittle, J.R. and Vaillant, F. and Serrano, A. and Gong, J.N. and Maragno, A.L. and Chanrion, M. and Schneider, E. and Pal, B. and Giner, G. and Li, X. and Dewson, G. and Gräsel, J. and Lalaoui, N. and Segal, D. and Herold, M.J. and Huang, D. and Smyth, G.K. and Geneste, O. and Lessene, G. and Visvader, J.E. and Lindeman, J.L. (2017) Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Science Translational Medicine, 9 (401). ISSN 19466242

Merz, Michael (2017) Emerging liver safety biomarkers: an evaluation in healthy volunteers and patients with drug-induced liver injury. Hepatology.

Metz, Martin and Staubach, Petra and Bauer, Andrea and Brehler, Randolf and Gericke, Janine and Kangas, Michael and Chess, Joanna and Jarvis, Philip and Georgiou, Panayiotis and Canvin, Janice and Hillenbrand, Rainer and Erpenbeck, Veit and Maurer, Marcus (2017) Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin. Theranostics, 7 (5). pp. 1266-1276.

Michlits, Georg and Hubmann, Maria and Wu, Szu-Hsien and Vainorius, Gintautas and Budusan, Elena and Zhuk, Sergei and Burkhard, Thomas and Novatchkova, Maria and Aichinger, Martin and Lu, Yiqing and Reece-Hoyes, John and Nitsch, Roberto and Schramek, Daniel and Hoepfner, Dominic and Elling, Ulrich (2017) CRISPR-UMI : single-cell lineage tracing of pooled CRISPR–Cas9 screens. Nature methods, 14 (12). pp. 1191-1197.

Milicevic Sephton, Selena and Vetterli, Peter and Pedani, Valentina and Cermak, Stjepko and Chiotellis, Aristeidis and Schibli, Roger and Auberson, Yves and Ametamey, Simon (2017) Synthesis and Biological Evaluation of Quinoxaline Derivatives for PET Imaging of the NMDA Receptor. Helvetica Chimica Acta, 100 (12). ISSN 15222675

Miller, Danforth and Tan, Trixie and Nakamura, John and Malcolmson, Richard and Tarara, Thomas and Weers, Jeff (2017) Physical characterization of Tobramycin Inhalation Powder: II. State Diagram of an Amorphous Engineered Particle. Molecular Pharmaceutics. ISSN 10.1021/acs.molpharmaceut.7b00036

Miltz, Wolfgang and Velcicky, Juraj and Dawson King, Janet and Littlewood-Evans, Amanda and Ludwig, Marie-Gabrielle and Seuwen, Klaus and Feifel, Roland and Oberhauser, Berndt and Meyer, Arndt and Gabriel, Daniela and Loetscher, Pius (2017) Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorganic & Medicinal Chemistry, 25 (16). pp. 4512-4525. ISSN 0968-0896

Miltz, Wolfgang and Velcicky, Juraj and Dawson King, Janet and Littlewood-Evans, Amanda and Ludwig, Marie-Gabrielle and Seuwen, Klaus and Feifel, Roland and Oberhauser, Berndt and Meyer, Arndt and Gabriel, Daniela and Loetscher, Pius (2017) Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorganic and Medicinal Chemistry, 25 (16). pp. 4512-4525. ISSN 14643391

Miraglia, Loren and Orth, Anthony and Bonamy, Ghislain and Britschgi, Adrian and Brinkhaus, Heike and Bentires-Alj, Mohamed and Reddy, Venkateshwar and Kim, Sungeun and Duss, Stephan and Cuoto, JP and Koren, S and De Silva, D and Mertz, KD and Kaud, D and Varga, Z and Voshol, H and Leroy, C and Roloff, T and Stadler, MB and Scheel, CH (2017) The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature, 541 (7638). pp. 541-545. ISSN 0028-0836, 1476-4687

Moebitz, Henrik and Jahnke, Wolfgang and Jacob, Sandra (2017) Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches. Current topics in medicinal chemistry, 17. pp. 59-70. ISSN 1873-4294

Moebitz, Henrik and Machauer, Rainer and Holzer, Philipp and Vaupel, Andrea and Stauffer, Frederic and Ragot, Christian and Caravatti, Giorgio and Scheufler, Clemens and Hommel, Ulrich and Tiedt, Ralph and Beyer, Kim and Chen, Chao and Zhu, Hugh and Gaul, Christoph (2017) Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Medicinal Chemistry Letters, 8 (3). pp. 338-343. ISSN 19485875

Moggs, Jonathan (2017) IMI MARCAR external communication materials - interview and factsheet. IMI web based dissemination.

Moggs, Jonathan (2017) A Synopsis of the “Influence of Epigenetics, Genetics, and Immunology” Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium. Toxicologic Pathology.

Morgan, Thomas and Rajman, Iris (2017) Implications of African allele frequency variation in CYP450 genes for drug safety, efficacy and the future of drug development. EBioMedicine.. ISSN 2352-3964

Morse, Morse Alyson and Schindeler, Aaron and McDonald, Michelle M and Kneissel, Michaela and Kramer, Ina and Little, David G (2017) Sclerostin antibody augments the anabolic bone formation response in a mouse model of mechanical tibial loading. Journal of bone and mineral research.. ISSN 1523-4681; 0884-0431

Morvan, Frederic and Rondeau, Jean-Michel and Zou, Chao and Minetti, Giulia and Scharenberg, Meike and Jacobi, Carsten and Brebbia, Pascale and Ritter, Veronique O. and Toussaint, Gauthier and Scheufler, Clemens and Lehmann, Sylvie and Koch, Elke and Koelbing, Claudia and Leber, Xavier Charles and Schilb, Alain and Witte, Florian and Geisse, Sabine and Glass, David and Trifilieff, Estelle (2017) Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 114 (47). pp. 12448-12453. ISSN 10916490

Moscaroli, Alessandra and Behe, Martin (2017) Radiolabeling and Characterization of 111In-FGF-2 for In Vivo Imaging. Mol Pharm. 2017 Mar 6;14(3):639-648. doi: 10.1021/acs.molpharmaceut.6b00913..

Murphy, Jason and Harrington, Edmund and Schirle, Markus and Wong, Margaret and Gower, Carrie and Maly, Dustin (2017) Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors. Proteome science, 15 (17). ISSN 1477-5956


Nakajima, Katsumasa and Chatelain, Ricardo and Clairmont, Kevin and Commerford, Susan and Coppola, Gary and Daniels, Thomas and Forster, Cornelia and Gilmore, Thomas and Gong, Yongjin and Jain, Monish and Kanter, Aaron and Kwak, Young-Shin and Li, Jingzhou and Meyers, Charles and Neubert, Alan and Szklennik, Paul and Tedesco, Vivienne and Thompson, Jed and Truong, David and Yang, Qing and Hubbard, Brian and Serrano-Wu, Michael (2017) Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans. Journal of Medicinal Chemistry, 60 (11). pp. 4657-4664. ISSN 15204804

Ngcungcu, Thandiswa and Oti, Martin and Sitek, Jan C and Haukanes, Bjørn I and Linghu, Bolan and Bruccoleri, Robert and Stokowy, Tomasz and Oakeley, Edward J and Yang, Fan and Zhu, Jiang and Sultan, Marc and Schalkwijk, Joost and van Vlijmen-Willems, Ivonne M J J and von der Lippe, Charlotte and Brunner, Han G and Ersland, Kari M and Grayson, Wayne and Buechmann-Moller, Stine and Sundnes, Olav and Nirmala, Nanguneri and Morgan, Thomas M and van Bokhoven, Hans and Steen, Vidar M and Hull, Peter R and Szustakowski, Joseph and Staedtler, Frank and Zhou, Huiqing and Fiskerstrand, Torunn and Ramsay, Michele (2017) Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families. American journal of human genetics, 100 (5). pp. 737-750. ISSN 1537-6605

Nguyen, Hung N. and Noss, Erika H. and Mizoguchi, Fumitaka and Huppertz, Christine and Wei, Kevin S. and Watts, Gerald F.M. and Brenner, Michael B. (2017) Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators. Immunity, 46 (2). pp. 220-232. ISSN 10974180

Niggemann, Birgit and Atorf, Jenny and Fridrichs-Gromoll, Stephanie and Korte, Sven and Kremers, Jan and Mecklenburg, Lars and Wiederhold, Andreas and Hill, Marilyn and Pilling, Andrew and Mansfield, Keith (2017) Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset (Callithrix jacchus) monkeys. Primate Biology, 4, 93- (4-93-2). pp. 93-100.

Nilsson, Inga and Grove, Kerri and Dovala, Dustin and Uehara, Tsuyoshi and Lapointe, Guillaume and Six, David (2017) Molecular characterization and verification of azido-3,8dideoxy-D-manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide. Journal of Biological Chemistry, 292 (48). pp. 19840-19848. ISSN 1083351X

Numao, Shin and Miltz, Wolfgang and Roehn, Till (2017) Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors. Scientific Reports.


Palacios, Daniel and Meredith, Erik and Kawanami, Toshio and Chen, Xin and Darsigny, Veronique and Geno, Erin and Palermo, Mark and Guy, Chantale and Hewett, Jeffrey and Tierney, Laryssa and Thigale, Sachin and Weihofen, Wilhelm and Argikar, Upendra and Boynton, Geoffrey and George, Elizabeth and Wang, Louis and Adams, Christopher and Baird, Daniel and Busby, Scott (2017) Structure based design of Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen. ACS medicinal chemistry letters.

Parmentier, Celine and Uteng, Marianne and Couttet, Philippe and Wolf, Armin and Zaccharias, Thomas and Heyd, Bruno and Bachellier, Philippe and Richert, Lysiane (2017) Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes. Archives of Toxicology, 91 (8). pp. 2879-2893. ISSN 1432-0738

Patel, Dhavalkumar and Antoni, Christian and Freedman, Steven and Levesque, Marc and Sundy, John (2017) Phase 2 to Phase 3 Clinical Trials: Reasons for Success and Failure in Immunologic Diseases. Journal of Allergy and Clinical Immunology.

Paterson, Andrew and McMullin, Claire and Mahon, Mary and Press, Neil and Frost, Christopher (2017) α-Halo carbonyls enable meta selective primary, secondary and tertiary C–H alkylations by ruthenium catalysis. Org. Biomol. Chem., 15 (28). pp. 5993-6000. ISSN 1477-05201477-0539

Pearlstein, Robert and Mckay, Daniel and Hornak, Viktor and Dickson, Callum and Golosov, Andrei and Harrison, Tyler and Camilo, Velez-Vega and Duca, Jose (2017) Building new bridges between in vitro and in vivo in early drug discovery: Where molecular modeling meets systems biology. Current Topics in Medicinal Chemistry, 17 (23). pp. 2642-2662. ISSN 1873-4294

Pearson, David and Weiss, H Markus and Jin, Yi and van Lier, Jan Jaap and Erpenbeck, Veit J and Glaenzel, Ulrike and End, Peter and Woessner, Ralph and Eggimann, Fabian and Camenisch, Gian (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Pearson, David and Weiss, Markus and Jin, Yi and van Lier, Jan Jaap and Erpenbeck, Veit and Glaenzel, Ulrike and End, Peter and Woessner, Ralph and Camenisch, Gian P. (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Pearson, David and Weiss, Markus and Jin, Yi and van Lier, Jan Jaap and Erpenbeck, Veit and Glaenzel, Ulrike and End, Peter and Woessner, Ralph and Camenisch, Gian P. and Eggimann, Fabian (2017) Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Drug Metabolism and Disposition. ISSN 0090-95561521-009X

Peng, Yunshan and Dobler, Markus and Patnaik, Anup and Liu, Eugene and Nunez, Jill and Kerrigan, John and Dean, Charles and Mckenney, David and Osborne, Colin and Dzink-Fox, Joann and Bojkovic, Jade and Lilly, Maria-Dawn and Sprague, Elizabeth and Hoffmaster, Keith and Ranjitkar, Srijan and Wang, Bing and hamann, lawrence and tommasi, ruben and glick, meir and yang, xia and wang, honming and parker, david and wattanasin, som and lenoir, francois and Xie, Lili and Yu, Donghui (2017) Design, Synthesis and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. Journal of medicinal chemistry. ISSN 1520-4804

Pepini, Timothy and Pulichino, Anne-Marie and Carsillo, Thomas and Carlson, Alicia and Sari-Sarraf, Farid and Ramsauer, Katrin and Debasitis, Jason and Maruggi, Giulietta and Otten, Gillis and Geall, Andrew and Yu, Dong and Ulmer, Jeffrey and Iavarone, Carlo (2017) Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design Response by a Self-Amplifying RNA. Journal of Immunology, 198.

Peter , Gedeck and Skolnik, Suzanne and Rodde, Stephane (2017) Developing collaborative QSAR models without sharing structures. Journal of Chemical Information and Modeling, 57 (8). pp. 1847-1858. ISSN 1549-95961549-960X

Pflanz, David and Birkhold, Annette I. and Albiol, Laia and Thiele, Tobias and Duda, Georg and Checa, Sara and Willie, Bettina M. and Kornak, Uwe and Kneissel, Michaela and Kramer, Ina (2017) Sost deficiency led to enhanced Dkk1 expression coincident with a greater cortical bone formation response to mechanical loading. Scientific reports. ISSN 2045-2322

Phizackerley, Kirsten and Jumaa, Mouhannad and Lopalco, Antonio and Wolfe, Bradley H. and Ablan, Christopher D. and Stella, Valentino J. (2017) Mechanism of Degradation of an -Keto-Epoxide, a Model for the Warhead for Various Proteasome Inhibitor Anticancer Agents. Journal of pharmaceutical sciences, 106. pp. 1051-1061.

Piirainen, Henni and Taura, Jaume and Kursula, Petri and Ciruela, Francisco and Jaakola, Veli-Pekka (2017) Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. Biochimica et biophysica acta. ISSN 0006-3002

Pikman, Yana and Furman, Emily S and Alexe, Gabriela and Place, Andrew E and Kim, Sunkyu and Sohal, Bindi and Modiste, Rebecca and Harris, Marian and Kung, Andrew L and Silverman, Lewis B and Stegmaier, Kimberly (2017) Synergistic drug combinations with a CDK4/6 inhibitor in T-cell acute lymphoblastic leukemia. Clinical Cancer Research, 23 (4). pp. 1012-1024. ISSN 1557-3265

Pillong, Max and Marx, Corinne and Piechon, Philippe and Wicker, Jerome GP and Cooper, Richard I and Wagner, Beatrix (2017) A publicly available crystallisation data set and its application in machine learning. CrystEngComm, 19 (27). pp. 3737-3745.

Plawinski, Jason and Reinker, Stefan and Kirkpatrick, Nathaniel and Oakeley, Edward James (2017) Summer internship at Novartis. Report to University of Strasbourg, France.

Pognan, Francois and Marc, Philippe (2017) Legacy data sharing to improve drug safety assessment: The eTOX project. Nature Reviews Drug Discovery, 16 (12). pp. 811-812. ISSN 14741784

Potting, Christoph and Sailer, Andreas and Helliwell, Stephen (2017) A genome-wide phenotypic CRISPR/Cas9 screen identifies novel regulators of PARK2 level and mitophagy priming. Proceedings of the National Academy of Sciences of the United States of America PNAS. (10.107). pp. 1-10. ISSN 1091-6490; 0027-8424

Proudfoot, Andrew and Bussiere, Dirksen and Lingel, Andreas (2017) High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. Journal of the American Chemical Society, 139 (49). pp. 17824-17833. ISSN 15205126

Pugsley, Michael K. and Authier, Simon and Brabham, Tiffini and Soloviev, Maxim and Markgraf, Carrie G. and Correll, Krystle and Traebert, Martin and Greiter-Wilke, Andrea and Valentin, Jean-Pierre and Vargas, Hugo and Botchway, Alfred and Leishman, Derek J. and Curtis, Michael J. (2017) The Safety Pharmacology Society salary survey. Journal of Pharmacological and Toxicological Methods, 88. pp. 85-91. ISSN 1873488X


Qi, Vicky and Zhao, Kehao and Gu, Justin and Huang, Ying and Wang, Youzhen and Zhang, Hailong and Zhang, Maya and Zhang, Jeff and Yu, Zhengtian and Li, Ling and Teng, Lin and Chuai, Shannon and Zhang, Chao and Zhao, Mengxi and Chen, Zijun and Fang, Douglas and Fei, Qi and Feng, Leying and Feng, Lijian and Gao, Yuan and Ge, Hui and Ge, Xinjian and Li, Guobin and Lingel, Andreas and Lin, Ying and Liu, Yueqin and Luo, Fangjun and Shi, Minlong and Wang, Long and Wang, Zhaofu and Yu, Yanyan and Zeng, Jue and Zeng, Chenhui and Chen, Ho Man and Zhang, Lijun and Zhang, Qiong and Zhou, Shaolian and Oyang, Counde and Atadja, Peter and Li, En (2017) An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nature Chemical Biology.


Radonjic-Hoesli, Susanne and Wang, Xiaoliang and de Graauw, Elisabeth and Merz-Stoeckle, Christina and Styp-Rekowska, Beata and Hlushchuk, Ruslan and Simon, Dagmar and Spaeth, Peter J and Yousefi, Shida and Simon, Hans-Uwe (2017) Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. The Journal of allergy and clinical immunology. ISSN 1097-6825

Ramos, Marcel and Schiffer, Lucas and Re, Angela and Azhar, Rimsha and Rodriguez Cabrera, Carmen and Chan, Tiffany and Chapman, Philip and Gomez-Cabrero, David and Haibe-Kains, Benjamin and Hansen, Kasper and Kodali, Hanish and Louis, Marie Stephie and Mer, Arvind and Riester, Markus and Morgan, Martin and Carey, Vincent and Waldron, Levi (2017) Software for the integration of multi-omics experiments in Bioconductor. Cancer research. ISSN 1538-7445; 0008-5472

Rao, Koneti V and Webster, Sharon and Dalm, Virgil ASH and Sediva, Anna and van Hagen, Martin P and Holland, Steven and Rosenzweig, Sergio D and Christ, Andreas Dominik and Sloth, Birgitte and Cabanski, Maciej and Joshi, Aniket and De Buck, Stefan and Doucet, Julie and Guerini, Danilo and Kalis, Christoph and Pylvaenaeinen, Ilona and Soldermann, Nicolas and Kashyap, Anuj and Gulbu, Uzel and Leonardo, Michael J and Patel, Dhavalkumar and Lucas, Carrie L and Burkhart, Christoph (2017) Effective ‘Activated PI3Kdelta Syndrome’-targeted therapy with PI3Kdelta inhibitor leniolisib. Blood, 130 (21). pp. 2307-2316. ISSN 1528-0020; 0006-4971

Rao, Koneti V and Webster, Sharon and Dalm, Virgil ASH and Sediva, Anna and van Hagen, Martin P and Holland, Steven and Rosenzweig, Sergio D and Christ, Andreas Dominik and Sloth, Birgitte and Cabanski, Maciej and Joshi, Aniket and De Buck, Stefan and Doucet, Julie and Guerini, Danilo and Kalis, Christoph and Pylvaenaeinen, Ilona and Soldermann, Nicolas and Kashyap, Anuj and Gulbu, Uzel and Leonardo, Michael J and Patel, Dhavalkumar and Lucas, Carrie L and Burkhart, Christoph (2017) Effective ‘Activated PI3Kdelta Syndrome’-targeted therapy with PI3Kdelta inhibitor leniolisib. Blood, 130 (21). pp. 2307-2316. ISSN 0006-4971

Rauch, Judith and Kallen, Joerg (2017) Hintergrundtext Medizinforschung am PSI. new magazine of the Paul Scherrer Institute PSI.

Ravagli, Carlo and Pognan, Francois and Marc, Philippe (2017) OntoBrowser: a tool for curating ontologies and code lists by subject matter experts. Bioinformatics, 33 (1). pp. 148-149. ISSN 1367-48031460-2059

Rebhan, Michael (2017) Towards a systems approach for chronic diseases, based on health state modeling. F1000Research., 6. p. 309. ISSN 2046-1402

Rehan, Shahid and Paavilainen, Ville O and Jaakola, Veli-Pekka (2017) Functional Reconstitution of Human Equilibrative Nucleoside Transporter-1 into Styrene Maleic Acid Co-polymer Lipid Particles. Biochimica et biophysica acta. ISSN 0006-3002

Reilly, John and Aliagas, Ignacio and Berger, Raphaelle and Goldberg, Kristin and Nishimura, Rachel and Richardson, Paul and Richter, Daniel and Sherer, Edward and Sparling, Brian and Marian, Bryan (2017) Sustainable Practices in Medicinal Chemistry Part 2: Green by Design. Journal of Medicinal Chemistry, 60 (14). pp. 5955-5968. ISSN 15204804

Ren, Shuang and Sechaud, Romain and Su, Frank and Tillmann, Hanns-Christian and Hara, Hisanori and Tan, Xuemei and Hou, Jie and Woessner, Ralph and Zhao, Rong (2017) Pharmacokinetics and safety of indacaterol and glycopyrronium (IND/GLY) following repeated once daily inhalation from a fixed-dose combination in healthy Chinese subjects. International Journal of Clinical Pharmacology and Therapeutics , 55 (2). pp. 147-155.

Riede, Julia and Camenisch, Gian P. and Jörg, Huwyler and Poller, Birk (2017) Current methods to determine hepatic Kpuu: a comparison of their usefulness and limitations. Journal of pharmaceutical sciences. ISSN 00223549

Riede, Julia and Poller, Birk and Huwyler, Jörg and Camenisch, Gian P. (2017) Assessing the risk of drug-induced cholestasis using unbound intrahepatic concentrations. Drug metabolism and disposition. ISSN 1521-009X

Riss, Bernard (2017) TMS-ent-Bisabolangelone. Tetrahedron, 73 (23). pp. 3202-3212. ISSN 00404020

Robbins, Ken (2017) Sparse set of AWS tips for an enterprise cloud transformation. Ken Robbins' LinkedIn blog.

Roggo, Yves (2017) Forensic investigation in the pharmaceutical industry: Identification procedure of visible particles in (drug) solutions and different containers by combining vibrational and X-ray spectroscopic techniques. Journal of pharmaceutical and biomedical analysis. ISSN 1873-264X; 0731-7085

Roggo, Yves (2017) Global regression model for moisture content determination using near-infrared spectroscopy. European journal of pharmaceutics and biopharmaceutics. ISSN 1873-3441; 0939-6411

Rooks, Daniel and Praestgaard, Jens and Hariry, Sam and Laurent, Didier and Petricoul, Olivier and Perry, Robert G. and Trifilieff, Estelle and Roubenoff, Ronenn (2017) Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. Journal of the American Geriatrics Society, 65 (9). pp. 1988-1995. ISSN 15325415

Rubic-Schneider, Tina and Kuwana, Masataka and Christen, Brigitte and Aßenmacher, Manuela and Hainzl, O. and Zimmermann, F. and Fischer, Robert and Koppenburg, Vera and Chibout, Salah-Dine and Wright, Timothy M. and Seidl, Andreas and Kammueller, Michael (2017) T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia. Blood Advances, 1 (6). pp. 367-379. ISSN 2473-9537

Ruetz, Stephan and Chene, Patrick and Stachyra, Therese-Marie and Brock, Roland and Wallbrecher, Rike (2017) A critical assessment of the synthesis and biological activity of p53/Hdm2 stapled peptide inhibitors. British journal of pharmacology, 2017 .

Ruffner, Heinz and Ley, Svenja and Galuba, Olaf and Melin, Nicolas and Salathe, Adrian and Aebi, Alexandra and Pikiolek, Monika and Knehr, Judith and Carbone, Walter and Beibel, Martin and Roma, Guglielmo and D'Ario, Giovanni and Gubser Keller, Caroline and Bouwmeester, Antonius and Parker, Christian and Bouchez, Laure and Kirkland, Susan and Nigsch, Florian (2017) Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology. Journal of biomolecular screening. ISSN 1552-454X; 1087-0571

Rutkowska, Aleksandra and Sailer, Andreas and Dev, Kumlesh (2017) EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination. Journal of Neuroinflammation, 14 (1). ISSN 1742-2094

Rutrick, Daniel and Stein, Dan and Fava, Maurizio and Hasler, Gregor and Cha, Jang-Ho and Donchev, Toni and Ocwieja, Magdalena and Gomez-Mancilla, Baltazar (2017) Mavoglurant in Obsessive-Compulsive Disorder Resistant to Selective Serotonin Reuptake Inhibitor: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 study. Advances in therapy..


Salick, Max and Wells, Michael F and Eggan, Kevin and Kaykas, Ajamete (2017) Modelling Zika virus infection of the developing human brain in vitro using stem cell-derived cerebral organoids. Journal of visualized experiments : JoVE (127). ISSN 1940-087X

Sandham, David and Barker, Lucy and Brown, Lyndon and Brown, Zarin and Budd, David and Charlton, Steven and Chatterjee, Devnandan and Cox, Brian and Dubois, Gerald and Duggan, Nicholas and Hall, Edward and Hatto, Julia and Maas, David and Manini, Jodie and Profit, Rachael and Riddy, Darren and Ritchie, Cathy and Sohal, Bindi and Shaw, Duncan and Stringer, Rowan and Sykes, David and Turner, Katharine and Watson, Simon and West, Ryan and Willard, Elizabeth and Williams, Gareth and Willis, Jennifer (2017) Discovery of Fevipiprant (NVP-QAW039), a potent and selective CRTh2 receptor antagonist for treatment of allergic diseases. ACS Medicinal Chemistry Letters.

Sangana, Ramachandra and Gu, Helen and Chun, Dung Yu and Einolf, Heidi (2017) Evaluation of clinical drug interaction potential of clofazimine using static and dynamic modeling approaches. Drug metabolism and disposition.

Sasseville, Vito and Milton, Mark and Maclachlan, Timothy and Newton, Ronald (2017) Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics. Regulatory Toxicology and Pharmacology, 86. pp. 221-230. ISSN 1096-0295

Schenkel, Berthold and Venturoni, Francesco and Aubry, Michel and Sevinc, Serbuelent and Sedelmeier, Joerg Mathias and Martin, Benjamin and Susanne, Flavien and Lima, Fabio and Piccioni, Lorenzo (2017) Match-making reactors to chemistry: a continuous manufacturing-enabled sequence to a key benzoxazole pharmaceutical intermediate. Organic process research & development, 21. pp. 1779-1793.

Schlesinger, Ann and Hunt, Ian (2017) Video of 2016 Novartis Open Framework Symposium. this link was shared with externals but not published.

Schuierer, Sven and Carbone, Walter and Petitjean, Virginie and Fernandez, Anita and Sultan, Marc and Roma, Guglielmo (2017) A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples. BMC Genomics, 18 (1). ISSN 14712164

Seefried, Lothar and Baumann, Jasmin and Hemsley, Sarah and Hofmann, Christine and Kunstmann, Erdmute and Kiese, Beate and Huang, Yue and Chivers, Simon and Valentin, Marie-Anne and Borah, Babul and Roubenoff, Ronenn and Junker, Uwe and Jakob, Franz (2017) Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia. Journal of Clinical Investigation, 127 (6). pp. 2148-2158. ISSN 1558-8238

Segatto, Marco and Fittipaldi, Raffaella and Pin, Fabrizio and Sartori, Roberta and Ko, Kyung Dae and Zare, Hossein and Fenizia, Claudio and Zanchettin, Gianpietro and Pierobon, Elisa Sefora and Hatakeyama, Shinji and Sperti, Cosimo and Merigliano, Stefano and Sandri, Marco and Filippakopoulos, Panagis and Costelli, Paola and Sartorelli, Vittorio and Caretti, Giuseppina (2017) Epigenetic Targeting of Bromodomain Protein BRD4 Counteracts Cancer Cachexia and Prolongs Survival. Nature Communications.

Seroutou, Abdelkader and Tian, Xianbin and Fernandez, Rose and Morozov, Alex and Sheng, Qing and Ramkumar, Thiruvamoor and Zubel, Angela (2017) A Phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer. BMC Cancer, 17(1) (646). ISSN 1471-2407

Shimshek, Derya R. and Bus, Thorsten and Schupp, Bettina and Jensen, Vidar and Marx, Verena and Layer, Liliana E. and Köhr, Georg and Sprengel, Rolf (2017) Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation. Frontiers in Molecular Neuroscience, 10. ISSN 1662-5099

Silver-Brown, Serena and Hoffman, Ann and Horvath, Peter and Lovitt, Carrie and Easton, Evan and LaBarbera, Daniel and Mendez, Melissa and Rothernberg, Mark and Seldin, Jan and Fennell, Myles (2017) SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium. Assay and drug development technologies, 15 (1). pp. 1-7.

Sivasankaran, Rajeev and Teider, Natalia and Mcnally, Anna and Bradner, Jay and Worringer, Katie (2017) Synthetic Transcription Elongation Factors license transcription across repressive heterochromatin. Science. pp. 1617-1622.

Skilitsi, Anastasia Ioanna and Turko, Timothé and Cianfarani, Damien and Barre, Sophie and Uhring, Wilfried and Hassiepen, Ulrich and Léonard, Jérémie (2017) Towards Sensitive, High-Throughput, Biomolecular Assays Based on Fluorescence Lifetime. Methods and applications in fluorescence /. ISSN 2050-6120

Skolnik, Suzanne and Geraci, Gina and Dodd, Stephanie (2017) AUTOMATED SUPERATURATION STABILITY ASSAY TO DIFFERENTIATE POORLY SOLUBLE COMPOUNDS IN DRUG DISCOVERY. Journal of pharmaceutical sciences. ISSN 1520-6017

Skolnik, Suzanne and Geraci, Gina and Dodd, Stephanie (2017) Automated Supersaturation Stability Assay to Differentiate Poorly Soluble Compounds in Drug Discovery. Journal of Pharmaceutical Sciences. ISSN 1520-6017

Skora, Lukasz and Jahnke, Wolfgang (2017) 19F-NMR-based dual-site reporter assay for the discovery and distinction of catalytic and allosteric kinase inhibitors. ACS medicinal chemistry letters, 8. pp. 632-635.

Skora, Lukasz and Jahnke, Wolfgang and Sijbesma, Eline and Leysen, Seppe and Brunsveld, Luc and Wolf, Alexander and Nussbaumer, Peter and Ottmann, Christian (2017) Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56 (30). pp. 3972-3982. ISSN 15204995

Smith, Aaron and Ni, ZJ and Poon, Daniel and Huang, Zilin and Chen, Zheng and Zhang, Qiong and Tandeske, Laura and Merritt, Hanne and Shoemaker, Kevin and Chang, John and Kaufman, Sue and Huh, Kay and Murray, Jeremy and Appleton, Brent A. and Jacob, Sandra and Scheufler, Clemens and Kanazawa, Takanori and Jansen, Hanneke and Stuart, Darrin and Shafer, Cynthia (2017) Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405

Smith, Nichola (2017) Epithelial Na+ channel inhibitors for the treatment of cystic fibrosis. Pharmaceutical Patent Analyst, 6 (4). pp. 179-188. ISSN 2046-8962

Smith, Philip and O’Sullivan, Catherine and Gergely, Peter (2017) Sphingosine 1-phosphate signalling in allogeneic hematopoietic stem cell transplantation (HSCT). International Journal of Molecular Sciences , 18 (10). pp. 1-12. ISSN 18102027

Snellman, Anniina and Rokka, Johanna and Lopez-Picon, Francisco R and Helin, Semi and La Ferla, Barbara and Torittu, Annamari and Löyttyniemi, Eliisa and Pihlaja, Rea and Masserini, Massimo and Solin, Olof and Rinne, Juha O and Haaparanta-Solin, Merja (2017) Treatment effect of functionalized nanoliposomes to beta-amyloid deposition in APP23 transgenic mouse model of Alzheimer’s disease – A follow-up study using [11C]PIB micro-PET imaging. Neurobiology of aging, 57. pp. 84-94. ISSN 01974580

Snowdon, Victoria K. and Lachlan, Neil J. and Hadoke, Patrick W.F. and Hoy, Anna M. and Semple, Scott and Patel, Dilip and Mungall, Will and Kendall, Timothy J. and Thomson, Adrian and Lennen, Ross J. and Jansen, Mauritis A. and Moran, Carmel M. and Pellicoro, Antonella and Ramachandran, Prakash and Shaw, Isaac and Aucott, Rebecca L. and Severin, Thomas and Saini, Rajnish and Pak, Judy and Yates, Denise and Dongre, Neelesh and Duffield, Jeremy S. and Webb, David J. and Iredale, John P. and Hayes, Peter C. and Fallowfield, Jonathan A. (2017) Serelaxin for the Treatment of Renal Dysfunction in Cirrhosis: Preclinical Evaluation and Results of a Randomized Phase 2 Trial. PLoS medicine. ISSN 1549-1676; 1549-1277

Solt, Andras and Bostock, Mark J. and Shrestha, Binesh and Kumar, Prashant and Warne, Tony and Tate, Christopher G and Nietlispach, Daniel (2017) Insight into partial agonism by observing ligand-modulated conformational equilibria of a Gs-mimetic nanobody-bound B1-adrenergic receptor. Nature communications, 8. p. 1795. ISSN 2041-1723

Sorde, Laetitia and Spindeldreher, Sebastian and Karle, Anette (2017) Massive immune response against IVIg interferes with response against other antigens in mice: A new mode of action? PLoS ONE, 12 (10). ISSN 19326203

Sorde, Laetitia and Spindeldreher, Sebastian and Karle, Anette (2017) Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg? European journal of immunology. ISSN 2050-4527

Srinivas, Honnappa and Wilcken, Rainer (2017) Manuscript: SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency. Note: Details of NIBR contribution to manuscript: The results of Mutational analysis of SGPL1: In silico modelling ( were approved in OAK before-ref link Mutational analysis of SGPL1: In silico modelling results were shared with Prof. Friedhelm Hildebrandt, Harvard medical school, Division of Nephrology Boston Children's Hospital. These results, that were shared with Prof. Friedhelm Hildebrandt is now a part of full manuscript for publication with Prof. Friedhelm Hildebrandt as corresponding author . Honnappa Srinivas and Rainer Wilcken are the co-authors from NIBR. Please find attached the full manuscript. The Journal of clinical investigation : JCI, 127. pp. 912-928. ISSN 1558-8238


Steger-Hartmann, Thomas and Pognan, Francois (2017) The eTOX Consortium: To Improve the Safety Assessment of New Drug Candidates. Pharmazeutische Medizin, 1. pp. 3-13. ISSN ISSN 2191-6039

Stein, Andrew (2017) Practical unidentifiability of receptor density in target mediated drug disposition models can lead to over-interpretation of drug concentration data. Practical unidentifiability of receptor density in target mediated drug disposition models can lead to over-interpretation of drug concentration data.

Stein, Andrew and Ramakrishna, Ramprasad (2017) AFIR: A dimensionless potency metric for characterizing the activity of monoclonal antibodies. CPT: pharmacometrics & systems pharmacology.. ISSN 21638306

Stiehl, Daniel Philipp and Tritto, Elaine and Chibout, Salah-Dine and Cordier, Andre and Moulin, Pierre (2017) The Utility of Gene Expression Profiling from Tissue Samples to Support Drug Safety Assessments. ILAR Journal. pp. 1-11. ISSN 1084-20201930-6180

Street, Steven T. G. and Chin, Donovan and Hollingworth, Greg and Berry, Monica and Morales, Juan C. and Galan, M. Carmen (2017) Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K+ buffer. Chemistry - a European journal, 23 (29). pp. 6953-6958. ISSN 09476539

Stringer, Rowan and Cordier, Valerie and Afatsawo, Catherine and Arabin, Philip and Desrayaud, Sandrine and Hoffmann, Laurent and Lehmann, Daniel and Lowe, Phil and Risser, Francis and Thiel, Julia and Widmer, Toni and Wipfli, Peter and Bigaud, Marc (2017) Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice. Xenobiotica. ISSN 1366-5928; 0049-8254

Stutz, Katharina and Hiss, Jan A. and Schneider, Petra and Blatter, Markus and Pfeiffer, Bernhard and Posselt, Gernot and Schneider, Gisbert (2017) Peptide-membrane interaction between targeting and lysis. ACS Chemical Biology. ISSN 1554-89291554-8937

Subramanian, Aravind and Narayan, Rajiv and Corsello, Steven M. and Peck, David D. and Natoli, Ted E. and Lu, Xiaodong and Gould, Joshua and Davis, John F. and Tubelli, Andrew A. and Asiedu, Jacob K. and Lahr, David L. and Hirschman, Jodi E. and Liu, Zihan and Donahue, Melanie and Julian, Bina and Khan, Mariya and Wadden, David and Smith, Ian and Lam, Daniel and Liberzon, Arthur and Toder, Courtney and Bagul, Mukta and Orzechowski, Marek and Enache, Oana M. and Piccioni, Frederica and Berger, Alice H. and Shamji, Alykhan and Brooks, Angela N. and Vrcic, Anita and Flynn, Corey and Rosains, Jacqueline and Takeda, David and Davison, Desiree and Lamb, Justin and Ardlie, Kristin and Hogstrom, Larson and Gray, Nathanael S. and Clemons, Paul A. and Silver, Serena and Wu, Xiaoyun and Zhao, Wen-Ning and Read-Button, Willis and Wu, Xiaohua and Haggarty, Stephen J. and Ronco, Lucienne V. and Boehm, Jesse S. and Schreiber, Stuart L. and Doench, John G. and Bittker, Joshua A. and Root, David E. and Wong, Bang and Golub, Todd R. (2017) A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles. Biorxiv.

Sullivan, Ryan (2017) CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. Journal of Clinical Investigation, 127 (11). pp. 4042-4058. ISSN 0021-9738

Summermatter, Serge and Bouzan, Anais and Pierrel, Eliane and Melly, Stefan and Gutzwiller, Sabine and Fryer, Christy and Nolin, Erin and Dornelas, Christina and Leighton-Davies, Juliet and Palmer , Amy and Qin, Yan and Glass, David and Fournier, Brigitte (2017) Blockade of metallothioneins 1 and 2 increases skeletal muscle mass and strength. Molecular and cellular biology, 37 (5). e000305-e000316. ISSN 1098-5549; 0270-7306

Suply, Thomas and Hannedouche, Sebastien and Carte, Nathalie and Li, Jianping and Grosshans, Bianka and Schaefer, Michael and Raad, Layla and Beck, Valerie and Vidal, Solange and Beluch, Noemie and Barbieri, Samuel and Wirsching, Johann and Lageyre, Nadine and Lannoy, Vincent and Detheux, Michel and Bitsch, Francis and Falchetto, Rocco Angelo and Bouwmeester, Antonius and Porter, Jeffrey and Baumgarten, Birgit and Mansfield, Keith and Carballido, Jose and Seuwen, Klaus and Bassilana, Frederic (2017) A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Science Signaling, 10 (496). ISSN 19379145

Surdziel, Ewa and Clay, Ieuan and Nigsch, Florian and Thiemeyer, Anke and Allard, Cyril and Hoffman, Gregory and Reece-Hoyes, John and Phadke, Tanushree and Gambert, Romain and Gubser Keller, Caroline and Ludwig, Marie-Gabrielle and Baumgarten, Birgit and Frederiksen, Mathias and Schuebeler, Dirk and Seuwen, Klaus and Bouwmeester, Antonius and Fodor, Barna (2017) Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization. PLoS ONE, 12 (8). pp. 1-20. ISSN 1932-6203

Surdziel, Ewa and Clay, Ieuan and Nigsch, Florian and Thiemeyer, Anke and Allard, Cyril and Hoffman, Gregory and Reece-Hoyes, John and Phadke, Tanushree and Gambert, Romain and Gubser Keller, Caroline and Ludwig, Marie-Gabrielle and Baumgarten, Birgit and Frederiksen, Mathias and Schuebeler, Dirk and Seuwen, Klaus and Bouwmeester, Antonius and Fodor, Barna (2017) Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization. PLoS ONE, 12 (8). ISSN 19326203

Swaller, Tim (2017) GNF recipient of the 2017 IEA Earth Month Award. GNF Website Recent Updates section.


Takahashi, Shunji and Kobayashi, Takayuki and Tomomatsu, Junichi and Ito, Yoshinori and Oda, Hisanobu and Kajitani, Tatsuhiro and Kakizume, Tomoyuki and Tajima, Takeshi and Takeuchi, Hiromi and Maacke, Heiko and Esaki, Taito (2017) Phase I study of LJM716 in Japanese patients. LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer, 79. pp. 131-138.

Tam, Yat Kong and Blasko, Andrei (2017) Mitigating the Effect of Surfactants in Sample Preparation of a Phospholipid Formulation for Impurities Analysis by Reversed-Phase Liquid Chromatography. LCGC North America, 35 (5). pp. 321-328. ISSN 1939-1889

Tan, Kian and Grob, Jonathan and Hajdin, Christine and Siuti, Piro and Lilly, Jeremiah and Andorfer, Mary and Chael, Julia and Lewis, Jared (2017) Understanding Flavin-Dependent Halogenase Reactivity via Sub-strate Activity Profiling. ACS Catalysis, 7 (3). pp. 1897-1904. ISSN 2155-54352155-5435

Tarselli, Mike (2017) Insights: Artificial Intelligence in Research. Science, 357 (6346). pp. 28-30.

Tarselli, Mike (2017) Nature Chemistry Reactions Follow-up Interview: Mike Tarselli. Nature chemistry.

Tarselli, Mike (2017) Tin can. Nature chemistry, 9. p. 500. ISSN doi:10.1038/nchem.2769

Teodoro, Douglas and Mottin, Luc and Gobeill, Julien and Gaudinat, Arnaud and Vachon, Therese and Ruch, Patrick (2017) Improving average ranking precision in user searches for biomedical research datasets. Database the journal of biological databases and curation., 2017. ISSN 1758-0463

Terranova, Remi and Vitobello, Antonio and Del Rio Espinola, Alberto and Wolf, Roland and Schwarz, Michael and Thomson, John and Meehan, Richard and Moggs, Jonathan (2017) Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis. Current Opinion in Toxicology, 3. pp. 62-70. ISSN 2468-2020

Tian, Hua and Six, David and Krucker, Thomas and Leeds, Jennifer and Winograd, Nicholas (2017) Subcellular chemical imaging of antibiotics in single bacteria using C60-secondary ion mass spectrometry. Analytical Chemistry, 89 (9). pp. 5050-5057. ISSN 0003-27001520-6882

Tiedt, Ralph and Delach, Scott and Kovats, Steven and Horn, Thomas and Acker, Michael and Schacher Engstler, Barbara and Su, Fei and Caponigro, Giordano (2017) Pre-clinical Selectivity Profile of the CDK4/6 Inhibitor Ribociclib Compared With That of Palbociclib and Abemaciclib. AACR Annual meeting 2017 .

Tosato, Matteo and Marzetti, Emanuele and Cesari, Matteo and Savera, Giulia and Miller, Ram R and Bernabei, Roberto and Landi, Francesco and Calvani, Riccardo (2017) Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging clinical and experimental research. ISSN 1720-8319

Tully, David and Rucker, Paul and Chianelli, Donatella and Williams, Jennifer and Biggart, Agnes and Alper, Phillip and Schmeits, James and Zoll, Jocelyn and Kim, Young and Molteni, Valentina and Liu, Bo and Phimister, Andrew and Joseph, Sean and Laffitte, Bryan and Wu, Xiangdong and Mcnamara, Peter and Seidel, Martin and Mutnick, Daniel and Bursulaya, Badry and Bao, Dingjiu and Groessl, Todd (2017) Discovery of tropifexor (LJN452), a highly potent non-bile acid FXR Agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH). Journal of Medicinal Chemistry, 60 (24). pp. 9960-9973. ISSN 0022-26231520-4804


Umehara, Ken-Ichi and Huth, Felix and Gu, Helen and Schiller, Hilmar and Heimbach, Tycho and He, Handan (2017) Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - A comparison with the chemical inhibition method. Drug Metabolism and Personalized Therapy, 32 (4). pp. 191-200. ISSN 23638915

Unterreiner, Adeline and Stoehr, Natacha and Huppertz, Christine and Calzascia, Thomas and Farady, Christopher and Bornancin, Frederic (2017) Selective MALT1 paracaspase inhibition does not block TNF-a production downstream of TLR4 in myeloid cells. Immunology letters.


Van Berkel, Gary and Kertesz, Vilmos and Orcutt, Matt and Bentley, Adam and Glick, Jim and Flarakos, Jimmy (2017) Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry. Analytical Chemistry, 89 (22). pp. 12578-12586. ISSN 0003-27001520-6882

Van Dam, Joris and Onyango, Kevin Omondi and Midamba, Brian and Groosman, Nele and Hooper, Norman and Spector, Jonathan and Pillai, Goonaseelan and Ogutu, Bernards (2017) An open-source mobile digital platform for clinical trial data collection in low-resource settings. BMJ Innovations. ISSN doi:10.1136/bmjinnov-2016-000164

Van Eis, Maurice and Evenou, Jean-Pierre and Schuler, Walter and Von Matt, Peter and Vangrevelinghe, Eric and Wagner, Juergen and Zenke, Gerhard (2017) Indolyl-naphthyl-maleimides as potent and selective Inhibitors of Protein Kinase C-alpha/beta. Bioorganic and medicinal chemistry letters, 27 (4). pp. 781-786. ISSN 1464-3405

Vapurcuyan, Arpine and Crouthamel, Matthew and Davis, John and Tran, Phi and Natrillo, Adrienne and Zhu, Bing (2017) Transport properties of valsartan, sacubitril, and its active metabolite (LBQ657) as determinants of disposition. Xenobiotica, omline (Publis). pp. 1366-5928. ISSN 0049-8254

Velcicky, Juraj and Miltz, Wolfgang and Oberhauser, Berndt and Orain, David and Vaupel, Andrea and Weigand, Klaus and Dawson King, Janet and Littlewood-Evans, Amanda and Nash, Mark and Feifel, Roland and Loetscher, Pius (2017) Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Verras, Andreas and Waller, Christopher and Gedeck, Peter and Green, Darren and Kogej, Thierry and Raichurkar, Anandkumar and Panda, Manoranjan and Shelat, Anang and Guy, Kip and Papadatos, George and Burrows, Jeremy (2017) Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition. Journal of chemical information and modeling, 57 (3). pp. 445-453. ISSN 1549-960X

Vigne, Solenne and Fanny, Chalmin and Duc, Donovan and Clottu, Aurélie and Apetoh, Lionel and Marc, Lobaccaro and Pot, Caroline and Zhang, Juan and Christen, Isabelle (2017) Interleukin-27 drives oxysterol production that regulate the adaptive Immune response. Frontiers in immunology, 8. ISSN 1664-3224

Vitobello, Antonio and Pouche, Lucie and Romer, Michael and Glogovac, Milica and MacLeod, Kenneth and Ellinger-Ziegelbauer, Heidrun and Westphal, Magdalena and Dubost, Valerie and Stiehl, Daniel Philipp and Dumotier, Berengere and Fekete, Alexander and Moulin, Pierre and Zell, Andreas and Schwarz, Michael and Moreno, Rita and Huang, Jeffrey and Elcombe, Cliff and Henderson, Colin and Wolf, Roland and Moggs, Jonathan and Terranova, Remi (2017) Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver. Toxicological sciences, 158 (2). pp. 367-378. ISSN 1096-0929; 1096-6080

Vorherr, Thomas and D'Alessandro, Pier Luca (2017) Evaluating Cellular Uptake of Drugs with Fluorescent Sensor Proteins. ACS Sensors, 8 (2). pp. 1191-1197.

Vorherr, Thomas and Lewis, Ian and Berghausen, Joerg and Desrayaud, Sandrine and Schaefer, Michael (2017) Modulation of oral bioavailability and metabolism for closely related cyclic hexapeptides. International journal of peptide research and therapeutics..

Vulpetti, Anna and Ruedisser, Simon and Ostermann, Nils and Erbel, Paulus and Zoller, Thomas and Salem, Bahaa and Gerhartz, Bernd and Hommel, Ulrich and Lorthiois, Edwige and Maibaum, Juergen Klaus (2017) Structure-based library design and fragment-based screening for the identification of novel Factor D inhibitors. Journal of medicinal chemistry.

vandenberghe, Rik and Riviere, Marie-Emmanuelle and Caputo, Angelika and Maguire, Paul and farlow, martin and marotta, giovanni and sanchez-valle, raquel and scheltens, philip and Graf, Ana and Ryan, Joseph and Sovago, Judit (2017) Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3 (1). pp. 10-22. ISSN 2352-8737


Waldkirch, Stephnie and d' Errico, Paolo and Sauer, Jonas-Frederic and Savanthrapadian, Shakuntala and Loreth, Desiree and Katzmarski, Natalie and Bartos, Marlene and Prinz, marco and Meyer-Luehmann, Melanie (2017) Seed-induced Abeta deposition impairs adult neurogenesis, triggers neurodegeneration and is modulated by microglia under environmental enrichment. The EMBO Journal, 37 (2). pp. 167-182. ISSN 0261-41891460-2075

Wang, Haizhen and Nicolay, Brandon N. and Chick, Joel and Gao, Xueliang and Geng, Yan and Ren, Hong and Ligon, Keith L. and Roberts, Thomas M. and Gao, Hui and Williams, Juliet and Polyak, Kornelia and Gygi, Steven P. and Dyson, Nicholas J. and Sicinski, Piotr (2017) The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature, 546 (7658). pp. 426-430. ISSN 1476-4687

Wang, Hui-Qin and Halilovic, Ensar and Li, Xiaoyan and Liang, Jinsheng and Cao, Yichen and Rakiec, Daniel and Ruddy, David and Jeay, Sebastien and Li, Nanxin and Williams, Juliet and Sellers, William and Huang, Alan and Li, Fang (2017) Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models. eLife, 6. ISSN 2050-084X

Wang, Tao and Glendinning, John and Grushka, Miriam and Hummel, Thomas and Mansfield, Keith (2017) Drug-induced taste disorders in clinical practice and preclinical safety evaluation. Toxicological Sciences, 156 (2). pp. 315-324. ISSN 1096-0929

Wang, Xinting and Koehne-Voss, Stephan and Anumolu, Sree and Yu, Jing (2017) Population Pharmacokinetics of Tobramycin Inhalation Solution in Pediatric Patients With Cystic Fibrosis. Journal of Pharmaceutical Sciences, 106 (11). pp. 3402-3409. ISSN 1520-6017

Wanke, Florian and Moos, Sonja and Croxford, Andrew L and Heinen, André P and Gräf, Stephanie and Kalt, Bettina and Tischner, Denise and Zhang, Juan and Christen, Isabelle and Bruttger, Julia and Yogev, Nir and Tang, Yilang and Zayoud, Morad and Israel, Nicole and Karram, Khalad and Reißig, Sonja and Lacher, Sonja M and Reichhold, Christian and Mufazalov, Ilgiz A and Ben-Nun, Avraham and Kuhlmann, Tanja and Wettschureck, Nina and Sailer, Andreas W and Rajewsky, Klaus and Casola, Stefano and Waisman, Ari and Kurschus, Florian C (2017) EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell reports, 18 (5). pp. 1270-1284. ISSN 2211-1247

Wei, Jun-Rong and Richie, Daryl and Mostafavi, Mina and Metzger Iv, Louis and Rath, Christopher and Sawyer, William and Takeoka, Ken and Dean, Charles (2017) LpxK is essential for growth of Acinetobacter baumannii ATCC 19606: relationship to toxic accumulation of lipid A pathway intermediates. mSphere, 2 (4).

Welink, Jan and Yang, Eric and Hughes, Nicola and Rago, Brian and Woolf, Eric and sydor, jens and coppola, laura and ackermann, brad and Li, Wenkui and alley, stephen and arnold, mark and berger, isabella and briscoe, chad and buonarati, michael and bustard, mark and cancilla, mark and cho, seongeun and duggan, jeff and fraier, daniela and garofolo, fabio and green, rachel and haidar, sam and hittle, lucinda and ishiiwatabe, akiko and islam, rafig and jenkins, rand and jones, barry and kadavil, john and kassim, sean and kavetska, olga and le blaye, olivier and lee, anita and liu, hanlan and mehl, john and mendes, gustavo and santos, lima and musuku, adien and ramanathan, ragu and saito, yoshiro and savoie, natasha and summerfield, scott and surapaneni, sekhaer and szapacs, matthew and tampal, nilufer and verhaegher, tom and vinter, stephen and whale, emma (2017) 2017 White Paper on recent issues in bioanalysis: Aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: Small molecules, peptides and small molecule biomarkers). Bioanalysis, 9 (22). pp. 1807-1825. ISSN 17576199

Witek, Jagna and Mühlbauer, Max and Keller, Bettina G. and Blatter, Markus and Meissner, Axel and Wagner, Beatrix and Riniker, Sereina (2017) Interconversion Rates Between Conformational States as Rationale for the Membrane Permeability of Cyclosporines. Chemphyschem. ISSN 14394235

Wong, Harvey and Bohnert, Tonika and Damian-Iordache, Valeriu and Gibson, Christopher and Hsu, Cheng-Pang and Krishnatry, Anu Shilpa and Liederer, Bianca M and Lin, Jing and Lu, Qiang and Mettetal, Jerome T and Mudra, Daniel R and Nijsen, Marjoleen JMA and Schroeder, Patricia and Schuck, Edgar and Suryawanshi, Satyendra and Trapa, Patrick and Tsai, Alice and Wang, Haiqing and Wu, Fan (2017) Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: An IQ Consortium PK-PD Discussion Group perspective. Drug Discovery Today. ISSN 18785832

Wozniak-Knopp, Gordana and Stadlmayr, Gerhard and Perthold, Jan Walther and Stadlbauer, Katharina and Woisetschläger, Maximilian and Sun, Haijun and Rüker, Florian (2017) Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments. Protein engineering, design & selection : PEDS, 30 (9). pp. 657-671. ISSN 1741-0134

Wright, Kirk (2017) Biophysics: for HTS hit validation, chemical lead optimization and beyond. Expert opinion on drug discovery, 12 (9). pp. 1-11. ISSN 1746-045X

Wright, Kirk (2017) Comparison of sensitivityBiacore™ S200, Biacore 8K and Biacore T200. GE Heathcare Tech Note.

Wu, Fan and Heimbach, Tycho and Hatsis, Panagiotis and Tang, Hai-Ming and Dugyala, Raviprakash and Yue, Qin and Wang, Tao and He, Handan (2017) Integrated TK–TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs. Journal of Pharmacokinetics and Pharmacodynamics. pp. 1-14. ISSN 15738744

Wylie, Andrew and Schoepfer, Joseph and Jahnke, Wolfgang and Jacob, Sandra and Loo, Alice and Furet, Pascal and Marzinzik, Andreas and Pelle, Xavier and Donovan, Jerry and Zhu, Wenjing and Buonamici, Silvia and Hassan, Quamrul and Lombardo, Franco and Iyer, Varsha and Palmer, Michael and Berellini, Giuliano and Dodd, Stephanie and Thohan, Sanjeev and Bitter, Hans and Branford, Susan and Ross, David and Hughes, Timothy and Petruzzelli, Lilli and Vanasse, K. Gary and Warmuth, Markus and Hofmann, Francesco and Keen, Nicholas and Sellers, William (2017) The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature.


Xie, Xiaoling and Mckay, Daniel and Kulathila, Raviraj and Wright, Kirk and Sage, David and Fortin, Pascal and Lin, Fallon and Chen, Jinyun and Levell, Julian and Pagliarini, Raymond (2017) Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25 (3). pp. 506-513. ISSN 1878-4186

Xiong, Tina and Meister, Glenna E. and Workman, Rachael E. and Kato, Nathaniel C. and Spellberg, Michael J. and Turker, Fulya and Timp, Winston and Ostermeier, Marc and Novina, Carl D. (2017) Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. Scientific Reports, 7 (1). ISSN 2045-2322

Xu, Chi and Govindarajan, Lakshmi Narasimha and Zhang, Yu and Stewart, James and Bichler, Zoë and Jesuthasan, Suresh and Claridge-Chang, Adam and Mathuru, Ajay Sriram and Tang, Wenlong and Zhu, Peixin and Cheng, Li (2017) Lie-X: Depth Image Based Articulated Object Pose Estimation, Tracking, and Action Recognition on Lie Groups. International journal of computer vision, 123 (3). pp. 454-478.


Yan, Si and Shaw, Duncan and Sandham, David and Healy, Mark and Reilly, John and Wang, Bing (2017) Interactions between β2-adrenoceptor Ligands and Membrane: Atomic-level Insights from Magic Angle Spinning NMR. Journal of Medicinal Chemistry, 60 (16). pp. 6867-6879. ISSN 0022-26231520-4804

Yang, Yang and Hardman, Clayton (2017) The Synthesis of Chiral Beta-Amino Acids and Beta-Lactams via Oxidative Cleavage of Chiral Dihydropyridones Derived from Vinylogous Mannich Reaction (VMR). Org. Biomol. Chem., 15 (40). pp. 8576-8593. ISSN 1477-05201477-0539

Yang, Zinger (2017) The Retromer Complex Member VPS35 regulates Iron Homeostasis through mediating Hepcidin-induced Ferroportin Degradation. Harvard University's Electronic Thesis and Dissertation .

Yilmaz, Yildiz and Williams, Gareth and Schiller, Hilmar and Faller, Thomas and Walles, Markus and Camenisch, Gian P. and Umehara, Ken-Ichi and Krähenbühl, Stephan and Manevski, Nenad (2017) Metabolism of AFQ056 (Mavoglurant) by Rat Pulmonary CYP1A1. Xenobiotica, Online. ISSN 0049-8254

Yilmaz, Yildiz and Williams, Gareth and Schiller, Hilmar and Faller, Thomas and Walles, Markus and Camenisch, Gian P. and Umehara, Ken-Ichi and Krähenbühl, Stephan and Manevski, Nenad (2017) Metabolism of AFQ056 (Mavoglurant) by Rat Pulmonary CYP1A1. Xenobiotica. ISSN 1366-5928


Zhang, Qiao and O'Rourke, Jason and Corbel, Stephane and Moran, Rita and Romero, Angelica and Miraglia, Loren and Zhang, Jia and Durrant, Eric and Schmedt, Christian and Sampath, Srinath and Sampath, Srihari (2017) The microprotein Minion controls cell fusion and muscle formation. Nature Communications, 8. ISSN 20411723

Zhang, Xian and Goette, Marjo and Ibig-Rehm, Yvonne and Kamke, Marion and Schuffenhauer, Ansgar and Beisner, Daniel and Siebert, Daniela and Guerini, Danilo and Bonamy, Ghislain and Gabriel, Daniela and Bodendorf, Ursula (2017) Multiparametric analysis of a high-content ultra-high-throughput screen identifies inhibitors of the intramembrane protease SPPL2a. SLAS discovery. ISSN 2472-5560

Zhou, Enhua and Paolucci, Michael and Dryja, Ted and Manley, Ted and Rice, Dennis and Prasanna, Ganesh and Chen, Amy (2017) A compact whole-eye perfusion system to evaluate pharmacologic responses of outflow facility. Investigative Ophthalmology and Visual Science, 58 (7). pp. 2991-3003. ISSN 15525783

This list was generated on Mon Dec 9 05:41:59 2019 UTC.


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