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Helios - History and Anatomy of a successful in-House Enterprise High-Throughput Screening and Profiling Data Analysis System

Gubler, Hanspeter and Clare, Nicholas and Galafassi, Laurent and Girod, Michel and Herr, Guy and Geissler, Uwe (2017) Helios - History and Anatomy of a successful in-House Enterprise High-Throughput Screening and Profiling Data Analysis System. SLAS Discovery, 23 (5). pp. 474-488. ISSN 2472-5552

Abstract

We describe the main characteristics of the Novartis ‘Helios’ data analysis software system for plate based screening and profiling assays which was designed and built already about 11 years ago. It is now in productive use for already more than 10 years and is one of the important standard software applications running for a large user community at all NIBR sites globally A high degree of automation is reached by embedding the data analysis capabilities into a software ecosystem which deals with the management of samples, plates and result data files, including automated data loading. The application provides a series of analytical procedures, ranging from very simple to advanced, which can easily be assembled by users in very flexible ways. This also includes the automatic derivation of a large set of quality control (QC) characteristics at every step. Any of the raw, intermediate and final results and QC-relevant quantities set can be easily explored through linked visualizations. Links to global assay metadata management, data warehouses and an electronic lab notebook system are also in place. Automated transfer of relevant data to data warehouses and electronic lab notebook systems are implemented as well.

Item Type: Article
Keywords: High-Throughput Screening, Data Quality Control, Screening Data Analysis Software, Advanced Plate Data Analysis, Advanced Dose Response Curve Analysis
Date Deposited: 07 Jun 2018 00:45
Last Modified: 07 Jun 2018 00:45
URI: https://oak.novartis.com/id/eprint/33972

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