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Sphingosine 1-phosphate signalling in allogeneic hematopoietic stem cell transplantation (HSCT)

Smith, Philip and O’Sullivan, Catherine and Gergely, Peter (2017) Sphingosine 1-phosphate signalling in allogeneic hematopoietic stem cell transplantation (HSCT). International Journal of Molecular Sciences , 18 (10). pp. 1-12. ISSN 18102027

Abstract

Allogeneic haemopoietic stem cell transplantation (HSCT) is increasingly used to treat
haematological malignant diseases via the graft-versus-leukaemia (GvL) or graft-versus-tumour
effects. Although improvements in infectious disease prophylaxis, immunosuppressive treatments,
supportive care, and molecular based tissue typing have contributed to enhanced outcomes, acute
graft-versus-host disease and other transplant related complications still contribute to high
mortality and significantly limit the more widespread use of HSCT. Sphingosine 1-phosphate (S1P)
is a zwitterionic lysophospholipid that has been implicated as a crucial signaling regulator in many
physiological and pathophysiological processes including multiple cell types such as macrophages,
dendritic cells, T cells, T regulatory cells and endothelial cells. Recent data suggested important
roles for S1P signaling in engraftment, graft-versus-host disease (GvHD), GvL and other processes
that occur during and after HSCT. Based on such data, pharmacological intervention via S1P
modulation may have the potential to improve patient outcome by regulating GvHD and
enhancing engraftment while permitting effective GvL.

Item Type: Article
Date Deposited: 17 Oct 2017 00:45
Last Modified: 17 Oct 2017 00:45
URI: https://oak.novartis.com/id/eprint/33785

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