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Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation

Shimshek, Derya R. and Bus, Thorsten and Schupp, Bettina and Jensen, Vidar and Marx, Verena and Layer, Liliana E. and Köhr, Georg and Sprengel, Rolf (2017) Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation. Frontiers in Molecular Neuroscience, 10. ISSN 1662-5099

Abstract

Spatial working memory (SWM) and the classical, tetanus-induced long-term
potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on
L-a-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing
GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout
mice LTP and SWM deficits could be partially recovered by transgenic re-installation of
full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal
LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the
activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site
truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LTP recovery
improved the SWM performance of GluA1-deficient mice suggesting a specific function
of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and
its associated behavior.

Item Type: Article
Date Deposited: 18 Jul 2017 00:45
Last Modified: 18 Jul 2017 00:45
URI: https://oak.novartis.com/id/eprint/33568

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