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Evaluation of combustion AMS “MICADAS” for ADME studies

Lozac'H, Frederic and Fahrni, Simon and De Maria, Daniele and Welte, Caroline and Synal, Hans-Arno and Pearson, David and Walles, Markus and Camenisch, Gian P. (2017) Evaluation of combustion AMS “MICADAS” for ADME studies. Bioanalysis (bio-20). ISSN ISSN 1757-6180

Abstract

Today, combustion AMS (accelerator mass spectrometry) technology, such as "MICADAS", is considered to enable completion of the human ADME study much earlier and, as a consequence, might represent an opportunity to change the current drug development paradigm.
To evaluate the applicability of this method, we successfully performed: a) the validation of MICADAS for radioactivity quantification in biomatrices and, b) a rat ADME study of Leniolisib (CDZ173), where conventional methodology was assessed against a microtracer and “MICADAS” approach.

Item Type: Article
Keywords: MICADAS, combustion accelerator mass spectrometry, cAMS, human ADME, microtracer, Leniolisib, mass balance, metabolism, clearance
Date Deposited: 07 Mar 2018 00:45
Last Modified: 07 Mar 2018 00:45
URI: https://oak.novartis.com/id/eprint/34140

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