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Peptide-membrane interaction between targeting and lysis

Stutz, Katharina and Hiss, Jan A. and Schneider, Petra and Blatter, Markus and Pfeiffer, Bernhard and Posselt, Gernot and Schneider, Gisbert (2017) Peptide-membrane interaction between targeting and lysis. ACS Chemical Biology. ISSN 1554-89291554-8937

Abstract

Certain cationic peptides interact with biological membranes. These often-complex interactions can result in peptide targeting to the membrane, or in membrane permeation, rupture, and cell lysis. We investigated the relationship between the structural features of membrane-active peptides and these effects, to better understand these processes. To this end, we employed a computational method for morphing a membranolytic antimicrobial peptide into a mitochondrial targeting peptide by “directed simulated evolution”. The results obtained demonstrate that superficially subtle sequence modifications can strongly affect the peptides’ membranolytic and membrane-targeting abilities. Spectroscopic analyses suggest that N- and C-terminal structural flexibility plays a crucial role in determining the mode of peptide-membrane interaction.

Item Type: Article
Date Deposited: 29 Aug 2017 00:45
Last Modified: 29 Aug 2017 00:45
URI: https://oak.novartis.com/id/eprint/32031

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