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Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy.

Radonjic-Hoesli, Susanne and Wang, Xiaoliang and de Graauw, Elisabeth and Merz-Stoeckle, Christina and Styp-Rekowska, Beata and Hlushchuk, Ruslan and Simon, Dagmar and Spaeth, Peter J and Yousefi, Shida and Simon, Hans-Uwe (2017) Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. The Journal of allergy and clinical immunology. ISSN 1097-6825

Abstract

Eosinophils are a subset of granulocytes which can be involved in the pathogenesis of different diseases, including allergy. Their effector functions are closely linked to their cytotoxic granule proteins. The release takes place by several different mechanisms, one of which is cytolysis, which is associated with the release of intact granules, so-called clusters of free eosinophil granules. The mechanism underlying this activation-induced form of cell death in eosinophils has remained unclear.

Item Type: Article
Date Deposited: 26 May 2017 00:45
Last Modified: 26 May 2017 00:45
URI: https://oak.novartis.com/id/eprint/33091

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