Lu, Chunliang, Dong, Minyu and Zhu, Hugh (2017) Regioselective Bromination of Thieno[2′,3′:4,5]pyrrolo[1,2‑d][1,2,4]triazin-8(7H)‑one and Sequential Suzuki Couplings. The Journal of Organic Chemistry. ISSN 0022-32631520-6904

Abstract

Regioselective bromination of thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7H)-one at 2 or 9-position was achieved by modulating the basicity of the reaction conditions. An anion directed site-specific bromination mechanism was proposed. In addition, a one-pot bromination-Suzuki coupling protocol was developed for quick access of analogs at 9-position.

Item Type:	Article
Date Deposited:	31 Aug 2017 00:45
Last Modified:	31 Aug 2017 00:45
URI:	https://oak.novartis.com/id/eprint/33389