Holzer, Philipp (2017) Discovery of potent and selective p53-MDM2 protein-protein interaction inhibitors as anticancer drugs. Chimia : international journal for chemistry, 71 (10). pp. 716-721. ISSN 0009-4293

Abstract

As a result of our efforts to discover novel inhibitors of the p53-MDM2 protein-protein interaction useful for the treatment of cancer, the potent and selective MDM2 inhibitors NVP-CGM097 and NVP-HDM201 with excellent in vivo profile were selected as clinical candidates and are currently in phase 1 clinical development. This review article provides an overview of the program history, the applied pharmacophore model and the discovery story of these novel p53-MDM2 inhibitor investigational drugs.

Item Type:	Article
Date Deposited:	07 Dec 2017 00:45
Last Modified:	07 Dec 2017 00:45
URI:	https://oak.novartis.com/id/eprint/33494