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Understanding Flavin-Dependent Halogenase Reactivity via Sub-strate Activity Profiling

Tan, Kian and Grob, Jonathan and Hajdin, Christine and Siuti, Piro and Lilly, Jeremiah and Andorfer, Mary and Chael, Julia and Lewis, Jared (2017) Understanding Flavin-Dependent Halogenase Reactivity via Sub-strate Activity Profiling. ACS Catalysis, 7 (3). pp. 1897-1904. ISSN 2155-54352155-5435

Abstract

The activity of eight different FDHs on 102 low molecular weight aromatic compounds was used to generate substrate activity profiles for these enzymes. These profiles provided fundamental insights into how substrate class, functional group substitution, electronic activation, and binding impact FDH activity and selectivity. These data, in turn, provide a useful framework for understanding and exploiting FDH reactivity in organic synthesis.

Item Type: Article
Date Deposited: 27 Apr 2017 00:45
Last Modified: 27 Apr 2017 00:45
URI: https://oak.novartis.com/id/eprint/30509

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