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A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters

Lima, Fabio and Sharma, Upendra and Grunenberg, Lars and Saha, Debasmita and Johannsen, Sandra and Sedelmeier, Joerg Mathias and Van der Eycken, Erik and Ley, Steven (2017) A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters. Angewandte Chemie. International edition.

Abstract

We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin-3-ol or 4-dimethylaminopyridine combined with a photoredox catalyst to
generate carbon radicals from either boronic esters or boronic acids. This system enabled a wide range of alkyl boronic esters and aryl or alkyl boronic acids to react via radical addition with electron-deficient olefins to efficiently form C–C bonds in a redox neutral fashion.

Item Type: Article
Date Deposited: 14 Nov 2017 00:45
Last Modified: 14 Nov 2017 00:45
URI: https://oak.novartis.com/id/eprint/34239

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